This landmark work is indispensable for anyone studying anxiety or seeking to deliver effective psychological and pharmacological treatments. David H. Barlow comprehensively examines the phenomena of anxiety and panic, their origins, and the roles that each plays in normal and pathological functioning. Chapters coauthored by Barlow with other leading experts then outline what is known about the classification, presentation, etiology, assessment, and treatment of each of the DSM-IV anxiety disorders. A definitive resource for researchers and clinicians, this is also an ideal text for graduate-level courses.
Many people think prisons are all the same-rows of cells filled with violent men who officials rule with an iron fist. Yet, life behind bars varies in incredible ways. In some facilities, prison officials govern with care and attention to prisoners' needs. In others, officials have remarkably little influence on the everyday life of prisoners, sometimes not even providing necessities like food and clean water. Why does prison social order around the world look so remarkably different? In The Puzzle of Prison Order, David Skarbek develops a theory of why prisons and prison life vary so much. He finds that how they're governed-sometimes by the state, and sometimes by the prisoners-matters the most. He investigates life in a wide array of prisons-in Brazil, Bolivia, Norway, a prisoner of war camp, England and Wales, women's prisons in California, and a gay and transgender housing unit in the Los Angeles County Jail-to understand the hierarchy of life on the inside. Drawing on economics and a vast empirical literature on legal systems, Skarbek offers a framework to not only understand why life on the inside varies in such fascinating and novel ways, but also how social order evolves and takes root behind bars.
Knoke and Yang′s handy primer on social network analysis offers a concise introduction to basic network concepts, data collection, and network analytical methodology.
It is the most famous home movie of all time, the most closely analyzed 26 seconds of film ever shot, the most disturbing visual record of what many have called “the crime of the century.” In 486 frames—a mere six feet of celluloid—Abraham Zapruder’s iconic film captures from beginning to end the murder of President John F. Kennedy in broad daylight. An essential piece of evidence, the film has become nearly synonymous with the assassination itself and has generated decades of debate among conspiracy theorists and defenders of the Warren Commission’s official report. Until now, however, no scholar has produced a comprehensive book-length study of the film and its relation to the tragic events of November 22, 1963. David Wrone, one of our nation’s foremost authorities on the assassination, re-examines Zapruder’s film with a fresh eye and a deep knowledge of the forensic evidence. He traces the film’s history from its creation on the “grassy knoll” by Dallas dressmaker Zapruder through its initial sale to Life magazine and early reproductions and its analysis by the Warren Commission and countless assassination researchers, licensing by the Zapruder family, legal battles over bootleg copies, and sale to the federal government for sixteen million dollars. Wrone’s major contribution, however, is to demonstrate how a close examination of the film itself necessarily refutes the Warren Commission’s lone-gunman and single-bullet theories. The film, as he reminds us, provides a scientifically precise timeline of events, as well as crucial clues regarding the timing, number, origins, and impact of the shots fired that day. Analyzing the film frame-by-frame in relation to other evidence—including two key photos by Phil Willis and Ike Altgens—he builds a convincing case against the official findings. Without fanfare, he concludes that more than three gunshots were fired from more than one direction and that most likely none were fired by alleged assassin Lee Harvey Oswald. If true, then JFK’s death was the result of a conspiracy, for the Commission’s nonconspiracy conclusion requires a maximum of three shots and one gunman. Wrone, however, does not speculate as to who actually shot JFK or why—or even if Oswald was a part of the conspiracy. In fact, he is no fan of conspiracy-think and is just as critical of the legion of conspiracy theorists as he is of the Warren Commission (which, he reveals, crushed dissent within its own ranks). Doggedly pursuing the evidence wherever it leads, Wrone has produced a meticulous, clear-eyed, and provocative new reading of this remarkable cinematic Rosetta Stone.
In his day Walter Wellman (1858-1934) was one of America's most famous men. To his contemporaries, he seemed like a character from a Jules Verne novel. He led five expeditions in search of the North Pole, two by dogsled and three by dirigible airship, and in 1910 made the first attempt to cross the Atlantic Ocean by air--which the self-styled expert on aerial warfare saw as a mission of world peace. He endured hardships, cheated death on more than one occasion, and surrounded himself with a team of assistants as eccentric and audacious as he was. In addition to his daring adventures, Wellman became a nationally known political reporter and unofficial spokesman for the McKinley and Roosevelt administrations. He was not the first newspaper-sponsored adventurer, but more than any of his predecessors he turned exploration into a real-time media event, and his reputation both flourished and suffered because of it. Wellman lived during a time of rapid social and technological change, when explorers were racing to fill in the last remaining blank spots on the map and when aviation promised to fulfill humanity's greatest hopes and darkest fears. Flight to the Top of the World is a window into Wellman's time and illuminates many of its dreams and contradictions.
After three decades of undying adoration, KISS fans will get their first fully authorized and total access look at the band who loves to "rock 'n' roll all nite and party every day!" Twenty years ago, KISS officially revealed the faces behind the stage makeup, and fans all over the world got their first look at the band. Now, in KISS: BEHIND THE MASK, the band's legion of fans and music enthusiasts alike will get to know the men behind the stage personas. After 30 years as a band, KISS are more than just a rock 'n' roll institution-they are legends. For decades, they have consistently remained among the most successful acts in the history of popular music. KISS' legendary stagemanship and extreme theatrics are well known by two generations of rock fans, and they are already pulling in the next one. Now, through their own words and exclusive material contributed by some of the biggest rock stars in the industry, KISS: BEHIND THE MASK will tell the band's full story.
For centuries, men dreamed of cutting a canal across the Florida peninsula. Intended to reduce shipping times, it was championed in the early twentieth century as a way to make the mostly rural state a center of national commerce and trade. Rejected by the Army Corps of Engineers as "not worthy," the project received continued support from Florida legislators. Federal funding was eventually allocated and work began in the 1930s, but the canal quickly became a lightning rod for controversy. Steven Noll and David Tegeder trace the twists and turns of the project through the years, drawing on a wealth of archival and primary sources. Far from being a simplistic morality tale of good environmentalists versus evil canal developers, the story of the Cross Florida Barge Canal is a complex one of competing interests amid the changing political landscape of modern Florida. Thanks to the unprecedented success of environmental citizen activists, construction was halted in 1971, though it took another twenty years for the project to be canceled. Though the land intended for the canal was deeded to the state and converted into the Cross Florida Greenway, certain aspects of the dispute--including the fate of Rodman Reservoir--have yet to be resolved.
Glaciers and Glaciation is the classic textbook for all students of glaciation. Stimulating and accessible, it has established a reputation as a comprehensive and essential resource. In this new edition, the text, references and illustrations have been thoroughly updated to give today's reader an up-to-the minute overview of the nature, origin and behaviour of glaciers and the geological and geomorphological evidence for their past history on earth. The first part of the book investigates the processes involved in forming glacier ice, the nature of glacier-climate relationships, the mechanisms of glacier flow and the interactions of glaciers with other natural systems such as rivers, lakes and oceans. In the second part, the emphasis moves to landforms and sediment, the interpretation of the earth's glacial legacy and the reconstruction of glacial depositional environments and palaeoglaciology.
Molluscs comprise the second largest phylum of animals (after arthropods), occurring in virtually all habitats. Some are commercially important, a few are pests and some carry diseases, while many non-marine molluscs are threatened by human impacts which have resulted in more extinctions than all tetrapod vertebrates combined. This book and its companion volume provide the first comprehensive account of the Mollusca in decades. Illustrated with hundreds of colour figures, it reviews molluscan biology, genomics, anatomy, physiology, fossil history, phylogeny and classification. This volume includes general chapters drawn from extensive and diverse literature on the anatomy and physiology of their structure, movement, reproduction, feeding, digestion, excretion, respiration, nervous system and sense organs. Other chapters review the natural history (including ecology) of molluscs, their interactions with humans, and assess research on the group. Key features of both volumes: up to date treatment with an extensive bibliography; thoroughly examines the current understanding of molluscan anatomy, physiology and development; reviews fossil history and phylogenetics; overviews ecology and economic values; and summarises research activity and suggests future directions for investigation. Winston F Ponder was a Principal Research Scientist at The Australian Museum in Sydney where he is currently a Research Fellow. He has published extensively over the last 55 years on the systematics, evolution, biology and conservation of marine and freshwater molluscs, as well as supervised post graduate students and run university courses. David R. Lindberg is former Chair of the Department of Integrative Biology, Director of the Museum of Paleontology, and Chair of the Berkeley Natural History Museums, all at the University of California. He has conducted research on the evolutionary history of marine organisms and their habitats on the rocky shores of the Pacific Rim for more than 40 years. The numerous elegant and interpretive illustrations were produced by Juliet Ponder.
Advances in forensic odontology have led to improvements in dental identification for individual cases as well as in disaster victim identification (DVI). New and updated technologies mean advances in bitemark analysis and age estimation. Growth in the field has strengthened missing persons networks leading to more and faster identifications of un
Global Environments through the Quaternary delves into the environmental changes that have taken place during the Quaternary: the two to three million years during which man has inhabited the Earth. It is essential reading for any students seeking a balanced, objective overview of this truly interdisciplinary subject.
This book is the first comprehensive volume on conifers detailing their genomes, variations, and evolution. The book begins with general information about conifers such as taxonomy, geography, reproduction, life history, and social and economic importance. Then topics discussed include the full genome sequence, complex traits, phenotypic and genetic variations, landscape genomics, and forest health and conservation. This book also synthesizes the research included to provide a bigger picture and suggest an evolutionary trajectory. As a large plant family, conifers are an important part of economic botany. The group includes the pines, spruces, firs, larches, yews, junipers, cedars, cypresses, and sequoias. Of the phylum Coniferophyta, conifers typically bear cones and evergreen leaves. Recently, there has been much data available in conifer genomics with the publication of several crop and non-crop genome sequences. In addition to their economic importance, conifers are an important habitat for humans and animals, especially in developing parts of the world. The application of genomics for improving the productivity of conifer crops holds great promise to help provide resources for the most needy in the world.
The Future Boldly Imagined From Breathtaking New Perspectives The world as we will know it is far different from the future once predicted in simpler times. For this newest collection of the finest short form SF to appear in print over the preceding year, acclaimed editors and anthologists David G. Hartwell and Kathryn Cramer have gathered remarkable works that reflect a new sensibility. Courageous and diverse stories from some of the finest authors in the field grace this amazing volume -- adventures and discoveries, parables and warnings, carrying those eager to fly to far ends of a vast, ever-shifting universe of alien worlds, strange cultures, and mind-bending technologies. Tomorrow has never been as spellbinding, terrifying, or transforming as it is here, today, in these extraordinary pages. Hang on! New tales from: Kage Baker • Gregory Benford • Terry BissonRick Moody • Michael Swanwick • John Varley and many more
Forensic Odontology: Principles and Practice details the aspects necessary to become an accomplished forensic odontologist, including an illustration of the skills necessary to become an expert witness. The book is ideal for both the experienced and novice forensic odontologist, covering many fields of expertise, including civil and criminal matters. The civil side involves standard of care and personal injury matters, while the criminal side involves not only dental identification, but management of mass fatality incidents, age assessment, child and elder abuse, and bitemark analysis. - Provides a comprehensive review of forensic odontology, including the skills necessary to become a competent expert witness - Covers the fields of forensic odontology, the basic skills, legal aspects, legal precedents, report writing and expert witness testimony - Includes numerous illustrations, including charts and graphs, along with B&W and color images
Since the first sailing ships spied the Antarctic coastline in 1820, the frozen continent has captured the world's imagination. David Day's brilliant biography of Antarctica describes in fascinating detail every aspect of this vast land's history--two centuries of exploration, scientific investigation, and contentious geopolitics. Drawing from archives from around the world, Day provides a sweeping, large-scale history of Antarctica. Focusing on the dynamic personalities drawn to this unconquered land, the book offers an engaging collective biography of explorers and scientists battling the elements in the most hostile place on earth. We see intrepid sea captains picking their way past icebergs and pushing to the edge of the shifting pack ice, sanguinary sealers and whalers drawn south to exploit "the Penguin El Dorado," famed nineteenth-century explorers like Scott and Amundson in their highly publicized race to the South Pole, and aviators like Clarence Ellsworth and Richard Byrd, flying over great stretches of undiscovered land. Yet Antarctica is also the story of nations seeking to incorporate the Antarctic into their national narratives and to claim its frozen wastes as their own. As Day shows, in a place as remote as Antarctica, claiming land was not just about seeing a place for the first time, or raising a flag over it; it was about mapping and naming and, more generally, knowing its geographic and natural features. And ultimately, after a little-known decision by FDR to colonize Antarctica, claiming territory meant establishing full-time bases on the White Continent. The end of the Second World War would see one last scramble for polar territory, but the onset of the International Geophysical Year in 1957 would launch a cooperative effort to establish scientific bases across the continent. And with the Antarctic Treaty, science was in the ascendant, and cooperation rather than competition was the new watchword on the ice. Tracing history from the first sighting of land up to the present day, Antarctica is a fascinating exploration of this deeply alluring land and man's struggle to claim it.
The origins of these Manuals lie in the increasing interest and importance of questions concerning the manner in which the freedom of religion and belief is to be enjoyed in Europe today, and how freedom of expression can be reconciled with other rights in a multi-cultural society. These volumes, written by human rights experts and commissioned by the Council of Europe, offer an overview of two contentious topics - the wearing of religious symbols in public areas and the issue of hate speech - and supply insight into key concepts in the jurisprudence of the Court, the role and responsibilities of the state and individuals, key definitions and essential questions for policy makers. This title is published in two parts, one in English and one in French. This publication is only available as a set.
This book directly addresses controversial issues like climate change, carbon taxes, fracking, offshoring, urban sprawl, globalization, income inequality, regulation, corruption, compliance and enforcement, providing an informed basis for mapping the way forward. Based on his experience consulting on hundreds of industrial mega-projects, Jacoby reveals dark secrets of international supply chains for familiar products such as coffee, bottled water, gasoline, and electronic devices, and explains how government policies and business norms around the world have evolved to allow practices that can deplete natural resources, blight native landscapes, and tolerate inhumane working conditions. Rich in facts and deep with first-hand experiences from around the world, Jacoby challenges embedded thinking about growth and progress, convenience, comfort, and quality of life. The book proposes a bold and realistic new policy framework that is ground-breaking and achievable for industry, government, and consumers, and supports the plan with achievable metrics, targets, and accountabilities. While his first book promoted global supply chain optimization based on industry “best practices” and his second book fine-tuned the techniques for oil, gas, and power companies, Jacoby takes a holistic perspective in this third book, acknowledging and proposing solutions for the problems caused in part by these “optimized” global supply chains.
A unique and accessible guide to contemporary psychodynamic therapy and its applications. An author line-up of experienced educators guide the reader through the breadth of psychodynamic concepts in a digestible and engaging way. The key applications of psychodynamic psychotherapy to a range of presentations are explored, including anxiety, depression, problematic narcissism as well as the dynamics of 'borderline' states. Specific chapters cover the dynamics of anger and aggression, and working with people experiencing homelessness. A valuable resource for novice and experienced therapists, presenting a clear, comprehensive review of contemporary psychodynamic theory and clinical practice. Highly relevant for general clinicians, third-sector staff and therapists alike, the authors also examine staff-client dynamics and the development of psychologically-informed services underpinned by reflective practice. Part of the Cambridge Guides to the Psychological Therapies series, offering all the latest scientifically rigorous, and practical information on a range of key, evidence-based psychological interventions for clinicians.
This book provides an understanding of the role of human activities in accelerating change in global carbon cycling summarizes current knowledge of the contemporary carbon budget. Starting from the geological history, this volume follows a multidisciplinary approach to analyze the role of human activities in perturbing carbon cycling by quantifying changes in different reservoirs and fluxes of carbon with emphasis on the anthropogenic activities, especially after the industrial revolution. It covers the role of different mitigation options – natural ecological, engineered, and geoengineered processes as well as the emerging field of climate engineering in avoiding dangerous abrupt climate change. Although the targeted audience is the educators, students, researchers and scientific community, the simplified analysis and synthesis of current and up to date scientific literature makes the volume easier to understand and a tool policy makers can use to make an informed policy decisions.
The Covid-19 pandemic reinforced the perception that capitalism is in crisis, that the future is volatile, uncertain, complex and ambiguous, and that, increasingly, our thinking about it and ability to manage and organize ourselves within it, are challenges we are ill-equipped for. Despite the efforts of many writers, and a surfeit of manuscripts concerning the need to rethink capitalism, questions concerning the struggle for social and economic justice remain unanswered. While some suggest that with corrective action, businesses can save the world, there is an acceptance that they cannot do so alone. However, while governments might strengthen their institutions, enacting more effective policies, the challenge is simply laid bare at the feet of industry and commerce. Is the challenge to confront the establishment just too big to face? Government institutions and the barons of industry and commerce are but interrelated, interconnected, interplaying components in one socio-economic system. This book offers readers a progressive, radical and academic provocation of that system; it also proposes a field of Applied Negative Dialectics. In 'Reimagining Capitalism', Atkinson confronts the need to rethink capitalism and presents an integrated range of thinking through a lens of applied negative dialectics, questioning how and why things might have occurred, and where and how we might begin to improve them.
Captain Alicia DeVries, Imperial Cadre, has been many things in her life. An Imperial Marine, dedicated to the protection and preservation of the Terran Empire she loves. An Imperial Cadre drop commando, personal liegewoman of Emperor Seamus II, whom she honors and reveres. Hero of the Terran Empire, one of only three living holders of the Banner of Terra. And now, outcast, rogue, pirate ... and madwoman." "From the time she graduated from high school, Alicia DeVries knew what she wanted to do with her life, and she did it well. On planets like Gyangtse, Chengchou, Fuller, and Louvain - in cities like Zhikotse and Shallingsport - she's put her life on the line in defense of her Empire and Emperor again and again. She's given her blood, and the lives of men and women closer to her than brothers and sisters." "But her dead have been betrayed in the name of political expediency. The justice they deserved has been denied, and a brokenhearted Alicia DeVries has resigned her commission and retired to the colony world of Mathison with her family to begin a new life." "Yet Alicia is still a warrior, and the pirates who attacked Mathison, tortured and murdered her family, and left her for dead, are about to discover just how big a mistake they made." "Imperial Intelligence can't find them. The Imperial Fleet can't catch them. Local defenses can't stop them. But Alicia has stolen an imperial A1 starship from the bleeding edge of technology and set out to teach them what vengeance truly is." "Her fellow veterans think she's gone mad, the Fleet has shoot-on-sight orders, and the "pirates" have allies at the highest levels of the Imperial government. But Alicia DeVries has two allies of her own. Allies no one knows about. Allies as implacable as she is: a self-aware computer, and a creature from the mists of Old Earth's most ancient legends."--BOOK JACKET.
David Kellogg Lewis (1941-2001) was one of the most influential philosophers of the twentieth century. He made significant contributions to almost every area of analytic philosophy including metaphysics, philosophy of language, philosophy of mind, and philosophy of science, and set the agenda for various debates in these areas which carry on to this day. In several respects he remains a contemporary figure, yet enough time has now passed for historians of philosophy to begin to study his place in twentieth century thought. His philosophy was constructed and refined not just through his published writing, but also crucially through his life-long correspondence with fellow philosophers, including leading figures such as D.M. Armstrong, Saul Kripke, W.V. Quine, J.J.C. Smart, and Peter van Inwagen. His letters formed the undercurrent of his published work and became the medium through which he proposed many of his well-known theories and discussed a range of philosophical topics in depth. A selection of his vast correspondence over a 40-year period is presented here across two volumes. Structured in three parts, Volume 2 explores Lewis' contributions to philosophical questions of mind, language, and epistemology respectively. The letters address Lewis's answer to the mind-body problem, propositional attitudes and the purely subjective character of conscious experience, meaning and reference as well as grammar in language, vagueness, truth in fiction, the problem of scepticism, and Lewis's work on decision theory and rationality, among many other topics. This volume is a testament to Lewis' achievement in these areas and will be an invaluable resource for those exploring contemporary debates concerning mind, language, and epistemology.
A best-seilling author explores his assertion that Barack Obama is the most destructive president in American history. Reprint. 150,000 first printing.
Biologists have known for decades that many traits involved in competition for mates or other resources and that influence mate choice are exaggerated, and their expression is influenced by the individuals' ability to tolerate a variety of environmental and social stressors. Evolution of Vulnerability applies this concept of heightened sensitivity to humans for a host of physical, social, psychological, cognitive, and brain traits. By reframing the issue entirely, renowned evolutionary psychologist David C. Geary demonstrates this principle can be used to identify children, adolescents, or populations at risk for poor long-term outcomes and identify specific traits in each sex and at different points in development that are most easily disrupted by exposure to stressors. Evolution of Vulnerability begins by reviewing the expansive literature on traits predicted to show sex-specific sensitivity to environmental and social stressors, and details the implications for better assessing and understanding the consequences of exposure to these stressors. Next, the book reviews sexual selection—mate competition and choice—and the mechanisms involved in the evolution of condition dependent traits and the stressors that can undermine their development and expression, such as poor early nutrition and health, parasites, social stress, and exposure to man-made toxins. Then it reviews condition dependent traits (physical, behavioral, cognitive, and brain) in birds, fish, insects, and mammals to demonstrate the ubiquity of these traits in nature. The focus then turns to humans and covers sex-specific vulnerabilities in children and adults for physical traits, social behavior, psychological wellbeing, and brain and cognitive traits. The sensitivity of these traits is related to exposure to parasites, poor nutrition, social maltreatment, environmental toxins, chemotherapy, and Alzheimer's disease, among others. The book concludes with an implications chapter that outlines how to better assess vulnerabilities in children and adults and how to more fully understand how, why, and when in development some types of environmental and social stressors are particularly harmful to humans. - Describes evolved sex differences, providing predictions on the traits that will show sex-specific vulnerabilities - Presents an extensive review of condition-dependent traits in non-human species, greatly expanding existing reviews published in scientific journals, and more critically, extending these to humans - Applies condition-dependent traits to humans to identify children, adolescents, or populations at risk for poor long-term outcomes
The second edition of this comprehensive textbook for students of Neuropsychology gives a thorough overview of the complex relationship between brain and behaviour. With an excellent blend of clinical, experimental and theoretical coverage, it draws on the latest research findings from neuroscience, cognitive neuroscience, neurochemistry, clinical neuropsychology and neuropsychology to provide students with new insights in this fast moving field. The book is organised around the main neuropsychological disorders in the areas of perception, executive dysfunction, attention, memory, cerebral asymmetry, language, emotion and consciousness. There is a clear emphasis on bridging the gap between theory and practice with links throughout to clinical issues of both assessment and rehabilitation to build a clear understanding of the application of the theoretical issues. The final section in each chapter illustrates the importance of a more systematic approach to intervention, which takes into account theoretical views of recovery from brain damage. New to this edition: A new chapter format that includes a "basic topic" section, which contains up-to-date essential knowledge of the topic and a "further topics" section for a more advanced treatment of the area. A new section on neuroscientific approaches to rehabilitation in each chapter to make links between scientific knowledge and clinical treatment. A brand new chapter on consciousness A new full colour layout with increased pedagogical features, including key terms, section summaries, ‘study questions’ and improved presentation of figures and brain diagrams A companion website including related weblinks, guidance on answering the ‘study questions’, and flashcards. This book will be invaluable for undergraduate students in Neuropsychology and students who wish to take the subject further to the various clinical fields.
Behavioral Dentistry, Second Edition, surveys the vast and absorbing topic of the role of behavioral science in the study and clinical practice of dentistry. An understanding of social sciences has long been a central part of dental education, and essential for developing a clinician’s appreciation of human behavior as it affects efficient dental treatment. This book gathers together contributions from leading experts in each of the major subspecialties of behavioral dentistry. Its aim is not merely to provide the student and clinician with a comprehensive review of the impressive literature or discussion of the theoretical background to the subject, but also with a practical guide to adapting the latest techniques and protocols and applying them to day-to-day clinical practice. This second edition of Behavioral Dentistry discusses biobehavioral processes, including the psychobiology of inflammation and pain, oral health and quality of life, saliva health, and hypnosis in dentistry. The book goes on to examine anxiety, fear, and dental and chronic orofacial pain, and then reviews techniques for designing and managing behavior change. It concludes with a section on professional practice, including care of special needs, geriatric, and diabetic patients, and interpersonal communication in dental education.
This book provides a concise overview of the current context and types of public sector audit and the varied structures within which public sector audit is practised across the world. It summarises the objectives of public sector audit as well as explores the role of the International Organisation of Supreme Audit Institutions in providing guidance to these. Drawing on public and private sector audit as well as the views of academics and practitioners on public sector audit, it provides a unique research-based guide to the current issues and future challenges in the field.
An expert guide to targeting protein kinases in cancer therapy Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells. Because of this fact, pharmaceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal roadblocks to sever their malignant means of communication. Complete with full-color presentations, Targeting Protein Kinases for Cancer Therapy defines the structural features of protein kinases and examines their cellular functions. Combining kinase biology with chemistry and pharmacology applications, this book enlists emerging data to drive the discovery of new cancer-fighting drugs. Valuable information includes: Comprehensive overviews of the major kinase families involved in oncology, integrating protein structure and function, and providing important tools to assist pharmaceutical researchers to understand and work in this dynamic area of cancer drug research Focus on small molecule inhibitors as well as other therapeutic modalities Discussion of kinase inhibitors that have entered clinical trials for the treatment of cancer, with an emphasis on molecules that have progressed to late stage clinical trials and, in a few cases, to market Providing a platform for further study, this important work reviews both the successes and challenges of kinase inhibitor therapy, and provides insight into future directions in the war against cancer.
Just a few years ago, people spoke of the US as a hyperpower-a titan stalking the world stage with more relative power than any empire in history. Yet as early as 1993, newly-appointed CIA director James Woolsey pointed out that although Western powers had "slain a large dragon" by defeating the Soviet Union in the Cold War, they now faced a "bewildering variety of poisonous snakes." In The Dragons and the Snakes, the eminent soldier-scholar David Kilcullen asks how, and what, opponents of the West have learned during the last quarter-century of conflict. Applying a combination of evolutionary theory and detailed field observation, he explains what happened to the "snakes"-non-state threats including terrorists and guerrillas-and the "dragons"-state-based competitors such as Russia and China. He explores how enemies learn under conditions of conflict, and examines how Western dominance over a very particular, narrowly-defined form of warfare since the Cold War has created a fitness landscape that forces adversaries to adapt in ways that present serious new challenges to America and its allies. Within the world's contemporary conflict zones, Kilcullen argues, state and non-state threats have increasingly come to resemble each other, with states adopting non-state techniques and non-state actors now able to access levels of precision and lethal weapon systems once only available to governments. A counterintuitive look at this new, vastly more complex environment, The Dragons and the Snakes will not only reshape our understanding of the West's enemies' capabilities, but will also show how we can respond given the increasing limits on US power.
Assessing Forest Ecosystem Health in the Inland West is a thorough reference for policymakers, resource managers, environmentalists, students, and anyone interested in using ecosystem management as a tool to address forest health problems in the Inland West. The book provides the reader with a survey of current conditions in the Inland West, their historical origins, assessments of available management tools, and analyses of the various choices available to policymakers. Its goal is to help people understand the Inland West forests so that public policies can reflect a constructive and realistic framework in which forests can be managed for sustained health. This resource is the product of a scientific workshop where 35 participants, including scientists, resource managers, administrators, and environmentalists, addressed the forest health problem in the Inland West. Synthesis chapters integrate the diverse knowledge and experience which participants brought to the workshop. They identify and link together many of the ecological, social, and administrative conditions which have created the forest health problem in the West. The book is unique in that it reflects a process that fostered the use of academic research, field realities, and industrial knowledge to define an interdisciplinary problem, establish rational policy objectives, and set-up “do-able” management approaches. The following topics are analyzed: Assessing forest ecosystem health in the Inland West Historical and anticipated changes in forest ecosystems in the Inland West Defining and measuring forest health Historical range of variability as a tool for evaluating ecosystem change Administrative barriers to implementing forest health problems Economic and social dimensions of the forest health problem Fire management Ecosystem and landscape management Assessing Forest Ecosystem Health in the Inland West will help facilitate sound resource planning because it brings together the problems facing the Inland West from an interdisciplinary perspective. This approach allows resource managers and policymakers creativity in planning and implementing strategies to confront forest health problems in the Inland West ecosystems.
This book explores a process perspective on design and development, grounded in research in design studies, engineering design and systems design. The design and development process is important---it creates all artificial products and systems and determines how well they address human needs. The process perspective set out in this book has value for design and development practice and education, and is in its own right a fascinating topic of investigation. This book expands on the foundations of a process perspective and discusses its realisation in many process models, theories and approaches that have been developed over the years. The chapters provide connected overviews of key concepts and introduce new conceptual frameworks to clarify relationships between the contributions discussed. Practical considerations and competencies required to realise the tangible benefits of a process perspective are also discussed. A unique aspect of this book is that it brings together many perspectives on the design and development process: those that focus on individual design activity through to those that focus on large-scale development projects; those of research interest and those of practical interest; and those of relevance to design contexts ranging from human-centered design to engineering design and systems design. The chapter bibliographies collect carefully-selected recommendations for further reading on each topic discussed. The book additionally contains many figures presented in colour, visually reflecting each topic's relationship to the new organising frameworks that are introduced.
This volume reviews recent developments in our understanding of che~ ical signaling in vertebrates. After sections dealing with general princi ples and chemical aspects of vertebrate pheromones, it follows a taxonomic approach, progressing from fish to. mammals. The editors asked a diverse, international group of leading investigators, working on a wide array of vertebrate taxa and specific issues, to consider their efforts from compar ative, evolutionary, and ecological viewpoints. The relative number of manuscripts in each part does not necessarily reflect current intensity of research, since the editors invited speakers who together would provide a balanced and comprehensive overview, while avoiding duplication. Still, the part on mammals is the longest. Fourth in a series dating from 1977, this volume illuminates current trends and likely future developments in the field of chemical signaling in vertebrates. Going back even farther, the first chapter, a personal account of the past quarter century by Dr. Mykytowycz recalls the most important milestones, such as symposia, or the founding of societies and journals. He also credits those investigators who stand out by their seminal studies.
This book is the most up to date and thorough account of the natural history of the plants that comprise the most important food crop on Earth, the grasses and grasslands.
From the books of H.G. Wells to the press releases of NASA, we are awash in clichéd claims about high technology's ability to change the course of history. Now, in The Shock of the Old, David Edgerton offers a startling new and fresh way of thinking about the history of technology, radically revising our ideas about the interaction of technology and society in the past and in the present. He challenges us to view the history of technology in terms of what everyday people have actually used-and continue to use-rather than just sophisticated inventions. Indeed, many highly touted technologies, from the V-2 rocket to the Concorde jet, have been costly failures, while many mundane discoveries, like corrugated iron, become hugely important around the world. Edgerton reassesses the significance of such acclaimed inventions as the Pill and information technology, and underscores the continued importance of unheralded technology, debunking many notions about the implications of the "information age." A provocative history, The Shock of the Old provides an entirely new way of looking historically at the relationship between invention and innovation.
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