For Better or Worse? offers a fresh look at how professional campaign consultants have both positive and negative effects on democracy in the United States. Questioning much of the prevailing conventional wisdom, David A. Dulio employs a unique set of data that empirically examines consultants' own attitudes and beliefs to evaluate where they stand in modern democratic elections. Furthermore, he explores their relationships with candidates, voters, political parties, and the media, revealing that political consultants play an integral role in U.S. elections.
It was the best of elections; it was the worst of elections. The 2004 presidential contest mobilized a record number of voters, with 121 million Americans showing up at the polls. But in many eyes, the 2004 race also plumbed new depths. It was the most expensive presidential election in history, with a price tag of $2.2 billion. It was also marked by unprecedented negativity—for example, both George W. Bush and John Kerry came under fire for their activities during the Vietnam War, which ended three decades ago. In V ital Signs, David Dulio and Candice Nelson analyze the Bush and Kerry campaigns and use them as the springboard for a broader exploration of the current U.S. campaign system and its strengths and weaknesses. The book addresses four key issues: Who's in charge of modern campaigns? How effective are the key players? What role does money play? And are campaigns being conducted in an ethical manner? In answering these questions, Dulio and Nelson draw on a wide range of sources, including focus groups, interviews with campaign professionals, and a unique dataset based on multiple surveys of political consultants, party operatives, and the public. The culmination of the seven-year "Improving Campaign Conduct" project, Vital Signs should become an integral part of the debate about American campaigns and elections.
This fully revised edition of the same authors' Governance, Administration and Development is the ideal introduction to public management and the policy process in developing countries. With a new chapter on issues of law and order, it also covers current debates on civil society, aid and intervention, and the relationship of states and markets.
Written by the foremost experts in maternity and pediatric nursing, Maternal Child Nursing Care, 5th Edition offers the accurate, practical information you need to succeed in the classroom, the clinical setting, and on the NCLEX® examination. This new edition offers numerous content updates throughout the text to keep you up-to-date on the latest topics and best practices. Plus hundreds of illustrations, alert boxes, and tables clarify key content and help you quickly find essential information. Atraumatic Care boxes in the pediatric unit teach you how to provide competent and effective care to pediatric patients with the least amount of physical or psychological stress.Community Focus boxes emphasize community issues, supply resources and guidance, and illustrate nursing care in a variety of settings.Critical thinking case studies offer opportunities to test and develop your analytical skills and apply knowledge in various settings.Emergency boxes in the maternity unit guide you through step-by-step emergency procedures.Expert authors of the market-leading maternity and pediatric nursing textbooks combine to ensure delivery of the most accurate, up-to-date content.Family-Centered Care boxes highlight the needs or concerns of families that you should consider to provide family-centered care. NEW! Content updates throughout the text give you the latest information on topics such as the late preterm infant, fetal heart rate pattern identification, obesity in the pregnant woman, shaken baby syndrome/traumatic brain injury, Healthy People 2020, car restraints, immunizations, and childhood obesity.NEW! Updated Evidence-Based Practice boxes including QSEN KSAs (knowledge, skills, attitudes) provide the most current practice guidelines to promote quality care.NEW! Medication Alerts stress medication safety concerns for better therapeutic management.NEW! Safety Alerts highlighted and integrated within the content draw attention to developing competencies related to safe nursing practice.
This international technology assessment study has focused on the emerging global trend toward the miniaturization of manufacturing processes, equipment and systems for microscale components and products. The study has investigated both the state-of-the-art as well as emerging technologies from the scientific, technological, and commercialization perspectives across key industrial sectors in the USA, Asia and Europe.
The Second Edition of Pharmacotherapy for Child and Adolescent Psychiatric Disorders contains new and expanded chapters on combination therapy pharmacoepidemiology pharmacoeconomics current social, ethical, and legal issues surrounding the administration of psychostimulants and antidepressants to children and teenagers serotonin reuptake inhibitors and discusses techniques to select the most appropriate drug and dosing schedule methods to adjust safely and tailor medical treatments for children during various stages of growth and development the effect of psychoactive drugs on cardiac function Offering nearly 3000 contemporary references to facilitate further research, Pharmacotherapy for Child and Adolescent Psychiatric Disorders, Second Edition is a timely and authoritative guide suitable for psychiatrists, psychologists, pediatricians, pharmaceutical and behavioral scientists, clinical neurologists, primary care physicians, social workers, and graduate and medical school students in these disciplines.
Recent research underscores a serious lack of preparedness among hospitals nationwide and a dearth of credible educational programs and resources on hospital emergency preparedness. As the only resource of its kind, Health Care Emergency Management: Principles and Practice specifically addresses hospital and health system preparedness in the face of a large scale disaster or other emergency. Important Notice: The digital edition of this book is missing some of the images or content found in the physical edition.
Bone Marrow Pathology has been extensively revised to reflect the significant advances which have occurred in the application of cytogenetics and in particular, molecular genetics in the diagnosis, classification and understanding of haematological disorders. This comprehensive book not only provides information on all common disease entities, but also covers rare disorders in which bone marrow examination is useful. It is designed as a practical resource with "problems and pitfalls" highlighted throughout to aid laboratory diagnosis.
Few events in American politics over the past two decades have generated more attention than the increasing number of voters calling themselves Independent. By the early 1970s Independents outnumbered Republicans, according to many eminent experts on voting behavior. Yet the authors of this incisive new commentary on American politics claim that most of this widespread speculation on declining party affiliation is simply wrong. They contend that most so-called Independents lean strongly toward one of the two parties and resemble—in all important respects—either Democrats or Republicans. Contrary to expert opinion, only a small segment of voters are truly "independent" of either major party. Based on the most up-to-date 1990 data, The Myth of the Independent Voter provides a roadmap of the political arena for the general reader and scholar alike. Debunking conventional wisdom about voting patterns and allaying recent concerns about electoral stability and possible third party movements, the authors uncover faulty polling practices that have resulted in a skewed sense of the American voting population. Demonstrating that most of what has been written about Independents for more than thirty years is myth, this challenging book offers a trenchant new understanding of the party system, voting behavior, and public opinion.
Provides expert help you need to make difficult bio-ethical decisions, covering a broad range of current and future health care issues, as well as institutional and social issues applicable to multiple disciplines and settings.
Introduction to Bioorganic Chemistry and Chemical Biology is the first textbook to blend modern tools of organic chemistry with concepts of biology, physiology, and medicine. With a focus on human cell biology and a problems-driven approach, the text explains the combinatorial architecture of biooligomers (genes, DNA, RNA, proteins, glycans, lipids, and terpenes) as the molecular engine for life. Accentuated by rich illustrations and mechanistic arrow pushing, organic chemistry is used to illuminate the central dogma of molecular biology. Introduction to Bioorganic Chemistry and Chemical Biology is appropriate for advanced undergraduate and graduate students in chemistry and molecular biology, as well as those going into medicine and pharmaceutical science.
The impending energy crisis brought on by the running out of finite and non-homogenously distributed fossil fuel reserves and the worldwide increase in energy demand has prompted vast research in the development of sustainable energy technologies in the last few decades. However, the efficiency of most of these new technologies is relatively small and therefore it needs to be increased to eventually replace conventional technologies based on fossil fuels. The required efficiency increase primarily relies on the ability to improve the performance of the functional materials which are at the heart of these technologies. The purpose of this book is to give a unified and comprehensive presentation of the fundamentals and the use and design of novel materials for efficient sustainable energy applications, such as conversion, storage, transmission, and consumption. The book presents general coverage of the use and design of advanced materials for sustainable energy applications. Thus, the book addresses all the relevant aspects, such as materials for energy conversion, storage, transmission, and consumption.
Maintaining the high standards that made the previous editions such well-respected and widely used references, Food Lipids: Chemistry, Nutrition, and Biotechnology, Third Edition tightens its focus to emphasize lipids from the point of entry into the food supply and highlights recent findings regarding antioxidants and lipid oxidation. Always representative of the current state of lipid science, this edition provides four new chapters reflecting the latest advances in antioxidant research. New chapters include: Polyunsaturated Lipid Oxidation in Aqueous Systems, Tocopherol Stability and the Prooxidant Mechanisms of Oxidized Tocopherols in Lipids, Effects and Mechanisms of Minor Compounds in Oil on Lipid Oxidation, and Total Antioxidant Evaluation and Synergism. The most comprehensive and relevant treatment of food lipids available, this book highlights the role of dietary fats in foods, human health, and disease. Divided into five parts, it begins with the chemistry and properties of food lipids covering nomenclature and classification, extraction and analysis, and chemistry and function. Part II addresses processing techniques including recovery, refining, converting, and stabilizing, as well as chemical interesterification. The third Part has been renamed and expanded to honor the growing data on oxidation and antioxidants. Part IV explores the myriad interactions of lipids in nutrition and health with information on heart disease, obesity, and cancer, and Part V continues with contributions on biotechnology and biochemistry including a chapter on the genetic engineering of crops that produce vegetable oil. Revised and updated with new information and references throughout the text, this third edition of a bestselling industry standard once again draws on the contributions of leading international experts to establish the latest benchmark in the field and provide the platform from which to further advance lipid science.
This book is a completely revised new edition of the definitive reference on disorders of hemoglobin. Authored by world-renowned experts, the book focuses on basic science aspects and clinical features of hemoglobinopathies, covering diagnosis, treatment, and future applications of current research. While the second edition continues to address the important molecular, cellular, and genetic components, coverage of clinical issues has been significantly expanded, and there is more practical emphasis on diagnosis and management throughout. The book opens with a review of the scientific underpinnings. Pathophysiology of common hemoglobin disorders is discussed next in an entirely new section devoted to vascular biology, the erythrocyte membrane, nitric oxide biology, and hemolysis. Four sections deal with α and β thalassemia, sickle cell disease, and related conditions, followed by special topics. The second edition concludes with current and developing approaches to treatment, incorporating new agents for iron chelation, methods to induce fetal hemoglobin production, novel treatment approaches, stem cell transplantation, and progress in gene therapy.
This book reviews the geochemical and petrological characteristics of potassic igneous rock complexes, and investigates the different tectonic settings in which these rocks occur. The authors provide an overview and classification of these rocks and elucidate the geochemical differences between barren and mineralized potassic igneous complexes. High-K rocks host a number of epithermal gold and porphyry copper-gold deposits. In recent years, there has also been growing recognition of an association of such rocks with iron-oxide copper-gold (IOCG) deposits, intrusion-related gold deposits (IRGDs) and possibly even Carlin-type gold deposits. This book is not only relevant to academic petrologists working on alkaline rocks, but also to exploration geologists prospecting for epithermal gold and/or porphyry copper-gold deposits in modern and ancient terrains. This fourth, updated and expanded edition incorporates new data and references from Africa, Australia, Brazil, China, Greece, Iran, Mongolia, North America, Russia and Turkey, including new maps and sections and new color plates of high-grade gold-copper ore from major deposits hosted by potassic igneous rocks.
Fundamentals of Revision Knee Arthroplasty: Diagnosis, Evaluation, and Treatment is a unique and very timely book designed for surgeons who are beginning to more commonly encounter knee revisions in their practice. Unlike many traditional books on revision, Fundamentals of Revision Knee Arthroplasty does not focus on the most difficult and challenging of cases. Rather, Fundamentals of Revision Knee Arthroplasty is intended to guide the surgeon in the evaluation of the failed or painful total joint replacement, review basic tenants and surgical principles of revision arthroplasty, and guide the surgeon in determining whether a given case is one that should be managed or is best referred to a tertiary orthopedic center. Along with their 32 contributors, Dr. David J. Jacofsky and Dr. Anthony K. Hedley provide detailed information inside Fundamentals of Revision Knee Arthroplasty, including appropriate preoperative evaluation, equipment requirements, surgical planning, need for augments and allograft, and surgical techniques. Surgeons will be tackling knee revision surgery more frequently as the number of these cases is exponentially increasing. Fundamentals of Revision Knee Arthroplasty provides a “go-to” resource to turn to for guidance by community arthroplasty surgeons, arthroplasty fellows, and residents.
The papers contained in the volume represent lectures delivered as a 1983 NATO ASI, held at Urbino, Italy. The lecture series was designed to identify the key submicron and ultrasubmicron device physics, transport, materials and contact issues. Nonequilibrium transport, quantum transport, interfacial and size constraints issues were also highlighted. The ASI was supported by NATO and the European Research Office. H. L. Grubin D. K. Ferry C. Jacoboni v CONTENTS MODELLING OF SUB-MICRON DEVICES.................. .......... 1 E. Constant BOLTZMANN TRANSPORT EQUATION... ... ...... .................... 33 K. Hess TRANSPORT AND MATERIAL CONSIDERATIONS FOR SUBMICRON DEVICES. . .. . . . . .. . . . .. . .. . .... ... .. . . . .. . . . .. . . . . . . . . . . 45 H. L. Grubin EPITAXIAL GROWTH FOR SUB MICRON STRUCTURES.................. 179 C. E. C. Wood INSULATOR/SEMICONDUCTOR INTERFACES.......................... 195 C. W. Wilms en THEORY OF THE ELECTRONIC STRUCTURE OF SEMICONDUCTOR SURFACES AND INTERFACES......................................... 223 C. Calandra DEEP LEVELS AT COMPOUND-SEMICONDUCTOR INTERFACES........... 253 W. Monch ENSEMBLE MONTE CARLO TECHNIqUES............................. 289 C. Jacoboni NOISE AND DIFFUSION IN SUBMICRON STRUCTURES................. 323 L. Reggiani SUPERLATTICES. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 361 . . . . . . . . . . . . K. Hess SUBMICRON LITHOGRAPHY 373 C. D. W. Wilkinson and S. P. Beaumont QUANTUM EFFECTS IN DEVICE STRUCTURES DUE TO SUBMICRON CONFINEMENT IN ONE DIMENSION.... ....................... 401 B. D. McCombe vii viii CONTENTS PHYSICS OF HETEROSTRUCTURES AND HETEROSTRUCTURE DEVICES..... 445 P. J. Price CORRELATION EFFECTS IN SHORT TIME, NONS TAT I ONARY TRANSPORT. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 477 . . . . . . . . . . . . J. J. Niez DEVICE-DEVICE INTERACTIONS............ ...................... 503 D. K. Ferry QUANTUM TRANSPORT AND THE WIGNER FUNCTION................... 521 G. J. Iafrate FAR INFRARED MEASUREMENTS OF VELOCITY OVERSHOOT AND HOT ELECTRON DYNAMICS IN SEMICONDUCTOR DEVICES............. 577 S. J. Allen, Jr.
Greenfield's Neuropathology, the worlds leading neuropathology reference, provides an authoritative, comprehensive account of the pathological findings in neurological disease, their biological basis and their clinical manifestations. This account is underpinned throughout by a clear description of the molecular and cellular processes and reactions that are relevant to the development, and normal and abnormal functioning of, the nervous system. While this scientific content is of paramount importance, however, care has been taken to ensure that the information is presented in a way that is accessible to readers working within a range of disciplines in the clinical neurosciences, and that also places the neuropathological findings within the context of a broader diagnostic process. The new eighth edition incorporates much new information, new illustrations and many new authors, while retaining the depth, breadth and quality of content so praised in previous editions. Each chapter opens with an introductory section designed to offer an integrated approach to diagnosis, taking account of clinical manifestations, neuroradiological and laboratory findings as well as the neuropathological and molecular genetic features of the diseases being considered. Strong emphasis has been placed on facilitating the retrieval of neuropathological information by non-neuropathologists grapping with differential diagnoses or seeking information on broad categories of neurological disease, and boxes and tables are used to present important symptoms and signs, patterns of disease and other features for ease of reference. High quality line and photographic illustrations, the majority in full colour, are all available on a companion CD, to complete the offering.
Thoroughly updated to reflect the latest advances and technologies, Braddom's Physical Medicine and Rehabilitation, 6th Edition, remains the market leader in the field of PM&R. For more than 20 years, this bestselling reference has been the go-to resource for the entire rehabilitation team, providing in-depth coverage of essential core principles along with the latest research, technologies, and procedures that enhance patient care and facilitate optimal return to function. In this edition, lead editor Dr. David X. Cifu and his team of expert associate editors and contributing authors employ a more succinct format that emphasizes need-to-know material, incorporating new key summary features, including high-yield information and study sheets for problem-based learning. - Focuses more heavily on rehabilitation, with case studies throughout and more comprehensive coverage of stroke evaluation, rehabilitation, and therapies. - Provides expanded information on key topics such as interventional pain management options, gait and prosthetics, USG, fluoroscopy, electrodiagnosis and more. - Features a new chapter on Occupational Medicine and Vocational Rehabilitation, plus enhanced coverage of the neurogenic bladder, rehabilitation and prosthetic restoration in upper limb amputation, and acute medical conditions including cardiac disease, medical frailty, and renal failure. - Discusses quality and outcome measures for medical rehabilitation, practical aspects of impairment rating and disability determination, integrative medicine in rehabilitation, and assistive technology. - Offers highly illustrated, templated chapters that are easy to navigate without sacrificing coverage of key topics. - Includes access to dozens of even more practical videos and hundreds of integrated self-assessment questions for more effective learning and retention. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Algorithms serve an important purpose in the field of psychopharmacology as heuristics for avoiding the biases and cognitive lapses that are common when prescribing for many conditions whose treatment is based on complex data. Unique in the field, this title compiles twelve papers from the Psychopharmacology Algorithm Project at the Harvard South Shore Psychiatry Residency Training Program and presents practical ways to adopt evidence-based practices into the day-to-day treatment of patients. Psychopharmacology Algorithms is a useful resource for practicing psychiatrists, residents, and fellows, as well as psychiatric nurse practitioners, psychiatric physician assistants who prescribe, advanced practice pharmacists who prescribe, and primary care clinicians. Teachers of psychopharmacology may find it particularly valuable. Researchers in clinical psychopharmacology may find it helpful in identifying important practice areas that are in need of further study.
The book deals with the role of both oxygen- and nitrogen-centred free radicals in inflammatory diseases such as rheumatoid arthritis. The well-known involvement of the superoxide anion radical in the bactericidal action of inflammatory cells suggests that radicals and the inflammatory response are inextricably linked. The widespread involvement of radicals in human disease seems inevitable, because inflammation is such a conspicuous component of human disease. For the first time, the present text integrates contributions from leading research groups who have been investigating the role of radicals within the context of all stages of inflammtion, such as the recruitment of inflammatory cells, their bactericidal action, inflammatory tissue destruction and inflammatory cell death by apoptosis. The chapters are broadly organised so that they trace the clinical course of the acute and chronic inflammtory response, emphasising the therapeutic implications of recent data on the contribution of nitric oxide and related nitrogen-centred species. The book will be of interest to academic and industrial researchers and clinicians with interests in the fields of inflammation or free radical biology.
Serpins constitute a superfamily of proteins that possess a unique tertiary structure and mechanism of proteinase inhibition. In humans, serpins constitute 10% of the plasma proteins and are best known as critical regulators of both the thrombotic and fibrinolytic systems. Serpins also participate in the regulation of the complement cascade, angiogenesis, tumor metastasis, apoptosis and innate immunity. Considering the importance of these molecules in regulating proteolytic cascades, it is not surprising to find that loss- and gain-of-function mutations result in significant human diseases. Massive thrombosis or bleeding, hereditary angioedema, Alzheimer''s disease, diabetic angiopathy and tumor invasion are some of the human diseases associated with serpins. In addition, mutations that alter serpin conformations (the serpinopathies) lead to lung disease, cirrhosis and a form of familial dementia. The goal of this text is to present the current knowledge on the molecular and cellular basis of serpins and their diseases.
Solve your toughest neurodiagnostic challenges with Neuropathology, 3rd Edition - the most information-packed, extensively illustrated neuropathology reference available! An expert author team presents more than 3,000 high-quality images - nearly all in full color - to provide unmatched visual guidance on the microscopic and gross pathologic presentation of a full range of neurologic diseases. Diagnose with confidence by consulting the most extensive published image collection in neuropathology, which includes an exceptional number of gross pathology images, a feature poorly represented in other texts. Access the complete contents online and download all the images at www.expertconsult.com. Understand the most recent developments in neurologic diseases and quickly identify important variants and outliers. Meet the needs of an aging population with expanded coverage of Alzheimer's and Parkinson's disease, motor neuron disorders, and prion diseases, as well as conditions such as multiple sclerosis. Apply the latest knowledge on molecular genetics and the growing role of genetic testing. Make optimal use of today’s functional imaging techniques with new information on PET, fMRI, and SPECT. Stay current with the newest diagnostic protocols and guidelines as endorsed by professional societies and national bodies, the most recent WHO classification of central nervous system diseases, and checklists for the handling and diagnosis of CNS tumors and tumor-like lesions. Get outstanding visual guidance with new full-color images, and new and updated drawings that clarify complex entities and concepts.
The Science and Physiology of Flexibility and Stretching is the most up-to-date and comprehensive book to cover the underlying physiology and psychology of flexibility enhancing techniques, critically assessing why, when, and how we should stretch, as well as offering a highly illustrated, practical guide to stretching exercises. This fully revised new edition not only updates the present information but adds new chapters on areas that have attracted substantial interest in the last 5 years such as foam rolling, vibration, global effects of stretching, alternative methods to increase flexibility (e.g., resistance training) and others. Richly illustrated, and including an online resource, The Science and Physiology of Flexibility and Stretching provides an important scientific inquiry into stretching as well as other flexibility enhancing techniques (e.g., foam rolling, vibration, resistance training, and others) and an invaluable reference for any strength and conditioning coach or student, personal trainer, sports coach, or exercise scientist.
Endothelial cells are early targets of radiation injury. Because these cells are tissues easily damaged by radiation, if we can understand the causes of radiation injury, then normal cells can be well protected and tumors can be destroyed. The Radiation Biology of the Vascular Endothelium brings together expert reviews on the biology and radiobiology of the vasculature, with emphasis on the endothelial cell component of blood vessels. The book covers both the basic aspects of endothelial cell biology and the practical consequences of this for the oncologist, with special reference to the radiation oncologist. After reading The Radiation Biology of the Vascular Endothelium, no clinical or experimental oncologist should be able to ignore the intimate relationship between tumor and normal tissue cells and endothelial cells that form the barrier to, and are the bearers of, essential nutrient supplies.
Hunter's Tropical Medicine and Emerging Infectious Disease is your comprehensive, go-to resource on the health conditions that arise in the tropics! From infectious diseases through environmental issues, poisoning and toxicology, animal injuries, and nutritional and micronutrient deficiencies, this medical reference book provides you with all the guidance you need to diagnose and manage even the most exotic health concerns. Stay at the forefront of this ever-changing field with Hunter's Tropical Medicine and Emerging Infectious Disease! Understand the common characteristics and methods of transmission for each disease, and learn all the applicable diagnosis, treatment, control, and prevention techniques. Get the information you need in the most organized way with infectious agents arranged by syndromes, as they typically present. Stay abreast of the latest maladies seen in returning travelers through useful chapters on delusional parasitosis, international adoptions, transplant patients, medical tourism, and more. Access the most up-to-date information on emerging and re-emerging diseases (such as H1N1), and see how progression occurs through all-new illustrative life cycles. Hone your techniques with a new skills-based section which includes dentistry, neonatal pediatrics and ICMI, and surgery in the tropics, and a service-based section covering transfusion in resource-poor settings, microbiology, and imaging. Learn everything you need to know about infrequently encountered tropical drugs and their practical application in the clinical setting. Seamlessly search the complete contents online at www.expertconsult.com.
Is depression simply the result of chemical imbalances, or Schizophrenia a wholly biological disorder? What role do the broader circumstances of an individual's social, cultural and heuristic world play in the wider scheme of their psychological wellbeing? In this ground-breaking and highly innovative text, Cromby et al deliver an introduction to the the biopsychosocial paradigm for understanding and treating psychological distress, taking into consideration the wider contexts that engender the onset of mental illness and critiquing the limitations in the sole use of the biomedical model in psychological practice. Rather than biologically determined or clinically measurable, readers are encouraged to consider mental illness as a subjective experience that is expressed according to the individual experiences of the sufferer rather than the rigidity of diagnostic categories. Similarly, approaches to recovery expand beyond psychiatric medication to consider the fundamental function of methods such as psychotherapy, community psychology and service-user movements in the recovery process. Offering a holistic account of the experience of psychological distress, this text draws upon not only statistical evidence but places an integral emphasis on the service-user experience; anecdotal accounts of which feature throughout in order to provide readers with the perspective of the mental health sufferer. Taking an integrative approach to the psychology of mental health, the authors draw from a wealth of experience, examples and approaches to present this student-friendly and engaging text. This is core reading for anyone serious about understanding mental health issues and is suitable for undergraduate students taking introductory courses in psychology and abnormal psychology.
Cancer Therapy with Radiolabeled Antibodies explores the most current experimental and clinical advances in the newly emerging field of cancer radioimmunotherapy (RAIT). Providing a multidisciplinary and international context, some of the world's leading experts examine the problems and prospects of RAIT from radiation, immunological, chemical, physical, physiological, and clinical perspectives with both overviews and original research. Discussions cover the up-to-date clinical results in the RAIT of ovarian, breast, colorectal, and brain cancers, as well as the current status of RAIT in the management of B cell lymphomas. Radiobiology, dosimetry, radiochemistry, targeting biology in experimental models, clinical experiences in hematopoietic and solid tumors, and new approaches to improve cancer radioimmunotherapy are also discussed. In addition, new dosimetry concepts, new labeling methods, new concepts of antibody pharmacokinetics, and new methods to enhance selective cancer radioimmunotherapy are included.
New Treatments of Leukemia and Lymphoma describes the most important advances in the therapy of hematopoietic cancers that have been derived from recent discoveries in cancer cell biology, kinase biochemistry, and immunology. Detailed descriptions of the large number of new and effective agents that have recently become available for the treatment of leukemias and lymphomas as well as an understanding of their mechanisms of action and their integration into current therapy are provided. A number of experimental drug reagents currently in clinical investigation are also discussed. The therapies include conventional anti-metabolites, monoclonal antibodies directed to cell surface receptors, antibodies tagged with toxins and radiopharmaceuticals, inhibitors of specific kinases, stem cell transplants, and engineered T-cells designed to selectively target hematopoietic cancers. The contents of the book will allow practitioners and investigators alike to understand what is current and state of the art as well as what to look for in the future.* Provides an up-to-date, state of the art discussion of a rapidly changing field * Great breadth covering conventional chemotherapeutic agents, biologic agents such as antibodies, novel small molecule inhibitors and genetically engineered cells * Written by international experts in each of the fields
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