David J. LeBlond's Books

Statistical Applications for Chemistry, Manufacturing and Controls (CMC) in the Pharmaceutical Industry

By: Richard K. Burdick,David J. LeBlond,Lori B. Pfahler,Jorge Quiroz,Leslie Sidor,Kimberly Vukovinsky,Lanju Zhang

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Statistical Applications for Chemistry, Manufacturing and Controls (CMC) in the Pharmaceutical Industry

By: Richard K. Burdick,David J. LeBlond,Lori B. Pfahler,Jorge Quiroz,Leslie Sidor,Kimberly Vukovinsky,Lanju Zhang

This book examines statistical techniques that are critically important to Chemistry, Manufacturing, and Control (CMC) activities. Statistical methods are presented with a focus on applications unique to the CMC in the pharmaceutical industry. The target audience consists of statisticians and other scientists who are responsible for performing statistical analyses within a CMC environment. Basic statistical concepts are addressed in Chapter 2 followed by applications to specific topics related to development and manufacturing. The mathematical level assumes an elementary understanding of statistical methods. The ability to use Excel or statistical packages such as Minitab, JMP, SAS, or R will provide more value to the reader. The motivation for this book came from an American Association of Pharmaceutical Scientists (AAPS) short course on statistical methods applied to CMC applications presented by four of the authors. One of the course participants asked us for a good reference book, and the only book recommended was written over 20 years ago by Chow and Liu (1995). We agreed that a more recent book would serve a need in our industry. Since we began this project, an edited book has been published on the same topic by Zhang (2016). The chapters in Zhang discuss statistical methods for CMC as well as drug discovery and nonclinical development. We believe our book complements Zhang by providing more detailed statistical analyses and examples.

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Page Count

383

Publisher

Springer

Published Date

ISBN 10

3319501860

ISBN 13

9783319501864

Midbrain Mutiny

The Picoeconomics and Neuroeconomics of Disordered Gambling: Economic Theory and Cognitive Science

By: Don Ross,Carla Sharp,Rudy E. Vuchinich,David Spurrett

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Midbrain Mutiny

The Picoeconomics and Neuroeconomics of Disordered Gambling: Economic Theory and Cognitive Science

By: Don Ross,Carla Sharp,Rudy E. Vuchinich,David Spurrett

An analysis of how economic theories can be used to understand disordered and pathological gambling that calls on empirical evidence about behavior and the brain and argues that addictive gambling is the basic form of all addiction. The explanatory power of economic theory is tested by the phenomenon of irrational consumption, examples of which include such addictive behaviors as disordered and pathological gambling. Midbrain Mutiny examines different economic models of disordered gambling, using the frameworks of neuroeconomics (which analyzes decision making in the brain) and picoeconomics (which analyzes patterns of consumption behavior), and drawing on empirical evidence about behavior and the brain. The book describes addiction in neuroeconomic terms as chronic disruption of the balance between the midbrain dopamine system and the prefrontal and frontal serotonergic system, and reviews recent evidence from trials testing the effectiveness of antiaddiction drugs. The authors argue that the best way to understand disordered and addictive gambling is with a hybrid picoeconomic-neuroeconomic model.

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Page Count

313

Publisher

MIT Press

Published Date

ISBN 10

0262264455

ISBN 13

9780262264457

The Boundless Sea

A Human History of the Oceans

By: David Abulafia

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The Boundless Sea

A Human History of the Oceans

By: David Abulafia

From the beginning of history to the present, a sweep of the world's oceans and seas and how they have shaped the course of civilization. From the author of the acclaimed The Great Sea, ("Magnificent . . . radiates scholarship and a sense of wonder and fun," Simon Sebag Montefiore; Book of the Year, The Economist), David Abulafia's new book guides readers along the world's greatest bodies of water to reveal their primary role in human history. The main protagonists are the three major oceans--the Atlantic, the Pacific, and the Indian--which together comprise the majority of the earth's water and cover over half of its surface. Over time, as passage through them gradually extended and expanded, linking first islands and then continents, maritime networks developed, evolving from local exploration to lines of regional communication and commerce and eventually to major arteries. These waterways carried goods, plants, livestock, and of course people--free and enslaved--across vast expanses, transforming and ultimately linking irrevocably the economies and cultures of Africa, Europe, Asia, and the Americas. Far more than merely another history of exploration, The Boundless Sea shows how maritime networks gradually formed a continuum of interaction and interconnection. Working chronologically, Abulafia moves from the earliest forays of peoples taking hand-hewn canoes into uncharted waters, to the routes taken daily by supertankers in the thousands. History on the grandest scale and scope, written with passion and precision, this is a project few could have undertaken. Abulafia, whom The Atlantic calls "superb writer with a gift for lucid compression and an eye for the telling detail," proves again why he ranks as one of the world's greatest storytellers.

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1115

Publisher

Oxford University Press

Published Date

ISBN 10

0190933135

ISBN 13

9780190933135

Control Systems Theory and Applications for Linear Repetitive Processes

By: Eric Rogers,Krzysztof Galkowski,David H. Owens

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Control Systems Theory and Applications for Linear Repetitive Processes

By: Eric Rogers,Krzysztof Galkowski,David H. Owens

After motivating examples, this monograph gives substantial new results on the analysis and control of linear repetitive processes. These include further applications of the abstract model based stability theory which, in particular, shows the critical importance to the dynamics developed of the structure of the initial conditions at the start of each new pass, the development of stability tests and performance bounds in terms of so-called 1D and 2D Lyapunov equations. It presents the development of a major bank of results on the structure and design of control laws, including the case when there is uncertainty in the process model description, together with numerically reliable computational algorithms. Finally, the application of some of these results in the area of iterative learning control is treated --- including experimental results from a chain conveyor system and a gantry robot system.

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Page Count

477

Publisher

Springer Science & Business Media

Published Date

ISBN 10

3540715371

ISBN 13

9783540715375

The Taos Trappers

The Fur Trade in the Far Southwest, 1540-1846

By: David J. Weber

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The Taos Trappers

The Fur Trade in the Far Southwest, 1540-1846

By: David J. Weber

In this comprehensive history, David J. Weber draws on Spanish, Mexican, and American sources to describe the development of the Taos trade and the early penetration of the area by French and American trappers. Within this borderlands region, colorful characters such as Ewing Young, Kit Carson, Peg-leg Smith, and the Robidoux brothers pioneered new trails to the Colorado Basin, the Gila River, and the Pacific and contributed to the wealth that flowed east along the Santa Fe Trail.

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Page Count

292

Publisher

University of Oklahoma Press

Published Date

ISBN 10

0806117028

ISBN 13

9780806117027

Oncology of Infancy and Childhood E-Book

By: Stuart H. Orkin,David E. Fisher,A. Thomas Look,Samuel Lux,David Ginsburg,David G. Nathan

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Oncology of Infancy and Childhood E-Book

By: Stuart H. Orkin,David E. Fisher,A. Thomas Look,Samuel Lux,David Ginsburg,David G. Nathan

To address the growing complexities of childhood cancer, Nathan and Oski’s Hematology and Oncology of Infancy and Childhood has now been separated into two distinct volumes. With this volume devoted strictly to pediatric oncology, and another to pediatric hematology, you will be on the cutting edge of these two fields. This exciting new, full-color reference provides you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children with cancer. It brings together the pathophysiology of disease with detailed clinical guidance on diagnosis and management for the full range of childhood cancers, including aspects important in optimal supportive care. Written by the leading names in pediatric oncology, this resource is an essential tool for all who care for pediatric cancer patients. Offers comprehensive coverage of all pediatric cancers, including less common tumors, making this the most complete guide to pediatric cancer. Covers emerging research developments in cancer biology and therapeutics, both globally and in specific pediatric tumors. Includes a section on supportive care in pediatric oncology, written by authors who represent the critical subdisciplines involved in this important aspect of pediatric oncology. Uses many boxes, graphs, and tables to highlight complex clinical diagnostic and management guidelines. Presents a full-color design that includes clear illustrative examples of the relevant pathology and clinical issues, for quick access to the answers you need. Incorporates the codified WHO classification for all lymphomas and leukemias.

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Page Count

1387

Publisher

Elsevier Health Sciences

Published Date

ISBN 10

1437721389

ISBN 13

9781437721386

A Guide to the Wildflowers of South Carolina

By: Patrick D. McMillan,Richard Dwight Porcher, Jr.,Douglas A. Rayner,David B. White

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A Guide to the Wildflowers of South Carolina

By: Patrick D. McMillan,Richard Dwight Porcher, Jr.,Douglas A. Rayner,David B. White

A comprehensive and indispensable reference for identifying and appreciating native flora From its summits to its shores, South Carolina brims with life and unparalleled beauty thanks to its abundant array of native and naturalized flora, all carefully documented in this revised and expanded edition of A Guide to the Wildflowers of South Carolina. Dramatic advances in plant taxonomy and ecology have occurred since the guide's publication 20 years ago; new species have been discovered while others struggle to survive in the face of vanishing habitats and climate change. The authors, all experienced botanists, offer essays on carnivorous plants, native orchids, Carolina bays, the roles and effects of fire and agriculture on the landscape, and detailed descriptions of the plant communities throughout the state's major natural regions. This expanded edition catalogs nearly 1,000 species organized by habitat, with descriptions, color photographs, range maps, and comments on pharmacological uses, suitability for garden cultivation, origin of common and scientific names, and conservation status.

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655

Publisher

Univ of South Carolina Press

Published Date

ISBN 10

164336264X

ISBN 13

9781643362649

Ryan's Retina E-Book

By: Charles P. Wilkinson,David R. Hinton,SriniVas R. Sadda,Peter Wiedemann

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Ryan's Retina E-Book

By: Charles P. Wilkinson,David R. Hinton,SriniVas R. Sadda,Peter Wiedemann

The undisputed gold standard text in the field, Ryan's Retina is your award-winning choice for the most current, authoritative information on new technologies, surgical approaches, scientific advances and diagnostic and therapeutic options for retinal diseases and disorders. Packed with timely updates throughout, new illustrations, and a dedicated team of editors who extend Dr. Ryan’s legacy in retina, this outstanding 6th Edition is a must-have reference for retinal specialists, ophthalmologists, and fellows in training. Offers the most comprehensive content available on retina, balancing the latest scientific research and clinical correlations, covering everything you need to know on retinal diagnosis, treatment, development, structure, function, and pathophysiology. Provides a truly global perspective from five highly esteemed section editors and more than 350 other world authorities from across Europe, Asia, Australasia, and the Americas. Bullets Includes new chapters on widefield imaging, intraoperative OCT imaging, medical management of diabetes mellitus and age-related macular degeneration, and senile retinoschisis. Includes more than 1,150 brand-new illustrations, scans, and photographs throughout. Covers the explosion of new imaging options across optical coherence tomography (OCT), fundus imaging, and autofluorescence imaging, including a greatly expanded OCT imaging chapter that features crucial information on OCT-Angiography (OCT-A). Presents new pharmacotherapy data and the latest approaches in anti-VEGF therapy for age-related macular degeneration, diabetic retinopathy, and venous occlusive disease. Contains thorough content updates in every area of retina, including advanced imaging technologies, gene therapy, inflammation and immune responses, white dot syndromes, epigenetic mechanisms, transplantation frontiers to improve retinal function, macular hole, myopic eye disease, ocular trauma, drug delivery to the posterior segment, advances in macular surgery, vitrectomy and complex retinal detachment, tumors, and retinal genetics and biology.

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2893

Publisher

Elsevier Health Sciences

Published Date

ISBN 10

0323401988

ISBN 13

9780323401982

Retina E-Book

3 Volume Set

By: Charles P. Wilkinson,David R. Hinton,SriniVas R. Sadda,Peter Wiedemann,Stephen J. Ryan

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Retina E-Book

3 Volume Set

By: Charles P. Wilkinson,David R. Hinton,SriniVas R. Sadda,Peter Wiedemann,Stephen J. Ryan

Unequalled in scope, depth, and clinical precision, Retina, 5th Edition keeps you at the forefront of today’s new technologies, surgical approaches, and diagnostic and therapeutic options for retinal diseases and disorders. Comprehensively updated to reflect everything you need to know regarding retinal diagnosis, treatment, development, structure, function, and pathophysiology, this monumental ophthalmology reference work equips you with expert answers to virtually any question you may face in practice. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. Examine and evaluate the newest diagnostic technologies and approaches that are changing the management of retinal disease, including future technologies which will soon become the standard. Put the very latest scientific and genetic discoveries, diagnostic imaging methods, drug therapies, treatment recommendations, and surgical techniques to work in your practice. Benefit from the extensive knowledge and experience of esteemed editor Dr. Stephen Ryan, five expert co-editors, and a truly global perspective from 358 other world authorities across Europe, Asia, Australasia, and the Americas. Make the best use of new technologies with expanded and updated coverage of optical coherence tomography (OCT), fundus imaging, and autofluorescence imaging. Apply the latest knowledge on anti-VEGF therapy for age related macular degeneration, diabetic retinopathy and vein disease. Learn about artificial vision, drug delivery to the posterior segment, advances in macular surgery, vitrectomy, and complex retinal detachment, with updates on tumors, retinal genetics, cell biology, important basic science topics, and much more. Get the most out of new pharmacologic approaches in the management of age-related macular degeneration and diabetic retinopathy. In your practice, diagnostic evaluations, and now even treatments, will be influenced by recent scientific discoveries such as in the areas of nanotechnology, neuro protection, stem cells and gene therapy, among other scientific contributions. View videos of surgical procedures and access the complete contents of Retina, 5th Edition online at www.expertconsult.com, fully searchable, with regular updates and a downloadable image gallery.

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Page Count

2498

Publisher

Elsevier Health Sciences

Published Date

ISBN 10

1455737801

ISBN 13

9781455737802

Book's by David J. LeBlond

Statistical Applications for Chemistry, Manufacturing and Controls (CMC) in the Pharmaceutical Industry

Statistical Applications for Chemistry, Manufacturing and Controls (CMC) in the Pharmaceutical Industry

Midbrain Mutiny

Midbrain Mutiny

The Boundless Sea

The Boundless Sea

Control Systems Theory and Applications for Linear Repetitive Processes

Control Systems Theory and Applications for Linear Repetitive Processes

The Taos Trappers

The Taos Trappers

Oncology of Infancy and Childhood E-Book

Oncology of Infancy and Childhood E-Book

A Guide to the Wildflowers of South Carolina

A Guide to the Wildflowers of South Carolina

Ryan's Retina E-Book

Ryan's Retina E-Book

Retina E-Book

Retina E-Book

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