Supporting People with Dementia at Home details a groundbreaking study of an intensive care management scheme designed for older people with dementia that are at risk of entry into residential care. The authors use a quasi-experimental approach to compare how the individuals on the mental health team in one community were matched to a similar community without the service. They analyze the evidence focusing on the eventual placement of the individual suffering, the quality of care they receive, and also the needs of their carers. This book offers valuable evidence about the factors which can maximize the independence and well being of older people with dementia, from the perspective of older people and their carers. For those who commission services, it is highly relevant to service models for the National Dementia Strategy in England.
JonBenet Ramsey was six years old when she was murdered on Christmas night, 1996 in her home in Boulder, Colorado. Her killer has never been brought to justice, because the police, prosecutors, lawyers, and her own family were too focused on their own careers, public images, political agendas, and social status. Experts sold out, lawyers used every dirty trick available, and police were hamstrung by political maneuvering and restrictions placed on them largely without public consent. She was An Angel Betrayed. The murder of JonBenet Ramsey was a tragedy for her and her loved ones. The corrupted investigation into her death was tragic for the entire country. Now, a common man tells how the American justice system has been compromised by money, politics and cowardice, and how it bodes ill for where our society is headed. About the Author: David J. Hughes was born to a working-class family in Vermont. He was inspired to write this book by frustration and a strong sense of duty. This is his first book. Publisher's website: http: //sbprabooks.com/DavidJHughes
At the core of the many debates throughout cognitive science concerning how decisions are made are the processes governing the time course of preference formation and decision. From perceptual choices, such as whether the signal on a radar screen indicates an enemy missile or a spot on a CT scan indicates a tumor, to cognitive value-based decisions, such as selecting an agreeable flatmate or deciding the guilt of a defendant, significant and everyday decisions are dynamic over time. Phenomena such as decoy effects, preference reversals and order effects are still puzzling researchers. For example, in a legal context, jurors receive discrete pieces of evidence in sequence, and must integrate these pieces together to reach a singular verdict. From a standard Bayesian viewpoint the order in which people receive the evidence should not influence their final decision, and yet order effects seem a robust empirical phenomena in many decision contexts. Current research on how decisions unfold, especially in a dynamic environment, is advancing our theoretical understanding of decision making. This Research Topic aims to review and further explore the time course of a decision - from how prior beliefs are formed to how those beliefs are used and updated over time, towards the formation of preferences and choices and post-decision processes and effects. Research literatures encompassing varied approaches to the time-scale of decisions will be brought into scope: a) Speeded decisions (and post-decision processes) that require the accumulation of noisy and possibly non-stationary perceptual evidence (e.g., randomly moving dots stimuli), within a few seconds, with or without temporal uncertainty. b) Temporally-extended, value-based decisions that integrate feedback values (e.g., gambling machines) and internally-generated decision criteria (e.g., when one switches attention, selectively, between the various aspects of several choice alternatives). c) Temporally extended, belief-based decisions that build on the integration of evidence, which interacts with the decision maker's belief system, towards the updating of the beliefs and the formation of judgments and preferences (as in the legal context). Research that emphasizes theoretical concerns (including optimality analysis) and mechanisms underlying the decision process, both neural and cognitive, is presented, as well as research that combines experimental and computational levels of analysis.
This book looks at why ethnographic approaches are popular in the design of computing devices for the workplace, for the home and elsewhere. It presents a history of ethnography, both as it was practiced before computer science picked it up and since, most especially in the CSCW and HCI domains. The focus of the book is on the practical relationship between theory and practice, a relationship that is fundamental to successful design.
Morson and Dawson's Gastrointestinal Pathology is one of the 'Gold Standards' of pathology textbooks. It has been completely revised to incorporate the latest advances in this rapidly evolving field including the developments in gastric cancer and Helicobacter pylori and the revised classification of other common gastrointestinal conditions. This new edition features a wealth of new material presented in full colour for the first time.
This text covers topics in algebraic geometry and commutative algebra with a strong perspective toward practical and computational aspects. The first four chapters form the core of the book. A comprehensive chart in the Preface illustrates a variety of ways to proceed with the material once these chapters are covered. In addition to the fundamentals of algebraic geometry—the elimination theorem, the extension theorem, the closure theorem and the Nullstellensatz—this new edition incorporates several substantial changes, all of which are listed in the Preface. The largest revision incorporates a new Chapter (ten), which presents some of the essentials of progress made over the last decades in computing Gröbner bases. The book also includes current computer algebra material in Appendix C and updated independent projects (Appendix D). The book may serve as a first or second course in undergraduate abstract algebra and with some supplementation perhaps, for beginning graduate level courses in algebraic geometry or computational algebra. Prerequisites for the reader include linear algebra and a proof-oriented course. It is assumed that the reader has access to a computer algebra system. Appendix C describes features of MapleTM, Mathematica® and Sage, as well as other systems that are most relevant to the text. Pseudocode is used in the text; Appendix B carefully describes the pseudocode used. Readers who are teaching from Ideals, Varieties, and Algorithms, or are studying the book on their own, may obtain a copy of the solutions manual by sending an email to jlittle@holycross.edu. From the reviews of previous editions: “...The book gives an introduction to Buchberger’s algorithm with applications to syzygies, Hilbert polynomials, primary decompositions. There is an introduction to classical algebraic geometry with applications to the ideal membership problem, solving polynomial equations and elimination theory. ...The book is well-written. ...The reviewer is sure that it will be an excellent guide to introduce further undergraduates in the algorithmic aspect of commutative algebra and algebraic geometry.” —Peter Schenzel, zbMATH, 2007 “I consider the book to be wonderful. ... The exposition is very clear, there are many helpful pictures and there are a great many instructive exercises, some quite challenging ... offers the heart and soul of modern commutative and algebraic geometry.” —The American Mathematical Monthly
Mollison's Blood Transfusion in Clinical Medicine is an icon in the field of transfusion and the first edition was published in 1951. The book arose from the concept of the transfusionist, as both scientist and expert consultant. For many years, this text has provided the primary, and often the sole, reference for detailed information and practical experience in blood transfusion. The book is completely revised and updated throughout to include the latest advances and developments in the field.
Greenfield's Neuropathology, the worlds leading neuropathology reference, provides an authoritative, comprehensive account of the pathological findings in neurological disease, their biological basis and their clinical manifestations. This account is underpinned throughout by a clear description of the molecular and cellular processes and reactions that are relevant to the development, and normal and abnormal functioning of, the nervous system. While this scientific content is of paramount importance, however, care has been taken to ensure that the information is presented in a way that is accessible to readers working within a range of disciplines in the clinical neurosciences, and that also places the neuropathological findings within the context of a broader diagnostic process. The new eighth edition incorporates much new information, new illustrations and many new authors, while retaining the depth, breadth and quality of content so praised in previous editions. Each chapter opens with an introductory section designed to offer an integrated approach to diagnosis, taking account of clinical manifestations, neuroradiological and laboratory findings as well as the neuropathological and molecular genetic features of the diseases being considered. Strong emphasis has been placed on facilitating the retrieval of neuropathological information by non-neuropathologists grapping with differential diagnoses or seeking information on broad categories of neurological disease, and boxes and tables are used to present important symptoms and signs, patterns of disease and other features for ease of reference. High quality line and photographic illustrations, the majority in full colour, are all available on a companion CD, to complete the offering.
Apley and Solomon’s Concise System of Orthopaedics and Trauma is firmly established as the leading introductory textbook of orthopaedic practice and the principles of fracture management. Praised in previous editions for its systematic approach, balanced content and easy-to-read style, the fourth edition has been brought fully up to date with more than 800 illustrations, many new to this edition, providing an invaluable pictorial account of this highly visual subject. Key features of the Fourth Edition: Reflects the changing pattern of musculoskeletal disease around the world Focuses on actual diseases and clinical signs, with additional coverage of anatomy where appropriate—ideal for the medical student and junior surgeon Provides helpful guidance on simple procedures without unnecessary operative detail Includes revised and expanded sections on developments in molecular biology and genetics—reflecting the growing clinical significance of these important areas Demonstrates new imaging technologies Retains popular features such as handy check points and text boxes—ideal for rapid assimilation during a clinical placement or exam revision This text remains the first choice for medical students, trainee surgeons and other health professionals seeking a concise introduction to this large and complex subject. It is a natural preface to the more detailed coverage offered by the parent book, Apley’s System of Orthopaedics and Trauma.
A comprehensive overview of clinically important infections of the urinary tract Urinary tract infections (UTIs) continue to rank among the most common infectious diseases of humans, despite remarkable progress in the ability to detect and treat them. Recurrent UTIs are a continuing problem and represent a clear threat as antibiotic-resistant organisms and infection-prone populations grow. Urinary Tract Infections: Molecular Pathogenesis and Clinical Management brings the scientific community up to date on the research related to these infections that has occurred in the nearly two decades since the first edition. The editors have assembled a team of leading experts to cover critical topics in these main areas: clinical aspects of urinary tract infections, including anatomy, diagnosis, and management, featuring chapters on the vaginal microbiome as well as asymptomatic bacteriuria, prostatitis, and urosepsis the origins and virulence mechanisms of the bacteria responsible for most UTIs, including uropathogenic Escherichia coli, Proteus mirabilis, and Klebsiella pneumoniae the host immune response to UTIs, the rise of antibiotic-resistant strains, and the future of therapeutics This essential reference serves as both a resource and a stimulus for future research endeavors for anyone with an interest in understanding these important infections, from the classroom to the laboratory and the clinic. If you are looking for online access to the latest clinical microbiology content, please visit www.wiley.com/learn/clinmicronow.
This book describes the complete iWarp system, from instruction-level parallelism to final parallel applications. The authors present a range of issues that must be considered to get a real system into practice. foreword by Gordon Bell and afterword by H.T. Kung Although researchers have proposed many mechanisms and theories for parallel systems, only a few have actually resulted in working computing platforms. The iWarp is an experimental parallel system that was designed and built jointly by Carnegie Mellon University and Intel Corporation. The system is based on the idea of integrating a VLIW processor and a sophisticated fine-grained communication system on a single chip. This book describes the complete iWarp system, from instruction-level parallelism to final parallel applications. The authors present a range of issues that must be considered to get a real system into practice. They also provide a start-to-finish history of the project, including what was done right and what was done wrong, that will be of interest to anyone who studies or builds computer systems.
The continued debate regarding the stage at which the human embryo conceived in the laboratory should be placed in the mother, combined with recent developments in culture media formulations, have brought the role of the human blastocyst in ART back into the spotlight. ART and the Human Blastocyst presents the proceedings of the International Symposium on ART and the Human Blastocyst held from March 30- April 2, 2000 in Dana Point, California. This book brings to the forefront the main issues raised with the transfer of embryos at the blastocyst stage, including the reduction of high order multiple gestations and the role of the blastocyst culture and transfer in facilitating successful single embryo transfer. Sections include gamete quality and pregnancy outcome, physiology of the embryo, blastocyst development in culture, blastocyst transfer and fate, and implantation. More than 40 illustrations and 25 tables complement the text.
Stream Ecology: Structure and Function of Running Waters is designed to serve as a textbook for advanced undergraduate and graduate students, and as a reference source for specialists in stream ecology and related fields. This Third Edition is thoroughly updated and expanded to incorporate significant advances in our understanding of environmental factors, biological interactions, and ecosystem processes, and how these vary with hydrological, geomorphological, and landscape setting. The broad diversity of running waters – from torrential mountain brooks, to large, lowland rivers, to great river systems whose basins occupy sub-continents – makes river ecosystems appear overwhelming complex. A central theme of this book is that although the settings are often unique, the processes at work in running waters are general and increasingly well understood. Even as our scientific understanding of stream ecosystems rapidly advances, the pressures arising from diverse human activities continue to threaten the health of rivers worldwide. This book presents vital new findings concerning human impacts, and the advances in pollution control, flow management, restoration, and conservation planning that point to practical solutions. Reviews of the first edition: ".. an unusually lucid and judicious reassessment of the state of stream ecology" Science Magazine "..provides an excellent introduction to the area for advanced undergraduates and graduate students..." Limnology & Oceanography "... a valuable reference for all those interested in the ecology of running waters." Transactions of the American Fisheries Society Reviews of the second edition: "Overall, a must for the field centre and a good starter text in stream ecology." (TEN News, October, 2007) "Highly recommended. Upper-division undergraduates through faculty." (P. R. Pinet, CHOICE, Vol. 45 (7), 2008) "... a very good, fluidly readable book which contains the latest key scientific knowledge of the ecology of running waters." (Daniel Graeber, International Review of Hydrobiology, Vol. 94 (2), 2009)
Aldridge evaluates the existing literature from across the disciplines to ascertain just how effective spiritual healing may be on the patient's well-being. He encourages us to redefine treatment strategies and our understanding of health, and argues that the spiritual elements of experience help the patient to find purpose, meaning and hope.
Given the evolution of cerebrospinal testing (CSF) testing methods, the near future is certain to see an explosion of new CSF analysis methodologies. Broad-based and extensively illustrated, Cerebrospinal Fluid in Clinical Practice provides in-depth coverage of CSF examination and analysis, CSF physiology and pathophysiology, approach to diagnosis, and future directions in CSF analysis. It examines the alterations of the composition of CSF in relation to diseases and disorders of the nervous system, emphasizing the findings that are useful in clinical practice. This expansive reference is perfect regardless of your level of experience in central nervous system diseases. Provides in-depth coverage of CSF examination and analysis, CSF physiology and pathophysiology, approach to diagnosis, and future directions in CSF analysis. Explores the gamut of all CNS infections for a broad but detailed review of the scope of neurological disease. Contains detailed discussion on the proper use of specific diagnostic screens on CSF, so you may gain knowledge on how new diagnostic methods impact clinical medicine. Incorporates extensive illustrations and tables, with visual emphasis on diagnostic, laboratory, and anatomic data.
Randomised Clinical Trials: Design, Practice and Reporting provides a detailed overview of the methodology for conducting clinical trials, including developing protocols, data capture, randomisation, analysis and reporting. Assuming no prior background, this user-friendly resource describes the statistical, regulatory, and practical components required for conducting randomised clinical trials. Numerous examples and case studies from industry, academia, and the research literature help readers understand each stage of the clinical trial process. This second edition contains extensively revised material throughout, including new chapters covering designs for repeated measures, non-inferiority, cluster and stepped wedge trials. Other new chapters describe data and safety monitoring, biomarker studies, and feasibility studies. Updated and expanded sections discuss situations where multiple organs, different body locations or competing risks are involved, subgroup analysis, and multiple outcomes. Written by an author team with extensive experience in conducting clinical trials, this book: Provides comprehensive coverage of randomised clinical trials, ranging from basic to advanced Features several new chapters, updated case studies and examples, and references to changes in regulations Explains basic randomised trials, including the parallel two-group controlled trial with a single outcome measure Covers paired trial designs and trials with more than two interventions Includes a chapter on miscellaneous topics such as adaptive designs, large simple trials, Bayesian methods for very small trials, alpha-spending functions and the predictive probability test Randomised Clinical Trials is essential reading for clinicians, nurses, data managers, and medical statisticians involved in clinical trials, and for health practitioners responsible for direct patient care in a clinical trial setting.
Paperback edition of a text which discusses the history of competency-based education and training in Australia and internationally. Analyses the major issues relating to competency and provides step-by-step applications of competency-based education and training. Includes an index and bibliography. Barry Hobart is a professor and Roger Harris an associate professor in adult education and human resource development at the University of South Australia. Hugh Guthrie is a senior research fellow and David Lundberg is the research manager at the National Centre for Vocational Education Research.
Psychologists can now quantify behaviours beyond the laboratory using a mass-adopted, unified system that is primed for data capture a.k.a. smartphones. This is the first book to bring together related areas of smartphone research and point towards how psychology can benefit and engage with these developments in the future. It critically considers how smartphones and related digital devices help answer and generate new research questions for psychological science. The book then guides readers through how smartphones are being used within psychology and social science more broadly. Drawing from examples of both good and bad practice within current research, a new perspective is brought to major themes and debates across behavioural science. In the digital age, smartphones and associated devices will be able to accomplish much more in the near future. Psychology has a key role to play when it comes to balancing this monumental potential with carefully considered research.
Effectively avoiding, recognizing, and managing complications is integral to your operative success. Let a multidisciplinary team of experts in otolaryngology, plastic surgery, oral and maxillofacial surgery, and general surgery guide you through the full range of complications associated with every type of head and neck procedure . . . so you will be equipped to produce the most favorable outcomes for even the most challenging cases! Expert, comprehensive, multidisciplinary coverage of head and neck complications helps you to safely incorporate new surgical techniques into your practice. An emphasis on complication prevention and recognition assists you in avoiding the "complication cascade." Coverage of both acute and long-term care of patients with head and neck complications prepares you to make effective choices in both instances. A new "Quality of Life" section examines the controversies that often surround selecting one procedure over another, illuminating why certain procedures aren't always best for some patients. A new section on complications of facial plastic and reconstructive surgery equips you to perform these techniques with greater confidence. A consistent, practical chapter format helps you focus on key clinical and surgical considerations. A new, more cohesive full-color illustration program richly captures visual nuances of clinical presentation and operative technique. A bonus CD-ROM allows you to use all of the images from the book in electronic presentations.
Written at a level appropriate to undergraduates, this book covers such topics as the Hilbert Basis Theorem, the Nullstellensatz, invariant theory, projective geometry, and dimension theory. The book bases its discussion of algorithms on a generalisation of the division algorithm for polynomials in one variable that was only discovered in the 1960's. Although the algorithmic roots of algebraic geometry are old, the computational aspects were neglected earlier in this century. This has changed in recent years, and new algorithms, coupled with the power of fast computers, have let to some interesting applications, for example in robotics and in geometric theorem proving. In preparing this new edition, the authors present an improved proof of the Buchberger Criterion as well as a proof of Bezout's Theorem.
Seismic surveys are subject to many different design criteria, but often the parameters are established based on an outdated view of how data can be acquired and how it will be processed. This book highlights what is possible using modern acquisition methods, techniques, and equipment, and how these may impact seismic survey design and acquisition.
Discover a comprehensive and up-to-date reference resource for bone marrow pathology, complete with an extensive list of references The diagnosis and treatment of bone marrow pathologies is one of the most critical areas of medical research and care. For years, Bone Marrow Pathology has served as the essential reference and teaching tool in the field of haematology, with an authoritative treatment of the subject written by acknowledged leaders in the field. Now fully updated to reflect urgent new changes to the theory and practice of haematology, it promises to serve a new generation of practitioners. In the book, the characteristics and function of normal bone marrow are extensively discussed. Bone marrow pathology, including both aspirate films and trephine biopsy sections, is examined in a clinical context. The content is augmented by discussion of the peripheral blood findings and supplementary bone marrow tests. Readers of the sixth edition of Bone Marrow Pathology will also find: Lavish illustrations with high-quality images of bone marrow and other associated images Incorporation of new classifications including the WHO and International Consensus classifications, as well as new and expanded research areas Emphasis on practical tools including differential diagnosis and common problems and pitfalls A practical, integrated approach to diagnosis Perfect for trainee and consultant haematologists and haematopathologists, Bone Marrow Pathology will also prove itself invaluable for cytogeneticists, molecular geneticists and anyone working in immunophenotyping.
Drugs and the Future presents 13 reviews collected to present the new advances in all areas of addiction research, including knowledge gained from mapping the human genome, the improved understanding of brain pathways and functions that are stimulated by addictive drugs, experimental and clinical psychology approaches to addiction and treatment, as well as both ethical considerations and social policy. The book also includes chapters on the history of addictive substances and some personal narratives of addiction. Introduced by Sir David King, Science Advisory to the UK Government and head of the Office of Science and Technology, and Nora Volkow, director of the National Institute on Drug Abuse in the USA, the book uniquely covers the full range of disciplines which can provide insight into the future of addiction, from genetics to the humanities. Written for a scientific audience, it is also applicable to non-specialists as well. - Provides an unique overview of what we know about addiction, and how scientific knowledge can and should be applied in the societal, ethical, and political context - Applies the state-of-the-art research in fields such as Genomics, Neuroscience, Pharmacology, Social Policy and Ethics to addiction research - Includes a preface by Sir David King, Science Advisory to the UK Government and head of the Office of Science and Technology, and in introduction by Nora Volkow, director of the National Institute on Drug Abuse in the USA
As adaptive capacities decline, and disease increases, the elderly become major consumers of drugs. Because of the special needs of older patients, physicians, geriatricians, health providers, and researchers must know how the aging process changes the pharmacokinetic and pharmacodynamic properties of drugs prescribed to the elderly. The Second Edition of this essential handbook is an up-to-date source that analyses the major drug groups, the disorders they treat, and the age-associated changes in cellular processes that affect drug action. Disorders prevalent in older people, such as Alzheimer's disease and Parkinson's disease, are examined in great detail. The book also discusses a wide range of drugs, including bronchodilators for asthma, nonsteroid anti-inflammatory drugs for arthritis, antibiotics, and treatments for cardiovascular disease, cancer, and mental disorders. The handbook also provides insight into future research problems dealing with the expanding aging population, their drug usage, and increasing adverse drug reactions.
Hyperacusis and Disorders of Sound Intolerance: Clinical and Research Perspectivesis a professional resource for audiology practitioners involved in the clinical management of patients who have sound tolerance concerns. The text covers emerging assessment and intervention strategies associated with hyperacusis, disorders of pitch perception, and other unusual processing deficits of the auditory system. In order to illustrate the patients' perspectives and experiences with disorders of auditory processing, cases are included throughout. This collection of basic science findings, diagnostic strategies and tools, evidence-based clinical research, and case reports provides practitioners with avenues for supporting patient management and coping. It combines new developments in the understanding of auditory mechanisms with the clinical tools developed to manage the effects such disorders exert in daily life. Topics addressed include unusual clinical findings and features that influence a patient's auditory processing such as their perceptual accuracy, recognition abilities, and satisfaction with the perception of sound. Hyperacusis is covered with respect to its effects, its relation to psychological disorders, and its management. Hyperacusis is often linked to trauma or closed head injury, and the text also considers the management of patients with traumatic brain injury as an opportunity to illustrate the effectiveness of interprofessional care in such cases. Interventions such as cognitive behavioral therapy, desensitization training, and hearing aid use are reported in a way that enhances clinicians' ability to weave such strategies into their own work or into their referral system. Hyperacusis and Disorders of Sound Intolerance illuminates increasingly observed auditory-related disorders that challenge students, clinicians, physicians, and patients. The text elucidates and reinforces audiologists' contributions to polytrauma and interprofessional care teams and provides clear definitions, delineation of mechanisms, and intervention options for auditory disorders.
Biochemistry: The Chemical Reactions of Living Cells is a 16-chapter reference source on chemical structures and reactions of living cells. The first three chapters of this book contain introductory material on cell structure, molecular architecture, and energetic. The subsequent chapters examine the allosteric effect of the binding structures of oligomeric enzymes, microtubules, viruses, and muscle. These chapters also describe the structures and chemical properties of membranes and of the surrounding cell coats. The discussions then shift to the general properties of enzymes, the kinetics of chemical reactions, and the various mechanisms employed in enzymatic catalysis. Considerable chapters are devoted to the reaction sequences found in metabolism. These chapters particularly examine the carbohydrate and lipid metabolism; photosynthesis; and biosynthesis and catabolism of an enormous number of nitrogenous compounds. The final chapters highlight the genetic and hormonal control of metabolism, development, and brain function. Biochemistry teachers and students will find this book of great value.
This unique textbook focuses exclusively on wound healing of the face and neck, integrating scientific principle with state-of-the-art clinical precept. Detailed, step-by-step surgical techniques demonstrate the best methods of repair of tissue. Contemporary healing concepts encompass the structures of the skin, cartilage, bone, nerve, oral mucosa, middle ear mucosa and airway mucosa. The book benefits from the diverse backgrounds and expertise of each of its authors bringing the reader new insights to the question of why some facial and neck wounds heal satisfactorily and others do not. Dr. Hom suggests a holistic approach to surgery of the face and neck that includes the healing process. Future directions for wound healing of the face and neck are also illuminated. The first section describes the healing aspects of the structures of the face and neck the second section addresses common clinical tissue healing problems encountered and methods to treat them. The third section discusses specific therapies used to optimize healing.
Textbook of Assisted Reproductive Technologies is a truly comprehensive manual for the whole team at the IVF clinic. Information is presented in a highly visual manner, allowing both methods and protocols to be consulted easily. The text provides clinical and scientific teams with the A to Zs of setting up an embryology laboratory, gives research fellows insight into technical developments, and supplies seasoned professionals with a review of the latest techniques and advances. New to the Third Edition: fully revised and expanded chapters, with new information on: single embryo transfer artificial gametes pharmacogenetics
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