A physiologist by training and a farmer at heart, Dr. David J. Henderson still outworks men half his age. In addition to being blessed by nature, he has also been a good steward of what he was given, and believes this is key to a long and healthy life. His passion is to share the knowledge he has accumulated from over forty years of field research and implementation, with the ultimate goal of overall health improvement for all those who choose to listen. His experiences with full-body nourishment from the ground up will give you insights to avoid the negative pitfalls and apply positive principles to get the most out of what you now have, no matter where you are on the health continuum. Adopt the positive patterns of nutrition, behavior, and thinking that Dr. Henderson describes in detail and they will lead you to a happier, healthier, and longer life.
The Fifth International Lymphokine Workshop was convened in Clearwater Beach, Florida, January 11-15, 1987. The theme chosen for the meeting was 'The Molecular Basis of Lymphokine Action," which reflected the opinion of the organizers as to how far the field had moved since the first Lymphokine Workshop only eleven years ago. As was evident at the last Lymphokine Workshop held in 1985, the contribution of molecular biology, particularly in the cloning of lymphokine genes, continues to play an important role in clarifying the structure of lymphokines, providing recombinant (read "pure") proteins for biological studies, and suggesting directions for studies of the molecular basis of lymphokine activity. The most recent lymphokines to yield to molecular cloning meth odology were the B-cell growth and differentiation factors, in partic ular BSF-1 or, as it is sometimes termed, interleukin 4. One of the surprises from this research is the broad spectrum of activities that can be attributed to this molecule, aside from its effects on B-cells, thus perhaps justifying its being called an interleukin. The interleukin 2 symposium demonstrated that even in a well-established research area, controversy and excitement can continue, when evidence was presented by several investigators indicating the presence of a second "converter" protein that changes the affinity of the now classical Tac antigen from a low to a high affinity IL-2 receptor.
It is generally understood that the present approachs to computing do not have the performance, flexibility, and reliability of biological information processing systems. Although there is a comprehensive body of knowledge regarding how information processing occurs in the brain and central nervous system this has had little impact on mainstream computing so far. This book presents a broad spectrum of current research into biologically inspired computational systems and thus contributes towards developing new computational approaches based on neuroscience. The 39 revised full papers by leading researchers were carefully selected and reviewed for inclusion in this anthology. Besides an introductory overview by the volume editors, the book offers topical parts on modular organization and robustness, timing and synchronization, and learning and memory storage.
Over five hundred years since it was named, utopia remains a vital concept for understanding and challenging the world(s) we inhabit, even in – or rather because of – the condition of ‘post-utopianism’ that supposedly permeates them. In Rethinking Utopia David M. Bell offers a diagnosis of the present through the lens of utopia and then, by rethinking the concept through engagement with utopian studies, a variety of ‘radical’ theories and the need for decolonizing praxis, shows how utopianism might work within, against and beyond that which exists in order to provide us with hope for a better future. He proposes paying a ‘subversive fidelity’ to utopia, in which its three constituent terms: ‘good’ (eu), ‘place’ (topos), and ‘no’ (ou) are rethought to assert the importance of immanent, affective relations. The volume engages with a variety of practices and forms to articulate such a utopianism, including popular education/critical pedagogy; musical improvisation; and utopian literature. The problems as well as the possibilities of this utopianism are explored, although the problems are often revealed to be possibilities, provided they are subject to material challenge. Rethinking Utopia offers a way of thinking about (and perhaps realising) utopia that helps overcome some of the binary oppositions structuring much thinking about the topic. It allows utopia to be thought in terms of place and process; affirmation and negation; and the real and the not-yet. It engages with the spatial and affective turns in the social sciences without ever uncritically being subsumed by them; and seeks to make connections to indigenous cosmologies. It is a cautious, careful, critical work punctuated by both pessimism and hope; and a refusal to accept the finality of this or any world.
At the turn of the 20th century, the township of Livonia was largely a rural community populated with farms, dirt roads, and a number of cheese factories. A few decades later, as the auto industry boomed in Detroit, white-collar workers sought places to raise their families outside of the city, and neighborhoods in Livonia went up seemingly overnight. The result was the creation of a quintessential American suburban city, one in which urban and rural lifestyles converged and formed a new kind of community. This book celebrates Livonia's development from the 19th to the 21st century, as it evolved from wilderness into a city that is routinely rated as one of the best places to raise a family in the United States.
A comprehensive overview of clinically important infections of the urinary tract Urinary tract infections (UTIs) continue to rank among the most common infectious diseases of humans, despite remarkable progress in the ability to detect and treat them. Recurrent UTIs are a continuing problem and represent a clear threat as antibiotic-resistant organisms and infection-prone populations grow. Urinary Tract Infections: Molecular Pathogenesis and Clinical Management brings the scientific community up to date on the research related to these infections that has occurred in the nearly two decades since the first edition. The editors have assembled a team of leading experts to cover critical topics in these main areas: clinical aspects of urinary tract infections, including anatomy, diagnosis, and management, featuring chapters on the vaginal microbiome as well as asymptomatic bacteriuria, prostatitis, and urosepsis the origins and virulence mechanisms of the bacteria responsible for most UTIs, including uropathogenic Escherichia coli, Proteus mirabilis, and Klebsiella pneumoniae the host immune response to UTIs, the rise of antibiotic-resistant strains, and the future of therapeutics This essential reference serves as both a resource and a stimulus for future research endeavors for anyone with an interest in understanding these important infections, from the classroom to the laboratory and the clinic.
There is evidence that the world has been witnessing more intense tropical cyclones. Accompanying these tropical cyclones are heightened levels of devastation that witness the loss of human life and wildlife, destruction of natural resources and property and the disruption of major economic and social activities. To this end, there is a growing demand for publications focusing on tropical cyclones at various levels that include regional, national and local levels, especially from Africa. One sub-region that has been witnessing the harsh realities of the increasing intensity of tropical cyclones in southern Africa. However, within this region, countries are usually impacted at varying degrees of damage. Among the countries that usually encounter the harshness of these tropical cyclones are the Comoros, Botswana, Madagascar, Mauritius, Malawi, Mozambique, Reunion, the Seychelles, South Africa and Zimbabwe. From the history books, the following tropical cyclones made landfall and hit southern Africa: Eline (2000), Favio (2007), Dineo (2017), Idai (2019), Kenneth (2019), Eliose (2021), and Chalane (2020). Although all these tropical cyclones had negative impacts, it is undoubtedly Tropical Cyclone Idai that shocked the world with its devastation mainly in Mozambique, Malawi and Zimbabwe in March 2019. Key infrastructure was destroyed, livelihoods were lost, and the environment was degraded. Thousands of people died, many more were injured, many remain unaccounted for and others remained homeless as of the time of finalising this book in February 2021. This book, therefore focuses on the devastating impacts of Tropical Cyclone Idai in Zimbabwe. The book interfaces Tropical Cyclone Idai’s impacts with the 2030 Agenda for Sustainable Development and some of the 17 Sustainable Development Goals (SDGs). This linkage was deliberate given that there is still time remaining until 2030, and the world has generally agreed to move into the future along the pathways of sustainable development and sustainability. The book adds to the first comprehensive profiling of the impacts of tropical cyclones on southern African economies, particularly that of Zimbabwe. It also comes up as the first in a three-volume series. The other volumes to look out for are Cyclones in Southern Africa Vol 2: Foundational and Fundamental Topics; and Cyclones in Southern Africa Vol 3: Implications for the Sustainable Development Goals. To this end, this book is suitable as a read for several professionals and disciplines such as tourism and hospitality studies, economics, sustainable development, development studies, environmental sciences, arts, geography, life sciences, politics, planning and public health.
This clear and compelling textbook provides a complete survey of the field of child abuse and neglect from the perspective of modern developmental attachment theory. It starts by describing the ways in which attachment difficulties manifest themselves in children's behaviour, and goes on looking at abuse, neglect, and compound cases of abuse and neglect, backing it all up with empirical research evidence and vivid case material. In its final section, it provides a comprehensive review of attachment-based interventions. Written by an extremely respected and successful author, this book, anchored in research evidence, places its emphasis on practice implementation and aims at answering all the kinds of questions practitioners and student practitioners specialising in child welfare are most likely to ask.
Everyone knows that child abuse is morally wrong. David A. Wolfe goes beyond this to explore how and why it affects the development of children. This is the story professionals need to know to plan their helping strategy." —James Garbarino, Ph.D.Co-Director, Family Life Development Center, Cornell University Child Abuse, Second Edition is devoted to a topic of major social and clinical significance. In this book, the author describes the different types of abuse and discusses the influence they have on development, including the emotional, cognitive, academic, and social consequences in childhood and adolescents. The book uses theory and research to convey the importance of multiple contextual influences that affect abuse and can be used to ameliorate it.
Textbook of Clinical Neuropsychiatry provides a comprehensive, encyclopedic and up to date coverage of the complete range of neuropsychiatric disorders. The text is clearly written and well organized, utilizing a consistent and easy to read format throughout. Part I describes the diagnostic assessment of patients and details the interview, mental s
This book represents the final work of the late Professor C. David Marsden, who was the most influential figure in the field of movement disorders, in terms of his contributions to both research and clinical practice, in the modern era. It was conceived and written by David Marsden and his colleague at the Institute of Neurology, Prof. Ivan Donaldson. It was their intention that this would be the most comprehensive book on movement disorders and also that it would serve as the 'clinical Bible' for the management of these conditions. It provides a masterly survey of the entire topic, which has been made possible only by vast laboratory and bedside experience. Marsden's Book of Movement Disorders covers the full breadth of movement disorders, from the underlying anatomy and understanding of basal ganglia function to the diagnosis and management of specific movement disorders, including the more common conditions such as Parkinson's Disease through to rare, and very rare conditions such as Niemann-Pick disease. Chapters follow a structured format with historical overviews, definitions, clinical features, differential diagnosis, investigations and treatment covered in a structured way. It is extensively illustrated with many original photographs and diagrams of historical significance. Among these illustrations are still images of some original film clips of some of Dr. Marsden's patients published here for the first time. Comprehensively referenced and updated by experts from the Institute of Neurology at Queen Square, this book is a valuable reference for, not just movement disorder specialists and researchers, but also for clinicians who care for patients with movement disorders.
Making use of untapped resources, Seim looks at the impact of the Rockefellers, viewed through the lens of their philanthropic support of social science from 1890-1940. Focusing specifically on the Rockefeller Foundation and the Laura Spelman Rockefeller Memorial, Seim connects the family's business success with its philanthropic enterprises.
Highly Commended, BMA Medical Book Awards 2013Previously published as Textbook of Clinical Neuropsychiatry, this book has been re-titled and thoroughly updated, redesigned, and enhanced to include the fundamentals of neuroscience. This highly acclaimed text provides a definitive, clinically oriented, yet comprehensive book covering neuropsychiatry
This comprehensive, but practical, reference is an informative guide to the management of acute respiratory problems in the hospital setting. Evaluation of the patient with breathing difficulties is often challenging, since the differential diagnosis is broad and the use of the wrong treatment can exacerbate the problem. This book helps the practising clinician to recognize both common and more unusual causes of respiratory distress in a patient, and assists them in making the correct diagnosis by enhancing their understanding of the application and significance of tests of pulmonary function and pulmonary imaging studies and through improved knowledge of the underlying physiology of acute and chronic respiratory failure that underpins clinical practice in this area. To enhance this 'bench to bedside' approach, authors illustrate their material with helpful management algorithms, and each chapter will conclude with a summary of key points.
This volume offers a comprehensive history of the Mount Desert Island Biological Laboratory (MDIBL), one of the major marine laboratories in the United States and a leader in using marine organisms to study fundamental physiological concepts. Beginning with its founding as the Harpswell Laboratory of Tufts University in 1898, David H. Evans follows its evolution from a teaching facility to a research center for distinguished renal and epithelial physiologists. He also describes how it became the site of major advances in cytokinesis, regeneration, cardiac and vascular physiology, hepatic physiology, endocrinology and toxicology, as well as studies of the comparative physiology of marine organisms. Fundamental physiological concepts in the context of the discoveries made at the MDIBL are explained and the social and administrative history of this renowned facility is described.
Guest edited by David Hunter, this issue of Rheumatic Disease Clinics provides an update on the latest diagnosis, treatment and long-term management strategies for osteoarthritis. Topics to be covered include pathogenesis, joint mechanics, imaging of osteoarthritis, muscle and disease genesis, disease modification, and surgical strategies for treatment.
Over the past two decades a number of attempts have been made, with varying degrees of success, to collect in a single treatise available information on the basic and applied pharmacology and biochemical mechanism of action of antineoplastic and immunosuppressive agents. The logarithmic growth of knowledge in this field has made it progressively more difficult to do justice to all aspects of this topic, and it is possible that the present handbook, more than four years in preparation, may be the last attempt to survey in a. single volume the entire field of drugs em ployed in cancer chemotherapy and immunosuppression. Even in the present instance, it has proved necessary for practical reasons to publish the material in two parts, although the plan of the work constitutes, at least in the editors' view, a single integrated treatment of this research area. A number of factors have contributed to the continuous expansion of research in the areas of cancer chemotherapy and immunosuppression. Active compounds have been emerging at ever-increasing rates from experimental tumor screening systems maintained by a variety of private and governmental laboratories through out the world. At the molecular level, knowledge of the modes of action of estab lished agents has continued to expand, and has permitted rational drug design to playa significantly greater role in a process which, in its early years, depended almost completely upon empirical and fortuitous observations.
Oncology Informatics: Using Health Information Technology to Improve Processes and Outcomes in Cancer Care encapsulates National Cancer Institute-collected evidence into a format that is optimally useful for hospital planners, physicians, researcher, and informaticians alike as they collectively strive to accelerate progress against cancer using informatics tools. This book is a formational guide for turning clinical systems into engines of discovery as well as a translational guide for moving evidence into practice. It meets recommendations from the National Academies of Science to "reorient the research portfolio" toward providing greater "cognitive support for physicians, patients, and their caregivers" to "improve patient outcomes." Data from systems studies have suggested that oncology and primary care systems are prone to errors of omission, which can lead to fatal consequences downstream. By infusing the best science across disciplines, this book creates new environments of "Smart and Connected Health." Oncology Informatics is also a policy guide in an era of extensive reform in healthcare settings, including new incentives for healthcare providers to demonstrate "meaningful use" of these technologies to improve system safety, engage patients, ensure continuity of care, enable population health, and protect privacy. Oncology Informatics acknowledges this extraordinary turn of events and offers practical guidance for meeting meaningful use requirements in the service of improved cancer care. Anyone who wishes to take full advantage of the health information revolution in oncology to accelerate successes against cancer will find the information in this book valuable. Presents a pragmatic perspective for practitioners and allied health care professionals on how to implement Health I.T. solutions in a way that will minimize disruption while optimizing practice goals Proposes evidence-based guidelines for designers on how to create system interfaces that are easy to use, efficacious, and timesaving Offers insight for researchers into the ways in which informatics tools in oncology can be utilized to shorten the distance between discovery and practice
Between 1980 and 1996 the number of arrests has increased considerably for offenders ages 12 and under. This increase is a cost to society in two ways: the cost of the crime and the cost of multiple agencies involved with these children. Several questions have developed due to this increase: How does the juvenile justice system deal with child delinquents? Is child delinquency a predictor of serious, violent, and chronic offending? How early can we predict, and what are early warning signs? In an effort to develop answers for these questions and many more, editors Rolf Loeber and David Farrington organized a study group on Very Young offenders comprising 39 experts on juvenile delinquency and child problem behavior. Over a two-year period of intense and collaborative work these individuals have produced the book Child Delinquents: Development, Intervention, and Service Needs. Presenting empirically derived insights, Child Delinquents is the definitive statement to date on the working knowledge of prevalence, development, risk and protective factors, and optimal intervention with preteen offenders. This book is an excellent source for a broad audience of researchers, scholars, psychiatry, and practitioners at the administrative level.
This report outlines preliminary field results of bedrock mapping of a central Baffin Island study area that straddles the eastern segment of the Trans-Hudson Orogen. Orthogneiss in the Archean basement and rocks of the Paleoproterozoic Piling Group are described from the lowest to highest structural levels (Dewar Lakes, Flint Lake, Astarte River, Bravo Lake, Longstaff Bluff and related formations, the Cumberland Batholith, and the diabase dikes of the Franklin swarm). The final sections discuss deformation & metamorphism in the study area and briefly assess the potential for mineral deposits.
Updated to reflect recent changes in the field, the 2nd Edition of Forensic Psychology presents a comprehensive overview of forensic psychology and its applications in the civil and criminal justice systems of the UK. Builds on the first edition to convey material in an engaging manner to postgraduate students in psychology Includes a significant expansion of pedagogical features, including text boxes highlighting key seminar issues and key debates in the field to further group discussion Provides an up-to-date summary of emerging evidence in the field, and its implications for evidence based practice Points to additional online learning resources at the conclusion of each chapter
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