First textbook-level account of basic examples and techniques in this area. Suitable for self-study by a reader who knows a little commutative algebra and algebraic geometry already. David Eisenbud is a well-known mathematician and current president of the American Mathematical Society, as well as a successful Springer author.
Now in its updated fifth edition, Strandness’s Duplex Scanning in Vascular Disorders proves why it’s still the classic text on the use of duplex scanning in the study and diagnosis of vascular disorders. This evidence-based, real-world text is now expanded to cover all vascular duplex ultrasound topics, including principles and instrumentation; cerebrovascular; aortoiliac and peripheral arterial; peripheral venous; visceral vascular; and preoperative planning, intraoperative assessment and procedural guidance.
The interactions of biogeochemical cycles influence and maintain our climate system. Land use and fossil fuel emissions are currently impacting the biogeochemical cycles of carbon, nitrogen and sulfur on land, in the atmosphere, and in the oceans.This edited volume brings together 27 scholarly contributions on the state of our knowledge of earth system interactions among the oceans, land, and atmosphere. A unique feature of this treatment is the focus on the paleoclimatic and paleobiotic context for investigating these complex interrelationships.* Eight-page colour insert to highlight the latest research* A unique feature of this treatment is the focus on the paleoclimatic context for investigating these complex interrelationships.
Is the Bible fundamentally at odds with science? Science and the Bible are often pitted against each other, causing many to either defend science at Scripture's expense, or vice versa. Instead, what if we saw them as friends? Can Christians appreciate scientific insights like they do archaeological discoveries--as a source of knowledge to illuminate the biblical world and our own? In Science a nd the Bible, David Instone-Brewer takes a refreshing and non-antagonistic approach, asking how science can aid our interpretation of the Bible. The result is stimulating on topics such as God's omnipresence, the origin of languages, the nature of eternity, the relationship of spirit and soul, the reality of resurrection, and Jesus' human experience. In short, readable chapters, Science and the Bible enables the curious layperson to reread the Bible with fresh perspectives from modern scientific insights. The Scripture in Context series is driven by the conviction that there is nothing as exciting, direct, provocative, and spiritually enlightening as the Bible when we read it as it was meant to be read. Each book in the series dives into the ancient cultural context behind Bible passages, examining the effect this context had on what the Bible writers were saying and how we should understand their words today. When we read the Bible in light of its context, it is anything but boring. Instead, God's word can speak to us as powerfully as it did to those who first read it.
Are all the moral commands of the Bible meant to be obeyed exactly for all time, or are there some that need to be adapted for our modern world? Scripture contains lots of guidance on ethical issues, including statements about polygamy, slavery, divorce, sex, and other things that sound strange to our modern ears. Even Christians, who believe the Bible is God's word, disagree on whether women should wear head coverings, whether Christians can ever lie, whether women should preach, and whether Christians should drink alcohol. How can we resolve these issues and figure out how to apply the Bible to our lives? David Instone-Brewer helps answer this question by showing how the Bible's moral commands were understood in their ancient cultural context. The more we understand what God and the biblical authors intended to communicate to the original audience, the better we will be able to make sense of how to apply those commands today. In brief chapters that address a wide variety of moral issues, Instone-Brewer equips Bible readers with a paradigm they can use to discern matters for themselves: Is a biblical command timeless or time-bound? If the command itself is time-bound, what is the timeless purpose behind it? And how do we remain faithful to the Bible's commands today even when handling subjects the Bible does not address? The Scripture in Context series is driven by the conviction that there is nothing as exciting, direct, provocative, and spiritually enlightening as the Bible when we read it as it was meant to be read. Each book in the series dives into the ancient cultural context behind Bible passages, examining the effect this context had on what the Bible writers were saying and how we should understand their words today. When we read the Bible in light of its context, it is anything but boring. Instead, God's word can speak to us as powerfully as it did to those who first read it. Chapters are short and informal, so it's easy to read one chapter at a time or the whole book straight through.
This is the first sustained, whole-Bible treatment on the theme of meeting God face to face. Starting with Genesis and ending with Revelation, the author systematically covers the major events in salvation history, all of which reveal the beauty of encountering God's grace in abundance.
Grow in the Scriptures throughout the church year with David deSilva as your mentor. Beginning with Advent and moving through the church year, David deSilva brings his years of experience as a biblical scholar to the church in the form of sermons delivered to his home congregation throughout the church year, now adapted into a thoughtful and inspiring collection of reflections. These reflections, which draw on readings from the Revised Common Lectionary, will inform and inspire your understanding of Scripture, written with Dr. deSilva's characteristic warmth and wisdom. In Season and Out makes for excellent devotional reading that will feed saints both in front of and behind the pulpit.
The Suffering Servant of the Lord: A Prophecy of Jesus Christ is a major new study of the fifty-third chapter of Isaiah. It is exegetical, expositional, devotional, and Christological: It is exegetical in that it is based on a careful study of the text. It is expositional in that it explains the meaning of chapter to both its original and modern readers. The book will give preachers and teachers help in outlining and illustrating their sermons and lectures. It is devotional in that this marvelous chapter addresses the deepest need of people, the need for forgiveness of sin and peace with God. It is Christological in that it focuses on the person of Jesus Christ. MacLeod writes, I have finished this work more convinced than ever that the passage is a straightforward prophecy of Jesus Christ written by the prophet Isaiah some seven hundred years before the birth of the Savior.
You know the doctrines, but are they biblical? Too often, Christians are content to state a doctrine, list a few supporting Bible passages, and proceed on to the next. But are these doctrines truly derived from the Bible, or are we slotting verses into our pre-determined theological grids? In Church Doctrine and the Bible, biblical scholar David Instone-Brewer applies his expertise in first-century backgrounds and culture to popular Christian doctrines. Peeling away thousands of years of theological development reveals how the Bible's original hearers would have understood these doctrines and helps us resolve some of our doctrinal disputes and misunderstandings. Through this process, Instone-Brewer answers the question, "is this doctrine biblical?" Church Doctrine and the Bible will help pastors, theologians, and laypersons see familiar doctrines with fresh, first-century, eyes. By restoring the revolutionary simplicity of the Bible's teachings, we gain new insights into these doctrines and what they mean for the church today.
Organ transplantation raises singularly difficult ethical and legal issues in its requirement for donated organs. Strategies to facilitate supply in the face of increasing demand must be ethically sound and subject to an appropriate and effective regulatory framework. Professor David Price reviews the ethical principles and positions underpinning such law and policies, probing for coherence, consistency and justification. The book incorporates a comprehensive analysis of existing laws and policies governing transplantation practices around the world. It examines the meaning of death, cadaver organ procurement policies, use of living donors, trading in human organs, experimental transplant procedures and xenotransplantation. Drawing upon a wide range of disciplinary and empirical materials Price explores the balance between the interests of donors, recipients, clinicians, and society, identifying the specific challenges of this subject and seeking to guide current practices and future developments in the context of cultural diversity and pluralistic societies.
An expert guide to targeting protein kinases in cancer therapy Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells. Because of this fact, pharmaceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal roadblocks to sever their malignant means of communication. Complete with full-color presentations, Targeting Protein Kinases for Cancer Therapy defines the structural features of protein kinases and examines their cellular functions. Combining kinase biology with chemistry and pharmacology applications, this book enlists emerging data to drive the discovery of new cancer-fighting drugs. Valuable information includes: Comprehensive overviews of the major kinase families involved in oncology, integrating protein structure and function, and providing important tools to assist pharmaceutical researchers to understand and work in this dynamic area of cancer drug research Focus on small molecule inhibitors as well as other therapeutic modalities Discussion of kinase inhibitors that have entered clinical trials for the treatment of cancer, with an emphasis on molecules that have progressed to late stage clinical trials and, in a few cases, to market Providing a platform for further study, this important work reviews both the successes and challenges of kinase inhibitor therapy, and provides insight into future directions in the war against cancer.
Mumford is a well-known mathematician and winner of the Fields Medal, the highest honor available in mathematics. Many of these papers are currently unavailable, and the commentaries by Gieseker, Lange, Viehweg and Kempf are being published here for the first time.
In this text, the small team of expert authors presents the field in a comprehensive and accessible manner that is well suited for students and junior researchers. The result is a highly readable and systematically structured introduction to antimicrobial peptides, their structure, biological function and mode of action. The authors point the way towards a rational design of this potentially highly effective new class of clinical antibiotics on the brink of industrial application. They do this by discussing their design principles, target membranes and structure-activity relationships. The final part of the book describes recent successes in the application of peptides as anticancer agents.
Semiconductor heterostructures represent the backbone for an increasing variety of electronic and photonic devices, for applications including information storage, communication and material treatment, to name but a few. Novel structural and material concepts are needed in order to further push the performance limits of present devices and to open up new application areas. This thesis demonstrates how key performance characteristics of three completely different types of semiconductor lasers can be tailored using clever nanostructure design and epitaxial growth techniques. All aspects of laser fabrication are discussed, from design and growth of nanostructures using metal-organic vapor-phase epitaxy, to fabrication and characterization of complete devices.
Mumford's famous "Red Book" gives a simple, readable account of the basic objects of algebraic geometry, preserving as much as possible their geometric flavor and integrating this with the tools of commutative algebra. It is aimed at graduates or mathematicians in other fields wishing to quickly learn aboutalgebraic geometry. This new edition includes an appendix that gives an overview of the theory of curves, their moduli spaces and their Jacobians -- one of the most exciting fields within algebraic geometry.
Advancing Practice in Cancer and Palliative Care critically explores and analyses the themes and pragmatics of advancing nursing practice in relation to cancer and palliative care. Written by a team of experienced practitioners and educationalists, each chapter considers key elements of advanced practice in terms of conceptual, practical and organisational themes. Case studies are used throughout to encourage the reader to take a reflective stance on the way in which the themes of the text can be applied to practice. The book will be a useful resource for cancer and palliative care nurses wanting to advance and lead practice effectively.
New emerging diseases, new diagnostic modalities for resource-poor settings, new vaccine schedules ... all significant, recent developments in the fast-changing field of tropical medicine. Hunter's Tropical Medicine and Emerging Infectious Diseases, 10th Edition, keeps you up to date with everything from infectious diseases and environmental issues through poisoning and toxicology, animal injuries, and nutritional and micronutrient deficiencies that result from traveling to tropical or subtropical regions. This comprehensive resource provides authoritative clinical guidance, useful statistics, and chapters covering organs, skills, and services, as well as traditional pathogen-based content. You'll get a full understanding of how to recognize and treat these unique health issues, no matter how widespread or difficult to control. - Includes important updates on malaria, leishmaniasis, tuberculosis and HIV, as well as coverage of Ebola, Zika virus, Chikungunya, and other emerging pathogens. - Provides new vaccine schedules and information on implementation. - Features five all-new chapters: Neglected Tropical Diseases: Public Health Control Programs and Mass Drug Administration; Health System and Health Care Delivery; Zika; Medical Entomology; and Vector Control – as well as 250 new images throughout. - Presents the common characteristics and methods of transmission for each tropical disease, as well as the applicable diagnosis, treatment, control, and disease prevention techniques. - Contains skills-based chapters such as dentistry, neonatal pediatrics and ICMI, and surgery in the tropics, and service-based chapters such as transfusion in resource-poor settings, microbiology, and imaging. - Discusses maladies such as delusional parasitosis that are often seen in returning travelers, including those making international adoptions, transplant patients, medical tourists, and more. - Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices.
Over the past two decades a number of attempts have been made, with varying degrees of success, to collect in a single treatise available information on the basic and applied pharmacology and biochemical mechanism of action of antineoplastic and immunosuppressive agents. The logarithmic growth of knowledge in this field has made it progressively more difficult to do justice to all aspects of this topic, and it is possible that the present handbook, more than four years in preparation, may be the last attempt to survey in a single volume the entire field of drugs employed in cancer chemotherapy and immunosuppression. Even in the present instance, it has proved necessary for practical reasons to publish the material in two parts, although the plan of the work constitutes, at least in the editors' view, a single integrated treatment of this research area. A number of factors have contributed to the continuous expansion of research in the areas of cancer chemotherapy and immunosuppression. Active compounds have been emerging at ever-increasing rates from experimental tumor screening systems maintained by a variety of private and governmental laboratories through out the world. At the molecular level, knowledge of the modes of action of established agents has continued to expand, and has permitted rational drug design to play a significantly greater role in a process which, in its early years, depended almost completely upon empirical and fortuitous observations.
Grothendieck’s beautiful theory of schemes permeates modern algebraic geometry and underlies its applications to number theory, physics, and applied mathematics. This simple account of that theory emphasizes and explains the universal geometric concepts behind the definitions. In the book, concepts are illustrated with fundamental examples, and explicit calculations show how the constructions of scheme theory are carried out in practice.
Great Groups is a practical and inspirational guide that serves as a foundational text to creating and leading groups. Designed primarily for the beginning group worker from any of the helping professions, the book also acts as a valuable resource for those with more group experience. Grounded in theory, but with a strong focus on practice and skill development, David R. Hutchinson strives to connect directly with the reader with his personal and engaging writing style and "learn by doing" approach. Following a hypothetical group from start to finish, with a plethora of examples and reflection exercises in each chapter, the book has a threefold purpose: to provide the reader with specific tools for creating, understanding, and leading effective groups; to help the reader consider the application of theory to practice; and to spur the reader to seriously consider making group work a cornerstone of his or her professional practice.
Winner of the CHOICE Outstanding Academic Titles, this key textbook offers an insight on the theory of emotional intelligence and its vital practical value. Elegantly and succinctly written, it makes a powerful case for the importance of understanding and managing emotions for effective professional practice. Written for students and practitioners alike across a range of human services and caring professions, Howe's work on attachment theory has been hugely influential. With a highly regarded reputation for setting the agenda in social work teaching, the author's skills in communicating important theory in an engaging language make of this essential textbook a must-have for all current and future practitioners of the field.
Geometric Invariant Theory" by Mumford/Fogarty (the firstedition was published in 1965, a second, enlarged editonappeared in 1982) is the standard reference on applicationsof invariant theory to the construction of moduli spaces.This third, revised edition has been long awaited for by themathematical community. It is now appearing in a completelyupdated and enlarged version with an additional chapter onthe moment map by Prof. Frances Kirwan (Oxford) and a fullyupdated bibliography of work in this area.The book deals firstly with actions of algebraic groups onalgebraic varieties, separating orbits by invariants andconstructionquotient spaces; and secondly with applicationsof this theory to the construction of moduli spaces.It is a systematic exposition of the geometric aspects ofthe classical theory of polynomial invariants.
This new edition of Corporate Insolvency Law builds on the unique and influential analytical framework established in previous editions - which outlines the values to be served by insolvency law and the need for it to further corporate as well as broader social ends. Examining insolvency law in the fast-evolving commercial world, the third edition covers the host of new laws, policies and practices that have emerged in response to the fresh corporate and financial environments of the post-2008 crisis era. This third edition includes a new chapter on the growing issue of cross border insolvency and deals with a host of recent developments, notably; the consolidation of the rescue culture in the UK, the rise of the pre-packaged administration, and the substantial replacement of administrative receivership with administration. Suitable for advanced undergraduate and graduate students, professionals and academics, Corporate Insolvency Law offers an organised basis for rising to the challenges of an ever-shifting area of the law.
Designed for graduate level courses in adult psychopathology, the Second Edition of this book incorporates the newly released (2013) DSM-5 . Unique in its approach, this text presents a historical context in which current diagnoses are made. Presenting an overview of the issues and methodologies of conducting assessments, each of the major psychological disorders is discussed in a standard format in the chapter dealing with that disorder. The text includes new chapters on nonalcohol substance abuse and contextual factors affecting diagnoses. Each chapter covers: description from DSM, using case examples; epidemiology; basic research, including neurobiology and neuroscience of the disorder; prevalence and consequences of the disorder; behavioral, social, cognitive, and emotional aspects of the disorder; and treatment of the disorder, using clinical examples showing how psychopathology and assessment influence treatment"--
This is the seventeenth volume in an annual series in which leading economists provide a concise and accessible evaluation of major developments in trade and trade policy. Examines key issues pertinent to the multinational trading system, as well as regional trade arrangements and policy developments at the national level Provides up-to-date assessments of the World Trade Organization's current Trade Policy Reviews A vital resource for researchers, analysts and policy-advisors interested in trade policy and other open economy issues Analyses global trade policy in Turkey, China and The Dominican Republic, and a survey by Tarlok Singh questions whether international trade does cause economic growth Includes chapters exploring WTO issues, and a section on regional trading agreements
This book is a completely revised new edition of the definitive reference on disorders of hemoglobin. Authored by world-renowned experts, the book focuses on basic science aspects and clinical features of hemoglobinopathies, covering diagnosis, treatment, and future applications of current research. While the second edition continues to address the important molecular, cellular, and genetic components, coverage of clinical issues has been significantly expanded, and there is more practical emphasis on diagnosis and management throughout. The book opens with a review of the scientific underpinnings. Pathophysiology of common hemoglobin disorders is discussed next in an entirely new section devoted to vascular biology, the erythrocyte membrane, nitric oxide biology, and hemolysis. Four sections deal with α and β thalassemia, sickle cell disease, and related conditions, followed by special topics. The second edition concludes with current and developing approaches to treatment, incorporating new agents for iron chelation, methods to induce fetal hemoglobin production, novel treatment approaches, stem cell transplantation, and progress in gene therapy.
Medical Licensing and Discipline in America traces the evolution of the U.S. medical licensing system from its historical antecedents in the 18th and 19th century to its modern structure, emphasizing a focus on public accountability and the policies, guidelines and practices of medical boards. In doing so, the book underscores the role of the Federation of State Medical Boards in facilitating state-based licensure and discipline and the promotion of quality health care.
David Boonin presents a new account of the non-identity problem: a puzzle about our obligations to people who do not yet exist. Our actions sometimes have an effect not only on the quality of life that people will enjoy in the future, but on which particular people will exist in the future to enjoy it. In cases where this is so, the combination of certain assumptions that most people seem to accept can yield conclusions that most people seem to reject. The non-identity problem has important implications both for ethical theory and for a number of topics in applied ethics, including controversial issues in bioethics, environmental ethics and disability ethics. It has been the subject of a great deal of discussion for nearly four decades, but this is the first book-length study devoted exclusively to its examination. Boonin begins by explaining what the problem is, why the problem matters, and what criteria a solution to the problem must satisfy in order to count as a successful one. He then provides a critical survey of the solutions to the problem that have thus far been proposed in the sizeable literature that the problem has generated and concludes by developing and defending an unorthodox alternative solution, one that differs fundamentally from virtually every other available approach.
The right to demonstrate is considered fundamental to any democratic system of government, yet in recent years it has received little academic attention. However, events following the recent G20 protests in April 2009 make this a particularly timely work. Setting out and explaining in detail the domestic legal framework that surrounds the right of peaceful protest, the book provides the first extensive analysis of the Strasbourg jurisprudence under Articles 10 and 11 of the European Convention on Human Rights, offering a critical look at recent cases such as Öllinger, Vajnai, Bukta, Oya Ataman, Patyi and Ziliberberg, as well as the older cases that form its bedrock. The principles drawn from this case-law are then synthesised into the remainder of the book to see how the right of protest enshrined in the Human Rights Act 1998 now operates. The five central chapters show how the right is defined: the restrictions on the choice of location of a protest; the constraints imposed on peaceful, persuasive protest; the near total intolerance of any form of obstructive or disruptive protest; the scope of preventive action by the police; and the extent to which commercial targets can avail themselves of private law remedies. This contemporary landscape is highlighted by critical analysis of the principles and case law -- including the leading decisions in Laporte, Austin, Jones and Lloyd and Kay. The book also highlights and develops themes that are currently under-theorised or ignored, including the interplay of the public and the private in regulating protest; the pivotal role played by land ownership rules; and the disjuncture between the law in the books and the law in action. While the book will appeal primarily to scholars, students and practitioners of law – as well as to campaigners and interest groups – it also offers political and socio-legal insights, which will be of interest equally to non-specialists.
Offers solutions and best practices to respond to recurrent problems and contemporary challenges in the field Since the publication of the first edition of Environmental Impact Assessment in 2003, both the practice and theory of impact assessment have changed substantially. Not only has the field been subject to a great deal of new regulations and guidelines, it has also evolved tremendously, with a greater emphasis on strategic environmental, sustainability, and human health impact assessments. Moreover, there is a greater call for impact assessments from a global perspective. This Second Edition, now titled Impact Assessment to reflect its broader scope and the breadth of these many changes, offers students and practitioners a current guide to today's impact assessment practice. Impact Assessment begins with an introduction and then a chapter reviewing conventional approaches to the field. Next, the book is organized around recurrent problems and contemporary challenges in impact assessment process design and management, enabling readers to quickly find the material they need to solve tough problems, including: How to make impact assessments more influential, rigorous, rational, substantive, practical, democratic, collaborative, ethical, and adaptive How each problem and challenge-reducing process would operate at the regulatory and applied levels How each problem can be approached for different impact assessment types—sustainability assessment, strategic environmental assessment, project-level EIA, social impact assessment, ecological impact assessment, and health impact assessment How to link and combine impact assessment processes to operate in situations with multiple overlapping problems, challenges, and impact assessment types How to connect and combine impact assessment processes Each chapter first addresses the topic with current theory and then demonstrates how that theory is applied, presenting requirements, guidelines, and best practices. Summaries at the end of each chapter provide a handy tool for structuring the design and evaluation of impact assessment processes and documents. Readers will find analyses and new case studies that address such issues as multi-jurisdictional impact assessment, climate change, cumulative effects assessment, follow-up, capacity building, interpreting significance, and the siting of major industrial and waste facilities. Reflecting current theory and standards of practice, Impact Assessment is appropriate for both students and practitioners in the field, enabling them to confidently respond to a myriad of new challenges in the field.
This book can form the basis of a second course in algebraic geometry. As motivation, it takes concrete questions from enumerative geometry and intersection theory, and provides intuition and technique, so that the student develops the ability to solve geometric problems. The authors explain key ideas, including rational equivalence, Chow rings, Schubert calculus and Chern classes, and readers will appreciate the abundant examples, many provided as exercises with solutions available online. Intersection is concerned with the enumeration of solutions of systems of polynomial equations in several variables. It has been an active area of mathematics since the work of Leibniz. Chasles' nineteenth-century calculation that there are 3264 smooth conic plane curves tangent to five given general conics was an important landmark, and was the inspiration behind the title of this book. Such computations were motivation for Poincaré's development of topology, and for many subsequent theories, so that intersection theory is now a central topic of modern mathematics.
This textbook describes the biomechanics of bone, cartilage, tendons and ligaments. It is rigorous in its approach to the mechanical properties of the skeleton yet it does not neglect the biological properties of skeletal tissue or require mathematics beyond calculus. Time is taken to introduce basic mechanical and biological concepts, and the approaches used for some of the engineering analyses are purposefully limited. The book is an effective bridge between engineering, veterinary, biological and medical disciplines and will be welcomed by students and researchers in biomechanics, orthopedics, physical anthropology, zoology and veterinary science. This book also: Maximizes reader insights into the mechanical properties of bone, fatigue and fracture resistance of bone and mechanical adaptability of the skeleton Illustrates synovial joint mechanics and mechanical properties of ligaments and tendons in an easy-to-understand way Provides exercises at the end of each chapter
Written by one of America's foremost authorities in preventive medicine, Nutrition in Clinical Practice is the practical, comprehensive, evidence-based reference that all clinicians need to offer patients effective, appropriate dietary counseling. Each chapter concludes with concise guidelines for counseling and treatment, based on consensus and the weight of evidence. Appendices include clinically relevant formulas, nutrient data tables, patient-specific meal planners, and print and Web-based resources for clinicians and patients. Enhanced coverage of probiotics, health effects of soy, and other topics Information derived from a rigorous analysis of the published literature New chapter on food processing New chapter on functional foods New chapter on nutritional profiling systems Short chapters written for the busy clinician who needs actionable information
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