Palliative medicine was first recognised as a specialist field in 1987. One hundred years earlier, London based doctor William Munk published a treatise on 'easeful death' that mapped out the principles of practical, spiritual, and medical support at the end of life. In the intervening years a major process of development took place which led to innovative services, new approaches to the study and relief of pain and other symptoms, a growing interest in 'holistic' care, and a desire to gain more recognition for care at the end of life. This book traces the history of palliative medicine, from its nineteenth-century origins, to its modern practice around the world. It takes in the changing meaning of 'euthanasia', assesses the role of religious and philanthropic organisations in the creation of homes for the dying, and explores how twentieth-century doctors created a special focus on end of life care. To Comfort Always traces the rise of clinical studies, academic programmes and international collaborations to promote palliative care. It examines the continuing need to support development with evidence, and assesses the dilemmas of unequal access to services and pain relieving drugs, as well as the periodic accusations of creeping medicalization within the field. This is the first history of its kind, and the breadth of information it encompasses makes it an essential resource for those interested in the long-term achievements of palliative medicine as well as the challenges that remain.
The story of 1966-67, Scottish football's greatest-ever season when Scottish clubs conquered Europe and the Scotland national football team humbled World champions England on their own Wembley turf.
2018 Nebraska Book Award The state of Nebraska has a rich and varied culture, from the eastern metropolitan cities of Omaha and Lincoln to the ranches of the western Sand Hills. The first atlas of Nebraska published in over thirty years, this collection chronicles the history of the state with more than three hundred original, full-color maps accompanied by extended explanatory text. Far more than simply the geography of Nebraska, this atlas explores a myriad of subjects from Native Americans to settlement patterns, agricultural ventures to employment, and voting records to crime rates. These detailed and beautifully designed maps convey the significance of the state, capturing the essence of its people and land. This volume promises to be an essential reference tool to enjoy for many years to come.
In the late 1920s an exciting discovery was made at the New Mexico site of Folsom - spear points, found embedded between the ribs of an Iron Age bison - that was to resolve decades of bitter conflict amongst archaeologists.
An expert guide to targeting protein kinases in cancer therapy Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells. Because of this fact, pharmaceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal roadblocks to sever their malignant means of communication. Complete with full-color presentations, Targeting Protein Kinases for Cancer Therapy defines the structural features of protein kinases and examines their cellular functions. Combining kinase biology with chemistry and pharmacology applications, this book enlists emerging data to drive the discovery of new cancer-fighting drugs. Valuable information includes: Comprehensive overviews of the major kinase families involved in oncology, integrating protein structure and function, and providing important tools to assist pharmaceutical researchers to understand and work in this dynamic area of cancer drug research Focus on small molecule inhibitors as well as other therapeutic modalities Discussion of kinase inhibitors that have entered clinical trials for the treatment of cancer, with an emphasis on molecules that have progressed to late stage clinical trials and, in a few cases, to market Providing a platform for further study, this important work reviews both the successes and challenges of kinase inhibitor therapy, and provides insight into future directions in the war against cancer.
Bacterial Endotoxic Lipopolysaccharides provides an up-to-date, two-volume review of the latest information regarding bacterial lipopolysaccharide structure and activities. These volumes cover the biochemistry, pharmacology, and pathophysiologic properties of endotoxins. The volumes also thoroughly discuss the strengths and weaknesses of new therapies for septic shock that are based on an immunological attack on endotoxins and the cytokines induced by endotoxins. All scientists involved in endotoxin research, clinical infectious disease specialists, and medical students interested in the pathogenesis of septic shock will find Bacterial Endotoxic Lipopolysaccharides invaluable as a reference resource.
David Newton, formerly Head of Patents Information at the British Library, has selected 220 of the most interesting and curious of the brands registered in the first 30 years of trade registration, between 1876 and 1906. He discusses the history and development of a number of household names including Shell, Listerine, Carlsberg beer, Triumph cars and Lea and Perrin sauces.
Examines the history of All-Star baseball, providing play-by-plays, rosters, and box scores of each game; and discusses how All-Star games have been influenced by racial integration, expansion teams, and the designated hitter.
A valuable resource for researchers and workers in the fields of both pharmaceuticals and biotechnology as well as undergraduates in biochemistry, applied biology, biomedical sciences and pharmacy, this book compares established techniques of antibody production with the new. Antibody structure and the implications of antibody engineering are fully discussed, and a case study approach illustrates how antibodies are finding increasing use in the diagnosis and treatment of disease. The volume ends with commercial expression, purification and large-scale manufacture of antibodies and their future potential, particularly as therapeutic agents.
The inside scoop... for when you want more than the official line! Microsoft Office Word 2007 may be the top word processor, but to use it with confidence, you'll need to know its quirks and shortcuts. Find out what the manual doesn't always tell you in this insider's guide to using Word in the real world. How do you use the new Ribbon? What's the best way to add pictures? From deciphering fonts to doing mass mailings, first get the official way, then the best way from an expert. Unbiased coverage on how to get the most out of Word 2007, from applying templates and styles to using new collaboration tools Savvy, real-world advice on creating document for the Web, saving time with macros, and punching up docs with SmartArt. Time-saving techniques and practical guidance on working around Word quirks, avoiding pitfalls, and increasing your productivity. Tips and hacks on how to customize keyboard shortcuts, how to embed fonts, and quick ways to get to Help. Sidebars and tables on TrueType versus Printer fonts, World 2007 View modes, and tabs in Word 2007. Watch for these graphic icons in every chapter to guide you to specific practical information. Bright Ideas are smart innovations that will save you time or hassle. Hacks are insider tips and shortcuts that increase productivity. When you see Watch Out! heed the cautions or warnings to help you avoid common pitfalls. And finally, check out the Inside Scoops for practical insights from the author. It's like having your own expert at your side!
In this guide, educators and authors David Upegui and David E. Fastovsky offer a pedagogical prescription for how you can integrate the study of racial justice with evolutionary biology in your existing high-school biology curriculum. Designed as a practical manual for teaching, the chapters focus on teaching concepts of equity through evolutionary biology modules, a cornerstone for building students’ scientific understanding of biotic diversity. The book provides pedagogical components alongside historical and scientific components, with contextual chapters that give teachers the background knowledge to understand the historical relationship between science and racism for topics such as natural selection, social justice, and American slavery and colonization. Ready-to-use lesson plans are situated in a historical and theoretical context of science as it relates to racial oppression, and demonstrate how rigorous science education can lead to your students’ liberation and personal empowerment despite the historically problematic history of some applications of science. These lesson plans and classroom exercises are presented in a way that introduces the timely extra dimension of anti-racism into the existing biology curricula without significantly increasing teaching loads. The contextual material provided allows the lessons to be implemented across a variety of classrooms regardless of initial familiarity with DEI. Ideal for secondary biology teachers and their students, particularly in grades 10-12, this book synthesizes timely ideas for high-school educators, harnessing the power of rigorous science to combat marginalization. Lessons and activities have been classroom-tested and are aligned with three different standards: Next Generation Science Standards (NGSS); College board (AP Biology); Vision and Change; and use the 5E format.
This book is comprised of extensive reviews and instructional chapters that discuss the quality of life in several aspects of cancer. The first six chapters deal with conceptual issues relating to measuring quality of life in adult and pediatric populations with cancer. The next five chapters provide practical information on how to select quality-of-life measures, the statistical analysis of trials, economic evaluations to be considered, and some possible abuses of quality-of-life measures. Five chapters review the results of studies using selected quality-of-life measures and provide recent information on their performance. These are followed by three chapters dealing with specific issues relating to nausea and vomiting associated with cancer therapy. Three chapters are devoted to the problems of assessing and controlling pain in patients who have cancer. There are also two chapters that deal with the quality of life in palliative care. Effect of Cancer on Quality of Life is intended for all who have an interest in measuring the quality of life in patients with cancer. This includes investigators who are just entering the field and can benefit from instructions on how to conduct quality-of-life research, as well as those who are experienced in conducting this kind of research.
A ground-breaking argument for better treatment of mental health from Richard Layard (author of Happiness) and David M. Clark. Britain has become a world leader in providing psychological therapies thanks to the work of Richard Layard and David Clark. But, even so, in Britain and worldwide the majority of people who need help still don't get treatment. This is both unjust and a false economy. This book argues for change. It shows that mental ill-health causes more of the suffering in our society than physical illness, poverty or unemployment. Moreover, greater spending on helping people to recover from mental health problems - and stay well - would generate massive savings to national economies, as those who suffer from depression and anxiety disorders account for nearly a half of all disability and are predominantly of working age. Modern talking therapies, such as CBT (Cognitive Behavioural Therapy), are highly effective, and if more sufferers got these treatments, lives would be turned around and the cost would be fully covered by the huge savings. Thrive explores the new effective solutions to the misery and injustice caused by mental illness. It describes how successful psychological treatments have been developed and explains what works best for whom. It also urges us to do all we can to prevent these problems in the first place, through better schools and a better society. And, most importantly, it offers real hope. 'This book is an inspiring success story and a stirring call to further action. Its message is as compelling as it is important: the social costs of mental illness are terribly high and the costs of effective treatments are surprisingly low' Daniel Kahneman 'Extremely easy and pleasurable to read. It's the most comprehensive, humane and generous study of mental illness that I've come across' Melvyn Bragg 'Remarkable . . . presents the issues in a style that easy for the professional, the general public, and policy makers to understand' Aaron T Beck 'Professors Layard and Clark (the Dream Team of British Social Science) make a compelling case for a massive injection of resources into the treatment and prevention of mental illness. This is simply the best book on public policy and mental health ever written' Martin Seligman RICHARD LAYARD is one of the world's leading labour economists, and in 2008 received the IZA International Prize for Labour Economics. A member of the House of Lords, he has done much to raise the public profile of mental health. His 2005 book Happiness has been translated into 20 languages. DAVID M. CLARK, Professor of Psychology at Oxford, is one of the world's leading experts on CBT, responsible for much progress in treatment methods. With Richard Layard, he was the main driver behind the UK's Improving Access to Psychological Therapies programme.
For nearly 20 years, Survey of Audiology: Fundamentals for Audiologists and Health Professionals has provided both the breadth of an introductory survey of audiology and the depth of a detailed textbook. Inside, Drs. David DeBonis and Constance Donohue have combined their years of work in clinical settings and their experience teaching audiology into a textbook intended to give students all the knowledge they’ll need in the most accessible and comprehensible format. In this Third Edition, updates have been made to include the latest information on the most current topics in audiology, including cognition and hearing loss, pharmacology, central auditory processing disorders, wireless technology, hearing aid accessibility, tinnitus, genetics and biotechnology, and noise exposure. New and updated inside the Third Edition: Ethical considerations for audiologists Auditory Neuropathy Spectrum Disorder (ANSD) Auditory processing disorders Tinnitus Evidence-based genetic counseling The latest hearing aid technology How to critically review evidence in literature and studies Included with the text are online supplemental materials for faculty use in the classroom. With its extensive glossary, numerous case examples, chapter abstracts, learning objectives, and questions for discussion, Survey of Audiology is designed to support learning and reinforce key points in every way. The text also works to integrate the humanistic aspects of audiology with the scientific ones into holistic discussions of assessment and intervention. Through this approach, students will learn to always remember that there is a person behind each set of symptoms. While aspiring audiologists will appreciate the depth of Survey of Audiology: Fundamentals for Audiologists and Health Professionals, Third Edition, students of speech-language pathology and other health professions looking for a crash course in audiology will benefit from its readability and wide scope.
This volume provides background knowledge useful to those setting out to do genetic studies of aging in mammals, and raises vital questions: How many genes are important in mammalian aging? What are the optimal methods for their study? To what degree are patterns of aging, and patterns of growth and development part of the same process? Do patterns of development predict subsequent patterns of growth and aging? Are there a few fundamental aging processes, or does every biological system age? The rapid rate of progress in this field required a new volume with a new approach, based on the combination of classical genetics and the powerful new tools of molecular genetics. Although mammalian systems are emphasized, representatives of the advanced genetic studies in Drosophila and other model systems are included. The purpose is to enrich and stimulate genetic studies of mammalian aging by suggesting and evaluating future possibilities.
Written by the leading names in pediatric oncology and hematology, Nathan and Oski's Hematology and Oncology of Infancy and Childhood offers you the essential tools you need to overcome the unique challenges and complexities of childhood cancers and hematologic disorders. Meticulously updated, this exciting full-color set brings together the pathophysiology of disease with detailed clinical guidance to provide you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children. - Form a definitive diagnosis and create the best treatment plans possible with comprehensive coverage of all pediatric cancers, including less-common tumors, as well as all hematologic disorders, including newly recognized ones. - Develop a thorough, understanding of the underlying science of diseases through summaries of relevant pathophysiology balanced with clear, practical clinical guidance. Nathan and Oski's is the only comprehensive product on the market that relates pathophysiology in such depth to hematologic and oncologic diseases affecting children. - Quickly and effortlessly access the key information you need with the help of a consistent organization from chapter to chapter and from volume to volume. - Stay at the forefront of your field thanks to new and revised chapters covering topics such as paroxysmal nocturnal hemoglobinuria, lysosomal storage diseases, childhood genetic predisposition to cancer, and oncology informatics. - Learn about the latest breakthroughs in diagnosis and management, making this the most complete guide in pediatric hematology and oncology. - Discover the latest in focused molecularly targeted therapies derived from the exponential growth of knowledge about basic biology and genetics underlying the field. - Rely on it anytime, anywhere! Access the full text, images, and more at Expert Consult.
In this authoritative text with generous annotations, a distinguished literary scholar has corrected errors and omissions from previous editions, with notes taken from Thoreau's draft manuscripts and quotes from sources Thoreau read.
Design and implement a rehab program on your own with Pathology and Intervention in Musculoskeletal Rehabilitation, 2nd Edition. Part of Magee's popular Musculoskeletal Rehabilitation Series, this pathology text for physical therapists provides clear guidance on patient management relative to specific musculoskeletal pathology, injury, and illness - all based on a sound understanding of basic science and principles of practice. It focuses on the specific pathologies most often seen in the clinic, and discusses the best methods for intervention for the different areas of the body in the context of the tissue-healing model. Each intervention features a rationale, along with the pathology and problem presented; stage of healing; evidence in the literature; and clinical reasoning considerations. Dedicated and focused information on the specific pathologies most often seen in the clinic, as well as the best methods for intervention for the different areas of the body, minimizes duplication of information by referring you to other titles in the Musculoskeletal Rehabilitation Series for basic scientific information regarding inflammation, healing, tissue deformation, and the development of muscular strength and endurance. Trusted experts in musculoskeletal rehabilitation, along with internationally recognized contributors, present the best evidence behind contemporary interventions directed toward the treatment of the impairments and functional limitations associated with acute, chronic, and congenital musculoskeletal conditions occurring across the lifespan. Evidence-based content, with over 4,000 references, supports the scientific principles for rehabilitation interventions, providing the best evidence for the management of musculoskeletal pathology and injury. NEW! The Skin and Wound Healing chapter looks at the numerous tools available to assist in objectively monitoring and treating a patient with an acute or chronic wound. NEW! Rotator Cuff Pathology chapter highlights the anatomy, function, and etiology of the rotary cuff, and addresses rotary cuff injuries, physical examination, and non-operative and operative treatment. UPDATED! Substantially revised chapter on the Thoracic Ring ApproachT facilitates clinical reasoning for the treatment of the thoracic spine and ribs through the assessment and treatment of thoracic spine disorders and how they relate to the whole kinetic chain. UPDATED! Revised Lumbar Spine - Treatment of Motor Control Disorders chapter explores some of the research evidence and clinical reasoning pertaining to instability of the lumbar spine so you can better organize your knowledge for immediate use in the clinical setting. UPDATED! Significantly revised chapter on the treatment of pelvic pain and dysfunction presents an overview of specific pathologies pertaining to the various systems of the pelvis - and highlights how "The Integrated Systems Model for Disability and Pain" facilitates evidence-based management of the often complex patient with pelvic pain and dysfunction. NEW! Musculoskeletal Bone and Soft Tissue Tumors chapter covers common bones tumors, anatomic considerations and rehabilitation, pediatric patients, and amputation related to cancer. UPDATED! Thoroughly revised chapters with additional references ensure you get the most recent evidence and information available. NEW! Full color design and illustration program reflects what you see in the physical world to help you recognize and understand concepts more quickly.
Written by leading food animal researchers, practitioners, and educators, this comprehensive guide provides quick access to the latest medical and surgical interventions for cattle, sheep, and goats. The concise, quick-reference format and logical body systems organization make it ideal for use in both the clinical setting and the field. You'll easily locate key information on preventing, treating, and managing disease in food animals, as well as expert insights on improving outcomes for individual animals and herd populations. - Authoritative, cutting-edge coverage offers clinically relevant strategies for diagnosing and managing a wide range of diseases and disorders in food animals, with a focus on cattle, sheep, and goats. - Logically organized content is easy-to-follow and provides a practical approach to determining appropriate medical and surgical interventions. - Concise, easy-to-read format helps you find essential information quickly and easily. - Expert editors, consultants, and writers ensure the accuracy, relevance, and timeliness of each topic to keep you on the cutting edge of food animal therapy. - New editors and a new team of section editors bring a fresh perspective and authoritative guidance on caring for food animals. - Completely revised and updated content includes new sections on topics such as: - Genital surgery - Pharmacology and therapeutics - Restraint, anesthesia, and pain management - Cow-calf/small ruminant production medicine - Feedlot production medicine - Coverage of hot topics in the field includes biosecurity in feedlots, therapy in organic livestock medicine, and ethical responsibilities in selecting drugs for use in food animals. - Expanded treatment options incorporate surgical interventions where appropriate, including laparoscopic procedures.
This book provides an original analysis of change management in organizations in the light of wider sociological perspectives, and critically examines the theoretical frameworks underpinning many contemporary accounts of organizational change.
In recent years, there has been an explosion of books on the nature of organisational change and the management skills needed to effectively carry it out. Many are written by change gurus and management consultants offering quick fixes and metaphor laden business toolkits, however, much of their advice is banal and under-theorized. This book redresses this balance by providing an original analysis of change management in organizations in the light of wider sociological perspectives. It critically examines the, often implicit, theoretical frameworks underpinning many contemporary accounts of organizational change, and covers subjects including: * the importance of explicit analysis of theory and context * a critique of populist management gurus and quick-fix 'how-to' solutions * 'under-socialized' models of change which emphasise structure over human action * trenchant analysis of 'soft' HRM solutions * the management of culture. Radical and innovative, this book, the first to adopt a sociological approach, is a much-needed challenge to the orthodoxies of change management.
Assessing where the red/blue political line lies in swing states and how it is shifting Democratic-leaning urban areas in states that otherwise lean Republican is an increasingly important phenomenon in American politics, one that will help shape elections and policy for decades to come. Blue Metros, Red States explores this phenomenon by analyzing demographic trends, voting patterns, economic data, and social characteristics of twenty-seven major metropolitan areas in thirteen swing states—states that will ultimately decide who is elected president and the party that controls each chamber of Congress. The book's key finding is a sharp split between different types of suburbs in swing states. Close-in suburbs that support denser mixeduse projects and transit such as light rail mostly vote for Democrats. More distant suburbs that feature mainly large-lot, single-family detached houses and lack mass transit often vote for Republicans. The book locates the red/blue dividing line and assesses the electoral state of play in every swing state. This red/blue political line is rapidly shifting, however, as suburbs urbanize and grow more demographically diverse. Blue Metros, Red States is especially timely as the 2020elections draw near.
Most of the research aimed at counterterrorism, fraud detection, or other forensic applications assumes that this is a specialized application domain for mainstream knowledge discovery. Unfortunately, knowledge discovery changes completely when the datasets being used have been manipulated in order to conceal some underlying activity. Knowledge Dis
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