Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. For more than 30 years, Perez and Brady's Principles and Practice of Radiation Oncology has been the must-have standard reference for radiation oncologists and radiation oncology residents who need a comprehensive text covering both the biological and physical science aspects of this complex field as well as disease site-specific information on the integrated, multidisciplinary management of patients with cancer. The book has established itself as the discipline’s "text-of-record," belonging on the shelf of all of those working in the field. The Seventh Edition continues this tradition of excellence with extensive updates throughout, many new chapters, and more than 1,400 full-color illustrations that highlight key concepts in tumor pathogenesis, diagnosis, and targeted radiation therapy.
Understanding the molecular mechanism of muscle contraction started with the discovery that striated muscle is composed of interdigitating filaments which slide against each other. Sliding filaments and the working-stroke mechanism provide the framework for individual myosin motors to act in parallel, generating tension and loaded shortening with an efficient use of chemical energy. Our knowledge of this exquisitely structured molecular machine has exploded in the last four decades, thanks to a bewildering array of techniques for studying intact muscle, muscle fibres, myofibrils and single myosin molecules. After reviewing the mechanical and biochemical background, this monograph shows how old and new experimental discoveries can be modelled, interpreted and incorporated into a coherent mathematical theory of contractility at the molecular level. The theory is applied to steady-state and transient phenomena in muscle fibres, wing-beat oscillations in insect flight muscle, motility assays and single-molecule experiments with optical trapping. Such a synthesis addresses major issues, most notably whether a single myosin motor is driven by a working stroke or a ratchet mechanism, how the working stroke is coupled to phosphate release, and whether one cycle of attachment is driven by the hydrolysis of one molecule of ATP. Ways in which the theory can be extended are explored in appendices. A separate theory is required for the cooperative regulation of muscle by calcium via tropomyosin and troponin on actin filaments. The book reviews the evolution of models for actin-based regulation, culminating in a model motivated by cryo-EM studies where tropomyosin protomers are linked to form a continuous flexible chain. It also explores muscle behaviour as a function of calcium level, including emergent phenomena such as spontaneous oscillatory contractions and direct myosin regulation by its regulatory light chains. Contraction models can be extended to all levels of calcium-activation by embedding them in a cooperative theory of thin-filament regulation, and a method for achieving this grand synthesis is proposed. Dr. David Aitchison Smith is a theoretical physicist with thirty years of research experience in modelling muscle contractility, in collaboration with experimental groups in different laboratories.
The fourth edition of this highly successful text has been extensively revised and restructured to take account of the many recent advances in the subject and bring it right up to date. The classic observations of recent years can now be interpreted with the powerful new techniques of molecular biology. Consequently there is much new material throughout the book, including many new illustrations and extensive references to recent work. Its essential philosophy remains the same, though: fundamental concepts are clearly explained, and key experiments are examined in some detail. This textbook will be used by students of physiology, neuroscience, cell biology and biophysics. Specializing undergraduates and graduates as well as lecturers and researchers will find the text thorough and clearly written.
Offering comprehensive coverage of this fast-changing field for more than 20 years, Urologic Surgical Pathology is an expert guide to all common and rare entities in the genitourinary system. The 4th Edition keeps you fully up to date with discussions of newly recognized tumors and terminologies, the latest classification schemes, current grading approaches, molecular alterations, and commonly used ancillary diagnostic techniques. With its clinical focus on day-to-day urological pathology sign-out and an emphasis on clinicopathologic and radiographic-pathologic correlations, this thoroughly revised uropathology reference is an excellent resource for diagnostic decision making. Includes expanded coverage of differential diagnosis for all tumor types encountered in urological surgical pathology practice. Incorporates the latest TNM staging and WHO classification systems, as well as new diagnostic biomarkers and their utility in differential diagnosis, newly described variants and new histologic entities. Discusses advances in molecular diagnostic testing, its capabilities, and its limitations, including targeted therapy/personalized medicine. Covers new developments in immunohistochemistry and the latest diagnostic tumor markers. Features more than 1,600 high-quality images – all in color – including gross pictures, histopathologic and cytopathologic images, special stains, other ancillaries, drawings, and illustrations. Helps you find information quickly with a consistent chapter format; an abundance of tables, diagrams and flowcharts; boxed lists of types and causes of diseases; differential diagnosis; characteristic features of diseases; complications; classifications; and staging.
Total Burn Care guides you in providing optimal burn care and maximizing recovery, from resuscitation through reconstruction to rehabilitation! Using an integrated, "team" approach, leading authority David N. Herndon, MD, FACS helps you meet the clinical, physical, psychological, and social needs of every patient. With Total Burn Care, you'll offer effective burn management every step of the way! Effectively manage burn patients from their initial presentation through long-term rehabilitation. Devise successful integrated treatment programs for different groups of patients, such as elderly and pediatric patients. Browse the complete contents of Total Burn Care online and download images, tables, figures, PowerPoint presentations, procedural videos, and more at www.expertconsult.com! Decrease mortality from massive burns by applying the latest advances in resuscitation, infection control, early coverage of the burn, and management of smoke inhalation and injury. Enhance burn patients' reintegration into society through expanded sections on reconstructive surgery (with an emphasis on early reconstruction), rehabilitation, occupational and physical therapy, respiratory therapy, and ventilator management.
The only text to cover lung function assessment from first principles including methodology, reference values and interpretation New for this edition: - More illustrations to convey concepts clearly to the busy physician - Text completely re-written in a contemporary style: includes user-friendly equations and more diagrams - New material covering the latest advances in the treatment of lung function, including more on sleep-related disorders, a stronger clinical and practical bias and more on new techniques and equipment - Uses the standard Vancouver referencing system What the experts say: "I have always considered Dr Cotes' book the most authoritative book published on lung function. It is also the most comprehensive." —Dr Robert Crapo, Pulmonary Division, LDS Hospital, Salt Lake City, USA "I think I can fairly speak on behalf of staff in lung function departments the length and breadth of the country - that a sixth edition of Cotes would be gratefully received." —Dr Brendan Cooper, Clinical Respiratory Scientist, Nottingham City Hospital
From the difficult to diagnose to the difficult to treat, Manson’s Tropical Diseases prepares you to effectively handle whatever your patients may have contracted. Featuring an internationally recognized editorial team, global contributors, and expert authors, this revised and updated medical reference book provides you with the latest coverage on parasitic and infectious diseases from around the world. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Incorporate the latest therapies into your practice, such as recently approved drugs and new treatment options. Find what you need easily and apply it quickly with highlighted key information, convenient boxes and tables, extensive cross-referencing, and clinical management diagrams. Make the most accurate Tropical Disease diagnoses through a completely redesigned and modernized format, which includes full-color images throughout. Apply the latest treatment strategies for HIV/AIDS, tropical neurology, malaria, and much more. Put the latest international expertise to work for you and your patients with new chapters covering Global Health; Global Health Governance and Tropical Diseases; Non-communicable Diseases; Obesity in the Tropics; and Emergency and Intensive Care Medicine in Resource-poor Settings. See which diseases are most prevalent in specific areas of the tropics through a new index of diseases by country, as well as online-only maps that provide additional detail. Better understand the variations in treatment approaches across the globe.
The debate about access to scientific research raises questions about the current effectiveness of scholarly communication processes. This book explores, from an independent point of view, the current state of the STM publishing market, new publishing technologies and business models as well as the information habit of researchers, the politics of research funders, and the demand for scientific research as a public good. The book also investigates the democratisation of science including how the information needs of knowledge workers outside academia can be embraced in future.
The first comprehensive treatment of stereotypes and stereotyping, this text synthesizes a vast body of social and cognitive research that has emerged over the past-quarter century. Provided is an unusually broad analysis of stereotypes as products both of individual cognitive activities and of social and cultural forces. While devoting careful attention to harmful aspects of stereotypes, their connections to prejudice and discrimination, and effective strategies for countering them, the volume also examines the positive functions of generalizations in helping people navigate a complex world. Unique features include four chapters addressing the content of stereotypes, which consider such topics as why certain traits are the focus of stereotyping and how they become attributed to particular groups. An outstanding text for advanced undergraduate- and graduate-level courses, the volume is highly readable and features many useful examples.
As a result of the molecular genetic analysis of development similar mechanisms for the regulation of gene expression are found in a wide range of organisms. In "Development - the Molecular Genetic Approach" these common mechanisms as well as the specific events leading to a differentiated cell are described. Particular items treated are, for example, how asymmetry is achieved, how cell size is determined, how cell division is controlled, how cell lineage influences development, how cells know their position, and how cells communicate during development.
How is each individual's unique personality formed? What is it about p ersonality that can change, and why is change often so slow? Promising approaches to these perennial questions are suggested by the explosio n of recent research in neuroscience and brain functioning. This timel y volume presents a coherent, empirically based, and clinically useful framework for understanding personality. Jim Grigsby and David Steven s illuminate links between the organization of the brain and the unfol ding of personality, and show how different aspects of personality are mediated by the brain's nonconscious learning and memory systems. Pro viding new insights for clinicians, students, and researchers, this bo ok builds a critical bridge between existing psychological theories of personality and emerging knowledge in clinical neuroscience.
This book was originallyconceived in the form ofa second edition ofa volume published in 1980 in Chapman and Hall's 'OutllneStudies in Biology' series and entitled Genetic Engineering - Cloning DNA. It very rapidly became apparent that with the impact ofrecombinant DNA techniques being feIt in so many areas ofblology, it was going to be difficultifnotimpossible to keepthe bookwithin the space confines of these little monographs. The stays were therefore loosened and the book expanded comfortably to its present size. I hope that this extra space has allowed me to clarify sections ofthe text that were 'heavy going' in the earlierversion. Theextraspace has certainlyallowed me to cover topics that were not mentioned at all in the earlier book. These are primarily to be found in Chapters 7 and 8, which cover the rapid advances that have been recently made in the use ofplantand animal cells as hosts for recombinant DNAmolecules. The develop ment ofother vectors has certainly not stood still over the past four years. This has necessitated a thorough revision ofChapters 3 and 4, which deal with bacteriophage and bacterial plasmid vectors. Numerous techniques for in vitromutagenesis have now been tried and tested allowing me to givecomprehensive coverage ofthisarea in Chapter 2 along with the biochemical techniques used to construct recombinant DNA molecules. Readers with some background knowledge of the approaches to gene cloning will be able to go straight toapart ofthe book in whichthey are specificallyinterested.
This volume provides background knowledge useful to those setting out to do genetic studies of aging in mammals, and raises vital questions: How many genes are important in mammalian aging? What are the optimal methods for their study? To what degree are patterns of aging, and patterns of growth and development part of the same process? Do patterns of development predict subsequent patterns of growth and aging? Are there a few fundamental aging processes, or does every biological system age? The rapid rate of progress in this field required a new volume with a new approach, based on the combination of classical genetics and the powerful new tools of molecular genetics. Although mammalian systems are emphasized, representatives of the advanced genetic studies in Drosophila and other model systems are included. The purpose is to enrich and stimulate genetic studies of mammalian aging by suggesting and evaluating future possibilities.
The new gold-standard in anesthesiology Written and edited by an internationally known team of experts, Anesthesiology gives you a 360-degree view of the field, covering all of the anesthetic considerations, preparations, and procedures for the surgical patient, the pain patient or the critical care patient. You'll find a unique balance between clinical information, practical clinical procedures, and the molecular and basic scientific underpinnings of anesthesiology practice. Anesthesiology delivers a multi-perspective, wide-ranging view of anesthetic drugs, procedures, co-morbid diseases, and need-to-know postoperative pain management strategies. This essential guide not only focuses on general anesthesia, but also is the first to feature a detailed look at the subspecialty of regional anesthesia. Features: Top-to-bottom coverage of the entire field-from preoperative evaluation and intraoperative anesthesia care to care of the critically ill or chronic pain patient Emphasis on safety, quality and patient-centered care, with an entire section on risk reduction A focus on the clinical applications of anesthesiology Complex concepts explained by graphics and illustrations, not equations and formulas Full-color format and illustrations Specific drug and interventional guidelines for the clinical management of every OR/post-OR scenario in the anesthesiology field Key points and key references presented in each chapter CD that allows you to download illustrations and images to your PowerPoint presentations
The gold-standard text in anesthesiology – from the field’s brightest, most respected minds A Doody's Core Title for 2024 & 2021! Written by an internationally known team of experts, Anesthesiology, Third Edition provides a 360-degree view of the field, covering all the anesthetic considerations from preoperative preparation through postoperative care, and the full breadth of anesthesia practice, including pain medicine and critical care medicine. Presented in full color and updated to capture the latest breakthroughs and advances, Anesthesiology is designed to provide the practitioner with an authoritative single-source reference that spans the full spectrum of anesthesia practice. Much more than a how-to manual of anesthetic techniques, Anesthesiology, Third Edition presents an accessible compilation of concepts and principles that affirms its status as the cornerstone text in anesthesiology. This edition emphasizes important trends in both the specialty and healthcare in general. These trends include team-based anesthesia care, the remarkable growth of pain medicine practice, and the expanded need for clinicians who are skilled in the practice of critical care medicine. Features: Four new pain medicine chapters, plus an expanded section on anesthetic considerations and perioperative management of co-existing disease Key Points and Key References encapsulate must-know information and guide you to important articles for further research Balanced presentations present clinical information, practical clinical procedures, and the molecular and scientific foundations of anesthesia practice Essential for residents and students preparing for initial certification, and for practitioners preparing for recertification
The American government, through its media, has convinced most Americans to support the Ukrainian government. This books shows why this is a mistake: The United States promised Mikhail Gorbachev that NATO would not expand “one inch eastward”; and there had been ample warnings, by George Kennan and others, that moving NATO eastward, especially moving into Georgia and Ukraine, would cause problems for Russia. In Ukraine prior to 2014, Ukrainian and Russian speakers were coexisting tolerably well. But in 2013 and 2014, neocons in Obama’s administration engineered a coup, with help from neo-Nazis, turning Ukraine into a Russia-hating nation. The war in Ukraine began that year (not in 2022, when Russia attacked in order to protect the Russian-speaking regions under attack by the new coup government in Kiev). Although this book is primarily about the war in Ukraine, it also shows how, in one sense, the war in Ukraine is simply one more instance in the trajectory of American imperialism. as illustrated by previous US interventions in Iran, Guatemala, Cuba, Brazil, Greece, Dominican Republic, Panama and Iraq. In another sense, this war reveals just how committed America is to maintaining a unipolar world order: Because this war illustrates that America is willing to threaten nuclear holocaust. it is almost as if people in the U.S. State Department and military believe that life is not worth living unless the US can control the world.
An authoritative and comprehensive review of our current knowledge of the vitamins, their metabolic functions and the scientific basis for setting recommended intakes for the prevention of deficiency and promotion of optimum health. This publication will be a valuable reference for students and specialists alike in the field of nutritional biochemistry.
Now in four convenient volumes, Field’s Virology remains the most authoritative reference in this fast-changing field, providing definitive coverage of virology, including virus biology as well as replication and medical aspects of specific virus families. This volume of Field’s Virology: RNA Viruses, Seventh Edition covers the latest information on RNA viruses, how they cause disease, how they can cause epidemics and pandemics, new therapeutics and vaccine approaches, as provided in new or extensively revised chapters that reflect these advances in this dynamic field. Bundled with the eBook, which will be updated regularly as new information about each virus is available, this text serves as the authoritative, up-to-date reference book for virologists, infectious disease specialists, microbiologists, and physicians, as well as medical students pursuing a career in infectious diseases.
A cochlear implant is a surgically implanted electronic device that provides a sense of sound to a person who has a severe or profound hearing loss. A cochlear implant does not cure deafness or hearing impairment, but is a prosthetic substitute which directly stimulates the cochlea. There are over 250,000 users worldwide with 12,000 in the UK. This book is a multidisciplinary guide to cochlear implantation in children and adults with sensorineural hearing loss (where the root cause lies in the inner ear or sensory organ, ie the cochlear and associated organs). Beginning with discussion on the aetiology of hearing loss and assessment of cochlear implant candidacy, the next chapter discusses preoperative cochlear implant imaging. Each of the following sections provides in depth coverage of different types of cochlear implantation and their potential outcomes. The final sections examine miscellaneous topics such as music perception in cochlear implantation, drug eluting electrodes, cost effectiveness, and reliability reporting. Authored by internationally recognised, US-based specialists, the text is further enhanced by clinical and surgical photographs and illustrations. Key points Multidisciplinary guide to cochlear implantation in children and adults Covers different types of cochlear implant and potential outcomes Includes miscellaneous topics such as music perception, drug eluting electrodes, and reliability reporting Internationally recognised, US-based author team
The health of scientific enterprise has become a critical political and social issue as nation states tackle austerity, diversity, global challenges, whilst simultaneously supporting a competitive and innovative national economy. A key asset in achieving such ambitions is for a scholarly information system which enables the fruits of the research effort to be disseminated efficiently. As the information support system struggles with adapting from a print-based to a digital process, the dysfunctionality current within STEM publishing in particular becomes evident. New ways of supporting research are emerging which require a new approach to publishing, an approach which takes on board the many demographic, social, technical and administrative changes taking place in both science itself and society. A radical strategic assessment is required and this book tracks key aspects required for any new future strategy. This book provides a catalogue of issues to which a future STEM information industry will need to adapt. They range from the effects of technology on the neurological processes of research to the growing use of technology to speed up the exchange of information among groups and collaboratories; from considerations about quality control yet maintaining intellectual ownership; from changing from an elitist STEM system favouring academics to a more democratic process with wider appeal. There is the neglected non-academic market and its need to share in the results of the research effort, often through partnership and being part of a ‘hive mind’. This is the large world of the unaffiliated knowledge workers, of which academia is numerically but a small part. The many changes taking place in scholarly information dictate that the future is unlikely to be a smooth and gradual evolution from the past. Radical new approaches are required, a revolution which takes on board the perfect storm of changes listed in this book. Just as such changes have changed the face of industries such as music and retail in recent years, so similar dramatic changes are likely to result in a restructuring of STEM into a more technologically-focused industry within the next decade. The implications for the current STEM stakeholders are profound.
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