David J. Birnbaum's Books

Targeting Protein Kinases for Cancer Therapy

By: David J. Matthews,Mary E. Gerritsen

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Targeting Protein Kinases for Cancer Therapy

By: David J. Matthews,Mary E. Gerritsen

An expert guide to targeting protein kinases in cancer therapy Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells. Because of this fact, pharmaceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal roadblocks to sever their malignant means of communication. Complete with full-color presentations, Targeting Protein Kinases for Cancer Therapy defines the structural features of protein kinases and examines their cellular functions. Combining kinase biology with chemistry and pharmacology applications, this book enlists emerging data to drive the discovery of new cancer-fighting drugs. Valuable information includes: Comprehensive overviews of the major kinase families involved in oncology, integrating protein structure and function, and providing important tools to assist pharmaceutical researchers to understand and work in this dynamic area of cancer drug research Focus on small molecule inhibitors as well as other therapeutic modalities Discussion of kinase inhibitors that have entered clinical trials for the treatment of cancer, with an emphasis on molecules that have progressed to late stage clinical trials and, in a few cases, to market Providing a platform for further study, this important work reviews both the successes and challenges of kinase inhibitor therapy, and provides insight into future directions in the war against cancer.

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Page Count

719

Publisher

John Wiley & Sons

Published Date

ISBN 10

1118210778

ISBN 13

9781118210772

Diagnosis and Management of Peripheral Nerve Disorders

By: Jerry R. Mendell,John T. Kissel,David R. Cornblath

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Diagnosis and Management of Peripheral Nerve Disorders

By: Jerry R. Mendell,John T. Kissel,David R. Cornblath

Peripheral neuropathies represent a challenging subject for most physicians. This is an up-to-date, comprehensive, and readable book on peripheral neuropathies that includes concise information on the clinical, electrophysiological, pathological, pathogenic, and treatment aspects of the most important disorders. New molecular and serologic diagnostic tests are discussed. Sections are devoted to nerve and skin biopsy techniques and findings, quantitative sensory and autonomic reflex tests. Case examples are used liberally throughout the text. The editors: Mendell, Kissel, and Cornblath are experienced clinicians that bring complementary knowledge to each of the subjects. Additional authors have been handpicked for specific topics which add to the value of the edition.

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Page Count

718

Publisher

Oxford University Press

Published Date

ISBN 10

0198030487

ISBN 13

9780198030485

Language Acquisition

The Age Factor

By: David Singleton,Lisa Ryan

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Language Acquisition

The Age Factor

By: David Singleton,Lisa Ryan

This book examines the evidence relative to the idea that there is an age factor in first and second language acquisition, evidence that has sources ranging from studies of feral children to evaluations of language programmes in primary schools. It goes on to explore the various explanations that have been advanced to account for such evidence. Finally, it looks at the educational ramifications of the age question, with particular regard to formal second language teaching in the early school years and in ‘third age’ contexts.

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Page Count

302

Publisher

Multilingual Matters

Published Date

ISBN 10

1847699294

ISBN 13

9781847699299

Introduction to the Electronic Properties of Materials

By: David C. Jiles

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Introduction to the Electronic Properties of Materials

By: David C. Jiles

Electronic materials provide the basis for many high tech industries that have changed rapidly in recent years. In this fully revised and updated second edition, the author discusses the range of available materials and their technological applications. Introduction to the Electronic Properties of Materials, 2nd Edition presents the principles of the behavior of electrons in materials and develops a basic understanding with minimal technical detail. Broadly based, it touches on all of the key issues in the field and offers a multidisciplinary approach spanning physics, electrical engineering, and materials science. It provides an understanding of the behavior of electrons within materials, how electrons determine the magnetic thermal, optical and electrical properties of materials, and how electronic properties are controlled for use in technological applications. Although some mathematics is essential in this area, the mathematics that is used is easy to follow and kept to an appropriate level for the reader. An excellent introductory text for undergraduate students, this book is a broad introduction to the topic and provides a careful balance of information that will be appropriate for physicists, materials scientists, and electrical engineers.

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Page Count

443

Publisher

CRC Press

Published Date

ISBN 10

1482289369

ISBN 13

9781482289367

Imaging of Diseases of the Chest E-Book

By: David M. Hansell,David A. Lynch,H. Page McAdams,Alexander A. Bankier

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Imaging of Diseases of the Chest E-Book

By: David M. Hansell,David A. Lynch,H. Page McAdams,Alexander A. Bankier

This is the ideal resource for all those requiring an authoritative and up-to-date review of imaging appearances of diseases of the lung, pleura and mediastinum. Chest radiography and CT are integrated with other imaging techniques, including MRI and PET, where appropriate. The clinical and pathologic features of different diseases are provided in varying degrees of detail with more in depth coverage given to rarer and less well understood conditions. A single volume, comprehensive reference text on chest radiology.Provides in a single resource all of the information a generalist in diagnostic radiology needs to know. Concisely and clearly written by a team of 4 internationally recognized authors.Avoids the inconsistency, repetition, and unevenness of coverage that is inherent in multi-contributed books. Multimodality coverage integrated throughout every chapter.All of the applicable imaging modalities are covered in a clinically relevant, diagnostically helpful way. Approximately 3,000 high quality, good-sized images.Provides a complete visual guide that the practitioner can refer to for help in interpretation and diagnosis. Covers both common and uncommon disorders.Provides the user with a single comprehensive resource, no need to consult alternative resources. Access the full text online and download images via Expert Consult Access the latest version of the Fleischner Society's glossary of terms for thoracic imaging. Outlines, summary boxes, key points used throughout.Makes content more accessible by highlighting essential information. Brand new color images to illustrate Functional imaging techniques.Many of the new imaging techniques can provide functional as well as anatomic information. Introduction of a second color throughout in summary boxes in order to better highlight key information. There’s a wealth of key information in the summary boxes—will be highlighted more from the narrative text and will therefore be easier to access. Practical tips on identifying anatomic variants and artefacts in order to avoid diagnostic pitfalls.Many misdiagnoses are the result of basic errors in correlating the anatomic changes seen with imaging to their underlying pathologic processes. Latest techniques in CT, MRI and PET as they relate to thoracic diseases. The pace of development in imaging modalities and new applications/refined techniques in existing modalities continues to drive radiology forward as a specialty. Emphasis on cost-effective image/modality selection.Addresses the hugely important issue of cost-containment by emphasizing which imaging modality is helpful and which is not in any given clinical diagnosis. COPD and Diffuse Lung Disease, Small Airway disease chapters extensively up-dated. Access the full text online and download images via Expert Consult Access the latest version of the Fleischner Society's glossary of terms for thoracic imaging.

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Page Count

1209

Publisher

Elsevier Health Sciences

Published Date

ISBN 10

0723436673

ISBN 13

9780723436676

D. Allan Bromley, Nuclear Scientist and Policy Innovator

Proceedings of the Memorial Symposium in Honor of D. Allan Bromley, Yale University, USA 8-9 December 2005

By: David Allan Bromley,Paul A. Fleury

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D. Allan Bromley, Nuclear Scientist and Policy Innovator

Proceedings of the Memorial Symposium in Honor of D. Allan Bromley, Yale University, USA 8-9 December 2005

By: David Allan Bromley,Paul A. Fleury

This book covers two aspects of the career of D Allan Bromley: the science policy aspect and the scientific aspect.In the first half of the book, contributions from Governor John Sununu, former White House Chief of Staff under President George H W Bush; Neal Lane, former Science Adviser to President William Clinton; John Marburger III, Science Adviser to President George W Bush; and Mary Good, former Undersecretary of Commerce, highlight the role of Bromley as Science Adviser to President George H W Bush and a maker of science policy in the second part of the 20th Century. This part is of interest to science policy scholars, historians, and young persons wishing to start a career in science policy.In the second half of the book, articles by directors of laboratories and leading scientists discuss future programs in all areas of nuclear physics ? low-energy, medium-energy and high-energy ? to which Bromley greatly contributed, in the USA, Europe and Japan. This part of the book is of interest to all researchers in the field of nuclear physics, as it provides a comprehensive but succinct overview of the field and indicates directions for future research in the first part of the 21st century.

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Page Count

318

Publisher

World Scientific

Published Date

ISBN 10

9812568115

ISBN 13

9789812568113

Human Gene Evolution

By: David Neil Cooper

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Human Gene Evolution

By: David Neil Cooper

Presents the principles of human gene evolution in a concise and easy to understand fashion. Uses examples of how evolutionary processes have molded present day genes, drawn from the evolution of humans and other primates, as well as from more primitive organisms. With increasing attention in this expanding area, this review forms a timely publication of our current knowledge of this important field. Structure and function in the human genome The evolution of gene structure Mutational mechanisms in evolution

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Page Count

520

Publisher

Elsevier

Published Date

ISBN 10

0121878708

ISBN 13

9780121878702

Decision Making in Otolaryngology

By: Cuneyt Alper,Eugene Myers,David Eibling

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Decision Making in Otolaryngology

By: Cuneyt Alper,Eugene Myers,David Eibling

The new edition of this algorithm-based resource provides clinicians and trainees with the latest advances in the evaluation and management of otolaryngologic disorders. Divided into seven sections, the book discusses numerous problems in each part of the ENT system, presenting up to date basic science and surgical techniques. Each chapter follows a logical, step by step approach covering both common and less common conditions. The second edition has been fully revised and includes 36 new chapters with a number of them focusing on paediatric disorders. Authored by an internationally recognised team of Pittsburgh-based experts, this book is enhanced by images and diagrams to assist learning. Key Points Fully revised, second edition providing latest advances in diagnosis and management of otolaryngologic disorders Covers both common and less common problems in all areas of the ENT system Includes 36 new chapters, many with focus on paediatric conditions Previous edition (9780721689654) published in 2001

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Page Count

440

Publisher

Jaypee Brothers Medical Publishers

Published Date

ISBN 10

9386056089

ISBN 13

9789386056085

Fixed in His Folly

By: David J. Walker

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Fixed in His Folly

By: David J. Walker

Looking for the child Harriet Mallory gave up for adoption 31 years ago, Foley locates the son, an alcohol priest on a downward spiral, a man trapped in a maelstrom of vengeance and death. Threats targeting all the priest's family, friends, and "fools" are being systematically carried out. Foley is left wondering if he is a friend or a fool. Martin's Press.

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Page Count

254

Publisher

Worldwide Library

Published Date

ISBN 10

0373263155

ISBN 13

9780373263158

Book's by David J. Birnbaum

Targeting Protein Kinases for Cancer Therapy

Targeting Protein Kinases for Cancer Therapy

Diagnosis and Management of Peripheral Nerve Disorders

Diagnosis and Management of Peripheral Nerve Disorders

Language Acquisition

Language Acquisition

Introduction to the Electronic Properties of Materials

Introduction to the Electronic Properties of Materials

Imaging of Diseases of the Chest E-Book

Imaging of Diseases of the Chest E-Book

D. Allan Bromley, Nuclear Scientist and Policy Innovator

D. Allan Bromley, Nuclear Scientist and Policy Innovator

Human Gene Evolution

Human Gene Evolution

Decision Making in Otolaryngology

Decision Making in Otolaryngology

Fixed in His Folly

Fixed in His Folly

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