An authoritative new examination of John Brown and his deep impact on American history.Bancroft Prize-winning cultural historian David S. Reynolds presents an informative and richly considered new exploration of the paradox of a man steeped in the Bible but more than willing to kill for his abolitionist cause. Reynolds locates Brown within the currents of nineteenth-century life and compares him to modern terrorists, civil-rights activists, and freedom fighters. Ultimately, he finds neither a wild-eyed fanatic nor a Christ-like martyr, but a passionate opponent of racism so dedicated to eradicating slavery that he realized only blood could scour it from the country he loved. By stiffening the backbone of Northerners and showing Southerners there were those who would fight for their cause, he hastened the coming of the Civil War. This is a vivid and startling story of a man and an age on the verge of calamity.
An expert guide to targeting protein kinases in cancer therapy Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells. Because of this fact, pharmaceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal roadblocks to sever their malignant means of communication. Complete with full-color presentations, Targeting Protein Kinases for Cancer Therapy defines the structural features of protein kinases and examines their cellular functions. Combining kinase biology with chemistry and pharmacology applications, this book enlists emerging data to drive the discovery of new cancer-fighting drugs. Valuable information includes: Comprehensive overviews of the major kinase families involved in oncology, integrating protein structure and function, and providing important tools to assist pharmaceutical researchers to understand and work in this dynamic area of cancer drug research Focus on small molecule inhibitors as well as other therapeutic modalities Discussion of kinase inhibitors that have entered clinical trials for the treatment of cancer, with an emphasis on molecules that have progressed to late stage clinical trials and, in a few cases, to market Providing a platform for further study, this important work reviews both the successes and challenges of kinase inhibitor therapy, and provides insight into future directions in the war against cancer.
This unflinching analysis explains the nature of precarity and its detrimental effects on the health and wellbeing of young people. It exposes physical educators’ unpreparedness to provide inclusive, fair and equitable forms of physical education that might empower young people to overcome the mal effects of precarity. Following a thorough analysis and critique of critical pedagogy, David Kirk advocates for critical pedagogies of affect as physical education’s response to precarity, providing detailed outlines of these pedagogies and their grounding in research. He argues that now more than ever physical educators need to be alive to the serious social and economic challenges that shape young people’s health, happiness and life chances. This bold and provocative book is essential reading for all researchers in the field of physical education and health education pedagogy, as well as teacher educators, curriculum policy makers, and other professionals who work with young people living in precarity.
Forest Growth and Yield Modeling synthesizes current scientific literature and provides insights in how models are constructed. Giving suggestions for future developments, and outlining keys for successful implementation of models the book provides a thorough and up-to-date, single source reference for students, researchers and practitioners requiring a current digest of research and methods in the field. The book describes current modelling approaches for predicting forest growth and yield and explores the components that comprise the various modelling approaches. It provides the reader with the tools for evaluating and calibrating growth and yield models and outlines the steps necessary for developing a forest growth and yield model. Single source reference providing an evaluation and synthesis of current scientific literature Detailed descriptions of example models Covers statistical techniques used in forest model construction Accessible, reader-friendly style
The process by which two neighborhood butchers turned themselves into landed industrialists depended to an extraordinary degree on the acquisition, manipulation, and exploitation of natural resources. Igler examines the broader impact of western industrialism - as exemplified by Miller & Lux - on landscapes and waterscapes, bringing to the forefront the important issues of land reclamation, water politics, San Francisco's unique business environment, and the city's relation to its surrounding hinterlands. He provides a rich discussion of the social relations engineered by Miller & Lux, from the dispossession of Californio rancheros to the ethnic segmentation of the firm's massive labor force."--Jacket.
Rereading the Fossil Record presents the first-ever historical account of the origin, rise, and importance of paleobiology, from the mid-nineteenth century to the late 1980s. Drawing on a wealth of archival material, David Sepkoski shows how the movement was conceived and promoted by a small but influential group of paleontologists and examines the intellectual, disciplinary, and political dynamics involved in the ascendency of paleobiology. By tracing the role of computer technology, large databases, and quantitative analytical methods in the emergence of paleobiology, this book also offers insight into the growing prominence and centrality of data-driven approaches in recent science.
This book provides unique access to the story of how scientists were accepted into the American Space Programme, and reveals how, after four difficult decades, the role of the heroic test pilot astronaut has been replaced by men and women who are science orientated space explorers.
David Burner's panoramic history of the 1960s conveys the ferocity of debate and the testing of visionary hopes that still require us to make sense of the decade. He begins with the civil rights and black power movements and then turns to nuanced descriptions of Kennedy and the Cold War, the counterculture and its antecedents in the Beat Generation, the student rebellion, the poverty wars, and the liberals' war in Vietnam. As he considers each topic, Burner advances a provocative argument about how liberalism self-destructed in the 1960s. In his view, the civil rights movement took a wrong turn as it gradually came to emphasize the identity politics of race and ethnicity at the expense of the vastly more important politics of class and distribution of wealth. The expansion of the Vietnam War did force radicals to confront the most terrible mistake of American liberalism, but that they also turned against the social goals of the New Deal was destructive to all concerned. Liberals seemed to rule in politics and in the media, Burner points out, yet they failed to make adequate use of their power to advance the purposes that both liberalism and the left endorsed. And forces for social amelioration splintered into pairs of enemies, such as integrationists and black separatists, the social left and mainline liberalism, and advocates of peace and supporters of a totalitarian Hanoi. Making Peace with the 60s will fascinate baby boomers and their elders, who either joined, denounced, or tried to ignore the counterculture. It will also inform a broad audience of younger people about the famous political and literary figures of the time, the salient moments, and, above all, the powerful ideas that spawned events from the civil rights era to the Vietnam War. Finally, it will help to explain why Americans failed to make full use of the energies unleashed by one of the most remarkable decades of our history.
I am unaware of any textbook which provides such comprehensive coverage of the field and doubt that this work will be surpassed in the foreseeable future, if ever!' From the foreword by Robert C. Moellering, Jr., M.D, Shields Warren-Mallinckrodt Professor of Medical Research, Harvard Medical School, USA Kucers' The Use of Antibiotics is the leading major reference work in this vast and rapidly developing field. More than doubled in length compared to the fifth edition, the sixth edition comprises 3000 pages over 2-volumes in order to cover all new and existing therapies, and emerging drugs not yet fully licensed. Concentrating on the treatment of infectious diseases, the content is divided into 4 sections: antibiotics, anti-fungal drugs, anti-parasitic drugs and anti-viral drugs, and is highly structured for ease of reference.Within each section, each chapter is structured to cover susceptibility, formulations and dosing (adult and paediatric), pharmacokinetics and pharmacodynamics, toxicity and drug distribution, detailed discussion regarding clinical uses, a feature unique to this title. Compiled by an expanded team of internationally renowned and respected editors, with a vast number of contributors spanning Europe, Africa, Asia, Australia, South America, the US and Canada, the sixth edition adopts a truly global approach. It will remain invaluable for anyone using antimicrobial agents in their clinical practice and provides in a systematic and concise manner all the information required when treating infections requiring antimicrobial therapy. Kucers' The Use of Antibiotics is available free to purchasers of the books as an electronic version on line or on your desktop: It provides access to the entire 2-volume print material It is fully searchable, so you can find the relevant information you need quickly Live references are linked to PubMed referring you to the latest journal material Customise the contents - you can highlight sections and make notes Comments can be shared with colleagues/tutors for discussion, teaching and learning The text can also be reflowed for ease of reading Text and illustrations copied will be automatically referenced to Kucers' The Use of Antibiotics
This volume marks a new approach to a seminal work of the new modern scientific imagination. Darwin's central theory of natural selection neither originated nor could be contained within the natural sciences, but continues to shape and challenge our most basic assumptions about human social and political life. Seven readings, crossing the fields of history, literature, sociology, anthropology and the history of science, demonstate the complex position of the text within the cultural debates past and present.
PIXELS & PAINTINGS “The discussion is firmly grounded in established art historical practices, such as close visual analysis and an understanding of artists’ working methods, and real-world examples demonstrate how computer-assisted techniques can complement traditional approaches.” —Dr. Emilie Gordenker, Director of the Van Gogh Museum The pioneering presentation of computer-based image analysis of fine art, forging a dialog between art scholars and the computer vision community In recent years, sophisticated computer vision, graphics, and artificial intelligence algorithms have proven to be increasingly powerful tools in the study of fine art. These methods—some adapted from forensic digital photography and others developed specifically for art—empower a growing number of computer-savvy art scholars, conservators, and historians to answer longstanding questions as well as provide new approaches to the interpretation of art. Pixels & Paintings provides the first and authoritative overview of the broad range of these methods, which extend from image processing of palette, marks, brush strokes, and shapes up through analysis of objects, poses, style, composition, to the computation of simple interpretations of artworks. This book stresses that computer methods for art analysis must always incorporate the cultural contexts appropriate to the art studies at hand—a blend of humanistic and scientific expertise. Describes powerful computer image analysis methods and their application to problems in the history and interpretation of fine art Discusses some of the art historical lessons and revelations provided by the use of these methods Clarifies the assumptions and applicability of methods and the role of cultural contexts in their use Shows how computation can be used to analyze tens of thousands of artworks to reveal trends and anomalies that could not be found by traditional non-computer methods Pixels & Paintings is essential reading for computer image analysts and graphics specialists, conservators, historians, students, psychologists and the general public interested in the study and appreciation of art.
Metaphors are ubiquitous and yet-or, for that very reason-go largely unseen. We are all variously susceptible to a blindness or blurry vision of metaphors; yet even when they are seen clearly, we are left to situate the ambiguities, conflations and contradictions they regularly present-logically, aesthetically and morally. David LaRocca's book serves as a set of 'reminders' of certain features of the natural history of our language-especially the tropes that permeate and define it. As part of his investigation, LaRocca turns to Ralph Waldo Emerson's only book on a single topic, English Traits (1856), which teems with genealogical and generative metaphors-blood, birth, plants, parents, family, names and race. In the first book-length study of English Traits in over half a century, LaRocca considers the presence of metaphors in Emerson's fertile text-a unique work in his expansive corpus, and one that is regularly overlooked. As metaphors are encountered in Emerson's book, and drawn from a long history of usage in work by others, a reader may realize (or remember) what is inherent and encoded in our language, but rarely seen: how metaphors circulate in speech and through texts to become the lifeblood of thought.
Explores the century-long controversy over the orgins of coral reefs, a debate that split the world of nineteenth-century science, looking at the diverse roles of Louis Agassiz, his son Alexander, and Charles Darwin and reflecting on how the search for the truth shed new light on the formation of Earth and its natural wonders.
Historical biogeography—the study of the history of species through both time and place—first convinced Charles Darwin of evolution. This field was so important to Darwin’s initial theories and line of thinking that he said as much in the very first paragraph of On the Origin of Species (1859) and later in his autobiography. His methods included collecting mammalian fossils in South America clearly related to living forms, tracing the geographical distributions of living species across South America, and sampling peculiar fauna of the geologically young Galápagos Archipelago that showed evident affinities to South American forms. Over the years, Darwin collected other evidence in support of evolution, but his historical biogeographical arguments remained paramount, so much so that he devotes three full chapters to this topic in On the Origin of Species. Discussions of Darwin’s landmark book too often give scant attention to this wealth of evidence, and we still do not fully appreciate its significance in Darwin’s thinking. In Origins of Darwin’s Evolution, J. David Archibald explores this lapse, showing how Darwin first came to the conclusion that, instead of various centers of creation, species had evolved in different regions throughout the world. He also shows that Darwin’s other early passion—geology—proved a more elusive corroboration of evolution. On the Origin of Species has only one chapter dedicated to the rock and fossil record, as it then appeared too incomplete for Darwin’s evidentiary standards. Carefully retracing Darwin’s gathering of evidence and the evolution of his thinking, Origins of Darwin’s Evolution achieves a new understanding of how Darwin crafted his transformative theory.
As David Matless argues in this book—updated in this accessible, pocket edition—landscape has been central to definitions of Englishness for centuries. It is the aspect of English life where visions of the past, present, and future have met in debates over questions of national identity, disputes over history and modernity, and ideals of citizenship and the body. Extensively illustrated, Landscape and Englishness explores just how important the aesthetics of Britain’s cities and countryside have been to its people. Matless examines a wide range of material, including topographical guides, health manuals, paintings, poetry, architectural polemics, photography, nature guides, and novels. Taking readers to the interwar period, he explores how England negotiated the modern and traditional, the urban and rural, the progressive and preservationist, in its decisions over how to develop the countryside, re-plan cities, and support various cultures of leisure and citizenship. Tracing the role of landscape to Englishness from then up until the present day, he shows how familiar notions of heritage in landscape are products of the immediate post-war era, and he unveils how the present always resonates with the past.
Adam Smith, asserting the common humanity of the street porter and the philosopher, articulated the classical economists' model of social interactions as exchanges among equals. This model had largely fallen out of favor until, recently, a number of scholars in the avant-garde of economic thought rediscovered it and rechristened it "analytical egalitarianism." In this volume, Sandra J. Peart and David M. Levy bring together an impressive array of authors to explore the ramifications of this analytical ideal and to discuss the ways in which an egalitarian theory of individuality can enable economists to reconcile ideas from opposite ends of the political spectrum. "The analytical egalitarianism project that Peart and Levy have advanced has come to occupy a prominent place in the current agenda of historians of economic thought." ---Ross Emmett, Associate Professor of Economics and Co-Director of the Michigan Center for Innovation and Economic Prosperity, Michigan State University "These essays and dialogs from the Summer Institute would make Adam Smith, economist and moral philosopher, proud." ---J. Daniel Hammond, Hultquist Family Professor of Economics, Wake Forest University With essays by: James M. Buchanan, Alfred Nobel Memorial Prize in Economic Sciences recipient (1985) and Professor Emeritus, George Mason University and Virginia Polytechnic and State University Juan Pablo Couyoumdijian, Universidad del Desearrollo, Chile Tyler Cowen, George Mason University Eric Crampton, University of Canterbury, New Zealand Andrew Farrant, Dickinson College Samuel Hollander, Professor Emeritus, University of Toronto M. Ali Khan, Johns Hopkins University Thomas Leonard, Princeton University Deirdre McCloskey, University of Illinois, Chicago Leonidas Montes, Dean of School of Government, Universidad Adolfo Ibañez, Chile Maria Pia Paganelli, Yeshiva University and New York University Warren J. Samuels, Professor Emeritus, Michigan State University Eric Schliesser, VENI post-doctoral research fellow, Leiden University, and University of Amsterdam Gordon Tullock, George Mason University Sandra J. Peart is Dean of the Jepson School of Leadership Studies, University of Richmond, Virginia. David M. Levy is Professor of Economics at George Mason University (GMU) and Research Associate at the Center for Study of Public Choice at GMU. They are Co-Directors of George Mason University's Summer Institute for the Preservation of the History of Economics.
The "Vanity of the Philosopher" continues the themes introduced in Levy's acclaimed book How the Dismal Science Got Its Name. Here, Peart and Levy tackle the issues of racism, eugenics, hierarchy, and egalitarianism in classical economics and take a broad view of classical economics' doctrine of human equality. Responding to perennial accusations from the left and the right that the market economy has created either inequality or too much equality, the authors trace the role of the eugenics movement in pulling economics away from the classical economist's respect for the individual toward a more racist view at the turn of the century. The "Vanity of the Philosopher" reveals the consequences of hierarchy in social science. It shows how the "vanity of the philosopher" has led to recommendations that range from the more benign but still objectionable "looking after" paternalism, to overriding preferences, and, in the extreme, to eliminating purportedly bad preferences. The authors suggest that an approach that abstracts from difference and presumes equal competence is morally compelling. "People in the know on intellectual history and economics await the next book from Peart and Levy with much the same enthusiasm that greets a new Harry Potter book in the wider world. This book delivers the anticipated delights big time!" -William Easterly, Professor of Economics and Africana Studies, NYU, and non-resident Senior Fellow, Center for Global Development "In their customary idiosyncratic manner, Sandra Peart and David Levy reexamine the way in which the views of classical economists on equality and hierarchy were shifted by contact with scholars in other disciplines, and the impact this had on attitudes towards race, immigration, and eugenics. This is an imaginative and solid work of scholarship, with an important historical message and useful lessons for scholars today." -Stanley Engerman, John Munro Professor of Economics and Professor of History, University of Rochester Sandra J. Peart, Professor of Economics at Baldwin-Wallace College, has published articles on utilitarianism, the methodology of J. S. Mill, and the transition to neoclassicism. This is her fourth book. David M. Levy is Professor of Economics at George Mason University and Director of the Center for Study of Public Choice. This is his third book.
During the second half of the nineteenth century the enormous increase in agricultural production, unmatched by technical advance in harvesting, drew vast numbers of rural and migrant workers into the harvest that lasted from June to October. This book, first published in 1982, examines the technology, conditions and customs of the harvest and, through that, the life of the rural population of central England from the 1840s until the end of the century when hand tools finally gave way to mechanisation. The economic framework of the period in agriculture is set out and there flows a detailed analysis of hand tools and work methods in the harvest. The population of harvesters, agricultural labourers and their entire families, townspeople and the gangs of migrant workers are studied, as are the crops they harvested.
Charles Darwin: A Reference Guide to His Life and Works provides an important new compendium presenting a detailed chronology of all aspects Darwin’s life. The extensive encyclopedia section includes many hundreds of entries of various kinds related to Darwin – people, places, institutions, concepts, and his publications. The bibliography provides a comprehensive listing of the vast majority of Darwin’s works published during and after his lifetime. It also provides a more selective list of publications concerning his life and work. Includes a nearly year by year chronology detailing Charles Darwin’s life, family, and work. The A to Z section includes many entries on concepts and people important in Charles Darwin’s life and his work, emphasizing during his lifetime but extending somewhat backwards and forwards from there. The bibliography includes all of Charles Darwin's articles and books published in his lifetime in English and other languages, as well as a selective list of works about him and his work. The index thoroughly cross-references the chronological and encyclopedic entries.
The true tale of an edenic Rocky Mountain town and what transpired when a predatory species returned to its ancestral home. When, in the late 1980s, residents of Boulder, Colorado, suddenly began to see mountain lions in their yards, it became clear that the cats had repopulated the land after decades of persecution. Here, in a riveting environmental fable that recalls Peter Benchley's thriller Jaws, journalist David Baron traces the history of the mountain lion and chronicles Boulder's effort to coexist with its new neighbors. A parable for our times, The Beast in the Garden is a scientific detective story and a real-life drama, a tragic tale of the struggle between two highly evolved predators: man and beast.
21 years passed between Charles Darwim's epiphany that 'natural selection' formed the basis of evolution and the scientist's publication of 'On the Origin of Species'. This text looks at why Darwin delayed the publication and examines what happened during the course of those two decades.
Emergent evolution combines three separate but related claims, whose background, origin, and development I trace in this work: firstly, that evolution is a universal process of change, one which is productive of qualitative novelties; secondly, that qualitative novelty is the emergence in a system of a property not possessed by any of its parts; and thirdly, that reality can be analyzed into levels, each consisting of systems characterized by significant emergent properties. In part one I consider the background to emergence in the 19th century discussion of the philosophy of evolution among its leading exponents in England - Charles Darwin, Herbert Spencer, T. H. Huxley, Alfred Russel Wallace, and G. J. Romanes. Unlike the scientific aspect of the debate which aimed to determine the factors and causal mechanism of biological evolution, this aspect of the debate centered on more general problems which form what I call the "philosophical framework for evolutionary theory." This considers the status of continuity and discontinuity in evolution, the role of qualitative and quantitative factors in change, the relation between the organic and the inorganic, the relation between the natural and the supernatural, the mind-body problem, and the scope of evolution, including its extension to ethics and morals.
Many of the earliest books, particularly those dating back to the 1900s and before, are now extremely scarce and increasingly expensive. We are republishing these classic works in affordable, high quality, modern editions, using the original text and artwork.
The most up-to-date edition of a critically acclaimed and widely read cross-cultural counseling resource In the newly revised Ninth Edition of Counseling the Culturally Diverse: Theory and Practice, a team of veteran practitioners delivers an up-to-date and comprehensive exploration of multicultural counseling combining the most recent research and theoretical concepts in the field. The book examines concepts like “cultural humility,” the role of white allies in multicultural counseling, social justice counseling, “minority stress,” and microaggressions. Readers will also find: Expansive discussions on the implications of numerous subjects for real-world clinical practice “Reflection and Discussion Questions” that encourage reader engagement, learning, and retention with the concepts discussed within Access to an instructor’s website that provides PowerPoint decks, exam questions, sample syllabi, and links to other valuable resources Perfectly suited to researchers and practitioners who work in or study mental health and interact with a racially, ethnically, culturally, or socio-demographically diverse population, Counseling the Culturally Diverse: Theory and Practice also belongs in the libraries of social workers and psychiatrists.
Comprehensive and complete, Shackelford’s Surgery of the Alimentary Tract delivers the definitive, clinically oriented, cutting-edge guidance you need to achieve optimal outcomes managing the entire spectrum of gastrointestinal disorders. Make effective use of the latest endoscopic, robotic, and minimally invasive procedures as well as medical therapies with unbeatable advice from a "who’s who" of international authorities! Find expert answers to any clinical question in gastrointestinal surgery, from the esophagus to the colon. See exactly what to look for and how to proceed from an abundance of beautifully detailed intraoperative and laparoscopic photographs.
An exciting reinterpretation of Social Darwinism, questioning conventional assumptions and proffering an alternative reading of a discourse of 'peace biology'.
This issue of Surgical Oncology Clinics of North America, guest edited by Dr. David Ilson, is devoted to Topics in Esophageal and Gastric Cancers. Dr. Ilson has assembled expert authors to review the following topics: Minimally Invasive Surgery: The Emerging Role in Esophageal and Gastric Cancer; Novel Targeted Therapies in Esophagogastric Cancer; The Role of Nutritional Support in Esophagogastric Cancer; Screening and Preventive Strategies in Esophagogastric Cancer; Current Progress in HER2 Targeted Therapies in Esophagogastric Cancer; The Role of Radiotherapy in Esophagogastric Cancer; Endoscopic Management of Early Esophagogastric Cancer; Current Progress in the Adjuvant Treatment of Gastric Cancer; Controversies and Consensus in Preoperative Therapy of Esophageal and GE Junction Cancers; Issues in the Management of Esophagogastric Cancer in Geriatric Patients; East versus West: The Asian Perspective on the Surgical and Adjuvant Management of Esophagogastric Cancer; The Current Status of Immunotherapies in Esophagogastric Cancer; and more!
The Child Psychotherapy Treatment Planner, Fourth Edition provides treatment planning guidelines and an array of pre-written treatment plan components for behavioral and psychological problems, including blended family problems, children of divorce, ADHD, attachment disorder, academic problems, and speech and language disorders. Clinicians with adult clients will find this up-to-date revision an invaluable resource.
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