The Oregon Trail, the route of the pioneers during the largest mass migration in United States history, was a long and difficult journey made by Americans nearly two centuries ago. This guidebook, rich with photos, interviews, and information about the famous landmarks, facilities, individuals, activities, and towns along the trail, will please both adventurers planning to travel the trail and individuals who wish to learn about and follow the trail from an easy chair. Complete with maps and details of each state from Missouri to Oregon, Exploring the Oregon Trail will give readers everything needed to follow in the footsteps of the American pioneers.
In 1895, an extraordinarily enigmatic faith healer emerged in the American West. An Alsatian immigrant and former cobbler, Francis Schlatter looked like popular depictions of Jesus, and it was said that his very touch could heal everything from migraines and arthritis to blindness and cancer. First in Albuquerque, and then in Denver, thousands flocked to him, hoping to receive his healing touch. Schlatter accepted no money for his work, behaved modestly, fasted heavily, and treated everyone, from wealthy socialites to impoverished immigrants, equally. He quickly captured national attention, and both the sick hoping to be cured and reporters hoping to expose a fraud hurried to Denver to see the celebrated healer. By November of 1895, it is estimated that Schlatter was treating thousands of people every day, and the neighborhood in which he was staying was overrun with the sick and lame, their families, reporters from across the country, and hucksters hoping to make a quick buck off the local attention. Then, one night, Schlatter simply vanished. Eighteen months later, his skeleton was reportedly found on a mountainside in Mexico’s Sierra Madre range, finally bringing Schlatter’s great healing ministry to an end. Or did it? Within hours of the announcement of Schlatter’s found remains, a long-haired man emerged in Cleveland to say that he was Francis Schlatter, and the next twenty-five years, several others claimed to be Denver’s great healer. In The Vanishing Messiah, a modern researcher painstakingly pieces together evidence from letters, newspaper reports, hospital records, mug shots, and published reminiscences of the healer to find out what really happened to Francis Schlatter after he left Denver in the middle of the night in November 1895. In doing so, David N. Wetzel uncovers a historical puzzle of lies, deception, and betrayal, and offers a tantalizing look into a nineteenth-century messiah and his twentieth-century reincarnations—one of whom may have been the healer himself.
The history of the dental program at Western University is a spirited and gritty story of grand visions, strong personalities, and contentious leadership. Focusing on the years from 1965 to 2015, Transforming Dentistry highlights Western University’s ambitious plans to create and situate a dental program within a health sciences complex; the practical challenges involved in implementing a curriculum and populating a new school; the influence of key dental faculty, community dentists, and students in shaping the program; and the school’s near closure during the 1990s. David J. Kenny and Shelley McKellar detail how and why the training of dentists was transformed by science, technology, and individual educators. The book focuses on the unique aspects of Western’s dental program and compares it with the programs offered at nine other Canadian schools. Today, the strong reputation of Western dentistry is a direct result of the ambitious visions, professional commitment, and steadfast leadership employed by London dentists and university educators over more than five decades.
Praised by JAMA as "The most complete description of the development, structure, function, pathophysiology, and treatment of the retina and its diseases to be found anywhere," this monumental three-volume work puts all of today's scientific and clinical knowledge of the retina at readers' fingertips. The New Edition has been comprehensively updated and reorganized to reflect all of the very latest scientific and genetic discoveries, diagnostic imaging methods, drug therapies, treatment recommendations, and surgical techniques. The result is an indispensable reference and diagnostic tool for generalists and specialists alike. Delivers the editorial expertise of four highly respected authorities, as well as contributions from internationally recognized leaders in visual science, ophthalmology, and vitreoretinal studies. Presents more than 3,400 superb illustrations (2,200 in full color) that capture all forms of retinal disease from every perspective. Offers the very latest information on the genetic basis of retinal disease, diagnostic retinal imaging, photodynamic therapy, and age-related macular degeneration. Examines the most recent advances in diagnostic indocyanine green angiography � optical coherence tomography (OCT) and quantitative fluoroscein angiography � macular translocation with 360� peripheral retinectomy � surgery for diffuse macular edema due to multiple causes, including proliferative vitreoretinopathy � artificial vision � and much more. Features a completely restructured section on age-related macular degeneration that includes epidemiology and risk factors � prophylaxis and prevention knowledge gained from large clinical trials like AREDS � proven and experimental treatments for AMD � and pharmacotherapy. Incorporates a multitude of new full-color images, 2200 in all.
Child Abuse brings together experts in both physical abuse and sexual abuse to create one of the few volumes that has addressed innovative approaches to treatment and prevention in these two areas. The resulting compendium of information provides insights into the current psychological perspectives on the causes and treatment of different forms of child maltreatment as well as the delivery of early intervention and prevention services. The book begins in the first part with a conceptual overview of the effect of physical abuse on the life course of children and adults. Chapters on physical abuse also examine recent findings related to child abuse offenders, children who witness domestic violence, treatment of abusive adults, and prevention programs aimed at dating adolescents and pregnant women. Contributors focusing on child sexual abuse note new approaches to the delivery of treatment services for these children as well as current developments in the interface between abuse victims and the court system. Considering the needs of both adult survivors and children, Child Abuse also discusses how child maltreatment interventions can be integrated into broader intervention services. An ideal book for use in professional training and development, Child Abuse will also guide policymakers at state and national levels to emerging new models and programs. This volume is likewise a useful resource for researchers and practitioners in social work, clinical/counseling psychology, mental health, and public health.
The challenge of transforming organizational culture is at the heart of many key movements in contemporary healthcare, and understanding culture change has become a core leadership competency. However, much current practice is based on antiquated and psychologically unsophisticated theories, leaving leaders inadequately prepared for the complex task of implementing change. Leading Change in Healthcare presents relationship-centered administration, an effective new evidence-based alternative to traditional culture change methodologies. It integrates fresh insights and methods from complexity science, positive psychology and relationship-centered care, enabling a more spontaneous and reflective approach to change management. This fosters greater organizational awareness and real participation, as well as improved productivity and creativity, as well as staff recruitment and retention. Case studies drawn from primary care, hospitals, long-term care, professional education, international NGOs and other settings, rather than emphasizing the end results, are demonstrations of how to apply relationship-centered administration in everyday practice. Leading Change in Healthcare is a key resource for all practitioners, students and teachers of healthcare management, medical educators, and leaders in all areas of healthcare provision. 'We need a new way of seeing, a new way of leading - and the authors provide a clear guide and resources for the path ahead. Leading Change in Healthcare offers hope - and a method. A daily dose is just what the change doctor ordered.' from the Foreword by Carol Aschenbrener.
Cytochromes are coloured iron-containing proteins that transfer electrons during cellular respiration and photosynthesis. The Cytochrome P450 family of enzymes catalyze reactions whereby water-insoluble drugs or metabolites, that would otherwise reach toxic levels in cell membranes, are rendered suitably water-soluble to leave the cell and be excreted in the urine. Due to the extensive nature of this subject, which is an area of intense scientific interest, the field is rapidly advancing and there is a need for new textbooks to keep abreast of the latest developments. The book fulfils that role in providing a fast-track approach for those coming into the P450 field, either at postgraduate level or in particular within the pharmaceutical industry. A Guide to Cytochrome P450 Structure and Function acts as an adjunct to the previous book Cytochromes P450: Structure, Function and Mechanism. It reviews the current status of the P450 field in terms of our present knowledge and understanding of the enzymes structure and function, including their multiplicity of forms, diversity of substrates, and selectivity. This is brought together with the latest research topics, including pharmacogenetics, regulation, human DMEs, toxicity screening and molecule modeling, to provide a fast-track approach for those new to the field.
Quantum Mechanics: An Introduction for Device Physicists and Electrical Engineers, Third Edition provides a complete course in quantum mechanics for students of semiconductor device physics and electrical engineering. It provides the necessary background to quantum theory for those starting work on micro- and nanoelectronic structures and is particularly useful for those beginning work with modern semiconductors devices, lasers, and qubits. This book was developed from a course the author has taught for many years with a style and order of presentation of material specifically designed for this audience. It introduces the main concepts of quantum mechanics which are important in everyday solid-state physics and electronics. Each topic includes examples which have been carefully chosen to draw upon relevant experimental research. It also includes problems with solutions to test understanding of theory. Full updated throughout, the third edition contains the latest developments, experiments, and device concepts, in addition to three fully revised chapters on operators and expectations and spin angular momentum, it contains completely new material on superconducting devices and approaches to quantum computing.
With expert contributions from experienced educators, research scientists and clinicians, Foye’s Principles of Medicinal Chemistry, Eighth Edition is an invaluable resource for professional students, graduate students and pharmacy faculty alike. This ‘gold standard’ text explains the chemical basis of drug action, emphasizing the structure-activity relationships, physicochemical-pharmacokinetic properties, and metabolic profiles of the most commonly used drugs.
A professional book aimed at practitioners and practitioners in training, this volume is the first attempt to provide a comprehensive, practical approach to the assessment and treatment of physically abused children. While there are other books that cover certain aspects of assessment and treatment, this book is comprehensive in that it covers child-specific, parent-specific, and family-specific interventions. The volume will present an overview of child physical abuse (including statistics and consequences), it will discuss outcome studies and treatment implications, and it will thoroughly discuss assessment and treatment. It will help practitioners: Understand children′s abuse experiences, views, exposures to violence, and it will help expose thinking errors or negative attributions. It will also help the practitioner help the children with anxiety management, anger management, social skills, and safety plans. Help parents with child management and development, expectations and cognitive distortions, behavior management, and discipline. Facilitate family communication and problem solving.
This is a highly practical book that focuses on the specifics of development in primary care research units. It discusses development of both research units and researchers themselves and offers helpful case studies that include an in-depth look at the development of one particular research unit. The issues and approaches used are applicable to all primary care researchers and administrators in medicine around the world. "Directing Research in Primary Care" is an easy to read, no-nonsense guide that provides invaluable information and guidance to individual researchers with, or contemplating, leadership roles, and deans, chairs and research directors supporting primary care research.
We live in a transformational time in the history of medicine and health care. The twenty-first century will be a time of dramatic change, incredible breakthroughs, and totally altered thinking about health, medicine, and health care delivery. This book sets forth what health care and medicine will look like in the years ahead. It takes a look at history, the transformational changes going on today, the health of Americans, the nine dynamic flows that are shaping health care in the United States, and definitions and descriptions of the new institutions of the future landscape of health care and medicine. It is already being called THE book to intelligently shape and guide the discussion and reorganization of health care reform in America. From leading futurist David Houle (recently named "Speaker of the Year" by Vistage International) and leading healthcare attorney Jonathan Fleece, comes this surprising, innovative look at the future of healthcare--and how we can lead the successful reorganization of healthcare in America.
Naylor's particular concern is with the nature and extent of the medical profession's opposition at both the provincial and federal levels. He details various developments in medical politics and policies, including the dispute over state health insurance plans in British Columbia during the depression, the national health insurance program drafted by the King government, the doctors' strike in Saskatchewan, and the development and eventual governmental rejections of prepayment plans sponsored by organized medicine. The author concludes that physicians regarded medical insurance schemes over which they had little administrative control, or where coverage was not limited to the indigent or to those earning below a modest wage, as threats to professional incomes and autonomy. His analysis of the evolution of the professional perspectives, policies, and pressure group activities suggests that physicians are as likely to act in their own economic and social interest as any other group, and that they oppose legislation that would threaten these interests while supporting laws that strengthen them. Since the Medical Care Act became law, Ottawa has moved to strengthen health care plans in the provinces, and once again the medical profession has resisted. The final chapter in Naylor's book puts these current conflicts in historical perspective by linking them to their political precedents.
The Second Edition presents a compact and concise alternative to the larger histology texts on the market today. Great for students with a limited amount of time to devote to the subject. Improvements to the art program--adding more color and new illustrations--have been made to this edition.
Written for teachers, trainers, and instructional designers -- anyone who is responsible for designing or preparing instruction -- this book begins with one basic premise: individual differences mediate learning at all levels and in all situations. That is, some learners find it easier or more difficult to learn some skills or to learn from certain forms of instruction because they vary in terms of aptitude, cognitive styles, personality, or learning styles. This volume describes most of the major differences in a readable and accessible way and demonstrates how to design various forms of instruction and predict the ease with which learners will acquire different skills. Most books that discuss any learner differences focus on those that characterize special education populations, whereas this book focuses on normal learners. Designed as a handbook, this volume is structured to provide easy and consistent access to information and answers, and prescriptions and hypotheses. When definitive answers are not possible because there is no research documentation, the authors suggest theories designed to stimulate future research.
The largest seaweed, giant kelp (Macrocystis) is the fastest growing and most prolific of all plants found on earth. Growing from the seafloor and extending along the ocean surface in lush canopies, giant kelp provides an extensive vertical habitat in a largely two-dimensional seascape. It is the foundation for one of the most species-rich, productive, and widely distributed ecological communities in the world. Schiel and Foster’s scholarly review and synthesis take the reader from Darwin’s early observations to contemporary research, providing a historical perspective for the modern understanding of giant kelp evolution, biogeography, biology, and physiology. The authors furnish a comprehensive discussion of kelp species and forest ecology worldwide, with considerations of human uses and abuses, management and conservation, and the current and likely future impacts of global change. This volume promises to be the definitive treatise and reference on giant kelp and its forests for many years, and it will appeal to marine scientists and others who want a better appreciation and understanding of these wondrous forests of the sea.
Recent advances in research have resulted in tremendous changes in burn management. Stay fully up to date with the new edition of Total Burn Care, by leading authority Dr. David N. Herndon. Detailed procedural guidelines walk you through every step of the process, from resuscitation through reconstruction and rehabilitation. Everyone on the burn care team, including general and plastic surgeons, intensivists, anesthestists, and nurses, will benefit from this integrated, multidisciplinary guide to safe and effective burn management. - Discusses infection control, early burn coverage, occupational physical exercise, respiratory therapy, and ventilator management. - Summarizes key points at the beginning of each chapter for quick reference. - Uses an integrated, team approach to help you meet the clinical, physical, psychological, and social needs of every patient. - Offers expert guidance on early reconstructive surgery and rehabilitation, with new content on improved surgical techniques. - Provides access to 15+ procedural operative videos and PowerPoint presentations on topics ranging from alopecia and anesthesia to radiation and treatment of infection – ideal for teaching and presenting. - Covers special populations such as elderly and pediatric patients, and includes a new chapter on burns in pregnancy. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
Biotechnology Biotechnology is is now now established established as as a a major major area area of of technology, technology, concerned concerned with with the' the' application application of of biological biological organisms, organisms, systems systems or or processes processes to to manufac turing turing or or service service industries'. industries'. Although Although the the exploitation exploitation of of organisms organisms by by man man is is not not new, new, many many of of the the techniques techniques which which are are stimulating stimulating the the rapid rapid advances advances in in biotechnology biotechnology have have developed developed from from recent recent scientific scientific discoveries. discoveries. Throughout Throughout history history man man has, has, knowingly knowingly or or not, not, been been exploiting exploiting yeast yeast in in the the production production of of alcoholic alcoholic beverages beverages and and bread, bread, and and these these processes processes still still represent represent major major biotechnological biotechnological industries. industries. The The brewer's brewer's and and baker's baker's yeast yeast Sac charomyces charomyces cerevisiae cerevisiae is, is, however, however, also also a a favoured favoured organism organism for for the the production production of of many many new new biotechnological biotechnological products. products.
Transcription, or the process by which DNA produces RNA, is a central aspect of gene expression. Transcription factors regulate transcription during development and in disease states. As such, it is critical for researchers to gain a good understanding of the relationship between the structure of various families of transcription factors and their function, as well as roles in human disease. Since publication of the Fourth Edition, there have been major advances, notably in the areas of chromatin remodeling and genome-scale analyses. This complete update includes all new coverage of the latest developments, from enabling genomic technologies to studies on the importance of post-translational modifications beyond phosphorylation events. - Potential of transcription factors as therapeutic targets in human disease - Importance of histone modifications - Use of genome-based sequence analysis and high-throughput methods - Applications of the chromatin immunoprecipitation (ChIP) assay - Transcriptional elongation - Regulation by post-translational modifications - Regulatory networks and bioinformatics
Figures of Time proposes radically new ideas about the very poetic ground of culture. Presenting unique close readings of six modern poets—Wallace Stevens, W. B. Yeats, H. D. (Hilda Doolittle), Ezra Pound, Langston Hughes, and T. S. Eliot—David Ben-Merre brings recent theoretical questions about the rhetoric of modernism and poetic figuration into current discussions in critical theory. He argues that poetic spaces, often disjunctions of sound and sense, disrupt our culturally inherited notions of time, reimagining with an often irrational and anachronistic backward glance what we take to be historical chronologies, psychological perceptions of time, and collective scripts about causality.
For over one hundred years International Critical Commentaries have had a special place among works on the Bible. They bring together all the relevant aids to exegesis - linguistic, textual, archaeological, historical, literary, and theological - to help the reader understand the meaning of the books of the Old and New Testaments. The new commentaries continue this tradition. All new evidence now available is incorporated and new methods of study are applied. The authors are of the highest international standing. No attempt has been made to secure a uniform theological or critical approach to the biblical text: contributors have been invited for their scholarly distinction, not for their adherence to any one school of thought.
This title was first published in 2003: As new medical technologies and treatments develop with increasing momentum, the legal and ethical implications of research involving human participants are being called into question as never before. Human Experimentation and Research explores the philosophical foundations of research ethics, ongoing regulatory dilemmas, and future challenges raised by the rapid globalisation and corporatisation of the research endeavour. This volume brings together some of the most significant published essays in the field. The editors also provide an informative introduction, summarizing the area and the relevance of the articles chosen.
This pocket book succinctly describes 215 common, serious errors made by attendings, residents, fellows, CRNAs, and practicing anesthesiologists in the practice of anesthesia and offers practical, easy-to-remember tips for avoiding these errors. The book can easily be read immediately before the start of a rotation or used for quick reference. Each error is described in a quick-reading one-page entry that includes a brief clinical scenario, a short review of the relevant physiology and/or pharmacology, and tips on how to avoid or resolve the problem. Illustrations are included where appropriate. The book also includes important chapters on human factors, legal issues, CPT coding, and how to select a practice.
This clear and compelling textbook provides a complete survey of the field of child abuse and neglect from the perspective of modern developmental attachment theory. It starts by describing the ways in which attachment difficulties manifest themselves in children's behaviour, and goes on looking at abuse, neglect, and compound cases of abuse and neglect, backing it all up with empirical research evidence and vivid case material. In its final section, it provides a comprehensive review of attachment-based interventions. Written by an extremely respected and successful author, this book, anchored in research evidence, places its emphasis on practice implementation and aims at answering all the kinds of questions practitioners and student practitioners specialising in child welfare are most likely to ask.
Gene regulation is an essential process in the development and maintenance of a healthy body, and as such, is a central focus in both basic science and medical research. Gene Regulation, Fifth Edition provides the student and researcher with a clear, up-to-date description of gene regulation in eukaryotes, distilling the vast and complex primary literature into a concise overview.
One of the classic works of marine biology, a favorite for generations, has now been completely revised and expanded. Between Pacific Tides is a book for all who find the shore a place of excitement, wonder, and beauty, and an unsurpassed introductory text for both students and professionals. This book describes the habits and habitats of the animals that live in one of the most prolific life zones of the world--the rocky shores and tide pools of the Pacific Coast of the United States. The intricate and fascinating life processes of these creatures are described with affectionate care. The animals are grouped according to their most characteristic habitat, whether rocky shore, sandy beach, mud flat, or wharf piling, and the authors discuss their life history, physiology, and community relations, and the influence of wave shock and shifting tide level. Though the basic purpose and structure--and much of the text--of the book remain the same, content has been increased by about 20 percent; a multitude of changes and additios has been made in the text; the Annotated Systematic Index and General Bibliography have been updated and greatly expanded (now almost 2,300 entries); more than 200 new photographs and drawings have been incorporated; and an entirely new chapter has been added--a topical presentation of the several factors influencing distribution of organisms along the shore. This edition also includes John Steinbeck's Foreword to the 1948 edition.
The assessment of patient reported outcomes and health-related quality of life continue to be rapidly evolving areas of research and this new edition reflects the development within the field from an emerging subject to one that is an essential part of the assessment of clinical trials and other clinical studies. The analysis and interpretation of quality-of-life assessments relies on a variety of psychometric and statistical methods which are explained in this book in a non-technical way. The result is a practical guide that covers a wide range of methods and emphasizes the use of simple techniques that are illustrated with numerous examples, with extensive chapters covering qualitative and quantitative methods and the impact of guidelines. The material in this new third edition reflects current teaching methods and content widened to address continuing developments in item response theory, computer adaptive testing, analyses with missing data, analysis of ordinal data, systematic reviews and meta-analysis. This book is aimed at everyone involved in quality-of-life research and is applicable to medical and non-medical, statistical and non-statistical readers. It is of particular relevance for clinical and biomedical researchers within both the pharmaceutical industry and clinical practice.
As adaptive capacities decline, and disease increases, the elderly become major consumers of drugs. Because of the special needs of older patients, physicians, geriatricians, health providers, and researchers must know how the aging process changes the pharmacokinetic and pharmacodynamic properties of drugs prescribed to the elderly. The Second Edition of this essential handbook is an up-to-date source that analyses the major drug groups, the disorders they treat, and the age-associated changes in cellular processes that affect drug action. Disorders prevalent in older people, such as Alzheimer's disease and Parkinson's disease, are examined in great detail. The book also discusses a wide range of drugs, including bronchodilators for asthma, nonsteroid anti-inflammatory drugs for arthritis, antibiotics, and treatments for cardiovascular disease, cancer, and mental disorders. The handbook also provides insight into future research problems dealing with the expanding aging population, their drug usage, and increasing adverse drug reactions.
This book investigates the role of bourgeoisie society and the political developments of the nineteenth century in the peculiarities of German history. Most historians attribute German exceptionalism to the failure or absence of bourgeois revolution in German history and the failure of the bourgeoisie to conquer the pre-industrial traditions of authoritarianism. However, this study finds that there was a bourgeois revolution in Germany, though not the traditional type. This so-called silent bourgeois revolution brought about the emergence and consolidation of the capitalist system based on the sanctity and disposability of private property and on production to meet individual needs through a system of exchange dominated by the market. In this connection, this book proposes a redefinition of the concept of bourgeois revolution to denote a broader pattern of material, institutional, legal, and intellectual changes whose cumulative effect was all the more powerful for coming to be seen as natural.
This will help us customize your experience to showcase the most relevant content to your age group
Please select from below
Login
Not registered?
Sign up
Already registered?
Success – Your message will goes here
We'd love to hear from you!
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.