A light-hearted nautical detective story of a seventeen-ton lead keel loaded with six kilos of weapons-grade plutonium (enough for a sizeable nuclear explosion) wandering around the Riviera. Searching for it are its owner, a millionaire who wants to make a killing by selling it to the Middle East's highest bidder, a former racing skipper, his teenage son, and a tall, blonde Swedish policewoman who can dive, punch hard and shoot straight. Mix into this Provençal Bouillabaisse the Corsican Mafia, an underwater hijacking, a pink-painted racing yacht advertising a non-existant beer, and a murderous off-shore shoot-out, and you have the menu for a good weekend read.
Biochemistry: The Chemical Reactions of Living Cells is a well-integrated, up-to-date reference for basic biochemistry, associated chemistry, and underlying biological phenomena. Biochemistry is a comprehensive account of the chemical basis of life, describing the amazingly complex structures of the compounds that make up cells, the forces that hold them together, and the chemical reactions that allow for recognition, signaling, and movement. This book contains information on the human body, its genome, and the action of muscles, eyes, and the brain. * Thousands of literature references provide introduction to current research as well as historical background * Contains twice the number of chapters of the first edition * Each chapter contains boxes of information on topics of general interest
Biochemistry: The Chemical Reactions of Living Cells is a well-integrated, up-to-date reference for basic chemistry and underlying biological phenomena. Biochemistry is a comprehensive account of the chemical basis of life, describing the amazingly complex structures of the compounds that make up cells, the forces that hold them together, and the chemical reactions that allow for recognition, signaling, and movement. This book contains information on the human body, its genome, and the action of muscles, eyes, and the brain.* Thousands of literature references provide introduction to current research as well as historical background* Contains twice the number of chapters of the first edition* Each chapter contains boxes of information on topics of general interest
Natural Autoantibodies provides an in-depth analysis of all aspects of natural antibodies. The book examines the advantages and pitfalls of every type of technique that is widely used for detecting autoantibodies. It also covers the sequencing of human autoantibody genes, discussing how sequencing is undertaken and the genetic clues available to elucidate the genetic origins of autoimmunity. Animal models of autoimmunity are also covered, and the up-to-date account provided in this book explains how natural autoantibodies have important regulatory functions and also occasionally serve as templates for autoimmunity. Other topics examined in Natural Autoantibodies: Their Physiological Role and Regulatory Significance include idiotypes of natural autoantibodies; the pathogenic role of natural autoantibodies; and methods to measure the effects of genetic and sex hormones, as well as aging, on natural autoantibodies. The book will be an excellent research tool and reference for immunologists, rheumatologists, and others interested in the topic.
To address the exponential growth in the fields of pediatric hematology and oncology, this classic reference has been separated into two distinct volumes. With this volume, devoted strictly to pediatric hematology, and another to pediatric oncology, you’ll keep you on the cutting-edge of these two specialties. The completely revised 7th edition of Nathan and Oski’s Hematology of Infancy and Childhood is now in full color, and provides you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children with hematologic disorders. It brings together the pathophysiology of disease with detailed clinical guidance on diagnosis and management for the full range of blood diseases that you encounter in everyday practice. Written by the leading names in pediatric hematology, this resource is an essential tool for anyone involved in caring for children with hematologic disorders. Balances summaries of relevant pathophysiology with clear, practical clinical guidance to help you thoroughly understand the underlying science of diseases. Offers comprehensive coverage of all hematologic disorders, including newly recognized ones, along with the latest breakthroughs in diagnosis and management. Uses many boxes, graphs, and tables to highlight complex clinical diagnostic and management guidelines at a glance. Presents an all-new full-color design that includes clear illustrative examples of relevant science and clinical problems for quick access to the answers you need.
Since the publication of High-Resolution Electrophorsesis and Immunofixation 2e, there have been ever-increasing advances in the analyses of proteins, by electrophoresis in particular. Protein Electrophoresis in Clinical Diagnosis shows the changes in both techniques and interpretation, presenting a comprehensive review of serum protein techniques,
This is the definitive guide to counselling adolescents. Now in its fourth edition, this bestseller has introduced thousands of trainees and practitioners to the theory, principals, skills and techniques of proactively counselling this client group. New to the fourth edition: - A new chapter on the contemporary context of adolescence, exploring the challenges, opportunities and influences facing young people today. - A new chapter on the use of technology when counselling young people - Useful links to relevant online resources at the end of each chapter - Updates to all chapters reflecting more recent understanding, research and literature - Additional case studies to help trainees apply theory and strategies to practice A multi-disciplinary book which recognises that a diversity of needs requires a diversity of approaches and skills, it uses case studies and examples to demonstrate this in a variety of settings. It is essential reading for trainees and practitioners in counselling, social work, the allied health professions and education.
Now in four convenient volumes, Field’s Virology remains the most authoritative reference in this fast-changing field, providing definitive coverage of virology, including virus biology as well as replication and medical aspects of specific virus families.
The glory years for the Toronto Maple Leafs—four Stanley Cups in the 1960s—may be distant memories, but what the team lacks in recent accomplishments is made up for by their history, which is rich in drama, pathos, and, most of all, humor. Figures connected to the Maple Leafs from the 1950s to the present offer their best stories, including some new takes on the team’s legends. Players, coaches, broadcasters, and team executives come together to share a long list of funny anecdotes about their time with the Leafs. Bobby Baun recalls the unprecedented moment in the 1964 Stanley Cup finals when he slammed a game-winning goal into the net while skating on a broken leg. Bob Haggert, a former Leafs trainer, shares his memories of Conn Smythe, the unyielding military man who founded the team. Also telling tales is Jim McKenny, defenseman-turned-forward-turned broadcaster, whose sense of humor is as deft as his skating. Joe Bowen, long the voice of the Maple Leafs on radio and television, is along for the ride, as are Bob McGill, Glenn Healy, Walter Gretzky, and so many more.
A candid explanation of how the labor market really works and is central to everything—and why it is not as healthy as we think Relying on unemployment numbers is a dangerous way to gauge how the labor market is doing. Because of a false sense of optimism prior to the COVID-19 shock, the working world was more vulnerable than it should have been. Not Working is about how people want full-time work at a decent wage and how the plight of the underemployed contributes to widespread despair, a worsening drug epidemic, and the unchecked rise of right-wing populism. David Blanchflower explains why the economy since the Great Recession is vastly different from what came before, and calls out our leaders for their continued failure to address one of the most unacknowledged social catastrophes of our time. This revelatory and outspoken book is his candid report on how the young and the less skilled are among the worst casualties of underemployment, how immigrants are taking the blame, and how the epidemic of unhappiness and self-destruction will continue to spread unless we deal with it. Especially urgent now, Not Working is an essential guide to strengthening the labor market for all when we need it most.
Musicals have been a major part of American theater for many years, and nowhere have they been more loved and celebrated than Broadway, the theater capital of the world. The music of such composers as Rodgers and Hammerstein, Berlin, the Gershwin brothers, Lerner and Loewe, Steven Sondheim, and Andrew Lloyd Webber continues to run through people's minds, and such productions as South Pacific, Cats, My Fair Lady, The Phantom of the Opera, Guys and Dolls, Rent, and West Side Story remain at the top of Broadway's most popular productions. This book is a survey of Broadway musicals all through the 20th century, from the Tin Pan Alley-driven comedy works of the early part of the century, to the integrated musical plays that flourished in the heyday years of midcentury, and to the rock era, concept musicals, and the arrival of British mega-musicals late in the century. It also profiles some of the theater world's leading composers, writers, and directors, considers some of the most unforgettable and forgettable shows, illustrates the elusive fragility of the libretto, explains the compensating nature of production elements, and examines representative shows from every decade. An extensive discography offers a brief critique of more than 300 show cast albums.
The Fifth International Lymphokine Workshop was convened in Clearwater Beach, Florida, January 11-15, 1987. The theme chosen for the meeting was 'The Molecular Basis of Lymphokine Action," which reflected the opinion of the organizers as to how far the field had moved since the first Lymphokine Workshop only eleven years ago. As was evident at the last Lymphokine Workshop held in 1985, the contribution of molecular biology, particularly in the cloning of lymphokine genes, continues to play an important role in clarifying the structure of lymphokines, providing recombinant (read "pure") proteins for biological studies, and suggesting directions for studies of the molecular basis of lymphokine activity. The most recent lymphokines to yield to molecular cloning meth odology were the B-cell growth and differentiation factors, in partic ular BSF-1 or, as it is sometimes termed, interleukin 4. One of the surprises from this research is the broad spectrum of activities that can be attributed to this molecule, aside from its effects on B-cells, thus perhaps justifying its being called an interleukin. The interleukin 2 symposium demonstrated that even in a well-established research area, controversy and excitement can continue, when evidence was presented by several investigators indicating the presence of a second "converter" protein that changes the affinity of the now classical Tac antigen from a low to a high affinity IL-2 receptor.
Now in four convenient volumes, Field’s Virology remains the most authoritative reference in this fast-changing field, providing definitive coverage of virology, including virus biology as well as replication and medical aspects of specific virus families. This volume of Field’s Virology: RNA Viruses, Seventh Edition covers the latest information on RNA viruses, how they cause disease, how they can cause epidemics and pandemics, new therapeutics and vaccine approaches, as provided in new or extensively revised chapters that reflect these advances in this dynamic field. Bundled with the eBook, which will be updated regularly as new information about each virus is available, this text serves as the authoritative, up-to-date reference book for virologists, infectious disease specialists, microbiologists, and physicians, as well as medical students pursuing a career in infectious diseases.
The Deposit Modeling Program was founded by UNESCO-IUGS with the major aim to disseminate knowledge from scientists in more developed countries to their counterparts from less developed ones. A fringe benefit of this effort was the compilation of information on existing models and promotion of topical workshops in developing countries. This book is the result of one such workshop that took place in Delhi and Udaipur, India, in December 2001. Sediment-hosted Lead-Zinc Sulphide Deposits compiles the work of renowned economic geologists from three continents. The authors highlight the recent advances in the understanding of the temporal and tectono-stratigraphic distribution of sediment-hosted Pb-Zn sulphide ores and processes governing their genesis. The first section comprises five chapters covering some of the most important deposits of this class in Australia and Canada in detail, emphasizing their genetic models. It also includes a paper on the "geoenvironmental model," which concerns behavior before mining and resulting from mining, processing, and smelting. The second section discusses the mineralized terranes in the state of Rajasthan, northwest India, which host three major sulphide deposits. This reference is packed with color and black and white photographs, illustrations, charts, and graphs, making it a valuable, up-to-date resource for any geologist or geotechnical scientist studying major mineral deposits.
Metallic Mineral Resources: The Critical Components for a Sustainable Earth serves the increasing interest in metal resources, especially the critical and strategic metals which are essential commodities for the green energy transition. The opening chapters introduce the heterogeneous distribution of metal resources as well as the industrial use of metals. The main chapters then work systematically through abundant metal systems, scarce critical metal systems, rare critical metal systems, trace critical metal systems, and precious metal systems. The book wraps with a close examination of temporal distribution of mineral resources and an insightful discussion of the future of mineral resources. Researchers and engineers in economic geology and mining and exploration industries will find themselves returning to this key reference for years to come.• Describes how mineable and economic metal concentrations form and are preserved in the Earth's upper crust • Explores how they are discovered by systematic mineral exploration at a variety of scales • Discusses how to educate the public on the scarcity of natural metal resources and the issues concerning the nexus between the energy transition and potential exhaustion of critical metals
Capitalism in its modern form has become universal and has a presence in practically every country in the world, including those which once called themselves Communist. This book studies its effects on different labor markets, from those linked to highly tertiary economies (EU-27, USA and Japan, to the most productive economies, such as China, and on to economic models that are in full transition from secondary to tertiary economies, as is the case in several Latin American countries.
An authoritative investigation of the sources andtreatment of osteoarthritic joint pain Millions of people throughout the world suffer from osteoarthritis (OA)—a medical condition causing its sufferers excruciating pain that is often disabling. This is the first book to offer clinicians an in-depth understanding of the biological sources of osteoarthritic pain and how they can be treated. Here, a team of leading international authorities has contributed state-of-the-art information on: The Neuroscience of Articular Pain—spinal and peripheral mechanisms of joint pain; experimental models for the study of osteoarthritic pain; inflammatory mediators and nociception in arthritis; phantoms in rheumatology; and more Osteoarthritis and Pain—joint mechanisms and neuromuscular aspects of OA; bone pain and pressure in OA joints; structural correlates of OA pain; and more Treatment of Osteoarthritic Pain—general approaches to treatment; treatments targeting pain receptors; treatments targeting biomechanical abnormalities; and treatments targeting inflammation Whether you're a medical professional, researcher, student, or a generalist or specialist focusing on pain or arthritis, this is your one-stop reference for understanding and treating joint pain in osteoarthritis.
Cancer Therapy with Radiolabeled Antibodies explores the most current experimental and clinical advances in the newly emerging field of cancer radioimmunotherapy (RAIT). Providing a multidisciplinary and international context, some of the world's leading experts examine the problems and prospects of RAIT from radiation, immunological, chemical, physical, physiological, and clinical perspectives with both overviews and original research. Discussions cover the up-to-date clinical results in the RAIT of ovarian, breast, colorectal, and brain cancers, as well as the current status of RAIT in the management of B cell lymphomas. Radiobiology, dosimetry, radiochemistry, targeting biology in experimental models, clinical experiences in hematopoietic and solid tumors, and new approaches to improve cancer radioimmunotherapy are also discussed. In addition, new dosimetry concepts, new labeling methods, new concepts of antibody pharmacokinetics, and new methods to enhance selective cancer radioimmunotherapy are included.
2017 Freedley Award Finalist, Theatre Library Association 2016 Best Circus Book of the Year, Stuart Thayer Prize, Circus Historical Society The 1960s American hippie-clown boom fostered many creative impulses, including neo-vaudeville and Ringling's Clown College. However, the origin of that impulse, clowning with a circus, has largely gone unexamined. David Carlyon, through an autoethnographic examination of his own experiences in clowning, offers a close reading of the education of a professional circus clown, woven through an eye-opening, sometimes funny, occasionally poignant look at circus life. Layering critical reflections of personal experience with connections to wider scholarship, Carlyon focuses on the work of clowning while interrogating what clowns actually do, rather than using them as stand-ins for conceptual ideas or as sentimental figures.
High-Resolution Electrophoresis and Immunofixation: Techniques and Interpretation acquaints the reader with the available methodologies and instrumentation for performing high-resolution electrophoresis and immunofixation. This text presents the use of procedures of high-resolution electrophoresis and immunofixation to facilitate the diagnosis of a variety of serum protein abnormalities. It also provides case examples to illustrate the uses of these procedures and their possible caveats. The book contains chapters devoted to the methods and rationale for high-resolution electrophoresis; interpretation of high-resolution electrophoresis patterns in serum, urine, and cerebrospinal fluid; the immunofixation technique; and strategies for diagnosing monoclonal gammopathies. Medical technologists, physicians, and pathologists will find the book invaluable.
This volume generates a new paradigm for researching and understanding the biological meaning of eicosanoids. Eicosanoid is a general term for oxygenated metabolites of certain polyunsaturated fatty acids. The compounds are extremely important in human biology, in which they are well understood. Their importance to humans, however, has tended to overshadow their broader biological significance. David Stanley seeks to change that in this book, providing a general sketch of the medical background on eicosanoids and then developing a detailed critical treatment of eicosanoid actions in invertebrates and some lower vertebrates. Stanley looks at the role of eicosanoids in, for example, invertebrate reproduction, immunity, and ion transport physiology. As he explains, eicosanoids also mediate important ecological interactions, particularly host-parasite interactions. Drawing on these physiological and ecological actions, the book develops a "biological paradigm," under which we understand that eicosanoids probably exert important actions in most, if not all, animals. Because eicosanoids mediate crucial events in the lives of animals, they are endowed with unusual explanatory power. Research designed to increase our understanding of eicosanoids has thus yielded and will continue to yield important new information about animal biology. In addition to representing a major advance in our understanding of eicosanoids in animals, this book serves as an unusually comprehensive and accessible introduction to eicosanoid research in general. Originally published in 1999. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.
This book comprehensively summarizes the adverse effects of tobacco smoking on human health. The current second edition has integrated a large set of new data that have been published in numerous scientifc studies and meta-analyses over the past few years. Unfortunately, the harmful sequelae of tobacco smoking are played down by the ind- try and politicians in many industrialized countries. However, about 800,000 people/year in the EU die from the immediate consequences of smoking. The particularly insidious feature of tobacco consumption is that smoking-attributable harmful effects on health do not generally become apparent until three or four decades after smoking initiation. Although some positive changes in the legislative handling of tobacco have appeared in the past fve years, we still need to form a pact, sealed by politicians, the medical prof- sionals, teachers and the media, to target the problem across nations. In this respect, a minority of countries, including the US and the UK, have given positive examples. There are four areas that need to be improved in future: (1) strict bans on tobacco adv- tisement on a global level, (2) better measures to protect against side-stream (passive) smoke exposure, (3) establishment of prevention programs, especially for children and (4) tre- ment of tobacco addiction.
This preeminent book in the field of Neurology has been extensively updated and expanded by 70 leading authorities, providing a single, encyclopedic summary the scientific advances and new clinical practices that can be immediately considered for your patients. It brings together nearly the entire spectrum of motor disorders and Neurology into one convenient resource to aid in a comprehensive evaluation, diagnosis, distinction, and treatment of various disorders. Additionally, by using the perspectives of different subspecialties, the book also provides a comprehensive yet concise account of any disorder with motor manifestations. This new edition now includes the following content and features: Edited by David S. Younger, MD, a highly respected practitioner and researcher, with scholarly chapters by leaders in the field and more international authors than other texts. Up-to-date articles on highly changing subjects related to Neurogenetics. Chapters on Neurorehabilitation – coverage not usually found in other neurological textbooks. Advances in Alzheimer Disease, Parkinson Disease, Amyotophic Lateral Sclerosis. Both adult and pediatric topics in one book. High quality figures of neuroimaging and neuropathology.
Physiology of Sport and Exercise, Seventh Edition With Web Study Guide, continues its legacy as a top physiology textbook and favorite of instructors and students alike. Combining research with extensive visual aids, this resource offers a simple way for students to develop an understanding of the body’s abilities to perform various types and intensities of exercise and sport, to adapt to stressful situations, and to improve its physiological capacities. Written by a team of distinguished researchers, all past presidents of the American College of Sports Medicine, this seventh edition has been updated based on the most recent position stands, standards, and guidelines in the field of sport and exercise physiology. Throughout the text, updated photos join with the superb illustrations and medical artwork to clarify difficult concepts and illustrate how the body performs. Digital components found in the web study guide now include 26 animations that offer a dynamic way to experience physiological concepts, and 66 audio clips that provide explanations of complex physiological processes to aid students’ understanding of important illustrations in the text. Leaders in the field discuss recent developments and real-world applications in 27 video clips to help students connect theoretical and practical concepts. Corresponding icons throughout the text notify students when digital elements are available to complement the materials. In addition to the expanded digital components, Physiology of Sport and Exercise, Seventh Edition, features new and updated content based on the latest research in the field: Additional information on overtraining and exercise addiction Expanded content on fatigue and mobility in aging New sections on epigenetics, bioinformatics, and neuromuscular function New information on exercise genomics New Research Perspectives emphasizing emerging findings in the field, and a new Research Perspectives Finder to help students locate key content quickly Ease of reading has been the standout feature of this popular text. The seventh edition continues to offer comprehensive coverage of the complex relationship between human physiology and exercise while maintaining an engaging and student-friendly tone. Unique learning features paired with an accessible layout, including chapter-opening outlines and review boxes throughout each chapter, will help students focus on the major concepts addressed. Study questions and a list of key terms at the end of the chapter increase students’ opportunities for recall and self-testing. A comprehensive glossary and lists of common abbreviations and conversions provide easy reference for students as they complete labs and assignments. To foster an enriched learning experience, both students and instructors can take advantage of the web-based ancillaries that accompany the text. In addition to animations, videos, and audio clips, the web study guide includes comprehension quizzes to provide immediate feedback to students on their knowledge retention as well as end-of-unit mastery checks that students can use for evaluating their progress. Instructors are provided with access to an instructor guide, test package, ready-to-use chapter quizzes, and a presentation package plus image bank. The presentation package includes PowerPoint slides with key points and content, which can be modified to suit a variety of class structures. An image bank features all of the graphics, artwork, and content photos from the text for easy insertion into tests, quizzes, handouts, and other course materials. Digital extras—composed of the animations, videos, and audio clips that students find in the web study guide—bolster comprehension of challenging concepts. Physiology of Sport and Exercise has been a pivotal textbook of the engaging field of exercise physiology. Through dynamic and interactive learning activities, easy-to-follow layouts, and research-oriented content enriched with visual supplements, students and instructors will find this an invaluable resource for their continued education.
Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. For more than 30 years, Perez and Brady's Principles and Practice of Radiation Oncology has been the must-have standard reference for radiation oncologists and radiation oncology residents who need a comprehensive text covering both the biological and physical science aspects of this complex field as well as disease site-specific information on the integrated, multidisciplinary management of patients with cancer. The book has established itself as the discipline’s "text-of-record," belonging on the shelf of all of those working in the field. The Seventh Edition continues this tradition of excellence with extensive updates throughout, many new chapters, and more than 1,400 full-color illustrations that highlight key concepts in tumor pathogenesis, diagnosis, and targeted radiation therapy.
The story of our evolutionary past is told in our genome sequence. Human Gene Evolution deals with the origins of human genes, describes their structure, function, organisation and expression. The text integrates our emerging knowledge of chromosome and genome structure, and discusses the nature of the mutational mechanisms underlying evolutionary change.
Principles of Physical Chemistry, Second Edition uniquely uses simple physical models as well as rigorous treatments for understanding molecular and supramolecular systems and processes. In this way the presentation assists students in developing an intuitive understanding of the subjects as well as skill in quantitative manipulations. The unifying nature of physical chemistry is emphasized in the book by its organization - beginning with atoms and molecules, and proceeding to molecular assemblies of increasing complexity, ending with the emergence of matter that carries information, i.e. the origin of life, a physicochemical process of unique importance. The aim is to show the broad scope and coherence of physical chemistry.
Transplant Infections is a practical, clinically focused reference covering the common and more unusual bacterial, viral, and fungal infections affecting patients who have received stem cell or solid organ transplants. It provides a comprehensive review of the epidemiology, diagnosis, and management of opportunistic infections and presents strategies for infection prevention and control. Highlights of the Third Edition include a chapter on new immunosuppressive agents and expanded coverage of tropical infections and West Nile virus.
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