Comprehensive and complete, Shackelford’s Surgery of the Alimentary Tract delivers the definitive, clinically oriented, cutting-edge guidance you need to achieve optimal outcomes managing the entire spectrum of gastrointestinal disorders. Make effective use of the latest endoscopic, robotic, and minimally invasive procedures as well as medical therapies with unbeatable advice from a "who’s who" of international authorities! Find expert answers to any clinical question in gastrointestinal surgery, from the esophagus to the colon. See exactly what to look for and how to proceed from an abundance of beautifully detailed intraoperative and laparoscopic photographs.
Interest in implementation research is growing, largely in recognition of the contribution it can make to maximizing the beneficial impact of health interventions. As a relatively new and, until recently, rather neglected field within the health sector, implementation research is something of an unknown quantity for many. There is therefore a need for greater clarity about what exactly implementation research is, and what it can offer. This Guide is designed to provide that clarity. Intended to support those conducting implementation research, those with responsibility for implementing programs, and those who have an interest in both, the Guide provides an introduction to basic implementation research concepts and language, briefly outlines what it involves, and describes the many opportunities that it presents. The main aim of the Guide is to boost implementation research capacity as well as demand for implementation research that is aligned with need, and that is of particular relevance to health systems in low- and middle-income countries (LMICs). Research on implementation requires the engagement of diverse stakeholders and multiple disciplines in order to address the complex implementation challenges they face. For this reason, the Guide is intended for a variety of actors who contribute to and/or are impacted by implementation research. This includes the decision-makers responsible for designing policies and managing programs whose decisions shape implementation and scale-up processes, as well as the practitioners and front-line workers who ultimately implement these decisions along with researchers from different disciplines who bring expertise in systematically collecting and analyzing information to inform implementation questions. The opening chapters (1-4) make the case for why implementation research is important to decision-making. They offer a workable definition of implementation research and illustrate the relevance of research to problems that are often considered to be simply administrative and provide examples of how such problems can be framed as implementation research questions. The early chapters also deal with the conduct of implementation research, emphasizing the importance of collaboration and discussing the role of implementers in the planning and designing of studies, the collection and analysis of data, as well as in the dissemination and use of results. The second half of the Guide (5-7) detail the various methods and study designs that can be used to carry out implementation research, and, using examples, illustrates the application of quantitative, qualitative, and mixed-method designs to answer complex questions related to implementation and scale-up. It offers guidance on conceptualizing an implementation research study from the identification of the problem, development of research questions, identification of implementation outcomes and variables, as well as the selection of the study design and methods while also addressing important questions of rigor.
Thoroughly revised and updated, this Fourth Edition is the most comprehensive, current reference on lung cancer, with contributions from the world's foremost surgeons, radiation oncologists, medical oncologists, pulmonologists, and basic scientists. Coverage includes complete information on combined modality treatments for small cell and non-small cell lung cancer and on complications of treatment and management of metastases. Emphasis is also given to early detection, screening, prevention, and new imaging techniques. This edition has expanded thoracic oncology chapters including thymus, mesothelioma, and mediastinal tumors, more detailed discussion of targeted agents, and state-of-the-art information on newer techniques in radiotherapy. Other highlights include more international contributors and greater discussion of changes in lung cancer management in each region of the world. A new editor, Giorgio Scagliotti, MD from the University of Turin, has coordinated the accounts of European activities. A companion website includes the full text online and an image bank.
Despite having the highest rates of cannabis use in the continent, France enforces the most repressive laws against the drug in all of Europe. Perhaps surprisingly, France was once the epicentre of a global movement to medicalize cannabis, specifically hashish, in the treatment of disease. In Taming Cannabis David Guba examines how nineteenth-century French authorities routinely blamed hashish consumption, especially among Muslim North Africans, for behaviour deemed violent and threatening to the social order. This association of hashish with violence became the primary impetus for French pharmacists and physicians to tame the drug and deploy it in the homeopathic treatment of mental illness and epidemic disease during the 1830s and 1840s. Initially heralded as a wonder drug capable of curing insanity, cholera, and the plague, hashish was deemed ineffective against these diseases and fell out of repute by the middle 1850s. The association between hashish and Muslim violence, however, remained and became codified in French colonial medicine and law by the 1860s: authorities framed hashish as a significant cause of mental illness, violence, and anti-state resistance among indigenous Algerians. As the French government looks to reform the nation's drug laws to address the rise in drug-related incarceration and the growing popular demand for cannabis legalization, Taming Cannabis provides a timely and fascinating exploration of the largely untold and living history of cannabis in colonial France.
A foundational textbook on the scientific principles of therapeutic herbalism and their application in medicine • A complete handbook for the medical practitioner • Includes the most up-to-date information on preparations, dosage, and contraindications • By the author of The Complete Illustrated Holistic Herbal Medical Herbalism contains comprehensive information concerning the identification and use of medicinal plants by chemical structure and physiological effect, the art and science of making herbal medicine, the limitations and potential of viewing herbs chemically, and the challenge to current research paradigms posed by complex plant medicines. It also includes information on toxicology and contraindications, the issues involved in determining dosage and formulation types for an individual, guides to the different measurement systems and conversion tables, and the pros and cons of both industrial and traditional techniques. With additional sections devoted to the principles of green medicine, the history of Western Herbalism, the variety of other medical modalities using medicinal plants, an extensive resource directory, and a discussion of treatments organized by body system, Medical Herbalism is the comprehensive textbook all students and practitioners of clinical herbalism need to develop their healing practices.
Hemophilia and Von Willebrand Disease: Factor VIII and Von Willebrand Factor serves as a must-have reference on the important role these essential blood-clotting proteins play in research and clinical medicine. Clinicians and researchers face the daily challenge of staying current on the vast amounts of research that is now generated. The reference to Janus in the title refers to the two roles of the Factor VIII/Von Willebrand Factor Complex: initiation of coagulation and propagation of clot formation. The complex prevents bleeding in hemophilia and Von Willebrand disease but also augments arterial and venous thrombosis. - Presents one source of information on Hemophilia and Von Willebrand Disease, as well as Factor VIII and Von Willebrand Factor, eliminating the search through hundreds of journal articles - Combines the multi-disciplinary research that is generated from Factor VIII/Von Willebrand Factor – hematology, drug discovery, genetics, cell biology, and oncology - Delves into unanswered questions and future directions of this important blood-clotting complex
Winner of the BMA 2011 book awards: psychiatry category Winner of the Australian Journal of Ageing book of the year award This definitive work on dementia and related disorders has been fully updated and revised to reflect recent advances in this fast-moving field. The incidence of dementia continues to rise as the population of the world ages, and the condition represents one of the most significant challenges facing societies and health professionals in the next half-century. In this, the most comprehensive single volume work available on the subject, the editors have met this challenge by assembling a team of the world's leading experts on all aspects of the condition, from history, epidemiology and social aspects to the latest neurobiological research and advanced therapeutic strategies.
To address the exponential growth in the fields of pediatric hematology and oncology, this classic reference has been separated into two distinct volumes. With this volume, devoted strictly to pediatric hematology, and another to pediatric oncology, you'll keep you on the cutting-edge of these two specialties. The completely revised 7th edition of Nathan and Oski's Hematology of Infancy and Childhood is now in full color, and provides you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children with hematologic disorders. It brings together the pathophysiology of disease with detailed clinical guidance on diagnosis and management for the full range of blood diseases that you encounter in everyday practice. Written by the leading names in pediatric hematology, this resource is an essential tool for anyone involved in caring for children with hematologic disorders. And, as an Expert Consult title, this thoroughly updated 7th edition comes with access to the complete contents online, fully searchable. Balances summaries of relevant pathophysiology with clear, practical clinical guidance to help you thoroughly understand the underlying science of diseases. Offers comprehensive coverage of all hematologic disorders, including newly recognized ones, along with the latest breakthroughs in diagnosis and management. Uses many boxes, graphs, and tables to highlight complex clinical diagnostic and management guidelines at a glance. Presents an all-new full-color design that includes clear illustrative examples of relevant science and clinical problems for quick access to the answers you need. Provides access to the complete contents online, fully searchable, enabling you to consult it rapidly from any computer with an Internet connection. Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.
Colorectal surgery is a key part of the general surgeon’s remit and it is essential for the surgeon to be aware of the range of preoperative, perioperative and disease management issues. This practical book provides practical knowledge and guidance necessary to manage colorectal diseases. A wide range of topics is included, including examination procedures, diagnostics, preoperative preparation and assessment, pain management and surgical skills and techniques. Key Points Concisely outlines practical information and guidance for any healthcare practitioner involved in the treatment and management of colorectal disorders Provides an overview of disease processes to assist with clinical treatment and diagnosis This revised 3rd Edition contains up-to-date information on advances in minimally invasive surgery, treatment and management of colon and rectal cancer, and haemorrhoids and fistulas.
A valuable resource for researchers and workers in the fields of both pharmaceuticals and biotechnology as well as undergraduates in biochemistry, applied biology, biomedical sciences and pharmacy, this book compares established techniques of antibody production with the new. Antibody structure and the implications of antibody engineering are fully
Apley and Solomon’s Concise System of Orthopaedics and Trauma is firmly established as the leading introductory textbook of orthopaedic practice and the principles of fracture management. Praised in previous editions for its systematic approach, balanced content and easy-to-read style, the fourth edition has been brought fully up to date with more than 800 illustrations, many new to this edition, providing an invaluable pictorial account of this highly visual subject. Key features of the Fourth Edition: Reflects the changing pattern of musculoskeletal disease around the world Focuses on actual diseases and clinical signs, with additional coverage of anatomy where appropriate—ideal for the medical student and junior surgeon Provides helpful guidance on simple procedures without unnecessary operative detail Includes revised and expanded sections on developments in molecular biology and genetics—reflecting the growing clinical significance of these important areas Demonstrates new imaging technologies Retains popular features such as handy check points and text boxes—ideal for rapid assimilation during a clinical placement or exam revision This text remains the first choice for medical students, trainee surgeons and other health professionals seeking a concise introduction to this large and complex subject. It is a natural preface to the more detailed coverage offered by the parent book, Apley’s System of Orthopaedics and Trauma.
This pocketbook serves as a concise and practical guide to the management of ADHD for child and adolescent psychiatrists and child psychologists, paediatricians, trainees, psychiatric specialist nurses, interested general practitioners, and other mental health professionals. The pocketbook provides a user-friendly introduction to the clinical understanding, evaluation, and treatment of ADHD. This edition has been updated to include new DSM-5 diagnostic criteria (May 2013) and to reflect more published studies on ADHD in the adult population, along with new data on the CNS stimulant drug LDX (Lisdexamfetamine Dimesylate).
Nuclear medicine is the bridge between a particular clinical problern and a relevant test using radionuclides. It began as a minor technical tool used in a few branches of medicine, notably endocrinology and nephrology. However, throughout the world it has now become established as a clinical discipline in its own right, with specific training programmes, special skills and a particular approach to patient management. Although the practising nuclear medicine physician must necessarily learn a great deal of basic science and technology, a sound medical training and a clinical approach to the subject remains of fundamental importance. It is for this reason that we have attempted in this book to approach the subject from a clinical standpoint, including where necessary relevant physiological material. There exist many excellent texts which cover the basic science and technology of nuclear medicine. We have, therefore, severely limited our coverage of these aspects of the subject to matters which we felt tobe essential, particularly those which have been less well covered in other texts- for example, the contents of Chapter 20 on Measurement by Royal and McNeill. Similarly, we have limited details of methodology to skeletal summaries of protocol (Appendix 1) and have included at the end of some chapters descriptions of particular techniques where we and the authors felt that it would be helpful.
Here is the most comprehensive and authoritative work on radiologic diagnosis of pediatric gastrointestinal disorders. Packed with hundreds of outstanding clinical images, Pediatric Gastrointestinal Imaging and Intervention offers explicit, step-by-step instructions for performing and interpreting the latest diagnostic techniques. It discusses the imaging methods practitioners are likely to employ, including sonography, plain film and contrast radiography, endoscopy, CT, MRI, nuclear medicine, angiography, and interventional radiology.
Stuttering and Cluttering provides a clear, accessible and wide-ranging overview of both the theoretical and clinical aspects of two disorders of fluency: stuttering and cluttering. This edition remains loyal to the idea that stuttering and cluttering can best be understood by first considering various overarching frameworks which can then be expanded upon, and provides a clear position from which to disentangle the often complex interrelationships of these frameworks. The book is divided into two parts, the first of which mainly deals with theory and aetiology, while the second focuses on clinical aspects of assessment, diagnosis and treatment. The book also provides frequent references across Parts I and II to help link the various areas of investigation together. This revised edition of Stuttering and Cluttering reflects the major changes in thinking regarding both theory and therapy that have taken place since the publication of the first edition. As well as those who stutter and clutter, the book will be invaluable for speech language therapy/speech language pathology students, practicing clinicians, psychologists and linguists around the world.
Biochemistry: The Chemical Reactions of Living Cells is a well-integrated, up-to-date reference for basic biochemistry, associated chemistry, and underlying biological phenomena. Biochemistry is a comprehensive account of the chemical basis of life, describing the amazingly complex structures of the compounds that make up cells, the forces that hold them together, and the chemical reactions that allow for recognition, signaling, and movement. This book contains information on the human body, its genome, and the action of muscles, eyes, and the brain. It also features: thousands of literature references that provide introduction to current research as well as historical background; twice the number of chapters of the first edition; and each chapter contains boxes of information on topics of general interest. -- Publisher description.
This book reviews the geochemical and petrological characteristics of potassic igneous rock complexes, and investigates the various tectonic settings in which these rocks occur. The authors provide an overview and classification of these rocks and elucidate the geochemical differences between barren and mineralized potassic igneous complexes. High-K rocks are genetically associated with a number of epithermal gold and porphyry copper-gold deposits. In recent years, there has also been growing recognition of an association of such rocks with iron-oxide copper-gold (IOCG) deposits, intrusion-related gold deposits (IRGDs) and Carlin-type gold deposits. This fifth updated and expanded edition incorporates new data and references from world-class copper and gold deposits worldwide. It also includes the latest publications on the petrogenesis of high-K magmatism and related mineral deposits. Numerous new representative ore photographs of the mineral deposits described are also included in the new edition. As such, the book offers a valuable guide not only for academic petrologists working on alkaline rocks, but also for exploration geologists prospecting for epithermal gold and/or porphyry copper-gold deposits in modern and ancient terrains.
To address the growing complexities of childhood cancer, Nathan and Oski’s Hematology and Oncology of Infancy and Childhood has now been separated into two distinct volumes. With this volume devoted strictly to pediatric oncology, and another to pediatric hematology, you will be on the cutting edge of these two fields. This exciting new, full-color reference provides you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children with cancer. It brings together the pathophysiology of disease with detailed clinical guidance on diagnosis and management for the full range of childhood cancers, including aspects important in optimal supportive care. Written by the leading names in pediatric oncology, this resource is an essential tool for all who care for pediatric cancer patients. Offers comprehensive coverage of all pediatric cancers, including less common tumors, making this the most complete guide to pediatric cancer. Covers emerging research developments in cancer biology and therapeutics, both globally and in specific pediatric tumors. Includes a section on supportive care in pediatric oncology, written by authors who represent the critical subdisciplines involved in this important aspect of pediatric oncology. Uses many boxes, graphs, and tables to highlight complex clinical diagnostic and management guidelines. Presents a full-color design that includes clear illustrative examples of the relevant pathology and clinical issues, for quick access to the answers you need. Incorporates the codified WHO classification for all lymphomas and leukemias.
Written by the leading names in pediatric oncology and hematology, Nathan and Oski's Hematology and Oncology of Infancy and Childhood offers you the essential tools you need to overcome the unique challenges and complexities of childhood cancers and hematologic disorders. Meticulously updated, this exciting full-color set brings together the pathophysiology of disease with detailed clinical guidance to provide you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children. - Form a definitive diagnosis and create the best treatment plans possible with comprehensive coverage of all pediatric cancers, including less-common tumors, as well as all hematologic disorders, including newly recognized ones. - Develop a thorough, understanding of the underlying science of diseases through summaries of relevant pathophysiology balanced with clear, practical clinical guidance. Nathan and Oski's is the only comprehensive product on the market that relates pathophysiology in such depth to hematologic and oncologic diseases affecting children. - Quickly and effortlessly access the key information you need with the help of a consistent organization from chapter to chapter and from volume to volume. - Stay at the forefront of your field thanks to new and revised chapters covering topics such as paroxysmal nocturnal hemoglobinuria, lysosomal storage diseases, childhood genetic predisposition to cancer, and oncology informatics. - Learn about the latest breakthroughs in diagnosis and management, making this the most complete guide in pediatric hematology and oncology. - Discover the latest in focused molecularly targeted therapies derived from the exponential growth of knowledge about basic biology and genetics underlying the field. - Rely on it anytime, anywhere! Access the full text, images, and more at Expert Consult.
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