This volume brings together a selection of the major articles of David Mills (1938-2013), which along with similar volumes by Alexandra F. Johnston, Peter Meredith and Meg Twycross makes up a set of "Shifting Paradigms in Early English Drama Studies". Mills was one of these four key scholars whose work has changed what is known about English medieval drama and theatre. He made major contributions to understanding English medieval theatre in the widest sense but more specifically to the nature and development of medieval plays and their performance at Chester. The scope of his work from manuscript to performance has created new knowledge and insights brought about by his remarkable technical skill as an editor and researcher. His texts of the Chester Cycle of Mystery Plays have become the standard works. In the light of this outstanding research the volume is comprised of four sections: 1. Editors and Editing; 2. Cultural Contexts; 3. Staging and Performance; 4. Criticism and Evaluation. An editorial introduction opens the work.
Gene therapy was conceived during the early and mid part of the 20th century. At first, it was considered a revolutionary biomedical procedure, which could potentially cure any disease for which the molecular bases were understood. Since then, gene therapy has gone through many stages and has evolved from a nearly unrealistic perspective to a real life application. Clinical efficacy in humans was demonstrated at the beginning of this century after its successful application in small-scale clinical trials to cure severe immunodeficiency in children. However, their successes were overshadowed some time later by the occurrence of vector-related leukaemia in a number of treated children. It is in this context that lentiviral vectors have appeared, with improved efficiency and, possibly, increased biosafety. Very recently, the first clinical trials with lentivectors have been carried out with some success. This Brief firstly defines gene therapy, and places lentivectors within this fascinating therapeutic strategy. Then follows a comprehensive description of the development of retroviral and lentiviral vectors and how to specifically target distinct cell types and tissues. The authors also discuss the application of lentivector gene therapy for the treatment of cancer and autoimmune diseases, ending with the application of lentivectors in human gene therapy clinical trials.
The story within recounts the life experiences of David H. Morris, a former Navy SEAL. In 1996 David was diagnosed with chronic severe Post Traumatic Stress Disorder (PTSD). This disorder was caused by events that took place in 1968 while serving as a member of Mike Platoon, SEAL Team One, in the Republic of Vietnam. The following is his story, told in his words. He hopes the words within will help those who have been diagnosed with this condition, and the thousands of others who walk around
Publishers Weekly’s “Top 10” Spring 2024 This groundbreaking book tracks the massive wealth amassed from slavery from pre-Civil War to today, showing how our modern economy was built on the backs of enslaved Black people—and lays out a clear argument for reparations that shows exactly what was stolen, who stole it, and to whom it is owed. In this timely, powerful, investigative history, The Stolen Wealth of Slavery, Emmy Award-nominated journalist David Montero follows the trail of the massive wealth amassed by Northern corporations throughout America’s history of enslavement. It has long been maintained by many that the North wasn’t complicit in the horrors of slavery. The truth, however, is that large Northern banks—including well-known institutions like Citibank, Bank of New York, and Bank of America—were critical to the financing of slavery; that they saw their fortunes rise dramatically from their involvement in the business of enslavement; and that white business leaders and their surrounding communities created enormous wealth from the enslavement and abuse of Black bodies. The Stolen Wealth of Slavery grapples with facts that will be a revelation to many: Most white Southern enslavers were not rich—many were barely making ends meet—with Northern businesses benefitting the most from bondage-based profits. And some of the very Northerners who would be considered pro-Union during the Civil War were in fact anti-abolition, seeing the institution of slavery as being in their best financial interests, and only supporting the Union once they realized doing so would be good for business. It is a myth that the wealth generated from slavery vanished after the war. Rather, it helped finance the industrialization of the country, and became part of the bedrock of the growth of modern corporations, helping to transform America into a global economic behemoth. In this remarkable book, Montero elegantly and meticulously details rampant Northern investment in slavery. He showcases exactly what was stolen, who stole it, and to whom it is owed, calling for corporate reparations as he details contemporary movements to hold companies accountable for past atrocities.
Molecular and Cellular Aspects of Basement Membranes reviews the knowledge about the molecular and cellular aspects of basement membranes. This book focuses on the composition of basement membranes and their organization in extracellular matrices and presents a structural analysis of the various components of the basement membrane. The importance of basement membranes with respect to cell-matrix interactions, differentiation, and pathology is also considered. This text is organized into three sections and is comprised of 20 chapters. It begins with historical perspectives and an overview of the extracellular matrix in general and the basement membrane in particular. The discussion then turns to the organization of basement membrane components into a three-dimensional and functional matrix, along with the unique characteristics of basement membranes in skin, nerve, and kidney. The reader is also introduced to the specificity of particular basement membranes in particular histological sites; the molecular characteristics of basement membrane collagens, laminins, and proteoglycans; and the interaction of specific peptide domains of basement membrane components with cell surface receptors. Finally, the book explains how subtle changes in basement membrane composition or protein structure can cause dramatic pathology. This book will be of value to cell biologists, molecular biologists, biochemists, and pathologists.
An expert guide to targeting protein kinases in cancer therapy Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells. Because of this fact, pharmaceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal roadblocks to sever their malignant means of communication. Complete with full-color presentations, Targeting Protein Kinases for Cancer Therapy defines the structural features of protein kinases and examines their cellular functions. Combining kinase biology with chemistry and pharmacology applications, this book enlists emerging data to drive the discovery of new cancer-fighting drugs. Valuable information includes: Comprehensive overviews of the major kinase families involved in oncology, integrating protein structure and function, and providing important tools to assist pharmaceutical researchers to understand and work in this dynamic area of cancer drug research Focus on small molecule inhibitors as well as other therapeutic modalities Discussion of kinase inhibitors that have entered clinical trials for the treatment of cancer, with an emphasis on molecules that have progressed to late stage clinical trials and, in a few cases, to market Providing a platform for further study, this important work reviews both the successes and challenges of kinase inhibitor therapy, and provides insight into future directions in the war against cancer.
Textbook of Clinical Neuropsychiatry provides a comprehensive, encyclopedic and up to date coverage of the complete range of neuropsychiatric disorders. The text is clearly written and well organized, utilizing a consistent and easy to read format throughout. Part I describes the diagnostic assessment of patients and details the interview, mental s
An exuberant, hands-on fly-on-the-wall account that combines the thrill of canyoneering and rock climbing with the intellectual sleuthing of archaeology to explore the Anasazi. David Roberts describes the culture of the Anasazi—the name means “enemy ancestors” in Navajo—who once inhabited the Colorado Plateau and whose modern descendants are the Hopi Indians of Arizona. Archaeologists, Roberts writes, have been puzzling over the Anasazi for more than a century, trying to determine the environmental and cultural stresses that caused their society to collapse 700 years ago. He guides us through controversies in the historical record, among them the haunting question of whether the Anasazi committed acts of cannibalism. Roberts’s book is full of up-to-date thinking on the culture of the ancient people who lived in the harsh desert country of the Southwest.
It is increasingly common for analysts to seek out the opinions of individuals and organizations using attitudinal scales such as degree of satisfaction or importance attached to an issue. Examples include levels of obesity, seriousness of a health condition, attitudes towards service levels, opinions on products, voting intentions, and the degree of clarity of contracts. Ordered choice models provide a relevant methodology for capturing the sources of influence that explain the choice made amongst a set of ordered alternatives. The methods have evolved to a level of sophistication that can allow for heterogeneity in the threshold parameters, in the explanatory variables (through random parameters), and in the decomposition of the residual variance. This book brings together contributions in ordered choice modeling from a number of disciplines, synthesizing developments over the last fifty years, and suggests useful extensions to account for the wide range of sources of influence on choice.
How can psychologists explain strange experiences such as hallucinations or unusual beliefs in ghosts and angels? This compelling introduction aims to uncover how and why such beliefs occur, exploring explanations based on different psychological models, and evaluating the scientific basis of parapsychology and the challenges that researchers face.
Good supervision is crucial to the training of any therapist. Yet most who are asked to supervise receive little instruction in how best to proceed. What is missing is a theory and technique of supervision that can help them be effective teachers, no matter from what mental health discipline they come. The authors of this book, who have supervised in a variety of educational settings and have taught students from a wide range of mental health disciplines, now provide a theoretical and technical framework for understanding and deepening the supervisory process. They clearly describe phases of supervision (from the opening session to termination), its goals, and the nature and purpose of a number of supervisory interventions. They delineate modes of thinking that are essential to being a good therapist and discuss how best to foster them. They demonstrate how supervision can be intimate, personal, and honest without becoming a form of therapy. Through clinical vignettes, they show how to diagnose impediments to learning and describe strategies for overcoming them. While providing an interesting history of supervision and a portrait of Freud as supervisor, they focus mainly on how newer theories such as self psychology, intersubjectivity, and an interactive two-person psychology influence the practice of supervision.
Illinois State Historical Society Superior Achievement Award, 2013 As the first African American elected to the Illinois General Assembly, John W. E. Thomas was the recognized leader of the state’s African American community for nearly twenty years and laid the groundwork for the success of future Black leaders in Chicago politics. Despite his key role in the passage of Illinois’ first civil rights act and his commitment to improving his community against steep personal and political barriers, Thomas’s life and career have been long forgotten by historians and the public alike. This fascinating full-length biography—the first to address the full influence of Thomas or any Black politician from Illinois during the Reconstruction Era—is also a pioneering effort to explain the dynamics of African American politics and divisions within the Black community in post–Civil War Chicago. In From Slave to State Legislator, David A. Joens traces Thomas’s trajectory from a slave owned by a doctor’s family in Alabama to a prominent attorney believed to be the wealthiest African American man in Chicago at the time of his death in 1899. Providing one of the few comprehensive looks at African Americans in Chicago during this period, Joens reveals how Thomas’s career represents both the opportunities available to African Americans in the postwar period and the limits still placed on them. When Thomas moved to Chicago in 1869, he started a grocery store, invested in real estate, and founded the first private school for African Americans before becoming involved in politics. From Slave to State Legislator provides detailed coverage of Thomas’s three terms in the legislature during the 1870s and 1880s, his multiple failures to be nominated for reelection, and his loyalty to the Republican Party at great political cost, calling attention to the political differences within a Black community often considered small and homogenous. Even after achieving his legislative legacy—the passage of the first state civil rights law—Thomas was plagued by patronage issues and an increasingly bitter split with the African American community frustrated with slow progress toward true equality. Drawing on newspapers and an array of government documents, Joens provides the most thorough review to date of the first civil rights legislation and the two controversial “colored conventions” chaired by Thomas. Joens cements Thomas’s legacy as a committed and conscientious lawmaker amid political and personal struggles. In revealing the complicated rivalries and competing ambitions that shaped Black northern politics during the Reconstruction Era, Joens shows the long-term impact of Thomas’s friendship with other burgeoning African American political stars and his work to get more black representatives elected. The volume is enhanced by short biographies of other key Chicago African American politicians of the era.
Highly Commended, BMA Medical Book Awards 2013Previously published as Textbook of Clinical Neuropsychiatry, this book has been re-titled and thoroughly updated, redesigned, and enhanced to include the fundamentals of neuroscience. This highly acclaimed text provides a definitive, clinically oriented, yet comprehensive book covering neuropsychiatry
This title is the second volume in a four volume series on the cemeteries of Jackson and Sandy Ridge Townships in Union County, North Carolina. It contains information on 144 cemeteries and 27,524 graves.
Structure and Function of Exercising Muscle -- Fuel for Exercise : Bioenergetics and Muscle Metabolism -- Neural Control of Exercising Muscle -- Hormonal Control During Exercise -- Energy Expenditure -- Fatigue, Muscle Soreness, and Muscle Cramps Fatigue and Its Causes -- The Cardiovascular System and Its Control -- The Respiratory System and Its Regulation -- Cardiorespiratory Responses to Acute Exercise -- Principles of Exercise Training -- Adaptations to Resistance Training -- Adaptations to Aerobic and Anaerobic Training -- Prescription of Exercise for Health and Fitness -- Exercise in Hot and Cold Environments -- Altitude, Hyperbaric Environments, and Microgravity -- Training for Sport -- Nutrition, Body Composition, and Obesity -- Ergogenic Aids in Sport -- Children and Adolescents in Sport and Exercise -- Aging in Sport and Exercise -- Sex Differences in Sport and Exercise -- Cardiovascular Disease and Physical Activity.
Cross-Cultural Management: An Introduction offers students a hands-on approach to cross-cultural management that they can apply to a wide variety of organizational contexts. Rather than focusing on specific countries, authors David C. Thomas and Kerr Inkson highlight the interactions of people from different cultures in organizational settings to provide students with practical applications of concepts in international management. Real-world examples and case studies help students understand and integrate differences between attitudes, values, beliefs, and assumptions so that they can thrive as managers.
As teachers around the world deal with the challenges of inclusive education, they must find effective ways of enhancing their classroom teaching methods. What Really Works in Special and Inclusive Education presents teachers with a range of evidence-based strategies they can immediately put into practice in their classrooms. This unique book will be an invaluable resource for educators who may not have the time or the inclination to engage with theory-heavy research, but who wish to ensure that their teaching strategies are up-to-the-minute and proven to be the most effective best practices. Each of the 27 strategies that this book comprises has a substantial research base, a strong theoretical rationale and clear guidelines on their implementation, as well as cautionary advice where necessary. In this new second edition, David Mitchell, a leading writer in special and inclusive education, continues to break new ground with revised and updated strategies based on evidence from the most recent studies in the field. From the myriad of related research available, only those studies with genuine potential for improving the practices of teachers and schools have been included, with the aim of facilitating high-quality learning and social outcomes for all learners in schools. Updates to this new edition include: four new chapters, on response to intervention, universal design for learning, inter-agency cooperation and one on the Finnish education system over 350 new references an even wider international focus, including evidence drawn from Asia references to recent developments in neuroscience a new companion website, with extra case studies, links to further reading, journal articles and videos, and an interactive quiz, at www.routledge.com/cw/mitchell This book will be essential reading for anyone with a vocational or academic interest in evidence-based special educational needs teaching strategies, whether a student in initial teacher education or a qualified classroom teacher, teacher educator, educational psychologist, special needs coordinator, parent, consultant or researcher. David Mitchell is an Adjunct Professor in the College of Education, University of Canterbury, Christchurch, New Zealand, and a consultant in inclusive education. ‘This is the book I wish I had written, synthesizing an enormous literature focused on special needs students. It is robust, it is readable, and it is your right-hand resource. A stunner of a book.’ –Professor John Hattie, University of Melbourne, author of Visible Learning
Children with brain and spinal tumors account for 20-25% of childhood cancers. Until the early 1990s there had been little progress in the development of new treatments, and outcomes were not improving despite advances seen in other childhood cancers. During the past 10 years, however, there has been a dramatic increase in interest in the subject a
The Neurology of Eye Movements provides clinicians with a synthesis of current scientific information that can be applied to the diagnosis and treatment of disorders of ocular motility. Basic scientists will also benefit from descriptions of how data from anatomical, electrophysiological, pharmacological, and imaging studies can be directly applied to the study of disease. By critically reviewing such basic studies, the authors build a conceptual framework that can be applied to the interpretation of abnormal ocular motor behavior at the bedside. These syntheses are summarized in displays, new figures, schematics and tables. Early chapters discuss the visual need and neural basis for each functional class of eye movements. Two large chapters deal with the evaluation of double vision and systematically evaluate how many disorders of the central nervous system affect eye movements. This edition has been extensively rewritten, and contains many new figures and an up-to-date section on the treatment of abnormal eye movements such as nystagmus. A major innovation has been the development of an option to read the book from a compact disc, make use of hypertext links (which bridge basic science to clinical issues), and view the major disorders of eye movements in over 60 video clips. This volume will provide pertinent, up-to-date information to neurologists, neuroscientists, ophthalmologists, visual scientists, otalaryngologists, optometrists, biomedical engineers, and psychologists.
Marsden's Book of Movement Disorders covers the full breadth of movement disorders, from the underlying anatomy and understanding of basal ganglia function to the diagnosis and management of specific movement disorders, including the more common conditions such as Parkinson's Disease through to very rare conditions such as Niemann-Pick disease.
lt is a tremendous achievement to have provided this highly comprehensive but readable text, which informs such a large group of researchers and clinicians." Christopher Kennard, PhD, FRCP, FMedSci, Professor of Clinical Neurology, Head, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom. "A monograph written with deep knowledge, understanding, wisdom, clarity, intelligibility - the superlatives could go on and on... A remarkable achievement and a great gift to all of us from the two modern giants of eye movement disorders." Michael Halmagyi, MD, Eye and Ear Research Unit, Neurology Department, Royal Prince Alfred Hospital, The University of Sydney, Australia. "The fifth edition of The Neurology of Eye Movements is a must for all neurologists and neuroscientists interested in how the human vestibular and oculomotor systems adapt to movement in space and to optimally viewing the world and its contents." Louis R. Caplan, MD, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
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