This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
How the specter of climate has been used to explain history since antiquity Scientists, journalists, and politicians increasingly tell us that human impacts on climate constitute the single greatest threat facing our planet and may even bring about the extinction of our species. Yet behind these anxieties lies an older, much deeper fear about the power that climate exerts over us. The Empire of Climate traces the history of this idea and its pervasive influence over how we interpret world events and make sense of the human condition, from the rise and fall of ancient civilizations to the afflictions of the modern psyche. Taking readers from the time of Hippocrates to the unfolding crisis of global warming today, David Livingstone reveals how climate has been critically implicated in the politics of imperial control and race relations; been used to explain industrial development, market performance, and economic breakdown; and served as a bellwether for national character and cultural collapse. He examines how climate has been put forward as an explanation for warfare and civil conflict, and how it has been identified as a critical factor in bodily disorders and acute psychosis. A panoramic work of scholarship, The Empire of Climate maps the tangled histories of an idea that has haunted our collective imagination for centuries, shedding critical light on the notion that everything from the wealth of nations to the human mind itself is subject to climate’s imperial rule.
An expert guide to targeting protein kinases in cancer therapy Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells. Because of this fact, pharmaceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal roadblocks to sever their malignant means of communication. Complete with full-color presentations, Targeting Protein Kinases for Cancer Therapy defines the structural features of protein kinases and examines their cellular functions. Combining kinase biology with chemistry and pharmacology applications, this book enlists emerging data to drive the discovery of new cancer-fighting drugs. Valuable information includes: Comprehensive overviews of the major kinase families involved in oncology, integrating protein structure and function, and providing important tools to assist pharmaceutical researchers to understand and work in this dynamic area of cancer drug research Focus on small molecule inhibitors as well as other therapeutic modalities Discussion of kinase inhibitors that have entered clinical trials for the treatment of cancer, with an emphasis on molecules that have progressed to late stage clinical trials and, in a few cases, to market Providing a platform for further study, this important work reviews both the successes and challenges of kinase inhibitor therapy, and provides insight into future directions in the war against cancer.
The past ten years have been marked by a series of high profile and heavily mediatised riots across the globe. From the overspill of racial tensions in Sydney to anti-police riots in London, democratic societies have witnessed powerful and costly outbursts of anger and violence. But what are the causes of these large-scale episodes of collective disorder? Do they share common features? And what can they tell us about the nature and significance of riots more broadly? In this book, the authors address these questions and more with a wide-ranging comparative study of rioting in five countries (Australia, England, France, Greece and the United States). Using a revised and expanded version of the Flashpoints Model of Public Disorder, Matthew Moran and David Waddington dissect these violent and ephemeral social phenomena, laying bare their internal logic and demonstrating the essentially political nature of riots.
The 20th century, especially the latter decades, was a time of explosive growth and importance in hymnody, and yet published material about the hymnody of this period has been scattered and difficult to come by. The present volume catalogues and categorizes the available writings to guide students and scholars in their research. Furthermore, this reference does not depend primarily on the view of the author/compiler, but guides users toward a broad spectrum of viewpoints about 20th-century hymnody. Listing the principal writings on the repertory, language, practice, and people of hymnody during the last century, this annotated bibliography offers students and researchers alike a handy reference for a vast and varied field. Beginning with a unique introduction to and summary of hymnody in the 20th century, Music arranges the entries by topic, dividing each chapter by helpful subject headings. The repertory of the twentieth century, and language issues are discussed. Practical elements of hymnody are covered, while the final chapter lists writings about individual hymn writers and other influential persons in the field. Music provides a brief annotation for each entry and uses numerous cross-references, guiding the reader to relevant material in other sections of the book. A comprehensive index concludes this essential reference.
Time-lapse (4D) seismic technology is a key enabler for improved hydrocarbon recovery and more cost-effective field operations. This book shows how 4D data are used for reservoir surveillance, add value to reservoir management, and provide valuable insight on dynamic reservoir properties such as fluid saturation, pressure, and temperature.
Diaspora Jews are increasingly likely to criticise Israel and support Palestinian rights. In the USA, Europe and elsewhere, Jewish organisations have sprung up to oppose Israel’s treatment of Palestinians, facing harsh criticism from fellow Jews for their actions. Why and how has this movement come about? What does it mean for Palestinians and for diaspora Jews? Jewish Identity and Palestinian Rights is a groundbreaking study of this vital and growing worldwide social movement, examining in depth how it challenges traditional diasporic Jewish representations of itself. It looks at why people join this movement and how they relate to the Palestinians and their struggle, asking searching questions about transnational solidarity movements. This book makes an important contribution to Israel/Palestine and Jewish studies and responds to urgent questions in social movement theory.
David Jones – author of In Parenthesis, the great poem of World War I – is increasingly recognized as a major voice in the first generation of British modernist writers. Acclaimed by the likes of T.S. Eliot, W.B. Yeats, and W.H. Auden, his writing was deeply informed by his Catholic faith and Welsh blood. This book makes available for the first time a number of previously unpublished statements by Jones that open new perspectives on his own work and the religious, political, and cultural engagements of British modernism more broadly. Annotated throughout, with detailed commentaries exploring the historical context of each document, the volume presents the restored text of Jones's essay on Hitler and includes a letter to Neville Chamberlain, an unfinished essay on Gerard Manley Hopkins, and the transcript of an interview with Jones a year before his death. These reveal an unknown side of Jones and give fresh insight into the influences and assumptions of 20th-century British literary culture.
In the face of impending global crises and stubborn conflicts, a conventional view of politics risks leaving us confused and fatalistic, feeling powerless because we are unaware of all that can be achieved by political means. David West highlights the many ways in which national and global institutions depend on a broader context of extra-institutional action or what is, in effect, the formative dimension of politics.
The New Gettysburg Campaign Handbook is an informative full-color guide for American Civil War and Gettysburg enthusiasts of all ages. Authors J. David Petruzzi and Steven Stanley use clear and concise writing broken down into short and easy to understand chapters complete with original maps, modern and historic photographs, tables, charts, and artwork to narrate the history of the Gettysburg Campaign from the opening battle at Brandy Station in Virginia on June 9, 1863, to the escape of Gen. Robert E. Lee’s Confederate Army of Northern Virginia across the Potomac River on July 14, 1863. Chapters include quotes of interest from participants, tables and charts of the ages and seniority ranking of the generals of both sides; weather observations during the battle; a stunning photographic study of the entire campaign; a discussion of the battle’s myths and controversies; biographies of select officers, civilians, and battlefield photographers; trivia about the campaign; a comprehensive order of battle; a suggested reading list and websites; and much more. As enjoyable to look at as it is easy to use, every casual and serious student of the Civil War and Gettysburg will want a copy of The New Gettysburg Campaign Handbook as a constant companion while reading other books on the campaign—and even as a supplement and general field guide while walking the hallowed Pennsylvania ground. About the Authors: J. David Petruzzi is an award-winning Civil War cavalry historian. He is the author of many articles for a wide variety of publications, and has written or co-authored several books including: (with Eric Wittenberg) Plenty of Blame to Go Around: Jeb Stuart’s Controversial Ride to Gettysburg (Savas Beatie, 2006); (with Wittenberg and Michael F. Nugent) One Continuous Fight: The Retreat from Gettysburg and the Pursuit of Lee’s Army of Northern Virginia, July 4-14, 1863 (Savas Beatie, 2008); and (with Steven Stanley) The Complete Gettysburg Guide: Walking and Driving Tours of the Battlefield, Town, Cemeteries, Field Hospital Sites, and other Topics of Historical Interest (Savas Beatie, 2009), winner of the U.S. Army Historical Foundation’s 2009 Distinguished Writing Award, Reference Category. With Stanley, he also produced The Complete Gettysburg Guide: Audio Driving and Walking Tour, Volume One: The Battlefield (Savas Beatie, 2010). Steven Stanley lives in Gettysburg and is a graphic artist specializing in historical map design and battlefield photography. His maps, considered among the best in historical cartography, have been a longtime staple of the Civil War Trust and have helped raise millions of dollars for the Trust through their preservation appeals and interpretation projects. Steve’s maps have appeared in a wide variety of publications. Co-authored by J. David Petruzzi, Steve produced the maps and the complete design of The Complete Gettysburg Guide: Walking and Driving Tours of the Battlefield, Town, Cemeteries, Field Hospital Sites, and other Topics of Historical Interest (Savas Beatie, 2009), the winner of the U.S. Army Historical Foundation’s 2009 Distinguished Writing Award, Reference Category, as well as The Complete Gettysburg Guide: Audio Driving and Walking Tour, Volume One: The Battlefield (Savas Beatie, 2010).
Scholars across the humanities, social sciences, and information sciences are grappling with how best to study virtual environments, use computational tools in their research, and engage audiences with their results. Classic work in science and technology studies (STS) has played a central role in how these fields analyze digital technologies, but many of its key examples do not speak to today’s computational realities. This groundbreaking collection brings together a world-class group of contributors to refresh the canon for contemporary digital scholarship. In twenty-five pioneering and incisive essays, this unique digital field guide offers innovative new approaches to digital scholarship, the design of digital tools and objects, and the deployment of critically grounded technologies for analysis and discovery. Contributors cover a broad range of topics, including software development, hackathons, digitized objects, diversity in the tech sector, and distributed scientific collaborations. They discuss methodological considerations of social networks and data analysis, design projects that can translate STS concepts into durable scientific work, and much more. Featuring a concise introduction by Janet Vertesi and David Ribes and accompanied by an interactive microsite, this book provides new perspectives on digital scholarship that will shape the agenda for tomorrow’s generation of STS researchers and practitioners.
A detailed history of the Confederate retreat after the Battle of Gettysburg and the Union effort to destroy the enemy during the American Civil War. The three-day Battle of Gettysburg left 50,000 casualties in its wake, a battered Southern army far from its base of supplies, and a rich historiographic legacy. Thousands of books and articles cover nearly every aspect of the battle, but One Continuous Fight is the first detailed military history of Lee’s retreat and the Union effort to destroy the wounded Army of Northern Virginia. Against steep odds and encumbered with thousands of casualties, Confederate commander Robert E. Lee’s post-battle task was to successfully withdraw his army across the Potomac River. Union commander George G. Meade’s equally difficult assignment was to intercept the effort and destroy his enemy. The responsibility for defending the exposed Southern columns belonged to cavalry chieftain James Ewell Brown (Jeb) Stuart. If Stuart fumbled his famous ride north to Gettysburg, his generalship during the retreat more than redeemed his flagging reputation. The long retreat triggered nearly two dozen skirmishes and major engagements, including fighting at Granite Hill, Monterey Pass, Hagerstown, Williamsport, Funkstown, Boonsboro, and Falling Waters. President Abraham Lincoln was thankful for the early July battlefield victory, but disappointed that General Meade was unable to surround and crush the Confederates before they found safety on the far side of the Potomac. Exactly what Meade did to try to intercept the fleeing Confederates, and how the Southerners managed to defend their army and ponderous 17-mile long wagon train of wounded until crossing into western Virginia on the early morning of July 14, is the subject of this study. One Continuous Fight draws upon a massive array of documents, letters, diaries, newspaper accounts, and published primary and secondary sources. These long ignored foundational sources allow the authors, each widely known for their expertise in Civil War cavalry operations, to carefully describe each engagement. The result is a rich and comprehensive study loaded with incisive tactical commentary, new perspectives on the strategic role of the Southern and Northern cavalry, and fresh insights on every engagement, large and small, fought during the retreat. The retreat from Gettysburg was so punctuated with fighting that a soldier felt compelled to describe it as “One Continuous Fight.” Until now, few students fully realized the accuracy of that description. Complete with 18 original maps, dozens of photos, and a complete driving tour with GPS coordinates of the army’s retreat and the route of the wagon train of wounded, One Continuous Fight is an essential book for every student of the American Civil War in general, and for the student of Gettysburg in particular.
This new book, from the editor of the highly successful Pharmaceutical Analysis, sets out to define the area of pharmaceutical chemistry as distinct from medicinal chemistry. It focuses less on prototypes of drugs that perhaps never came to market and more on the drugs currently in use. The emphasis in the book is on the physicochemical properties of drug molecules and, in so far as they are known, the way that these properties govern the interaction of the drug with its target. Important physicochemical properties include pKa and partition coefficient and the properties of the structural elements within the drug which provide interactions with the target via a range of intermolecular forces. The last fifteen years has seen a great advance in the knowledge of protein structures and a strong emphasis is given to the interaction of drugs with proteins which shape the majority of drug mechanisms. Features: Focus on intramolecular actions Mechanisms of action richly illustrated Self-assessment included Comprehensive chapters on vitamins and biotechnological products This new book, from the editor of the highly successful Pharmaceutical Analysis, sets out to define the area of pharmaceutical chemistry as distinct from medicinal chemistry. It focuses less on prototypes of drugs that perhaps never came to market and more on the drugs currently in use. The emphasis in the book is on the physicochemical properties of drug molecules and, in so far as they are known, the way that these properties govern the interaction of the drug with its target. Important physicochemical properties include pKa and partition coefficient and the properties of the structural elements within the drug which provide interactions with the target via a range of intermolecular forces. The last fifteen years has seen a great advance in the knowledge of protein structures and a strong emphasis is given to the interaction of drugs with proteins which shape the majority of drug mechanisms. Features: Focus on intramolecular actions Mechanisms of action richly illustrated Self-assessment included Comprehensive chapters on vitamins and biotechnological products
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.