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Derived from the acclaimed online “WormAtlas,†C. elegansAtlas is a large-format, full-color atlas of the hermaphroditic form of the model organism C. elegans, known affectionately as “the worm†by workers in the field. Prepared by the editors of the WormAtlas Consortium, David H. Hall and Zeynep F. Altun, this book combines explanatory text with copious, labeled, color illustrations and electron micrographs of the major body systems of C. elegans. Also included are electron microscopy cross sections of the worm. This laboratory reference is essential for the working worm biologist, at the bench and at the microscope, and provides a superb companion to the C. elegansII monograph. It is also a valuable tool for investigators in the fields of developmental biology, neurobiology, reproductive biology, gene expression, and molecular biology.
Frank Drew Hall (1864-1937) was the son of a Civil War veteran and preacher who grew up in small town Ohio. He learned the printing trade, took up the work of a missionary in the Dakota Territory, and later became Superintendent of the North Dakota Children's Home Society in Fargo - a role that earned him the title "Daddy Hall." In this newly published autobiography, Hall shares from the time of his birth to just before the United States entered World War I, at which time in 1916, he sat down to write his story. Additionally, Frank Hall was a family historian, and his research of genealogical charts and family records are included in the appendices. This wonderfully written biography, compiled with family photos, historical documents, and commentary by his great-great grandson, gives first-hand accounts of a time and place in American history few have the pleasure of reading about.
Instant Notes in Plant Biology covers all aspects of modern plant biology. The scope and depth of this text are suitable for a first and second year undergraduate student of plant biology, including molecular biologists and biotechnologists.
A Heart Promptly Offered"" presents the basic story of Calvin's life, along with numerous excerpts from his own pen'writings from his letters, commentaries, and sermons. In addition to summarizing the main topics of Calvin's ""Institutes,"" it lays out his ground-breaking political theory, which is an unparelleled contribution to human freedom.
DNA in the nucleus of plant and animal cells is stored in the form of chromatin. Chromatin and the chromatin remodelling enzymes play an important role in gene transcription. Genetic assays of chromatin modification and remodeling Histone modifying enzymes ATP-dependent chromatin remodeling enzymes
The Handbook of Mushroom Poisoning provides an in-depth examination of mushroom poisoning, including case examples for each toxic class. The book contains specific chapters on mushroom poison pharmacology and approaches to treatment of cases caused by an unknown mushroom or unknown poison. For those who want a broader background, there are sections on gross and microscopic mushroom identification, general information about the types of toxic substances found in various mushroom families, and tables detailing the results of various field and laboratory tests. For those interested in learning more about mushroom poisonings and how to treat them, this book is a must.
Richard Baxter, one of the 17th century's most famous Puritans, is known as an author of devotional literature. But he was also skilled in medieval philosophy. In this work, David Sytsma draws on largely unexamined works to present a chronogolical and thematic account of Baxter's relation to the people and concepts involved in the rise of mechanical philosophy in late-17th-century England
The quantification of contractual money awards is a topic of both significant theoretical interest and immense practical importance. Recent debates have ranged from the availability of gain-based relief to the basis for principles of remoteness and mitigation. While these and other important issues, such as the recovery of damages for non-pecuniary loss, are touched upon, the book's principal objective is to challenge the conventional interpretation of the principle generally acknowledged to govern this area of the law, which Parke B famously laid down in Robinson v Harman. According to this conventional interpretation, the objective of all money awards given in accordance with the Robinson v Harman principle is simply to 'compensate' the promisee for the 'loss' that can be attributed to the promisor's failure to perform as promised. After challenging this orthodoxy, Dr Winterton proposes a new understanding of the Robinson v Harman principle, which draws an important distinction between money awards that substitute for the performance promised and money awards that aim to make good certain detrimental factual consequences that can be attributed to a promisor's breach. In exploring the significance of this distinction, the different principles underpinning the quantification and restriction of each kind of award are explored in addition to some important theoretical issues such as the effect that the occurrence of a breach has on the rights generated by contract formation. The book's unifying objective is to outline a coherent picture of the law of contractual money awards. It will be of interest to judges, practitioners and academics alike. Nominated for the 2018 St Petersburg International Legal Forum Private Law Prize!
This book covers a wide range of novel biochemical targets that appear to be the best leads in terms of designing novel targets for anticancer drug design. New Molecular Targets for Cancer Chemotherapy is a unique, multi-disciplinary effort, with internationally respected authors from the fields of growth factor-receptor interaction, phosphoinositide and phospholipase signal transduction, and DNA-drug binding interactions. The science is placed in clinical context and illustrations explain how clinicians can incorporate a mechanistic, pharmacodynamic approach into early clinical trial design.
Electricity is all around us: cars, telephones, computers, lights -- the modern world runs entirely on electrons. But what are electrons? How do they behave? How do we control them? This book will show you how to build a battery, detect static electricity and construct a basic current meter, all using common items from your kitchen. Along the way you'll learn about the meaning of "voltage" and "current", what makes an LED work and the difference between AC and DC. The last chapter uses transistors -- the basic building blocks of every computer -- for lots of interesting experiments. With plenty of colorful illustrations, historical stories and an easy, accessible style, "A Kitchen Course in Electricity and Magnetism" will be a great start for budding and amateur scientists who want to learn more about how the world works.
Magnetic resonance (MR) imaging and spectroscopy are powerful tools for demonstrating and monitoring pathological processes of the brain and spinal cord. Multiple sclerosis (MS), a common and as yet incurable disease of the brain and spinal cord, is being studied intensively using these techniques. They perform a major role in facilitating the diagnosis, understanding the mechanisms of symptoms, and monitoring the effect of new treatments. Written by experts in the field, this extensively illustrated text provides a comprehensive review of the benefits and limitations of MR in the study of MS. Coverage ranges through the contributions of MR, the variety of techniques available, diagnosis and differential diagnosis, MR as a predictor of the clinical course, MR views of pathophysiology, and finally monitoring new treatment efficacy.
In this provocative study, David W. Hall argues that the American founders were more greatly influenced by Calvinism than contemporary scholars, and perhaps even the founders themselves, have understood. Calvinism's insistence on human rulers' tendency to err played a significant role in the founders' prescription of limited government and fed the distinctly American philosophy in which political freedom for citizens is held as the highest value. Hall's timely work countervails many scholars' doubt in the intellectual efficacy of religion by showing that religious teachings have led to such progressive ideals as American democracy and freedom.
Handbook of Behavioral Medicine presents a comprehensive overview of the current use of behavioral science techniques in the prevention, diagnosis, and treatment of various health related disorders. Features contributions from a variety of internationally recognized experts in behavioral medicine and related fields Includes authors from education, social work, and physical therapy Addresses foundational issues in behavioral medicine in Volume 1, including concepts, theories, treatments, doctor/patient relationships, common medical problems, behavioral technologies, assessment, and methodologies Focuses on medical interface in Volume 2, including issues relating to health disorders and specialties; social work, medical sociology, and psychosocial aspects; and topics relating to education and health 2 Volumes
David A. Houndshell's widely acclaimed history explores the American "genius for mass production" and races its origins in the nineteenth-century "American system" of manufacture. Previous writers on the American system have argued that the technical problems of mass production had been solved by armsmakers before the Civil War. Drawing upon the extensive business and manufacturing records if leading American firms, Hounshell demonstrates that the diffusion of arms production technology was neither as fast now as smooth as had been assumed. Exploring the manufacture of sewing machines and furniture, bicycles and reapers, he shows that both the expression "mass production" and the technology that lay behind it were developments of the twentieth century, attributable in large part to the Ford Motor Company. Hounshell examines the importance of individuals in the diffusion and development of production technology and the central place of marketing strategy in the success of selected American manufacturers. Whereaas Ford was the seedbed of the assembly line revolution, it was General motors that initiated a new era with its introduction of the annual model change. With the new marketing strategy, the technology of "the changeover" became of paramount importance. Hounshell chronicles how painfully Ford learned this lesson and recounts how the successful mass production of automobiles led to the establishment of an "ethos of mass production," to an era in which propoments of "Fordism" argued that mass production would solve all of America's social problems.
This book on organization theory adopts a distinctive stance. In contrast to the traditional rational approach, it develops a transformational perspective which focuses on the organizational world as a projection of each organizational member's consciousness. While covering all the basic topics of organization theory, the author's approach reflects today's changing management paradigms.
Molecular biology has always been a discipline of rapid development. Despite this, we are presently experiencing a period of unprecedented proliferation of information in nucleic acid studies and molecular biology. These areas are intimately interwoven, so that each influences the other to their mutual benefit. The rapid growth in information leads to ever-increasing specialization, so that it becomes increasingly difficult for a scientist to keep abreast of developments in all the various aspects of the field, although an up-to-date knowledge of the field as a whole is highly desirable. With this background in mind we present the series Nucleic Acids and Molecular Biology. It comprises focused review articles by active researchers who report on the newest developments in their areas of particular interest.
The phenomenon of colonization by big land companies, common throughout the history of the United States, came late to the Panhandle-Plains of West Texas. Ranchers held sway there up into the 20th century. Then, realizing that the future followed the plow, they, joined by business owners and speculators, founded towns on their land, competed for railroad connections, provided irrigation wells and other improvements, and engaged in a variety of advertising activities to interest prospective settlers and to sell the land to farmers at a profit. Trainloads of such "prospectors" were brought in to tour the land; and salesmen of all kinds roamed all the more settled states painting enticing pictures of the fertile lands which their employers offered for sale. Major George W. Littlefield created the Littlefield Lands Company and founded the town of Littlefield, Texas, in 1912, in order to sell as farmland a part of his Yellow House Ranch. His sales manager, Arthur P. Duggan (his nephew by marriage, and grandfather of the author of this study), used many of the techniques then current to attract buyers for the Lamb County land in and around Littlefield. He dug wells and operated a demonstration farm; he planted trees, planned a park, and otherwise beautified the town; he helped to create and maintain a school, a bank, and a number of businesses; and he negotiated contracts and coordinated the activities of innumerable independent land agents. Because the role of the big land company in the settlement of the United States has not, on the whole, received the attention which it deserves, this detailed examination of the operations of one such company is of particular significance. Most of the book is devoted to the creation of the company, the steps taken to make the area attractive to potential settlers, and the problems which beset the building of the community. One chapter discusses the techniques and the difficulties of selling land through independent agents. The final chapter considers the people who moved onto the Littlefield tracts—where they came from, why they came, what their reactions were to the plains country, and how they learned to cope with their new environment. An appendix gives pertinent information about all land transactions conducted by the company between 1912 and 1920, and about each buyer. For this study the author made use of previously unknown records discovered while he was gathering information for a biography of Major Littlefield.
In response to Kitchener's famous call for a million volunteers, local communities raised entire battalions for the service on the Western Front. Hull folk are reticent people and the Hull Pals were no exception. This book tells their inspiring story of sacrifice and gallantry under appaling conditions. Hull Pals contains a great number of hitherto unpublished eye-witnessed accounts and photographs.??As featured on BBC Radio Humberside and in The Yorkshire Post.
David Healy follows his widely praised study, The Antidepressant Era, with an even more ambitious and dramatic story: the discovery and development of antipsychotic medication. Healy argues that the discovery of chlorpromazine (more generally known as Thorazine) is as significant in the history of medicine as the discovery of penicillin, reminding readers of the worldwide prevalence of insanity within living memory. But Healy tells not of the triumph of science but of a stream of fruitful accidents, of technological discovery leading neuroscientific research, of fierce professional competition and the backlash of the antipsychiatry movement of the 1960s. A chemical treatment was developed for one purpose, and as long as some theoretical rationale could be found, doctors administered it to the insane patients in their care to see if it would help. Sometimes it did, dramatically. Why these treatments worked, Healy argues provocatively, was, and often still is, a mystery. Nonetheless, such discoveries made and unmade academic reputations and inspired intense politicking for the Nobel Prize. Once pharmaceutical companies recognized the commercial potential of antipsychotic medications, financial as well as clinical pressures drove the development of ever more aggressively marketed medications. With verve and immense learning, Healy tells a story with surprising implications in a book that will become the leading scholarly work on its compelling subject.
Paperback edition of a text which discusses the history of competency-based education and training in Australia and internationally. Analyses the major issues relating to competency and provides step-by-step applications of competency-based education and training. Includes an index and bibliography. Barry Hobart is a professor and Roger Harris an associate professor in adult education and human resource development at the University of South Australia. Hugh Guthrie is a senior research fellow and David Lundberg is the research manager at the National Centre for Vocational Education Research.
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