At least since Descartes, philosophers have been interested in the special knowledge or authority that we exhibit when we speak about our own thoughts, attitudes, and feelings. Expression and the Inner contends that even the best work in contemporary philosophy of mind fails to account for this sort of knowledge or authority because it does not pay the right sort of attention to the notion of expression. Following what he takes to be a widely misunderstood suggestion of Wittgenstein's, Finkelstein argues that we can make sense of self-knowledge and first-person authority only by coming to see the ways in which a self-ascription of, say, happiness (a person's saying or thinking, "I'm happy this morning") may be akin to a smile--akin, that is, to an expression of happiness. In so doing, Finkelstein contrasts his own reading of Wittgenstein's philosophy of mind with influential readings set out by John McDowell and Crispin Wright. By the final chapter of this lucid work, what's at stake is not only how to understand self-knowledge and first-person authority, but also what it is that distinguishes conscious from unconscious psychological states, what the mental life of a nonlinguistic animal has in common with our sort of mental life, and how to think about Wittgenstein's legacy to the philosophy of mind.
Ion channels are crucial components of living cells. Situated in the cell's membranes. they allow particular ions to pass from one side of the membrane to the other. In recent years the patch clamp technique has allowed the activity of individual channels to be measured, and recombinant DNA technology has led to fascinating detail on their structure. Together, these technical advances have produced a great flowering of knowledge and understanding about the subject, itself leading to further breakthroughs in science and medicine. Ion Channels provides an introduction to this scientific endeavour. It emphasises the molecular structure of channels as determined by gene cloning technology. This knowledge illuminates discussions of the permeability and selectivity of channels, their gating and modulation, their responses to drugs and toxins and the human diseases caused when they do not function properly.
Introduction to Bioorganic Chemistry and Chemical Biology is the first textbook to blend modern tools of organic chemistry with concepts of biology, physiology, and medicine. With a focus on human cell biology and a problems-driven approach, the text explains the combinatorial architecture of biooligomers (genes, DNA, RNA, proteins, glycans, lipids, and terpenes) as the molecular engine for life. Accentuated by rich illustrations and mechanistic arrow pushing, organic chemistry is used to illuminate the central dogma of molecular biology. Introduction to Bioorganic Chemistry and Chemical Biology is appropriate for advanced undergraduate and graduate students in chemistry and molecular biology, as well as those going into medicine and pharmaceutical science.
The Great Depression was a worldwide business slump that began with the crash of the New York Stock Exchange. The author recounts the fascinating events leading to the crash and the tragic personal tales of the Great Depression.
A stimulating introduction to the many debates surrounding the Dadaist and Surrealist movements, such as the Marquis de Sade's position as a Surrealist deity, attitudes towards the city, the impact of Freud, and attitudes towards women.
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