This volume offers a comprehensive history of the Mount Desert Island Biological Laboratory (MDIBL), one of the major marine laboratories in the United States and a leader in using marine organisms to study fundamental physiological concepts. Beginning with its founding as the Harpswell Laboratory of Tufts University in 1898, David H. Evans follows its evolution from a teaching facility to a research center for distinguished renal and epithelial physiologists. He also describes how it became the site of major advances in cytokinesis, regeneration, cardiac and vascular physiology, hepatic physiology, endocrinology and toxicology, as well as studies of the comparative physiology of marine organisms. Fundamental physiological concepts in the context of the discoveries made at the MDIBL are explained and the social and administrative history of this renowned facility is described.
Pharmacology of Pain provides a complete review of the pharmacology of pain, including mechanisms of drug actions, clinical aspects of drug usage, and new developments. This authoritative book describes the different systems involved in the perception, transmission, and modulation of pain and discusses the available options for pharmacological treatment of pain. Who should buy this book? Pharmacology of Pain is a particularly useful resource for: Basic researchers and clinicians, including physicians, dentists, pharmacists, nurses, and physical therapists Other professionals in the field of pain research and treatment Students and trainees
Covering the history of the U.S. Coast Guard from 1790--when it was called the U.S. Revenue Marine--through World War I, this book describes the service's national defense missions, including actions during the War of 1812, clashes with pirates, slave ships and Seminole Indians, the Civil War and the Spanish-American War. During World War I the USCG supported U.S. Navy operations across the Atlantic, escorted merchant convoys and engaged in anti-submarine warfare. Original maps are included.
Biochemistry: The Chemical Reactions of Living Cells is a well-integrated, up-to-date reference for basic chemistry and underlying biological phenomena. Biochemistry is a comprehensive account of the chemical basis of life, describing the amazingly complex structures of the compounds that make up cells, the forces that hold them together, and the chemical reactions that allow for recognition, signaling, and movement. This book contains information on the human body, its genome, and the action of muscles, eyes, and the brain. * Thousands of literature references provide introduction to current research as well as historical background * Contains twice the number of chapters of the first edition * Each chapter contains boxes of information on topics of general interest
Researchers and practitioners alike are increasingly turning to search, op timization, and machine-learning procedures based on natural selection and natural genetics to solve problems across the spectrum of human endeavor. These genetic algorithms and techniques of evolutionary computation are solv ing problems and inventing new hardware and software that rival human designs. The Kluwer Series on Genetic Algorithms and Evolutionary Computation pub lishes research monographs, edited collections, and graduate-level texts in this rapidly growing field. Primary areas of coverage include the theory, implemen tation, and application of genetic algorithms (GAs), evolution strategies (ESs), evolutionary programming (EP), learning classifier systems (LCSs) and other variants of genetic and evolutionary computation (GEC). The series also pub lishes texts in related fields such as artificial life, adaptive behavior, artificial immune systems, agent-based systems, neural computing, fuzzy systems, and quantum computing as long as GEC techniques are part of or inspiration for the system being described. This encyclopedic volume on the use of the algorithms of genetic and evolu tionary computation for the solution of multi-objective problems is a landmark addition to the literature that comes just in the nick of time. Multi-objective evolutionary algorithms (MOEAs) are receiving increasing and unprecedented attention. Researchers and practitioners are finding an irresistible match be tween the popUlation available in most genetic and evolutionary algorithms and the need in multi-objective problems to approximate the Pareto trade-off curve or surface.
This monograph is dedicated to the lives and scientific achievements of the physiology pioneers Warren and Margaret Lewis. Their story spans the first half of the 20th century, from their respective educations through early, independent research to joint research from 1910 to 1955. Among the numerous developments they initiated, were the discovery of pinocytosis, the beginnings of video microscopy and the development of the first mammalian tissue cultures. Their research expanded the theoretical knowledge of cell structure and function. On a more practical level, they advanced many laboratory methods, like the first recipes for culture media. The text is beautifully enriched with personal anecdotes about their lives. This is the story of two scientific pioneers in the context of early 20th century biology and physiology. It is an inspiration for senior and aspiring researchers.
In William Faulkner, William James, and the American Pragmatic Tradition, David H. Evans pairs the writings of America's most intellectually challenging modern novelist, William Faulkner, and the ideas of America's most revolutionary modern philosopher, William James. Though Faulkner was dubbed an idealist after World War II, Evans demonstrates that Faulkner's writing is deeply connected to the emergence of pragmatism as an intellectual doctrine and cultural force in the early twentieth century. Tracing pragmatism to its very roots, Evans examines the nineteenth-century confidence man of antebellum literature as the original practitioner of the pragmatic principle that a belief can give rise to its own objects. He casts this figure as the missing link between Faulkner and James, giving him new prominence in the prehistory of pragmatism. Moving on to Jamesian pragmatism, Evans contends that James's central innovation was his ability to define truth in narrative terms -- just as the confidence man did -- as something subjective and personal that continually shapes reality, rather than a set of static, unchanging facts. In subsequent chapters Evans offers detailed interpretations of three of Faulkner's most important novels, Absalom, Absalom!, Go Down, Moses, and The Hamlet, revealing that Faulkner, too, saw truth as fluid. By avoiding conclusion and finality, these three novels embody the pragmatic belief that life and the world are unstable and constantly evolving. Absalom, Absalom! stages a conflict of historical discourses that -- much like the pragmatic concept of truth -- can never be ultimately resolved. Evans shows us how Faulkner explores the conventional and arbitrary status of racial identity in Go Down, Moses, in a way that is strikingly similar to James's criticism of the concept of identity in general. Finally, Evans reads The Hamlet, a work that is often used to support the idea that Faulkner is opposed to modernity, as a depiction of a distinctly pragmatic and modern world. With its creative coupling of James's philosophy and Faulkner's art, Evans's lively, engaging book makes a bold contribution to Faulkner studies and studies of southern literature.
The exponential expansion of knowledge in the field of hepatobiliary diseases makes systematic revisions of current concepts almost mandatory nowadays. This eBook summarizes the progress in understanding the molecular mechanism of cholesterol and bile acid metabolism and the physical-chemistry of biliary lipids, with emphasis on biliary lipid metabolism that is regulated by nuclear receptors in the hepatobiliary system. By guiding the readers through the various aspects of anatomy, physiology, and biochemistry of all "players" involved in bile formation, this eBook is intended to be a compendium of recent progresses in understanding the molecular mechanisms of cholesterol and bile acid metabolism.
This volume is concerned with the clinical aspects of urology in childhood; the anatomy, physiology and pathology are discussed only where they have a direct bearing upon the clinical problem, and for a detailed description of these aspects, and of operative technique, the reader is referred to other volumes of this series. Emphasis is laid upon the disorders peculiar to infants and children, so that diseases such as tuberculosis, the manifestations of which in the child differ little from those in the adult, receive less attention. Childhood is deemed to cease with the completion of puberty, though illustrations have sometimes been taken from adolescent cases. The personal views expressed in this work are based upon experience at The Hospital for Sick Children, Great Ormond Street, at St. Peter's and St. Paul's Hospitals, and at the Institute of Urology, University of London. I am deeply indebted to all my colleagues and assistants at these institutions for their help and co-operation both in the trea.tment of cases and in the preparation of this volume. I would particularly wish to thank Mr. T.T. TwrSTINGTON HIGGINS for introducing me to the urology of childhood, Drs. M. BODIAN, R.C.B. PUGH and L.L.R. WHITE for their assistance in matters of pathology, and for preparing specimens for illustration, Dr. "\V. W. PAYNE for his advice on biochemistry, Dr.
A landmark work from one of the preeminent historians of our time: the first published biography of Andrew W. Mellon, the American colossus who bestrode the worlds of industry, government, and philanthropy, leaving his transformative stamp on each. Andrew Mellon, one of America’s greatest financiers, built a legendary personal fortune from banking to oil to aluminum manufacture, tracking America’s course to global economic supremacy. As treasury secretary under Presidents Harding, Coolidge, and finally Hoover, Mellon made the federal government run like a business–prefiguring the public official as CEO. He would be hailed as the architect of the Roaring Twenties, but, staying too long, would be blamed for the Great Depression, eventually to find himself a broken idol. Collecting art was his only nonprofessional gratification and his great gift to the American people, The National Gallery of Art, remains his most tangible legacy.
The book deals with the role of both oxygen- and nitrogen-centred free radicals in inflammatory diseases such as rheumatoid arthritis. The well-known involvement of the superoxide anion radical in the bactericidal action of inflammatory cells suggests that radicals and the inflammatory response are inextricably linked. The widespread involvement of radicals in human disease seems inevitable, because inflammation is such a conspicuous component of human disease. For the first time, the present text integrates contributions from leading research groups who have been investigating the role of radicals within the context of all stages of inflammtion, such as the recruitment of inflammatory cells, their bactericidal action, inflammatory tissue destruction and inflammatory cell death by apoptosis. The chapters are broadly organised so that they trace the clinical course of the acute and chronic inflammtory response, emphasising the therapeutic implications of recent data on the contribution of nitric oxide and related nitrogen-centred species. The book will be of interest to academic and industrial researchers and clinicians with interests in the fields of inflammation or free radical biology.
A comprehensive overview of clinically important infections of the urinary tract Urinary tract infections (UTIs) continue to rank among the most common infectious diseases of humans, despite remarkable progress in the ability to detect and treat them. Recurrent UTIs are a continuing problem and represent a clear threat as antibiotic-resistant organisms and infection-prone populations grow. Urinary Tract Infections: Molecular Pathogenesis and Clinical Management brings the scientific community up to date on the research related to these infections that has occurred in the nearly two decades since the first edition. The editors have assembled a team of leading experts to cover critical topics in these main areas: clinical aspects of urinary tract infections, including anatomy, diagnosis, and management, featuring chapters on the vaginal microbiome as well as asymptomatic bacteriuria, prostatitis, and urosepsis the origins and virulence mechanisms of the bacteria responsible for most UTIs, including uropathogenic Escherichia coli, Proteus mirabilis, and Klebsiella pneumoniae the host immune response to UTIs, the rise of antibiotic-resistant strains, and the future of therapeutics This essential reference serves as both a resource and a stimulus for future research endeavors for anyone with an interest in understanding these important infections, from the classroom to the laboratory and the clinic.
Politics in Europe introduces students to the power of the EU and seven political systems—the UK, France, Germany, Italy, Sweden, Russia, and Poland—while addressing key social and political issues including globalization, terrorism, immigration, gender, and religion. Packed with robust country descriptions from regional specialists, the Eighth Edition encourages critical thinking and meaningful cross-national comparisons.
Biochemistry: The Chemical Reactions of Living Cells is a well-integrated, up-to-date reference for basic biochemistry, associated chemistry, and underlying biological phenomena. Biochemistry is a comprehensive account of the chemical basis of life, describing the amazingly complex structures of the compounds that make up cells, the forces that hold them together, and the chemical reactions that allow for recognition, signaling, and movement. This book contains information on the human body, its genome, and the action of muscles, eyes, and the brain.* Thousands of literature references provide introduction to current research as well as historical background * Contains twice the number of chapters of the first edition * Each chapter contains boxes of information on topics of general interest
Established by Congress in 1901, the National Bureau of Standards (NBS), now the National Institute of Standards and Technology (NIST), has a long and distinguished history as the custodian and disseminator of the United States' standards of physical measurement. Having reached its centennial anniversary, the NBS/NIST reflects on and celebrates its first century with this book describing some of its seminal contributions to science and technology. Within these pages are 102 vignettes that describe some of the Institute's classic publications. Each vignette relates the context in which the publication appeared, its impact on science, technology, and the general public, and brief details about the lives and work of the authors. The groundbreaking works depicted include: A breakthrough paper on laser-cooling of atoms below the Doppler limit, which led to the award of the 1997 Nobel Prize for Physics to William D. Phillips The official report on the development of the radio proximity fuse, one of the most important new weapons of World War II The 1932 paper reporting the discovery of deuterium in experiments that led to Harold Urey's1934 Nobel Prize for Chemistry A review of the development of the SEAC, the first digital computer to employ stored programs and the first to process images in digital form The first paper demonstrating that parity is not conserved in nuclear physics, a result that shattered a fundamental concept of theoretical physics and led to a Nobel Prize for T. D. Lee and C. Y. Yang "Observation of Bose-Einstein Condensation in a Dilute Atomic Vapor," a 1995 paper that has already opened vast new areas of research A landmark contribution to the field of protein crystallography by Wlodawer and coworkers on the use of joint x-ray and neutron diffraction to determine the structure of proteins
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