Molecular and Cellular Aspects of Basement Membranes reviews the knowledge about the molecular and cellular aspects of basement membranes. This book focuses on the composition of basement membranes and their organization in extracellular matrices and presents a structural analysis of the various components of the basement membrane. The importance of basement membranes with respect to cell-matrix interactions, differentiation, and pathology is also considered. This text is organized into three sections and is comprised of 20 chapters. It begins with historical perspectives and an overview of the extracellular matrix in general and the basement membrane in particular. The discussion then turns to the organization of basement membrane components into a three-dimensional and functional matrix, along with the unique characteristics of basement membranes in skin, nerve, and kidney. The reader is also introduced to the specificity of particular basement membranes in particular histological sites; the molecular characteristics of basement membrane collagens, laminins, and proteoglycans; and the interaction of specific peptide domains of basement membrane components with cell surface receptors. Finally, the book explains how subtle changes in basement membrane composition or protein structure can cause dramatic pathology. This book will be of value to cell biologists, molecular biologists, biochemists, and pathologists.
Disorders related to the intervertebral disc (IVD) are common causes of morbidity and of severe life quality deterioration. IVD degeneration, although in many cases asymptomatic, is often the origin of painful neck and back diseases. In Western societies IVD related pain and disability account for enormous health care costs as a result of work absenteeism and thus lost production, disability benefits, medical and insurance expenses. Although only a small percentage of patients with disc disorders finally will undergo surgery, spinal surgery has been one of the fastest growing disciplines in the musculoskeletal field in recent years. Nevertheless, current treatment options are still a matter of controversial discussion. In particular, they hardly can restore normal spine biomechanics and prevent degeneration of adjacent tissues. While degeneration affects all areas of the IVD, the most constant and noticeable changes occur in the gel-like central part, the nucleus pulposus (NP). Recent emphasis has therefore been put in biological ways to regenerate the NP; however, there are a number of obstacles to overcome, considering the exceptional biological and biomechanical environment of this tissue. Different biological approaches such as molecular, gene, and cell based therapies have been investigated and have shown promising results in both in vitro and in vivo studies. Nonetheless, considerable hurdles still exist in their application for IVD regeneration in human patients. The choice of the cells and the choice of the cell carrier suitable for implantation pose major challenges for research and development activities. This lecture recapitulates the basics of IVD structure, function, and degeneration mechanisms. The first part reviews the recent progress in the field of disc and stem cell based regenerative approaches. In the second part, most appropriate biomaterials that have been evaluated as cell or molecule carrier to cope with degenerative disc disease are outlined. The potential and limitations of cell- and biomaterial-based treatment strategies and perspectives for future clinical applications are discussed. Table of Contents: Cell Therapy for Nucleus Pulposus Regeneration / Recent Advances in Biomaterial Based Tissue Engineering for Intervertebral Disc Regeneration
The magnificent, unrivaled history of codes and ciphers -- how they're made, how they're broken, and the many and fascinating roles they've played since the dawn of civilization in war, business, diplomacy, and espionage -- updated with a new chapter on computer cryptography and the Ultra secret. Man has created codes to keep secrets and has broken codes to learn those secrets since the time of the Pharaohs. For 4,000 years, fierce battles have been waged between codemakers and codebreakers, and the story of these battles is civilization's secret history, the hidden account of how wars were won and lost, diplomatic intrigues foiled, business secrets stolen, governments ruined, computers hacked. From the XYZ Affair to the Dreyfus Affair, from the Gallic War to the Persian Gulf, from Druidic runes and the kaballah to outer space, from the Zimmermann telegram to Enigma to the Manhattan Project, codebreaking has shaped the course of human events to an extent beyond any easy reckoning. Once a government monopoly, cryptology today touches everybody. It secures the Internet, keeps e-mail private, maintains the integrity of cash machine transactions, and scrambles TV signals on unpaid-for channels. David Kahn's The Codebreakers takes the measure of what codes and codebreaking have meant in human history in a single comprehensive account, astonishing in its scope and enthralling in its execution. Hailed upon first publication as a book likely to become the definitive work of its kind, The Codebreakers has more than lived up to that prediction: it remains unsurpassed. With a brilliant new chapter that makes use of previously classified documents to bring the book thoroughly up to date, and to explore the myriad ways computer codes and their hackers are changing all of our lives, The Codebreakers is the skeleton key to a thousand thrilling true stories of intrigue, mystery, and adventure. It is a masterpiece of the historian's art.
Medicine and Healing Practices in Ancient Egypt provides a new perspective on healthcare and healing treatments in Egypt from the Predynastic to the Roman periods. Rather than concentrating exclusively on diseases and medical conditions as evidenced in ancient sources, it provides a ‘people-focused’ perspective, asking what it was like to be ill or disabled in this society? Who were the healers? To what extent did disease occurrence and treatment reflect individual social status? As well as geographical, environmental and dietary factors, which undoubtedly affected general health, some groups were prone to specific hazards. These are discussed in detail, including soldiers’ experience of trauma, wounds and exposure to epidemics; and conditions - blindness, sand pneumoconiosis, trauma and limb amputations – resulting from working conditions at building and other sites. Methods of diagnosis and treatment were derived from special concepts about disease and medical ethics. These are explored, as well as the individual contributions and professional interactions of various groups of healers and carers. Medical training and practice occurred in various locations, including temples and battlefields; these are described, as well as the treatments and equipment that were available. Ancient writers generally praised the Egyptian healers’ knowledge, expertise, and professional relationship with their patients. A brief comparison is drawn between this approach and those prevailing elsewhere in Mesopotamia, Greece and Rome. Finally, Egypt’s legacy, transmitted through Greek, Roman and Arabic sources, is confirmed as the source of some principles and practices still found in modern ‘Western’ medicine. Combining information from the latest studies on human remains and the authors’ biomedical research, this book brings the subject up to date, enabling a wide readership to access often scattered information in a fascinating synthesis.
Concise and portable, Braddom's Clinical Handbook of Physical Medicine and Rehabilitation, by Drs. David X. Cifu and Henry L. Lew, gives you dependable, up-to-date content in a handbook format ideally suited for use at the bedside or in outpatient clinics. This quick reference covers the everyday topics you need – assistive devices and orthoses, spasticity, pediatric, adult, and geriatric care, pain management, outcome measures, and much more – all derived from the most trusted name in the field of PM&R. - Reader-friendly format with succinct, templated chapters for ease of use. - Authoritative content derived from the #1 comprehensive reference in the field: Braddom's Physical Medicine and Rehabilitation. - An ideal resource for the entire rehabilitation team as a quick reference or study guide. - Highlights key concepts spanning the full spectrum of rehabilitation medicine to help optimize outcomes for patients with a range of chronic diseases, impairments, and disabilities. - Includes eSlides complied by internationally renowned experts to summarize key teaching points and clinical pearls.
Discusses the basic physical principles underlying Biomedical Photonics, spectroscopy and microscopy This volume discusses biomedical photonics, spectroscopy and microscopy, the basic physical principles underlying the technology and its applications. The topics discussed in this volume are: Biophotonics; Fluorescence and Phosphorescence; Medical Photonics; Microscopy; Nonlinear Optics; Ophthalmic Technology; Optical Tomography; Optofluidics; Photodynamic Therapy; Image Processing; Imaging Systems; Sensors; Single Molecule Detection; Futurology in Photonics. Comprehensive and accessible coverage of the whole of modern photonics Emphasizes processes and applications that specifically exploit photon attributes of light Deals with the rapidly advancing area of modern optics Chapters are written by top scientists in their field Written for the graduate level student in physical sciences; Industrial and academic researchers in photonics, graduate students in the area; College lecturers, educators, policymakers, consultants, Scientific and technical libraries, government laboratories, NIH.
**Selected for Doody's Core Titles® 2024 with "Essential Purchase" designation in Veterinary Medicine** Learn to recognize, diagnose, and manage a wide range of common ocular conditions with Slatter's Fundamentals of Veterinary Ophthalmology, 6th Edition. This thoroughly updated text provides the latest, most practical information on structure and function of the eye, the ophthalmic examination and diagnostic techniques, medical and surgical management of ocular disease, and management of ocular emergencies. Enhanced and logically organized coverage includes dogs, cats, horses, livestock, birds, and exotic pets. In addition, over 1,000 color photos and illustrations accurately depict ocular conditions encountered in practice and demonstrate diagnostic and surgical techniques. Edited by three of the most revered authorities in the field of veterinary ophthalmology, this reference is an essential aid to successful veterinary practice and education. - Clinical Tips boxes such as "The Controversy Remains", "Did You Know?", "Look Again", and "Note" offer helpful practice advice and facts. - UPDATED Additional species added to the exotics chapter include birds, small mammals, and others. - A team of internationally respected veterinary ophthalmologists provide comprehensive, clinical expertise in all areas needed to evaluate, diagnose, manage, and monitor a patient with ophthalmic disease. - Practical, clinically focused coverage provides a one-stop diagnostic guide to ophthalmic disease in small and large animals including dogs, cats, horses, livestock (cows, sheep, goats), birds, and exotic pets. - Chapters on equine, livestock, and exotic pet ophthalmology written by specialists in these fields for the most clinically relevant coverage. - NEW! Chapter on ophthalmic surgical techniques describes instrument and suture choice, patient positioning, surgical preparation, and general techniques. - NEW! Additional drawings depict ophthalmic surgeries. - NEW! In-depth equine and livestock ophthalmology content - NEW! Suggested reading lists included at the end of each chapter.
This volume summarizes the current state of knowledge in the economic literature of management of agricultural biotechnology and biodiversity in agricultural and economic development. It identifies key issues confronting policy makers in managing biodiversity and biotechnology and provides a broad, multi-disciplinary analysis of the linkage between the two. It is especially innovative in its use of plant genetic resource management as the basis for is analysis.
Like no other conflict in our history, the Civil War casts a long shadow onto modern America," writes David Eicher. In his compelling new account of that war, Eicher gives us an authoritative modern single-volume battle history that spans the war from the opening engagement at Fort Sumter to Lee's surrender at Appomattox (and even beyond, to the less well-known but conclusive surrender of Confederate General Edmund Kirby Smith in Galveston, Texas, on June 2, 1865). Although there are other one-volume histories of the Civil War -- most notably James M. McPherson's Pulitzer Prize-winning Battle Cry of Freedom, which puts the war in its political, economic, and social context -- The Longest Night is strictly a military history. It covers hundreds of engagements on land and sea, and along rivers. The Western theater, often neglected in accounts of the Civil War, and the naval actions along the coasts and major rivers are at last given their due. Such major battles as Gettysburg, Antietam, and Chancellorsville are, of course, described in detail, but Eicher also examines lesser-known actions such as Sabine Pass, Texas, and Fort Clinch, Florida. The result is a gripping popular history that will fascinate anyone just learning about the Civil War while at the same time offering more than a few surprises for longtime students of the War Between the States. The Longest Night draws on hundreds of sources and includes numerous excerpts from letters, diaries, and reports by the soldiers who fought the war, giving readers a real sense of life -- and death -- on the battlefield. In addition to the main battle narrative, Eicher analyzes each side's evolving strategy and examines the tactics of Lee, Grant, Johnston, Sherman, and other leading figures of the war. He also discusses such militarily significant topics as prisons, railroads, shipbuilding, clandestine operations, and the expanding role of African Americans in the war. The Longest Night is a riveting, indispensable history of the war that James McPherson in the Foreword to this book calls "the most dramatic, violent, and fateful experience in American history.
This book explains how today's insurance industry developed and highlights the role of the reinsurance industry in spreading risks globally. The book examines the development of insurance markets and of the reinsurance industry in particular, and the history of Swiss Re, one of the leading reinsurance companies in the world.
This book traces cultural landscape as the manifestation of the state and national community under the Nazi regime, and how the Nazi era produced what could be referred to as a totalitarian cultural landscape. For the Nazi regime, cultural landscape was indeed a heritage resource, but it was much more than that: cultural landscape was the nation. The project of Nazi racial purification and cultural renewal demanded the physical reshaping and reconceptualization of the existing environment to create the so-called "new Nazi cultural landscape." One of the most important components of this was a set of monumental sites thought to embody blood and soil beliefs through the harmonious synthesis of architecture and landscape. This special group of "landscape-bound" architectural complexes was interconnected by the new autobahn highway system, itself thought to be a monumental work embedded in nature. Behind this intentionally aestheticized view of the nation as cultural landscape lay the all-pervasive system of deception and violence that characterized the emerging totalitarian state. This is the first historical study to consider the importance of these monumental sites together with the autobahn as evidence of key Nazi cultural and geographic strategies during the pre-war years. This book concludes by examining racial and nationalistic themes underlying cultural landscape concepts today, against this historic background.
Discusses the basic physical principles underlying the technology instrumentation of photonics This volume discusses photonics technology and instrumentation. The topics discussed in this volume are: Communication Networks; Data Buffers; Defense and Security Applications; Detectors; Fiber Optics and Amplifiers; Green Photonics; Instrumentation and Metrology; Interferometers; Light-Harvesting Materials; Logic Devices; Optical Communications; Remote Sensing; Solar Energy; Solid-State Lighting; Wavelength Conversion Comprehensive and accessible coverage of the whole of modern photonics Emphasizes processes and applications that specifically exploit photon attributes of light Deals with the rapidly advancing area of modern optics Chapters are written by top scientists in their field Written for the graduate level student in physical sciences; Industrial and academic researchers in photonics, graduate students in the area; College lecturers, educators, policymakers, consultants, Scientific and technical libraries, government laboratories, NIH.
New possibilities have recently emerged for producing optical beams with complex and intricate structures, and for the non-contact optical manipulation of matter. Structured Light and Its Applications fully describes the electromagnetic theory, optical properties, methods and applications associated with this new technology. Detailed discussions are given of unique beam characteristics, such as optical vortices and other wavefront structures, the associated phase properties and photonic aspects, along with applications ranging from cold atom manipulation to optically driven micromachines. Features include: Comprehensive and authoritative treatments of the latest research in this area of nanophotonics, written by the leading researchers Accounts of numerous microfluidics, nanofabrication, quantum informatics and optical manipulation applications Coverage that fully spans the subject area, from fundamental theory and simulations to experimental methods and results Graduate students and established researchers in academia, national laboratories and industry will find this book an invaluable guide to the latest technologies in this rapidly developing field. Comprehensive and definitive source of the latest research in nanotechnology written by the leading people in the field From theory to applications - all is presented in detail Editor is Chair of the SPIE Nanotechnology Technical Group and is leading the way in generation and manipulation of complex beams
Many tens of thousands of mental health and health care professionals have used this essential book--now significantly revised with 70% new content reflecting important advances in the field--to develop and sharpen their skills in motivational interviewing (MI). Clear explanations of core MI concepts are accompanied by carefully crafted sample dialogues, exercises, and practice opportunities. Readers build proficiency for moving through the four processes of MI--engaging, focusing, evoking, and planning--using open-ended questions, affirmations, reflective listening, and summaries (OARS), plus information exchange. In a large-size format for easy photocopying, the volume includes more than 80 reproducible worksheets. Purchasers get access to a companion website where they can download and print the reproducible materials. New to This Edition *Fully revised and restructured around the new four-process model of MI. *Chapters on exploring values and goals and "finding the horizon." *Additional exercises, now with downloadable worksheets. *Teaches how to tailor OARS skills for each MI process. *Integrates key ideas from positive psychology. Winner (First Place)--American Journal of Nursing Book of the Year Award, Adult Primary Care Category This book is in the Applications of Motivational Interviewing series, edited by Stephen Rollnick, William R. Miller, and Theresa B. Moyers.
This book reviews the geochemical and petrological characteristics of potassic igneous rock complexes, and investigates the various tectonic settings in which these rocks occur. The authors provide an overview and classification of these rocks and elucidate the geochemical differences between barren and mineralized potassic igneous complexes. High-K rocks are genetically associated with a number of epithermal gold and porphyry copper-gold deposits. In recent years, there has also been growing recognition of an association of such rocks with iron-oxide copper-gold (IOCG) deposits, intrusion-related gold deposits (IRGDs) and Carlin-type gold deposits. This fifth updated and expanded edition incorporates new data and references from world-class copper and gold deposits worldwide. It also includes the latest publications on the petrogenesis of high-K magmatism and related mineral deposits. Numerous new representative ore photographs of the mineral deposits described are also included in the new edition. As such, the book offers a valuable guide not only for academic petrologists working on alkaline rocks, but also for exploration geologists prospecting for epithermal gold and/or porphyry copper-gold deposits in modern and ancient terrains.
Headache syndromes rank amongst the most common presenting symptoms in general practice and neurology, affecting up to 15% of the adult population. Part of the Oxford Textbooks in Clinical Neurology series, the Oxford Textbook of Headache Syndromes provides clinicians with a definitive resource for diagnosing and managing patients with primary and secondary forms of headaches, either as isolated complaints or as part of a more complex syndrome. Split into 7 key sections with 59 chapters, this comprehensive work discusses the scientific basis and practical management of headache syndromes in a logical format. Each chapter is written by international experts in neurology who share their research and extensive experience by providing a wealth of practical advice for use in clinical situations. In addition, all content is up-to-date and chapters incorporate discussions on the latest International Classification of Headache Disorders 3rd edition when relevant.
This book highlights the methods and applications for roadside video data analysis, with a particular focus on the use of deep learning to solve roadside video data segmentation and classification problems. It describes system architectures and methodologies that are specifically built upon learning concepts for roadside video data processing, and offers a detailed analysis of the segmentation, feature extraction and classification processes. Lastly, it demonstrates the applications of roadside video data analysis including scene labelling, roadside vegetation classification and vegetation biomass estimation in fire risk assessment.
Includes details of alkaloid and anti-tumour screening of nearly 2000 species, the pharmacological testing of the alkaloids of selected species, and the chemical fractionation of those species which had reproducible tumour-inhibiting properties.
Scholars and policymakers increasingly call for evidence-based, prevention-oriented, and community-driven approaches to improve public health and reduce youth crime, substance use, and related problems. However, few functional models exist. In Communities that Care, four leading experts on prevention describe one such system to illustrate how communities effectively engage in prevention activities. Communities That Care (CTC) is a coalition-based prevention system implemented successfully in dozens of communities across the world that promotes healthy development and reduces crime rates for youth. Drawing on literature from criminology, community psychology, and prevention science this book describes the conditions and actions necessary for effective community-based prevention. The authors illustrate how effective community-based prevention can be undertaken by describing how the CTC prevention system has been developed, implemented, evaluated, and disseminated across the U.S. and internationally. Communities that Care shares invaluable lessons about the implementation and evaluation of community-level interventions and establishes a set of best practices for anyone seeking to engage in and/or evaluate effective prevention efforts.
Offering a unique combination of expert lectures, vast image collections, and an easy-to-use print atlas, Dermatopathology, 3rd Edition, helps you master the complexities of this challenging and fast-changing subspecialty. Dr. Elston and his colleagues make dermatopathology easier to understand, leading you to efficient, accurate diagnoses of the most important common dermatologic findings seen in practice. - Covers the essentials of dermatopathology using an enjoyable, easily understood approach and a consistent chapter template that includes key points and pearls. - Features 27 lectures and 2,000 high-quality slides online – more than 8 hours of targeted teaching that take you through the must-know elements of each topic in a dynamic, engaging manner. - Offers extensive, visually stunning image atlases, including an extensive infectious disease atlas with 2,500 slides, a soft tissue tumor atlas with 300 images, a lymphoma atlas, and more. - Includes abundant high-resolution histopathology examples with labels and pointers highlighting key aspects of each slide, providing additional clarity. - The text has been expanded by over 70 pages, with over 130 new images, and 50 newer entities ranging from cutaneous collagenous vasculopathy to EBV+ mucocutaneous ulcer.
There has been a recent explosion of knowledge in the field of respiratory genetics. This authoritative text brings together current knowledge in respiratory genetics in a single volume. The book includes a comprehensive introductory section to provide guidance and aid understanding of key basic concepts in respiratory genetics, including statistical methods, sample collection, bioinformatics, and functional genomics. This is followed by a series of disease-specific chapters that review epidemiology, natural history, monogenic determinants, complex disease components, disease management, and likely future developments. Respiratory Genetics is an essential reference for pulmonologists, translational researchers, and clinical geneticists, and the text will also be a useful library reference.
This volume will describe both growth-inhibitory and mucin-depleting effects of bromelain and N-acetylcysteine, on their own or in combination, in cancer. It will coherently review the pathophysiological aspects of the mucin glycoproteins in malignancies and provide an updated account of the status of bromelain and N-acetylcysteine in cancer therapy. The volume will develop the idea of using these two drugs as a combination formulation for mucin-depleting effects.
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