Why do we grow up to look, act, and feel as we do? Through most of the twentieth century, scientists and laypeople answered this question by referring to two factors alone: our experiences and our genes. But recent discoveries about how genes work have revealed a new way to understand the developmental origins of our characteristics. These discoveries have emerged from the new science of behavioral epigenetics--and just as the whole world has now heard of DNA, "epigenetics" will be a household word in the near future. Behavioral epigenetics is important because it explains how our experiences get under our skin and influence the activity of our genes. Because of breakthroughs in this field, we now know that the genes we're born with don't determine if we'll end up easily stressed, likely to fall ill with cancer, or possessed of a powerful intellect. Instead, what matters is what our genes do. And because research in behavioral epigenetics has shown that our experiences influence how our genes function, this work has changed how scientists think about nature, nurture, and human development. Diets, environmental toxins, parenting styles, and other environmental factors all influence genetic activity through epigenetic mechanisms; this discovery has the potential to alter how doctors treat diseases, and to change how mental health professionals treat conditions from schizophrenia to post-traumatic stress disorder. These advances could also force a reworking of the theory of evolution that dominated twentieth-century biology, and even change how we think about human nature itself. In spite of the importance of this research, behavioral epigenetics is still relatively unknown to non-biologists. The Developing Genome is an introduction to this exciting new discipline; it will allow readers without a background in biology to learn about this work and its revolutionary implications.
Understanding the molecular mechanism of muscle contraction started with the discovery that striated muscle is composed of interdigitating filaments which slide against each other. Sliding filaments and the working-stroke mechanism provide the framework for individual myosin motors to act in parallel, generating tension and loaded shortening with an efficient use of chemical energy. Our knowledge of this exquisitely structured molecular machine has exploded in the last four decades, thanks to a bewildering array of techniques for studying intact muscle, muscle fibres, myofibrils and single myosin molecules. After reviewing the mechanical and biochemical background, this monograph shows how old and new experimental discoveries can be modelled, interpreted and incorporated into a coherent mathematical theory of contractility at the molecular level. The theory is applied to steady-state and transient phenomena in muscle fibres, wing-beat oscillations in insect flight muscle, motility assays and single-molecule experiments with optical trapping. Such a synthesis addresses major issues, most notably whether a single myosin motor is driven by a working stroke or a ratchet mechanism, how the working stroke is coupled to phosphate release, and whether one cycle of attachment is driven by the hydrolysis of one molecule of ATP. Ways in which the theory can be extended are explored in appendices. A separate theory is required for the cooperative regulation of muscle by calcium via tropomyosin and troponin on actin filaments. The book reviews the evolution of models for actin-based regulation, culminating in a model motivated by cryo-EM studies where tropomyosin protomers are linked to form a continuous flexible chain. It also explores muscle behaviour as a function of calcium level, including emergent phenomena such as spontaneous oscillatory contractions and direct myosin regulation by its regulatory light chains. Contraction models can be extended to all levels of calcium-activation by embedding them in a cooperative theory of thin-filament regulation, and a method for achieving this grand synthesis is proposed. Dr. David Aitchison Smith is a theoretical physicist with thirty years of research experience in modelling muscle contractility, in collaboration with experimental groups in different laboratories.
In the midst of life's many ordinary moments, some experiences feel extraordinary. They can mark inflection points in one's life, after which one is never quite the same. Most brief experiences capable of making a long-lasting impact involve obvious changes in one's outward circumstances, like a birth, a death, a marriage, or an illness. Yet some life-changing moments seem to come wholly from another source, appearing as mental states or altered states of consciousness either from deep within a person's mind or, perhaps, from a source beyond the self. These experiences have been called by different names over time: spiritual, religious, mystical, peak, or self-transcendent, and people around the world and throughout history have experienced them, up to and including the present day. The sacred texts of every major religion describe these moments, philosophers since the ancient Greeks have pondered them, and according to recent Gallup polls (2003), well over 30% of contemporary Americans have experienced them"--
Politics, Labor, and the War on Big Business details the rise, fall, and impact of the anticorporate reform effort in Arizona during the Progressive reform era, roughly 1890–1920. Drawing on previously unexamined archival files and building on research presented in his previous books, author David R. Berman offers a fresh look at Progressive heritage and the history of industrial relations during Arizona’s formative period. In the 1890s, once-heavily courted corporations had become, in the eyes of many, outside “money interests” or “beasts” that exploited the wealth of the sparsely settled area. Arizona’s anticorporate reformers condemned the giant corporations for mistreating workers, farmers, ranchers, and small-business people and for corrupting the political system. During a thirty-year struggle, Arizona reformers called for changes to ward off corporate control of the political system, increase corporate taxation and regulation, and protect and promote the interests of working people. Led by George W.P. Hunt and progressive Democrats, Arizona’s brand of progressivism was heavily influenced by organized labor, third parties, and Socialist activists. As highly powerful railroad and mining corporations retaliated, conflict took place on both political levels and industrial backgrounds, sometimes in violent form. Politics, Labor and the War on Big Business places Arizona’s experience in the larger historical discussion of reform activity of the period, considering issues involving the role of government in the economy and the possibility of reform, topics highly relevant to current debates.
The roots of most plants are colonized by symbiotic fungi to form mycorrhiza, which play a critical role in the capture of nutrients from the soil and therefore in plant nutrition. Mycorrhizal Symbiosis is recognized as the definitive work in this area. Since the last edition was published there have been major advances in the field, particularly in the area of molecular biology, and the new edition has been fully revised and updated to incorporate these exciting new developments. - Over 50% new material - Includes expanded color plate section - Covers all aspects of mycorrhiza - Presents new taxonomy - Discusses the impact of proteomics and genomics on research in this area
* Selected as One of the Best Books of the 21st Century by The New York Times * Winner of the Pulitzer Prize in History * “Extraordinary…a great American biography” (The New Yorker) of the most important African American of the 19th century: Frederick Douglass, the escaped slave who became the greatest orator of his day and one of the leading abolitionists and writers of the era. As a young man Frederick Douglass (1818–1895) escaped from slavery in Baltimore, Maryland. He was fortunate to have been taught to read by his slave owner mistress, and he would go on to become one of the major literary figures of his time. His very existence gave the lie to slave owners: with dignity and great intelligence he bore witness to the brutality of slavery. Initially mentored by William Lloyd Garrison, Douglass spoke widely, using his own story to condemn slavery. By the Civil War, Douglass had become the most famed and widely travelled orator in the nation. In his unique and eloquent voice, written and spoken, Douglass was a fierce critic of the United States as well as a radical patriot. After the war he sometimes argued politically with younger African Americans, but he never forsook either the Republican party or the cause of black civil and political rights. In this “cinematic and deeply engaging” (The New York Times Book Review) biography, David Blight has drawn on new information held in a private collection that few other historian have consulted, as well as recently discovered issues of Douglass’s newspapers. “Absorbing and even moving…a brilliant book that speaks to our own time as well as Douglass’s” (The Wall Street Journal), Blight’s biography tells the fascinating story of Douglass’s two marriages and his complex extended family. “David Blight has written the definitive biography of Frederick Douglass…a powerful portrait of one of the most important American voices of the nineteenth century” (The Boston Globe). In addition to the Pulitzer Prize, Frederick Douglass won the Bancroft, Parkman, Los Angeles Times (biography), Lincoln, Plutarch, and Christopher awards and was named one of the Best Books of 2018 by The New York Times Book Review, The Wall Street Journal, The Boston Globe, The Chicago Tribune, The San Francisco Chronicle, and Time.
David Griffiths sketches the musical history of one of the important musical families of York. John Camidge (1734-1803), Matthew Camidge (1764-1844) and John Camidge (1790-1859) were successive organists of York Minster, prominent players in York concerts and composers. The paper also deals with Thomas Simpson Camidge who was organist at Hexham, Swindon and Swansea, and his son, John Henry Camidge who was organist at Beverely Minster for many years. The work of a hitherto unnoticed member of the family, Elizabeth Margaret Camidge, is also dealt with. A appendix of musical works is included.
This book covers the entire field of research in the area of minor tranquillizers and its application to current clinical practice in the treatment of anxiety and insomnia. These drugs are principally the benzodiazepines and related drugs with a similar mechanism of action, such as zolpidem and zopiclone. The molecular mechanism of action of benzodiazepines is described, focussing on the interaction of these drugs with the different isoform of the GABAA^O >receptor, and the consequences of this for brain function. Recent advances in this knowledge have provided a framework for defining the physiochemical nature of the interaction between such drugs and their receptor protein, and thus pave the way for the design of new anxiolytic and hypnotic drugs. The animal models available for evaluating the potential of such new therapeutic agents in the treatment of anxiety and insomnia are discussed. Furthermore, understanding of the physiological regulation of the GABAA receptor may provide insights into the aetiopathology of these diseases. The clinical use of benzodiazepines and related drugs in the treatment of anxiety, insomnia, epilepsy and as anaesthetics are explored. The advantages and limitations of such treatments are discussed, and the impact of drugs evaluated. A chapter is devoted to the issue of independence, the clinical pertinence of tolerence and dependence, and evaluates treatment options that may minimise the risk of dependence.
Moral Struggle and Religious Ethics offers a comparative discussion of the challenges of living a moral religious life. This is illustrated with a study of two key thinkers, Bonaventure and Buddhaghosa, who influenced the development of moral thinking in Christianity and Buddhism respectively. Provides an important and original contribution to the comparative study and practice of religious ethics Moves away from a comparison of theories by discussing the shared human problem of moral weakness Offers an fresh approach with a comparison of the understanding of the problem of moral weakness between the two key thinkers, Bonaventure and Buddhaghosa Written by a highly respected academic in the dynamic and fast-growing field of comparative religious ethics
Written as a collection of problems, hints and solutions, this book should provide help in learning about both fundamental and applied aspects of this vast field of knowledge, where rapid and exciting developments are taking place.
Acute Pain brings coverage of this diverse area together in a single comprehensive clinical reference, from the basic mechanisms underlying the development of acute pain, to the various treatments that can be applied to control it in different clinical settings. Much expanded in this second edition, the volume reflects the huge advances that continue to be made in acute pain management. Part One examines the basic aspects of acute pain and its management, including applied physiology and development neurobiology, the drugs commonly used in therapy, assessment, measurement and history-taking, post-operative pain management and its relationship to outcome, and preventive analgesia. Part Two reviews the techniques used for the management of acute pain. Methods of drug delivery and non-pharmacological treatments including psychological therapies in adults and children and transcutaneous electrical nerve stimulation are considered here. Part Three looks at the many clinical situations in which acute pain can arise, and the methods of treatment that may be suitable in each circumstance, whether the patient is young or old, has pain due to surgery, trauma, medical illness or childbirth, or is undergoing rehabilitation. Issues specific to the management of acute pain in the developing world are also covered here.
Sleepy rustic Carmarthenshire was secretly a hotbed of debauchery, violence and drunkenness according to Russell Davies in a new edition of his very successful book, ‘Secret Sins’. Behind the facade of idyllic rural life, there was a twilight world of mental illness, suicide, crime, vicious assaults, infanticide, cruelty and other assorted acts of depravity. This almost anecdotal historical study is often funny, sometimes disturbing, always revealing.
Explore fundamental communication concepts, theories, and skills aimed at helping students apply communication skills to their personal and professional lives—with a thematic integration of the relational perspective and a focus on demonstrating its direct relevance to their own everyday communication.
What role does history play in contemporary society? Has the frenetic pace of today’s world led people to lose contact with the past? A high-profile team of researchers from across Canada sought to answer these questions by launching an ambitious investigation into how Canadians engage with history in their everyday lives. The results of their survey form the basis of this eye-opening book. Canadians and Their Pasts reports on the findings of interviews with 3,419 Canadians from a variety of cultural and linguistic communities. Along with yielding rich qualitative data, the surveys generated revealing quantitative data that allows for comparisons based on gender, ethnicity, migration histories, region, age, income, and educational background. The book also brings Canada into international conversation with similar studies undertaken earlier in the United States, Australia, and Europe. Canadians and Their Pasts confirms that, for most Canadians, the past is not dead. Rather, it reveals that our histories continue to shape the present in many powerful ways.
First full biography of MacArthur's chief intelligence officer Charles Willoughby, reflecting on the consequences of prioritizing loyalty to a superior over objectivity of intelligence. Major General Charles A. Willoughby served as Douglas MacArthur's stalwart chief intelligence officer (G-2} for over a decade, throughout World War II and the Korean War. This first full biography examines Willoughby's shadowy origins in his native Germany, his curious arrival in the United States, and his military service in World War I, as well as his work during the interwar years as a junior diplomat, budding historian, and neophyte intelligence officer. His chance encounter with MacArthur in the mid-1930s would prove to be the genesis of a near-symbiotic relationship between the two, with significant consequences for both. Throughout his life, Willoughby identified with strong, authoritarian leaders, notably Franco, and—especially—MacArthur. The author also assesses Willoughby's performance as a professional intelligence officer both in World War II and Korea, where he is often vilified for his inaccurate assessments of enemy strength and most likely courses of action, as well as his sycophantic relationship with his commander. Willoughby is most often criticized for his failing to foresee the entry of Chinese forces into the Korean War and its impact upon the US Army and the prosecution of the war. Following MacArthur’s removal by President Truman in 1951, Willoughby retired and spent the rest of his days engaged in right-wing political activity and in staunchly defending his much-maligned boss. The legacy he left is one filled with lingering and important questions about loyalty to superiors, in civilian as well as military environments, how far that loyalty should extend, and walking the tightrope involved in telling truth to power.
Any healthcare professional with, or developing an interest in, clinical nutrition will be able to use this textbook, first published in 2001, as a source of information for the formation of a clinical nutrition support service of excellence. The first three parts of the book will enable a clear perspective of the metabolism and physiology of clinical nutrition to be related to the practical application of support techniques. The fourth part of the book highlights the role of nutrition support in specific disease groups. A number of additional chapters have been added for this second edition, and modifications made to the content of chapters from the first edition to cover newer areas or areas of omission.
The book deals with the role of both oxygen- and nitrogen-centred free radicals in inflammatory diseases such as rheumatoid arthritis. The well-known involvement of the superoxide anion radical in the bactericidal action of inflammatory cells suggests that radicals and the inflammatory response are inextricably linked. The widespread involvement of radicals in human disease seems inevitable, because inflammation is such a conspicuous component of human disease. For the first time, the present text integrates contributions from leading research groups who have been investigating the role of radicals within the context of all stages of inflammtion, such as the recruitment of inflammatory cells, their bactericidal action, inflammatory tissue destruction and inflammatory cell death by apoptosis. The chapters are broadly organised so that they trace the clinical course of the acute and chronic inflammtory response, emphasising the therapeutic implications of recent data on the contribution of nitric oxide and related nitrogen-centred species. The book will be of interest to academic and industrial researchers and clinicians with interests in the fields of inflammation or free radical biology.
This text tackles the traditional topics of media psychology--sex, violence, advertising--along with developmental aspects of media influence and the psychology of the audience. It examines specific media genres--news, sports, soaps, audience participation media, the internet -- and asks what light psychology can shed on the popularity of these genres and the response of their audiences.
Over the last two decades public services have been directly affected by the radical, political and economic changes which have characterized Britain. As 'businesses' public service employers are now becoming more responsive to their clients and customers and have moved to a more decentralized and proactive style, based on private sector practices. This book describes past practices and current developments in public sector organizations, looking at in-depth case studies covering NHS trusts, the Civil Service, local government, police and education. It examines implications for the future and will provide an invaluable guide for both students of personnel and business studies and managers in the public sector.
A novel proposal that the unified nature of our cognition can be partially explained by a cognitive architecture based on graphical models. Our ordinary, everyday thinking requires an astonishing range of cognitive activities, yet our cognition seems to take place seamlessly. We move between cognitive processes with ease, and different types of cognition seem to share information readily. In this book, David Danks proposes a novel cognitive architecture that can partially explain two aspects of human cognition: its relatively integrated nature and our effortless ability to focus on the relevant factors in any particular situation. Danks argues that both of these features of cognition are naturally explained if many of our cognitive representations are understood to be structured like graphical models. The computational framework of graphical models is widely used in machine learning, but Danks is the first to offer a book-length account of its use to analyze multiple areas of cognition. Danks demonstrates the usefulness of this approach by reinterpreting a variety of cognitive theories in terms of graphical models. He shows how we can understand much of our cognition—in particular causal learning, cognition involving concepts, and decision making—through the lens of graphical models, thus clarifying a range of data from experiments and introspection. Moreover, Danks demonstrates the important role that cognitive representations play in a unified understanding of cognition, arguing that much of our cognition can be explained in terms of different cognitive processes operating on a shared collection of cognitive representations. Danks's account is mathematically accessible, focusing on the qualitative aspects of graphical models and separating the formal mathematical details in the text.
Acute Pain brings coverage of this diverse area together in a single comprehensive clinical reference, from the basic mechanisms underlying the development of acute pain, to the various treatments that can be applied to control it in different clinical settings. Much expanded in this second edition, the volume reflects the huge advances that contin
Social work is a discipline committed to social justice and human rights, and to improving the well-being of individuals, families, communities and societies. But the world is changing, with environmental disasters, an increase in violent conflict and the aftermath of the Global Financial Crisis impacting negatively on human and ecological well-being. Social workers are often working at the forefront of these and other challenging situations, and they must apply knowledge and skills to their practice in a thoughtful and ethical way. What kind of knowledge and skills will social workers need to succeed in this intellectually and emotionally demanding job? Broad-ranging in scope and depth, this highly readable text introduces readers to the key concepts in social work – such as empathy, reflective practice and notions of risk – and provides both a focus on the theory and research literature that informs each one, and an examination of how each will aid practitioners in their day-to-day work. With the help of engaging practice examples that contextualize the topics under discussion, the book also draws on ideas and literature from other disciplines – including philosophy, sociology and psychology – in order to promote the open-mindedness and depth of understanding required for practice with people from all walks of life. An accessible text that brings all of the major social work concepts together in one place, Key Concepts and Theory in Social Work is an essential book for students and practitioners alike.
Molluscs comprise the second largest phylum of animals (after arthropods), occurring in virtually all habitats. Some are commercially important, a few are pests and some carry diseases, while many non-marine molluscs are threatened by human impacts which have resulted in more extinctions than all tetrapod vertebrates combined. This book and its companion volume provide the first comprehensive account of the Mollusca in decades. Illustrated with hundreds of colour figures, it reviews molluscan biology, genomics, anatomy, physiology, fossil history, phylogeny and classification. This volume includes general chapters drawn from extensive and diverse literature on the anatomy and physiology of their structure, movement, reproduction, feeding, digestion, excretion, respiration, nervous system and sense organs. Other chapters review the natural history (including ecology) of molluscs, their interactions with humans, and assess research on the group. Key features of both volumes: up to date treatment with an extensive bibliography; thoroughly examines the current understanding of molluscan anatomy, physiology and development; reviews fossil history and phylogenetics; overviews ecology and economic values; and summarises research activity and suggests future directions for investigation. Winston F Ponder was a Principal Research Scientist at The Australian Museum in Sydney where he is currently a Research Fellow. He has published extensively over the last 55 years on the systematics, evolution, biology and conservation of marine and freshwater molluscs, as well as supervised post graduate students and run university courses. David R. Lindberg is former Chair of the Department of Integrative Biology, Director of the Museum of Paleontology, and Chair of the Berkeley Natural History Museums, all at the University of California. He has conducted research on the evolutionary history of marine organisms and their habitats on the rocky shores of the Pacific Rim for more than 40 years. The numerous elegant and interpretive illustrations were produced by Juliet Ponder.
A collection of the theories, practices, and policies of vocational education and training written by international experts The Wiley Handbook of Vocational Education and Training offers an in-depth guide to the theories, practices, and policies of vocational education and training (VET). With contributions from a panel of leading international scholars, the Handbook contains 27 authoritative essays from a wide range of disciplines. The contributors present an integrated analysis of the complex and dynamic field of VET. Drawing on the most recent research, thinking, and practice in the field, the book explores the key debates about the role of VET in the education and training systems of various nations. The Handbook reveals how expertise is developed in an age of considerable transformation in work processes, work organization, and occupational identities. The authors also examine many of the challenges of vocational education and training such as the impact of digital technologies on employment, the demand for (re)training in the context of extended working lives, the emergence of learning regions and skill ecosystems, and the professional development of vocational teachers and trainers. This important text: Offers an original view of VET’s role in both the initial and continuing development of expertise Examines the theories and concepts that underpin international perspectives and explores the differences about the purposes of VET Presents various models of learning used in VET, including apprenticeship, and their relationship with general education Explores how VET is shaped in different ways by the political economy of different countries Reviews how developments in digital technologies are changing VET practice Discusses the challenges for universities offering higher vocational education programs Draws on both recent research as well as historical accounts Written for students, researchers, and scholars in the fields of educational studies, human resource development, social policy, political economy, labor market economics, industrial relations, sociology, The Wiley Handbook of Vocational Education and Training offers an international perspective on the topic of VET.
This book examines the division of labour between nurses and other health professions and occupations. It connects classic sociological concerns with practical problems affecting the contemporary NHS, such as: skill-mix in hospitals; the emergence of new roles; the shifting boundaries between medicine and nursing; and the barriers to change that exist. The book contains a series of case studies illustrating tensions, conflict and accommodation observable when occupations, or sub-groups within occupations, negotiate new working relationships.
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