In this book, the four leading experts on the ACE inhibitors donepezil, galantamine, and rivastigmine and the NMDA receptor antagonist memantine explain the practical pharmacology of these symptomatic drugs with the aim of providing a sound basis for their clinical use in patients with Alzheimer’s disease. In addition, an introductory chapter considers the basic theory of pharmacology for Alzheimer’s disease and the book closes with an overview of the ways in which symptomatic drugs for dementia are used. The wide acceptance of the amyloid cascade hypothesis has led to vigorous development of disease-modifying drugs for Alzheimer’s disease, such as amyloid vaccinations and gamma- or beta-secretase inhibitors. The failure of clinical trials of these drugs to yield satisfactory results has, however, meant that for the time being patients continue to be treated only with symptomatic drugs. There is accordingly a need to become more proficient in the use of symptomatic medicines, and it is against the background of this quest that Practical Pharmacology for Alzheimer’s Disease will be of wide interest.
Whatiwhatihoe investigates a complex bundle of issues often referred to simply as a tribal "resource claim" but that really concern factors spanning the total social, political, and economic spectrum. Whatiwhatihoe tracks the origins and history of the Waikato raupatu claim, focusing particularly on the ways the claim has been handled.
When the 1st Michigan Volunteer Infantry regiment arrived in Washington, DC, President Lincoln exclaimed: "Thank God for Michigan!" The state raised more than 90,000 men to serve during the Civil War, and 69 of them received the Medal of Honor. Notable Michiganders include Gens. Israel Richardson, Orlando Poe, Alpheus Williams, Orlando Willcox, and George Hartsuff, as well as "The Boy General," George Armstrong Custer, and Officer Norman Hall, who was stationed at Fort Sumter when the war began. Featuring images of the 4th Michigan Cavalry, which captured Confederate president Jefferson Davis at the war's end, and never-before-published photographs of Wolverine soldiers, Images of America: Remembering Michigan's Civil War Soldiers highlights hundreds of Michiganians who were committed to preserving the Union.
In response to Kitchener's famous call for a million volunteers, local communities raised entire battalions for the service on the Western Front. Hull folk are reticent people and the Hull Pals were no exception. This book tells their inspiring story of sacrifice and gallantry under appaling conditions. Hull Pals contains a great number of hitherto unpublished eye-witnessed accounts and photographs.As featured on BBC Radio Humberside and in The Yorkshire Post.
Bailey is largely forgotten today, a victim of the recording industry's emphasis on the blues during the 1920s--a decision which segregated forever "black" folk music from "white" folk music. Bailey was from an African American mountain culture that shared much of its musical heritage with its Anglo-Saxon neighbors, producing a unique hybrid which Bailey called "black hillbilly." A virtuoso on the harmonica, guitar, and banjo, Bailey became one of the Grand Old Opry's earliest stars during the 1920s, only to be fired from the Opry in 1941 during one of the Opry's more repressive eras. Bailey's story is told mainly in his own words through interviews conducted by his longtime friend Morton, with Wolfe (English and folklore, Middle Tennessee State Univ.) providing cultural and historical background. The authors' stated goal was to write a book of universal appeal, and indeed the work is a fascinating cultural history. -- Library Journal
Dangerous Talk examines the 'lewd, ungracious, detestable, opprobrious, and rebellious-sounding' speech of ordinary men and women who spoke scornfully of kings and queens. Eavesdropping on lost conversations, it reveals the expressions that got people into trouble, and follows the fate of some of the offenders. Introducing stories and characters previously unknown to history, David Cressy explores the contested zones where private words had public consequence. Though 'words were but wind', as the proverb had it, malicious tongues caused social damage, seditious words challenged political authority, and treasonous speech imperilled the crown. Royal regimes from the house of Plantagenet to the house of Hanover coped variously with 'crimes of the tongue' and found ways to monitor talk they deemed dangerous. Their response involved policing and surveillance, judicial intervention, political propaganda, and the crafting of new law. In early Tudor times to speak ill of the monarch could risk execution. By the end of the Stuart era similar words could be dismissed with a shrug. This book traces the development of free speech across five centuries of popular political culture, and shows how scandalous, seditious and treasonable talk finally gained protection as 'the birthright of an Englishman'. The lively and accessible work of a prize-winning social historian, it offers fresh insight into pre-modern society, the politics of language, and the social impact of the law.
Roberts intertwines McGregor's corporate, civic, and personal lives to trace his pioneering role in the automobile industry. Some themes from McGregor's career that are considered here include company growth, the technical and cultural concept of the automobile, the impact of automotive transportation, technological reliance on Detroit, parent-branch relations, the effects of border proximity, industrial and political lobbying, labor relations, secondary manufacturing, public involvement, and the Great War. In addition, Roberts probes McGregor's often-subservient relationship with the enigmatic Henry Ford and examines how McGregor drew praise and political ire in calling for regional governance in the "Border Cities" opposite Detroit. In the years before his premature death, McGregor and his company dominated and defined the growing automotive industry in Windsor-Detroit, and their story deserves to be more widely known.".
Don't let the gruesome murders of a man and a woman in the basement of a former government building just off Capitol Hill in Washington, DC lull you into thinking this is just another mystery novel. It will take careful reading of this compelling and different kind of novel tounderstand the O. Henry-type ending. Page after page, and chapter after chapter, will bring together a series of intrigues. For example, the heads of the Italian mafia and the Russian mafiya work out a historic cooperative scheme to assassinate a high U.S. government official. This is to take place in late October 2007 during the 100th anniversary of Union Station on Capitol Hill, and the 78th anniversary of the 1929 Stock Market crash. (These two events truly are historically correct.) Once youdiscover that asecret Middle East terrorist organization is involved, the two events will make sense, because thatorganizationhas learned of the mafia and mafiya alliance's plan and will take advantage of them to execute its own event that will make a mockery of Capitol Hill's security procedures. The organization uses a small bank in a Caribbean nation to lauder the money needed to carry out its mission. The organization calls its effort OPERATION RED HERRING. The term stems from animal rights activists in England whoconfusehunt dogs bydragging bags of that dead fish across the trail so the fox is not killed. To the organization, the term means deception. A curmudgeon private detective and his Capitol Police niece not only solve the two murders, but they help unravel the Union Station plot. The murders take place in what used to be, for the novel's purpose, the former Government Printing Office. The GPO now houses an innovative semi-government agency, but few of the current and former occupants know the existence of a underground tunnel between the building and Union Station. (It actually exists.) The assassination attempt will make use of that tunnel to avoid discovery. Many clues are scattered throughout the novel. You may have to reread sections of the novel to discover them. Even the murder weapons are unusual. And, at least one character will turn out to be someonewho really is not what you think.
This volume sheds light on the pride of the region - the great medieval churches of York Minster, the Minster and St Mary at Beverley, and Holy Trinity, Hull but also on less well known architectural pleasures of town and county. Outstanding Victorian village churches, including masterpieces by Street & Pearson, are as rewarding as the major country houses of Burton Agnes, Burton Constable and Sledmere. The countryside offes a wide range of monuments, from the beautifully sited ruins of Kirkham Priory to the spectacular Humber Bridge. Farmhouses and cottages of the Wolds, picturesque estate villages and chapels, and industrial structures are all brought into focus. A large section is devoted to York and includes a survey of the historic buildings of the city centre from the Roman period onwards. This is complemented by a detailed exploration of York's eighteenth and nineteenth-century suburbs. Equal care has been applied to the descriptions of Beverley, with its attractive townscape, and the port of Hull, where unexpected highlights include seventeenth-century merchant houses, Georgian almshouses, ornate Victorian pubs, and grand Edwardian public buildings.
Nelson's William Alexander, Lord Stirling, (1726-83) is the biographical account of a man who served 18th-century American society as a prominent citizen in peacetime and as a soldier in the Seven Years' War and the American Revolution.
At the beginning of the eighteenth century the landed estate represented the largest and most clearly defined type of business organisation in existence in pre-industrial England. Given the need for capital, wayleave rights and a ready supply of coal, iron and other raw materials it is unsurprising that most historians tend to place Britain's formative industrial development on such estates where all these elements were available. Yet despite this consensus, relatively little attention has been paid to the management and accountancy practices of these estates, which have the potential to reveal much about the development of the industrial revolution. In this study the management practice on estates in the north-east of England (c.1700-1780) is examined through the lens of the accounts and supporting documentation. Accounts encompassed every aspect of estate operations from the housekeeper's groceries to the lead and coal mines, and thus provide direct evidence of the underlying management systems over a diverse range of activities. The information flows on estates serve as an excellent medium for testing hypotheses concerning the management of estates and the attitudes of their owners and stewards. Focusing on the surviving accounts of three leading gentry families, Bowes, Ridley and Cotesworth, who came from contrasting social backgrounds, two main issues are addressed. The first concerns the productivity of estates. Were estates managed efficiently as productive investments, and more specifically, to what extent can the landowners and their stewards legitimately be described as capitalists? The second, related, question asks in what ways did accounting aid managerial activity at this early stage of industrial development? These are the central questions this book addresses through examination of the nature and function of accounts within the organisation. By looking in detail at records from this crucial region during the period of transition to an industrial
Sir George Porter (Lord Porter of Luddenham) was one of the most highly regarded and well known scientists in Britain. He was appointed Director of the Royal Institution in 1966, awarded a Nobel Prize in Chemistry in 1967, and was the only Director of the Royal Institution to later become President of the Royal Society (1985-1990). Porter had a marvellous gift for communicating his infectious enthusiasm for science, and as President of the Royal Society, he worked hard to improve the status of science, and employed his communication skills ably in the defence of British science under attack from inadequate government funding, of which he was fiercely critical.It was for his work on flash photolysis in Cambridge that ultimately led him to win the Nobel Prize. Together with Ronald Norrish and Manfred Eigen, he shared the 1967 Nobel Prize for Chemistry, for their work on techniques for observing and studying extremely fast chemical reactions during the processes of combustion, explosion and chain reaction.In this volume, his peers, former colleagues, students and friends — themselves highly regarded and well known scientists in their own right — come together to honour and celebrate the enormous contributions of this man. They comment on their respective personal and working relationships with Porter and on his work.The contributors include Mary Archer (University of Cambridge, UK), James Barber (Imperial College London, UK), Godfrey Beddard (University of Leeds, UK), Graham Fleming (University California, Berkeley, USA), Michael George (University of Nottingham, UK), Anthony Harriman (University of Newcastle Upon Tyne, UK), David Klug (Imperial College London, UK), Harry Kroto (University of Sussex, UK), Edward Land (Keele University, UK), A J MacRobert (University of College London, UK), David Phillips (Imperial College London, UK), Martyn Poliakoff (University of Nottingham, UK), F Sherwood Rowland (University of California, Irvine, USA), Brian Thrush (University of Cambridge, UK), George Truscott (Keele University, UK), James Turner (University of Nottingham, UK), Barry Ward (UK), Frank Wilkinson (Loughborough University of Technology, UK), Keitaro Yoshihara (Japan Advanced Institute of Science and Technology, Japan), and Ahmed Zewail (California Institute of Technology, USA)./a
A fascinating and illuminating account of how George Washington became the dominant force in the creation of the United States of America, from award-winning author David O. Stewart “An outstanding biography . . . [George Washington] has a narrative drive such a life deserves.”—The Wall Street Journal Washington's rise constitutes one of the greatest self-reinventions in history. In his mid-twenties, this third son of a modest Virginia planter had ruined his own military career thanks to an outrageous ego. But by his mid-forties, that headstrong, unwise young man had evolved into an unassailable leader chosen as the commander in chief of the fledgling Continental Army. By his mid-fifties, he was unanimously elected the nation's first president. How did Washington emerge from the wilderness to become the central founder of the United States of America? In this remarkable new portrait, award-winning historian David O. Stewart unveils the political education that made Washington a master politician—and America's most essential leader. From Virginia's House of Burgesses, where Washington mastered the craft and timing of a practicing politician, to his management of local government as a justice of the Fairfax County Court to his eventual role in the Second Continental Congress and his grueling generalship in the American Revolution, Washington perfected the art of governing and service, earned trust, and built bridges. The lessons in leadership he absorbed along the way would be invaluable during the early years of the republic as he fought to unify the new nation.
George Crumb is a composer at the forefront of post-World War II American music, and never before has one volume combined a portrait of his life with a catalogue of his extensive work. David Cohen's George Crumb: A Bio-Bibliography corrects this by providing the reader and researcher with an overview of Crumb's life, career, and compositions; and an annotated guide to literature by and about the composer—including not only articles and books, but also album reviews, concert reviews, and interviews. The biographical portion, written in close consultation with the subject, has resulted in perhaps the most complete and accurate biography currently in existence—an irreplaceable resource for anyone seeking a full understanding of 20th-century music.
Part of an eleven-volume set which contains all of Ricardo's published and unpublished writings, and provides great insight into the early era of political economics.
This is the story of James, John, and Hamilton Armstrong, three sons of a yeoman farmer living on the Pennsylvania frontier at the outset of the American Revolution. James and John joined the Continental Army in 1776, rose from the ranks to become officers, and served until the army was disbanded in 1783. Hamilton remained home to work the farm, protect the family, and serve in militia and “ranger” units to defend the frontier from repeated attacks from hostile Indian tribes. Their combined wartime experiences encompassed almost the totality of the American Revolution, from Canada in the north to South Carolina in the south and along the western frontier. James and John fought in most of the major battles of the revolution, including Princeton, Brandywine, Germantown, Monmouth, Guilford Courthouse, Eutaw Springs, and Yorktown, where they distinguished themselves in the eyes of generals like the Marquis de Lafayette, Mad Anthony Wayne, Light- Horse Harry Lee, Nathanael Greene, and George Washington.
Annotation George John Beto (1916-1991) is best known for his contributions to criminal justice. This book, authored by two of his former students, examines the entire life of Beto and his many achievements in the fields of both education and criminal justice.
Six months after the Declaration of Independence, the American Revolution was all but lost. A powerful British force had routed the Americans at New York, occupied three colonies, and advanced within sight of Philadelphia. Yet, as David Hackett Fischer recounts in this riveting history, George Washington--and many other Americans--refused to let the Revolution die. On Christmas night, as a howling nor'easter struck the Delaware Valley, he led his men across the river and attacked the exhausted Hessian garrison at Trenton, killing or capturing nearly a thousand men. A second battle of Trenton followed within days. The Americans held off a counterattack by Lord Cornwallis's best troops, then were almost trapped by the British force. Under cover of night, Washington's men stole behind the enemy and struck them again, defeating a brigade at Princeton. The British were badly shaken. In twelve weeks of winter fighting, their army suffered severe damage, their hold on New Jersey was broken, and their strategy was ruined. Fischer's richly textured narrative reveals the crucial role of contingency in these events. We see how the campaign unfolded in a sequence of difficult choices by many actors, from generals to civilians, on both sides. While British and German forces remained rigid and hierarchical, Americans evolved an open and flexible system that was fundamental to their success. The startling success of Washington and his compatriots not only saved the faltering American Revolution, but helped to give it new meaning.
In May 1947 a sixteen-year-old Jewish activist named Alexander Rubowitz was abducted in broad daylight from the streets of Jerusalem. At the abduction scene, a gray hat was found, purportedly belonging to Major Roy Farran, a decorated World War II officer who was in charge of British counterterrorism in Palestine. As evidence mounted against Farran, the Zionist underground swore vengeance. The episode precipitated a series of nail-biting twists and turns that had far-reaching consequences. An engaging mix of true crime and polemical narrative history, peopled by a cast of luminaries including Field Marshal Bernard Montgomery, Menachem Begin, and Golda Meir, Major Farran's Hat investigates shady violence, scandaluos cover-ups, and political expediency. It also explores why Britain lost Palestine, as well as how its counterinsurgency and diplomatic strategies collided so disastrously. By exposing Britain's legacy in the Middle East, this historical thriller echoes today's war on terror and pointedly illustrates the circumstances surrounding the birth of the State of Israel.
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