From the author of Let's Get Digital and Amazon Decoded, this book will change how you think about marketing. Strangers to Superfans puts you in the shoes of your Ideal Readers, and forces you to view your marketing from their perspective. *Learn the five stages in the Reader Journey. *Identify where your blockages are and how to fix them. *Optimize each stage to increase conversion. *Boost sales by making the process more frictionless. *Build an army of passionate readers who do the selling for you. It's not enough to know who your Ideal Readers are, you also need to imagine how they feel when a recommendation email arrives containing your cover. You must figure out why they hesitated before clicking the Buy button. And it's crucial to determine why they liked your book enough to finish it... but not sufficiently to recommend it to their friends. The Reader Journey is a new marketing paradigm that maps out the journey your Ideal Readers take in their transformation from strangers to superfans.
Publish like a pro and start building your audience today with the most comprehensive guide on the market. Packed with practical, actionable advice, this brand new fourth edition of Let's Get Digital delivers the very latest best practices on publishing your work and finding readers. · Boost your writing career with marketing strategies that are proven to sell more books. · Get expert tips on platform building, blogging and social media. · Discover which approaches are best for selling fiction vs. non-fiction. · Implement powerful ways to make your ebooks more discoverable. · Increase your visibility by optimizing keywords and categories. · Weigh the pros and cons of Kindle Unlimited, and find out exactly how to tweak your promotional plans depending on whether you stay exclusive to Amazon or opt for wider distribution. And that's just for starters...
Publish like a pro and start building your audience today with the most comprehensive guide on the market. Packed with practical, actionable advice, this brand new fourth edition of Let's Get Digital delivers the very latest best practices on publishing your work and finding readers. · Boost your writing career with marketing strategies that are proven to sell more books. · Get expert tips on platform building, blogging and social media. · Discover which approaches are best for selling fiction vs. non-fiction. · Implement powerful ways to make your ebooks more discoverable. · Increase your visibility by optimizing keywords and categories. · Weigh the pros and cons of Kindle Unlimited, and find out exactly how to tweak your promotional plans depending on whether you stay exclusive to Amazon or opt for wider distribution. And that's just for starters...
From the author of Let's Get Digital and Strangers to Superfans comes a guide to advertising on the world's hottest book marketing platform: BookBub Ads. *Create attractive ad images to turn browsers into buyers. *Optimize your targeting to attract the right readers. *Manage your bids effectively to drive more sales for less money. *Learn when to run your BookBub campaigns for maximum impact. *Boost discovery of your books and improve visibility. *Train the retailers to recommend your books to the right customers. *Turbocharge series sales to dominate the charts with multiple books simultaneously. BookBub Ads Expert will teach you everything you need to know, from what makes a killer ad to discovering your comparable authors so you can improve your targeting. It gives you a step-by-step guide to creating your first ads and shows you how to optimize your campaigns until you are achieving excellent results. Not only that, this guide will also show you how to level up and truly master the platform, with tons of strategic advice on how to use BookBub Ads to support launches, promote backlist, create an international audience, push an entire series, or build up your readership at any retailer. You will also learn a series of ninja tricks and killer moves to help take your sales to the next level. EXTRA RESOURCES INCLUDED: All purchasers of this book get access to a special set of free resources to help you master BookBub Ads including a gallery of winning images, detailed optimization advice, case studies, and a place to ask questions too!
Want to sell more books on the world's biggest retailer? Fancy Amazon doing the selling for you instead? Amazon Decoded: A Marketing Guide to the Kindle Store will show you how. * Learn about Visibility Marketing and how understanding Amazon’s philosophy can boost your sales. * Discover the algorithms that really go into Sales Rank and dispel some remarkably common myths. * Decode the ways Amazon recommends millions of books to readers every single day. * Understand the critical differences between the Best Seller list and the Popularity list. * Implement proven marketing plans, optimized for maximum Amazon visibility. Whether you are exclusive to Amazon and chasing those page reads, or a wide author trying to survive the onslaught of Kindle Unlimited titles, Amazon Decoded will share the secrets of the Kindle Store and how you can sell more books.
From the author of Let's Get Digital and Amazon Decoded, this book will change how you think about marketing. Strangers to Superfans puts you in the shoes of your Ideal Readers, and forces you to view your marketing from their perspective. *Learn the five stages in the Reader Journey. *Identify where your blockages are and how to fix them. *Optimize each stage to increase conversion. *Boost sales by making the process more frictionless. *Build an army of passionate readers who do the selling for you. It's not enough to know who your Ideal Readers are, you also need to imagine how they feel when a recommendation email arrives containing your cover. You must figure out why they hesitated before clicking the Buy button. And it's crucial to determine why they liked your book enough to finish it... but not sufficiently to recommend it to their friends. The Reader Journey is a new marketing paradigm that maps out the journey your Ideal Readers take in their transformation from strangers to superfans.
Dublin 1803: the city has been on a knife-edge since the failed rebellion in July, and Jimmy O'Flaherty suspects a newcomer to The Liberties - Kitty Doyle - is mixed up in it. She accuses him of spying for the English, and he thinks she's a reckless troublemaker. All Jimmy wants is to earn enough coin to buy passage to America. But when the English turn his trading patch into a gallows, Jimmy finds himself drawn into the very conflict he's spent his whole life avoiding. "Liberty Boy is a riveting tale of an overlooked rebellion, told from the perspective of the streets, with gifted dialogue that is more heard than read and unexpected twists that leave you breathless from first page to last." - Cindy Vallar, Historical Novel Society Review. Keywords: Ireland | Irish | historical fiction | literary fiction | Robert Emmett | United Irishmen | Dublin | adventure fiction | historical novel
Lee Christmas gets drunk and falls asleep at the throttle of his locomotive, plowing straight into an oncoming train. Blacklisted from the railroad and his marriage in tatters, he flees New Orleans on a steamer bound for the tropics. In Honduras, he begins a quiet new life. But trouble has a way of finding Christmas. With unrest sweeping the countryside, he’s kidnapped by bandits. Soon, he finds himself taking sides in an all-out civil war–as leader of the rebellion. MERCENARY is the story of the USA’s most famous soldier of fortune: the hard-drinking drifter who changed the fate of a nation. Praise for MERCENARY: “Highly recommended to readers of adventure fiction and history, as well as anyone interested in American adventurism and meddling in Latin America.” - Michael Wallace, Wall Street Journal and USA Today bestselling author. “Lee Christmas led a roaring life on and off the battlefield. Gaughran's great, fast-paced read keeps you right alongside all his exploits.” - Richard Sutton, author of The Red Gate. Keywords: Historical fiction | Literary fiction | Biographical fiction | Adventure novel | Central America | Latin America | Honduras | New Orleans | Lee Christmas | History
Want to sell more books on the world's biggest retailer? Fancy Amazon doing the selling for you instead? Amazon Decoded: A Marketing Guide to the Kindle Store will show you how. * Learn about Visibility Marketing and how understanding Amazon’s philosophy can boost your sales. * Discover the algorithms that really go into Sales Rank and dispel some remarkably common myths. * Decode the ways Amazon recommends millions of books to readers every single day. * Understand the critical differences between the Best Seller list and the Popularity list. * Implement proven marketing plans, optimized for maximum Amazon visibility. Whether you are exclusive to Amazon and chasing those page reads, or a wide author trying to survive the onslaught of Kindle Unlimited titles, Amazon Decoded will share the secrets of the Kindle Store and how you can sell more books.
Learn to improve your assessment, investigation, and management of physical health conditions in people with severe mental illness The Maudsley Practice Guidelines for Physical Health Conditions in Psychiatry offers psychiatric and general practitioners an evidence-based and practical guide for the appropriate assessment, investigation, and management of common physical health conditions seen in people with severe mental illness. Written by a renowned team of respected experts in medicine, surgery, pharmacy, dietetics, physiotherapy, and psychiatry, the book bridges the gap between psychiatric and physical health services for the severely mentally ill. The Maudsley Practice Guidelines for Physical Health Conditions in Psychiatry also provides practitioners with expert guidance on making effective referrals to other medical and surgical subspecialties, telling readers what information subspecialties would expect to receive. Its use will improve the quality of clinical care received by mentally ill patients and, by promoting a holistic approach to treatment that considers both body and mind, will enhance the therapeutic relationship between patient and practitioner. The Maudsley Practice Guidelines for Physical Health Conditions in Psychiatry covers the following: Guidance on assessment and management of well over a hundred different medical and surgical presentations commonly seen in people with serious mental illness Management of physical health emergencies in a psychiatric setting Evidence-based approaches to management of physical side effects of psychiatric medications Advice on approaches to promote a healthy lifestyle in people with serious mental illness, such as smoking cessation and changes to diet and physical activity Perfect for both psychiatrists and general practitioners who wish to improve the quality of care they provide to people with serious mental illness, The Maudsley Practice Guidelines for Physical Health Conditions in Psychiatry will be of use to anyone setting out to navigate the divide between the treatment of psychiatric and physical health conditions.
Succeed as a Professional Writer, outside of the Traditional Publishing World by having the right guide: that is your best chance for survival... And this is your guide!. ----A step by step guide for Professional Indie Writers and authors, from final draft to publication and launch marketing. This handbook covers publishing / Self-Publishing, editing, cover, and design resources dedicated to moving writers out of the "self-Publishing" associated with vanity presses and into the world of professional Indie writing--the world of Independently self-published authors — Florida Authors and Publishers Association, HOW-TO Book of the Year: Bronze Medallion — A B.R.A.G. MEDALLION HONOREE .... With a Foreword by Mel Jolly! --David Wind is a Hybrid author with 40 books of fiction published both Traditionally and Independently. He is a member of the Authors Guild, The Mystery Writers of America, The Science Fiction and Fantasy Writers of America, and Novelists Inc, and is the President of the Florida Chapter of the MWA for 2020. TAGS: Writing Skills, Indie Writing, Self-publishing guides. publishing guides, Book Publishing Industry, Independent Writing, independent Publishing, self Publishing, Creativity Self-Help, Publishing & Books, Media & Communications Industry, Fiction Writing Reference, Writing Skill Reference, Web Marketing, Business Writing Skill, Writing Skills in Advertising, Nonfiction Writing Reference, Genre Fiction Writing Reference, Education Research, Writing Skills in Advertising
From the author of Let's Get Digital and Strangers to Superfans comes a guide to advertising on the world's hottest book marketing platform: BookBub Ads. *Create attractive ad images to turn browsers into buyers. *Optimize your targeting to attract the right readers. *Manage your bids effectively to drive more sales for less money. *Learn when to run your BookBub campaigns for maximum impact. *Boost discovery of your books and improve visibility. *Train the retailers to recommend your books to the right customers. *Turbocharge series sales to dominate the charts with multiple books simultaneously. BookBub Ads Expert will teach you everything you need to know, from what makes a killer ad to discovering your comparable authors so you can improve your targeting. It gives you a step-by-step guide to creating your first ads and shows you how to optimize your campaigns until you are achieving excellent results. Not only that, this guide will also show you how to level up and truly master the platform, with tons of strategic advice on how to use BookBub Ads to support launches, promote backlist, create an international audience, push an entire series, or build up your readership at any retailer. You will also learn a series of ninja tricks and killer moves to help take your sales to the next level. EXTRA RESOURCES INCLUDED: All purchasers of this book get access to a special set of free resources to help you master BookBub Ads including a gallery of winning images, detailed optimization advice, case studies, and a place to ask questions too!
An indispensable guide for university students, government officials and legal practitioners alike. The European Convention on Human Rights – Principles and law is the essential handbook for university students, government officials, lawyers and human rights advocates seeking a comprehensive and concise account of the case law generated under the European Convention on Human Rights. Written by experts on the Convention, it: • cites nearly 1 500 cases, providing links to each case in the HUDOC database; • identifies key challenges and current legal developments; • provides suggestions for further reading on contentious issues; • is a companion text to Council of Europe’s book The individual application under the European Convention on Human Rights – Procedural guide by Linos-Alexandre Sicilianos and Maria-Andriani Kostopoulou.
Lee Christmas gets drunk and falls asleep at the throttle of his locomotive, plowing straight into an oncoming train. Blacklisted from the railroad and his marriage in tatters, he flees New Orleans on a steamer bound for the tropics. In Honduras, he begins a quiet new life. But trouble has a way of finding Christmas. With unrest sweeping the countryside, he’s kidnapped by bandits. Soon, he finds himself taking sides in an all-out civil war–as leader of the rebellion. MERCENARY is the story of the USA’s most famous soldier of fortune: the hard-drinking drifter who changed the fate of a nation. Praise for MERCENARY: “Highly recommended to readers of adventure fiction and history, as well as anyone interested in American adventurism and meddling in Latin America.” - Michael Wallace, Wall Street Journal and USA Today bestselling author. “Lee Christmas led a roaring life on and off the battlefield. Gaughran's great, fast-paced read keeps you right alongside all his exploits.” - Richard Sutton, author of The Red Gate. Keywords: Historical fiction | Literary fiction | Biographical fiction | Adventure novel | Central America | Latin America | Honduras | New Orleans | Lee Christmas | History
With thirty revised and updated chapters the new edition of this classic text brings benefits to professors and students alike who will find new sections on many topics concerning modern food microbiology. This authoritative book builds on the trusted and established sections on food preservation by modified atmosphere, high pressure and pulsed electric field processing. It further covers food-borne pathogens, food regulations, fresh-cut produce, new food products, and risk assessment and analysis. In-depth references, appendixes, illustrations, index and thorough updating of taxonomies make this an essential for every food scientist.
The Maudsley® Prescribing Guidelines in Psychiatry The new edition of the world-renowned reference guide on the use of medications for patients presenting with mental health problems The Maudsley Prescribing Guidelines in Psychiatry is the essential evidence-based handbook on the safe and effective prescribing of psychotropic agents. Covering both common and complex prescribing situations encountered in day-to-day clinical practice, this comprehensive resource provides expert guidance on drug choice, minimum and maximum doses, adverse effects, switching medications, prescribing for special patient groups, and more. Each clear and concise chapter includes an up-to-date reference list providing easy access to the evidence on which the guidance is based. The fourteenth edition has been fully updated to incorporate the latest available research, the most recent psychotropic drug introductions, and all psychotropic drugs currently used in the UK, USA, Canada, Australia, New Zealand, and Japan. Several new sections cover topics such as deprescribing of major psychiatric drugs, prescribing psychotropics at the end of life, the treatment of agitated delirium, the genetics of clozapine prescribing, the use of weekly penfluridol, and the treatment of psychotropic withdrawal. Featuring contributions by an experienced team of psychiatrists and specialist pharmacists, the new edition of The Maudsley Prescribing Guidelines in Psychiatry: Provides succinct coverage of drug treatment of psychiatric conditions and formulating prescribing policy in mental health Covers a wide range of psychiatric conditions including schizophrenia, bipolar disorder, depression and anxiety, borderline personality, eating disorders, and many others Provides advice on prescribing for children and adolescents, older people, pregnant women, and other special patient groups Offers new sections on genetic prescribing, long-acting injectable formulations, ketamine administration and uses, and dopamine super-sensitivity Includes referenced information on off-label prescribing, potential interactions with other substances such as alcohol, tobacco, and caffeine, and treating patients with comorbid physical conditions Whether in the doctor’s office, in the clinic, or on the ward, The Maudsley Prescribing Guidelines in Psychiatry, Fourteenth Edition is a must-have for psychiatrists, pharmacists, neuropharmacologists, clinical psychologists, nurses, and other healthcare professionals working in mental health, as well as trainees and students in medicine, pharmacy, and nursing.
Meet the challenges of mental health treatments for the physically unwell with this essential guide Treating mental health conditions in physically unwell patients presents unique challenges for clinicians and other practitioners. Psychotropic medications, so effective in physically healthy patients, can have disappointing outcomes in the physically unwell, not to mention generating serious possible side effects that can complicate or impair physical treatment plans. Many clinicians face difficult decisions about prescribing for mental health conditions in such cases, and reliable information for them is scarce. The Maudsley Prescribing Guidelines for Mental Health Conditions in Physical Illness meets this urgent need with a comprehensive guide to the safe and effective pharmacological management of mental illness in physically unwell patients. Covering a wide range of physical health conditions and comorbidities, the book summarizes the key evidence and incorporates the full battery of potential pharmacological measures. It's an essential resource for any clinical practitioner looking to balance the physical and mental wellbeing of seriously ill patients. The Maudsley Prescribing Guidelines for Mental Health Conditions in Physical Illness readers will also find: Coverage of mental health conditions including depression, anxiety, psychosis, and bipolar affective disorder Detailed discussion of physical health conditions including cardiac disease, diabetes, chronic obstructive pulmonary disease, and many more Treatment of complex and frequently encountered clinical scenarios such as restarting psychotropics after overdose and steroid-induced psychiatric conditions The Maudsley Prescribing Guidelines for Mental Health Conditions in Physical Illness is ideal for clinical pharmacists, nurses, or doctors who work with mentally ill patients with physical comorbidities.
This new textbook provides a comprehensive overview of sustainable tourism framed around the UN’s sustainable development goals. It examines the origins and dimensions of sustainable tourism and offers a detailed account of sustainable initiatives and management across destinations, the tourism industry, public sector and leading agencies. The book explores the principal values and priorities in sustainable development through a better understanding of values, ethics and human nature. It covers a broad range of studies from an array of disciplinary perspectives and includes learning objectives, discussion questions and international case studies throughout. It is an important text for students and researchers in tourism and sustainability.
A guide to treating psychosis that provides information on drug options and side-effects in order to allow for weighing treatment options knowledgably The Maudsley Guidelines on Advanced Prescribing in Psychosis offers a resource that puts the focus on the need to treat the individual needs of a patient. The authors – noted experts on the topic – offer an alternative to the one-size-fits-all treatment of psychosis and shows how to build psychiatrist and patient relationships that will lead to effective individual treatment plans. The book provides up-to-date data and information about commonly used anti-psychotic drugs and drugs used in bipolar disorder. The text weighs both the upsides and downsides of each pharmaceutical presented, and helps prescribers and patients weigh the costs and benefits of various options to reach an appropriate treatment plan. The authors highlight the treatment at a population level and the systems in which individual treatments take places. This important resource: Facilitates the tailoring of an appropriate treatment plan for clients manifesting signs of psychosis Offers a comparative strategy that helps gauge the suitability of one treatment plan over another Provides at-hand data and information about commonly used anti-psychotic drugs Includes an understanding of the origins and side-effects of each drug presented The Maudsley Guidelines on Advanced Prescribing in Psychosis offers psychiatrists and other mental health practitioners an essential guide for treating psychosis on an individualized level.
The first in an all new fantasy series from USA TODAY Bestseller, David Dalglish Six islands float high above the Endless Ocean, where humanity's final remnants are locked in brutal civil war. Their parents slain in battle, twins Kael and Brenna Skyborn are training to be Seraphim, elite soldiers of aerial combat who wield elements of ice, fire, stone and lightning. When the invasion comes, they will take to the skies, and claim their vengeance.
This is a comprehensive and nuanced historical survey of the death penalty in Ireland from the immediate post-civil war period through to its complete abolition. Using original archival material, this book sheds light on the various social, legal and political contexts in which the death penalty operated and was discussed. In Ireland the death penalty served a dual function: as an instrument of punishment in the civilian criminal justice system, and as a weapon to combat periodic threats to the security of the state posed by the Irish Republican Army (IRA). Through close examination of cases dealt with in the ordinary criminal courts, this study elucidates ideas of class, gender, community and sanity and explores their impact on the administration of justice. The application of the death penalty also had a strong political dimension, most evident in the enactment of emergency legislation and the setting up of military courts specifically aimed at the IRA. As the book demonstrates, the civilian and the political strands converged in the story of the abolition of the death penalty in Ireland. Long after decision-makers accepted that the death penalty was no longer an acceptable punishment for 'ordinary' cases of murder, lingering anxieties about the threat of subversives dictated the pace of abolition and the scope of the relevant legislation.
A single source of much of the information that doctors and other health care workers need in order to learn if a birth defect or genetic condition can be diagnosed prenatally." -- American Journal of Human Genetics
The essential reference for anyone responsible for prescribing drugs for patients with mental health disorders. Widely and regularly used: the place to check for all relevant information on which drugs to prescribe, which side effects to look out for, how best to augment or switch drugs, such as antipsychotics, antidepressants, and anxiolytics. The book provides brief but detailed reviews of psychiatric disorders and relevant psychopharmacology, with general guidance based on the data reviewed and current clinical practice. Sections cover plasma monitoring, schizophrenia, bipolar disorder, depression, anxiety, children and adolescents, substance abuse and special patient groups. Each section has a full reference list so that the evidence base can be checked quickly, if required. The book covers prescribing drugs outside their licensed indications and their interaction with substances such as alcohol, nicotine and caffeine. Trainees will gain important information regarding the rational, safe and effective use of medications for patients with mental illness. Experienced clinicians will find excellent guidance regarding more complex issues that they may not encounter regularly.
Introduction to Bioorganic Chemistry and Chemical Biology is the first textbook to blend modern tools of organic chemistry with concepts of biology, physiology, and medicine. With a focus on human cell biology and a problems-driven approach, the text explains the combinatorial architecture of biooligomers (genes, DNA, RNA, proteins, glycans, lipids, and terpenes) as the molecular engine for life. Accentuated by rich illustrations and mechanistic arrow pushing, organic chemistry is used to illuminate the central dogma of molecular biology. Introduction to Bioorganic Chemistry and Chemical Biology is appropriate for advanced undergraduate and graduate students in chemistry and molecular biology, as well as those going into medicine and pharmaceutical science.
This text book is an essential resource representing the medical treatment of psychological disorders for the mental health professional. The book provides information concerning neuron and glia cell functions. Neuroinflammatory activation by stress is described and importance of two glia cells in the brain’s immune response to stress via the interaction with of cytokines which coordinates the immune response and activates neuroinflammation. This activation causes the expression of vulnerable phenotypes which produces the particular psychological disorder. Pharmacokinetics of psychotropic drugs are described in-terms of half-life, steady state, enzyme metabolism of the medication in the liver, and the production of active metabolites which dictates the psychological actions of the drug. The particular drug actions are discussed via down-stream transduction cascades in the neuron which actives or de-actives neuronal genes which leads to the psychotropic drug’s psychological actions. The book delineates the three main transporter genes of the Solute Carrier-6 (SLC6) gene family, which produces neurotransmitters and the therapeutic actions of psychotropic drugs. These neurotransmitters are: serotonin (5-HT), dopamine (DA), norepinephrine (NE), acetylcholine (Ach), glutamate (Glu), and gamma-amino butyric acid (GABA). The drugs’ side-effects include, restless leg syndrome, hyponatremia, serotonin side-effects, malignant serotonin syndrome, anti-cholinergic side-effects, extrapyramidal symptoms (EPS), tardive dyskinesia (TD), neuroleptic malignant syndrome, and suicide risk. This section of the book concludes with a discussion of negative drug effects on dental health, diet, and physical complications. The remainder of the text discusses psychological disorders, diagnostic criteria, epidemiology, theoretical models, genetics, neuroanatomy, psychological treatment, and the particular medication used to treat the disorder. For each psychotropic drug the following are provided: dosage, titration, taper, time to work, neurotransmitter profile, specific side effects, enzymes, and metabolites. Switching from one drug to other schedules are listed, along with diagnosis treatment resistant medication strategies. A sample of psychotropic drugs include: Schizophrenia (clozapine, risperidone, paliperidone, and others), anxiety disorders (diazepam, clonazepam, lorazepam, etc.), anti-depressants (fluoxetine, venlafaxine, desvenlafaxine, duloxetine, etc), bipolar disorders (mood stabilizers: lithium, valproic acid, carbamazepine, lamotrigine, etc., and anti-psychotics: aripiprazole, lurasidone, rexulti, and cariprazine), Alzheimer Disease (rivastigmine, donepezil, memantine, aducanumab-avwa, et al.), Attention Deficit Disorder (amphetamine D, methylphenidate, etc.), sleep dysfunctions (suvorexant, exzopiclone, zolpidem, benzodiazepines, etc), and addiction (Eating: naltrexone + bupropion, tirzepatide, etc; Smoking: bupropion; Alcohol: disulfiram, naltrexone, etc; and Opioid: methadone, buprenex + naloxone, etc). The text book concludes with a discussion of psychotropic treatment of children and the elderly, including drug dosing adjustments.
Comprehensive resource describing guidelines for safely reducing or stopping (deprescribing) antidepressants, benzodiazepines, gabapentinoids and z-drugs for patients, including step-by-step guidance for all commonly used medications, covering common pitfalls, troubleshooting, supportive strategies, and more. Most formal guidance on psychiatric medication relates to starting or switching medications with minimal guidance on deprescribing medication. In 2023, the World Health Organisation and the United Nations called for patients, as a human right, to be informed of their right to discontinue treatment and to receive support to do so. The Maudsley Deprescribing Guidelines fills a significant gap in guidance for clinicians by providing comprehensive and authoritative information on this important aspect of treatment. The evidence-based handbook provides an overview of principles to be used in deprescribing. This is derived from fundamental scientific principles and the latest research on this topic, combined with emerging insights from clinical practice (including from patient experts). Building on the recognised brand of The Maudsley Prescribing Guidelines, and the prominence of the authors' work, including in The Lancet Psychiatry on tapering antidepressants (the most read article across all Lancet titles when it was released). The Maudsley Deprescribing Guidelines covers topics such as: Why and when to deprescribe antidepressants, benzodiazepines, gabapentinoids and z-drugs Barriers and enablers to deprescribing including physical dependence, social circumstances, and knowledge about the discontinuation process Distinguishing withdrawal symptoms from dose reduction, such as poor mood, anxiety, and insomnia, from symptoms of the underlying disorder that medication was intended to treat The difference between physical dependence and addiction/substance use disorder Explanation of why and how to implement hyperbolic tapering in clinical practice Specific guidance on formulations of medication and techniques for making gradual reductions, including using liquid forms of medication, and other approaches Step-by-step guidance for safely stopping all commonly used antidepressants, benzodiazepines, gabapentinoids and z-drugs, including fast, moderate and slow tapering regimens or schedules for each drug, and guidance on how to tailor these to an individual Troubleshooting issues which can arise on stopping these medications, including akathisia, withdrawal symptoms, acute or protracted, and relapse. Written for anyone interested in safe deprescribing of psychiatric medications including psychiatrists, GPs, pharmacists, nurses, medical trainees, and interested members of the public. The Maudsley Deprescribing Guidelines is an essential resource on the subject that provides practical guidance on how to improve patient outcomes in this field of medicine.
For more than fifty years, the Terran Republic and the Terran League have been killing one another. The death toll has climbed ever higher, year after year, with no end in sight. But the members of the Five Hundred, the social elite of the Republic’s Heart Worlds, don’t care. Rear Admiral Terrence Murphy is a Heart Worlder. His family is part of the Five Hundred. His wife is the daughter of one of the Five Hundred’s wealthiest, most powerful industrialists. His sons and his daughter can easily avoid military service, and political power is his for the taking. There is no end to how high he can rise in the Republic’s power structure. All he has to do is successfully complete a risk-free military “governorship” in the backwater Fringe System of New Dublin without rocking the boat. But the people sending him to New Dublin have miscalculated, because Terrence Murphy is a man who believes in honor. Who believes in duty—in common decency and responsibility. Who believes there are dark and dangerous secrets behind the façade of what “everyone knows.” Terrence Murphy intends to meet those responsibilities, to unearth those secrets, and he doesn’t much care what the Five Hundred want. He intends to put a stop to the killing. Terrence Murphy is coming for whoever has orchestrated fifty-six years of bloodshed and slaughter, and Hell itself is coming with him. At the publisher's request, this title is sold without DRM (Digital Rights Management). About The Gordian Protocol: “Tom Clancy-esque exposition of technical details . . . absurd humor and bloody action. Echoes of Robert Heinlein . . . lots of exploding temporal spaceships and bodies . . . action-packed . . .” —Booklist “[A] fun and thrilling standalone from Weber and Holo. . . . Time travel enthusiasts will enjoy the moral dilemmas, nonstop action, and crisp writing.”—Publishers Weekly
With recent updates, the second edition of Evolutionary Medicine presents general principles of evolutionary biology and organismal design, then applies them to medical issues where these principles bring useful insights.
The human factors profession is currently attempting to take a more proactive role in the design of man-machine systems than has been character istic of its past. Realizing that human engineering contributions are needed well before the experimental evaluation of prototypes or operational systems, there is a concerted effort to develop tools that predict how humans will interact with proposed designs. This volume provides an over view of one category of such tools: mathematical models of human performance. It represents a collection of invited papers from a 1988 NATO Workshop. The Workshop was conceived and organized by NATO Research Study Group 9 (RSG.9) on "Modelling of Human Operator Behaviour in Weapon Systems". It represented the culmination of over five years of effort, and was attended by 139 persons from Europe, Canada, and the United States. RSG.9 was established in 1982 by Panel 8 of the Defence Research Group to accomplish the following objectives: * Determine the utility and state of the art of human performance modelling. * Encourage international research and the exchange of ideas. * Foster the practical application of modelling research. * Provide a bridge between the models and approaches adopted by engineers and behavioral scientists. * Present the findings in an international symposium.
I am unaware of any textbook which provides such comprehensive coverage of the field and doubt that this work will be surpassed in the foreseeable future, if ever!' From the foreword by Robert C. Moellering, Jr., M.D, Shields Warren-Mallinckrodt Professor of Medical Research, Harvard Medical School, USA Kucers' The Use of Antibiotics is the leading major reference work in this vast and rapidly developing field. More than doubled in length compared to the fifth edition, the sixth edition comprises 3000 pages over 2-volumes in order to cover all new and existing therapies, and emerging drugs not yet fully licensed. Concentrating on the treatment of infectious diseases, the content is divided into 4 sections: antibiotics, anti-fungal drugs, anti-parasitic drugs and anti-viral drugs, and is highly structured for ease of reference.Within each section, each chapter is structured to cover susceptibility, formulations and dosing (adult and paediatric), pharmacokinetics and pharmacodynamics, toxicity and drug distribution, detailed discussion regarding clinical uses, a feature unique to this title. Compiled by an expanded team of internationally renowned and respected editors, with a vast number of contributors spanning Europe, Africa, Asia, Australia, South America, the US and Canada, the sixth edition adopts a truly global approach. It will remain invaluable for anyone using antimicrobial agents in their clinical practice and provides in a systematic and concise manner all the information required when treating infections requiring antimicrobial therapy. Kucers' The Use of Antibiotics is available free to purchasers of the books as an electronic version on line or on your desktop: It provides access to the entire 2-volume print material It is fully searchable, so you can find the relevant information you need quickly Live references are linked to PubMed referring you to the latest journal material Customise the contents - you can highlight sections and make notes Comments can be shared with colleagues/tutors for discussion, teaching and learning The text can also be reflowed for ease of reading Text and illustrations copied will be automatically referenced to Kucers' The Use of Antibiotics
As the BOTOX ECONOMY was laid bare and the financial filler of other people's money became evident, the JAGGERS, JUGGLERS and BONO BOOMERS struggled to maintain their slice of a diminished pie. However the author saw a possible solution to Ireland's quandaries. Taking a trip around the globe from Shanghai to New York, from Latin America to Central Europe, he says we can learn from history and appreciate that Ireland has a unique economic resource: OUR GLOBAL TRIBE. If we exploit the demographic potential of the Diaspora, we can re-invigorate the nation. The prosperity of future Irish generations is based on harnessing the collective power of past generations. This is the global GENERATION GAME.
An index to the census of 1901 for the entire county of Longford, indexing 10,000 householders and 7,000 other persons resident within these households. but whose names are different to the householder. Location of a family in the 1901 census can be very relevant to researchers of Longford families who left Ireland in the mid to late 19th Century. Attached is a map of the Townlands of Co. Longford, which is indexed within the book.
Dublin 1803: the city has been on a knife-edge since the failed rebellion in July, and Jimmy O'Flaherty suspects a newcomer to The Liberties - Kitty Doyle - is mixed up in it. She accuses him of spying for the English, and he thinks she's a reckless troublemaker. All Jimmy wants is to earn enough coin to buy passage to America. But when the English turn his trading patch into a gallows, Jimmy finds himself drawn into the very conflict he's spent his whole life avoiding. "Liberty Boy is a riveting tale of an overlooked rebellion, told from the perspective of the streets, with gifted dialogue that is more heard than read and unexpected twists that leave you breathless from first page to last." - Cindy Vallar, Historical Novel Society Review. Keywords: Ireland | Irish | historical fiction | literary fiction | Robert Emmett | United Irishmen | Dublin | adventure fiction | historical novel
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