Pharmaceutical analysis determines the purity, concentration, active compounds, shelf life, rate of absorption in the body, identity, stability, rate of release etc. of a drug. Testing a pharmaceutical product involves a variety of chemical, physical and microbiological analyses. It is reckoned that over £10 billion is spent annually in the UK alone on pharmaceutical analysis, and the analytical processes described in this book are used in industries as diverse as food, beverages, cosmetics, detergents, metals, paints, water, agrochemicals, biotechnological products and pharmaceuticals. This is the key textbook in pharmaceutical analysis, now revised and updated for its fourth edition. Worked calculation examples Self-assessment Additional problems (self tests) Practical boxes Key points boxes New chapter on electrochemical biosensors. New chapter on the quality control of biotechnologically produced drugs. Extended chapter on molecular emission spectroscopy. Now comes with an e-book on StudentConsult. Self-assessment is interactive in the accompanying online e-book. 65 online animations show concepts such as ionization partitioning of drug molecules etc. ~
Pharmaceutical analysis determines the purity, concentration, active compounds, shelf life, rate of absorption in the body, identity, stability, rate of release etc. of a drug. Testing a pharmaceutical product involves a variety of analyses, and the analytical processes described in this book are used in industries as diverse as food, beverages, cosmetics, detergents, metals, paints, water, agrochemicals, biotechnological products and pharmaceuticals.The mathematics involved is notoriously difficult, but this much-praised and well established textbook, now revised and updated for its fifth edition, guides a student through the complexities with clear writing and the author's expertise from many years' teaching pharmacy students. Worked calculation examples and self-assessment test questions aid continuous learning reinforcement throughout Frequent use of figures and diagrams clarify points made in the text Practical examples are used to show the application of techniques Key points boxes summarise the need to know information for each topic Focuses on the most relevant and frequently used techniques within the field
This introductory text highlights the most important aspects of a wide range of techniques used in the control of the quality of pharmaceuticals. Written with the needs of the student in mind, this clear, practical guide includes self-testing sections with arithmetical examples and tests to help students brush up on their arithmetical skills in an applied context.
This new book, from the editor of the highly successful Pharmaceutical Analysis, sets out to define the area of pharmaceutical chemistry as distinct from medicinal chemistry. It focuses less on prototypes of drugs that perhaps never came to market and more on the drugs currently in use. The emphasis in the book is on the physicochemical properties of drug molecules and, in so far as they are known, the way that these properties govern the interaction of the drug with its target. Important physicochemical properties include pKa and partition coefficient and the properties of the structural elements within the drug which provide interactions with the target via a range of intermolecular forces. The last fifteen years has seen a great advance in the knowledge of protein structures and a strong emphasis is given to the interaction of drugs with proteins which shape the majority of drug mechanisms. Features: - Focus on intramolecular actions - Mechanisms of action richly illustrated - Self-assessment included - Comprehensive chapters on vitamins and biotechnological productsThis new book, from the editor of the highly successful Pharmaceutical Analysis, sets out to define the area of pharmaceutical chemistry as distinct from medicinal chemistry. It focuses less on prototypes of drugs that perhaps never came to market and more on the drugs currently in use. The emphasis in the book is on the physicochemical properties of drug molecules and, in so far as they are known, the way that these properties govern the interaction of the drug with its target. Important physicochemical properties include pKa and partition coefficient and the properties of the structural elements within the drug which provide interactions with the target via a range of intermolecular forces. The last fifteen years has seen a great advance in the knowledge of protein structures and a strong emphasis is given to the interaction of drugs with proteins which shape the majority of drug mechanisms. Features: - Focus on intramolecular actions - Mechanisms of action richly illustrated - Self-assessment included - Comprehensive chapters on vitamins and biotechnological products
Wigner's quasi-probability distribution function in phase space is a special (Weyl) representation of the density matrix. It has been useful in describing quantum transport in quantum optics; nuclear physics; decoherence, quantum computing, and quantum chaos. It is also important in signal processing and the mathematics of algebraic deformation. A remarkable aspect of its internal logic, pioneered by Groenewold and Moyal, has only emerged in the last quarter-century: it furnishes a third, alternative, formulation of quantum mechanics, independent of the conventional Hilbert space, or path integral formulations.In this logically complete and self-standing formulation, one need not choose sides ? coordinate or momentum space. It works in full phase space, accommodating the uncertainty principle, and it offers unique insights into the classical limit of quantum theory. This invaluable book is a collection of the seminal papers on the formulation, with an introductory overview which provides a trail map for those papers; an extensive bibliography; and simple illustrations, suitable for applications to a broad range of physics problems. It can provide supplementary material for a beginning graduate course in quantum mechanics.
Thoroughly updated to reflect the latest advances and technologies, Braddom's Physical Medicine and Rehabilitation, 6th Edition, remains the market leader in the field of PM&R. For more than 20 years, this bestselling reference has been the go-to resource for the entire rehabilitation team, providing in-depth coverage of essential core principles along with the latest research, technologies, and procedures that enhance patient care and facilitate optimal return to function. In this edition, lead editor Dr. David X. Cifu and his team of expert associate editors and contributing authors employ a more succinct format that emphasizes need-to-know material, incorporating new key summary features, including high-yield information and study sheets for problem-based learning. - Focuses more heavily on rehabilitation, with case studies throughout and more comprehensive coverage of stroke evaluation, rehabilitation, and therapies. - Provides expanded information on key topics such as interventional pain management options, gait and prosthetics, USG, fluoroscopy, electrodiagnosis and more. - Features a new chapter on Occupational Medicine and Vocational Rehabilitation, plus enhanced coverage of the neurogenic bladder, rehabilitation and prosthetic restoration in upper limb amputation, and acute medical conditions including cardiac disease, medical frailty, and renal failure. - Discusses quality and outcome measures for medical rehabilitation, practical aspects of impairment rating and disability determination, integrative medicine in rehabilitation, and assistive technology. - Offers highly illustrated, templated chapters that are easy to navigate without sacrificing coverage of key topics. - Includes access to dozens of even more practical videos and hundreds of integrated self-assessment questions for more effective learning and retention. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
On 14 October 1939, HMS Royal Oak, one of the British navy's top battleships, was destroyed at the Royal Navy's main anchorage at Scapa Flow, Orkney. The audacious attack, by a German U-boat, was the first major blow against Britain of the Second World War. Over 800 lives were lost, including sailors as young as 14. This book is a revealing account of the tragedy. Told through declassified photographs and naval records, as well as statements from survivors, it is a dramatic and moving reassessment of one of the most shattering events in British naval history.
An urgent plea for a broader understanding and awareness of the unconsidered dangers of new genetic technologies Since 2010 it has been possible to determine a person’s genetic makeup in a matter of days at an accessible cost for many millions of people. Along with this technological breakthrough there has emerged a movement to use this information to help prospective parents “eliminate preventable genetic disease.” As the prospect of systematically excluding the appearance of unwanted mutations in our children comes within reach, David B. Goldstein examines the possible consequences from these types of choices. Engaging and accessible, this clarion call for responsible and informed stewardship of the human genome provides an overview of what we do and do not know about human genetics and looks at some of the complex, yet largely unexplored, issues we must be most careful about as we move into an era of increasing numbers of parents exercising direct control over the genomes of their children.
This book offers an introduction to the newest, fastest-growing field in laboratory science. Explaining and clarifying the molecular techniques used in diagnostic testing, this text provides both entry-level and advanced information. It covers the principles of molecular biology along with genomes and nucleic acid alterations, techniques and instrumentation, and applications of molecular diagnostics. Written by leading experts, including Patrick Bossuyt, Angela Caliendo, Rossa W.K. Chiu, Kojo S.J. Elenitoba-Johnson, Andrea Ferreira-Gonzalez, Amy Groszbach, Sultan Habeebu, Doris Haverstick, Malek Kamoun, Anthony Killeen, Noriko Kusukawa, Y.M. Dennis Lo, Elaine Lyon, Gwendolyn McMillin, Christopher Price, James Versalovic, Cindy Vnencak-Jones, Victor Weedn, Peter Wilding, Thomas Williams, and Carl Wittwer, this book includes illustrations, tables, and a colorful design to make information easy to find and easy to use. A full-color, 4-page insert shows realistic images of the output for many molecular tests. Learning Objectives open each chapter with an overview of what you should achieve. Key Words are listed and defined at the beginning of each chapter, and are bolded in the text. Review Questions at the end of every chapter let you measure your comprehension. Advanced Concepts are included, but set apart from the rest of the text, for students who want a higher level of learning. Ethics boxes address ethical issues, allowing you to apply your knowledge to real-life scenarios. A glossary of all key words may be easily accessed in the back of the book.
Concise and portable, Braddom's Clinical Handbook of Physical Medicine and Rehabilitation, by Drs. David X. Cifu and Henry L. Lew, gives you dependable, up-to-date content in a handbook format ideally suited for use at the bedside or in outpatient clinics. This quick reference covers the everyday topics you need – assistive devices and orthoses, spasticity, pediatric, adult, and geriatric care, pain management, outcome measures, and much more – all derived from the most trusted name in the field of PM&R. - Reader-friendly format with succinct, templated chapters for ease of use. - Authoritative content derived from the #1 comprehensive reference in the field: Braddom's Physical Medicine and Rehabilitation. - An ideal resource for the entire rehabilitation team as a quick reference or study guide. - Highlights key concepts spanning the full spectrum of rehabilitation medicine to help optimize outcomes for patients with a range of chronic diseases, impairments, and disabilities. - Includes eSlides complied by internationally renowned experts to summarize key teaching points and clinical pearls.
An argument that technology accelerates biological discovery, with case studies ranging from chromosome discovery with early microscopes to how DNA replicates using radioisotope labels. Engineering has been an essential collaborator in biological research and breakthroughs in biology are often enabled by technological advances. Decoding the double helix structure of DNA, for example, only became possible after significant advances in such technologies as X-ray diffraction and gel electrophoresis. Diagnosis and treatment of tuberculosis improved as new technologies—including the stethoscope, the microscope, and the X-ray—developed. These engineering breakthroughs take place away from the biology lab, and many years may elapse before the technology becomes available to biologists. In this book, David Lee argues for concurrent engineering—the convergence of engineering and biological research—as a means to accelerate the pace of biological discovery and its application to diagnosis and treatment. He presents extensive case studies and introduces a metric to measure the time between technological development and biological discovery. Investigating a series of major biological discoveries that range from pasteurization to electron microscopy, Lee finds that it took an average of forty years for the necessary technology to become available for laboratory use. Lee calls for new approaches to research and funding to encourage a tighter, more collaborative coupling of engineering and biology. Only then, he argues, will we see the rapid advances in the life sciences that are critically needed for life-saving diagnosis and treatment.
Peripheral neuropathies represent a challenging subject for most physicians. This is an up-to-date, comprehensive, and readable book on peripheral neuropathies that includes concise information on the clinical, electrophysiological, pathological, pathogenic, and treatment aspects of the most important disorders. New molecular and serologic diagnostic tests are discussed. Sections are devoted to nerve and skin biopsy techniques and findings, quantitative sensory and autonomic reflex tests. Case examples are used liberally throughout the text. The editors: Mendell, Kissel, and Cornblath are experienced clinicians that bring complementary knowledge to each of the subjects. Additional authors have been handpicked for specific topics which add to the value of the edition.
This is the first comprehensive study of an ingenious number-notation from the Middle Ages that was devised by monks and mainly used in monasteries. A simple notation for representing any number up to 99 by a single cipher, somehow related to an ancient Greek shorthand, first appeared in early-13th-century England, brought from Athens by an English monk. A second, more useful version, due to Cistercian monks, is first attested in the late 13th century in what is today the border country between Belgium and France: with this any number up to 9999 can be represented by a single cipher. The ciphers were used in scriptoria - for the foliation of manuscripts, for writing year-numbers, preparing indexes and concordances, numbering sermons and the like, and outside the scriptoria - for marking the scales on an astronomical instrument, writing year-numbers in astronomical tables, and for incising volumes on wine-barrels. Related notations were used in medieval and Renaissance shorthands and coded scripts. This richly-illustrated book surveys the medieval manuscripts and Renaissance books in which the ciphers occur, and takes a close look at an intriguing astrolabe from 14th-century Picardy marked with ciphers. With Indices. "Mit Kings luzider Beschreibung und Bewertung der einzelnen Funde und ihrer Beziehungen wird zugleich die Forschungsgeschichte - die bis dato durch Widerspruechlichkeit und Diskontinuit�t gepr�gt ist - umfassend aufgearbeitet." Zeitschrift fuer Germanistik.
Since its inception, Introduction to Genetic Analysis (IGA) has been known for its prominent authorship including leading scientists in their field who are great educators. This market best-seller exposes students to the landmark experiments in genetics, teaching students how to analyze experimental data and how to draw their own conclusions based on scientific thinking while teaching students how to think like geneticists. Visit the preview site at www.whfreeman.com/IGA10epreview
Transplant Infections is a practical, clinically focused reference covering the common and more unusual bacterial, viral, and fungal infections affecting patients who have received stem cell or solid organ transplants. It provides a comprehensive review of the epidemiology, diagnosis, and management of opportunistic infections and presents strategies for infection prevention and control. Highlights of the Third Edition include a chapter on new immunosuppressive agents and expanded coverage of tropical infections and West Nile virus.
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