Human Intestinal Microflora in Health and Disease deals with human indigenous intestinal flora, the vast assemblage of microorganisms that reside in the intestinal tract. It contains information on the composition of the flora, its development, metabolic activities, importance to the host, and the consequences of upsetting its ecology. The book is organized into four parts. Part I examines the composition and development of intestinal flora. Part II deals with the metabolic activities of intestinal microflora. These include studies on carbohydrate metabolism in the human colon; the compounds used as nitrogen sources by gastrointestinal tract bacteria; and metabolic transformations of xenobiotic compounds carried out by intestinal flora. Part III examines the importance of intestinal microflora, including its role in intestinal structure and function and in suppressing the growth of pathogens. Part IV discusses the factors that can disrupt the ecology of intestinal microflora, such as antimicrobial agents, pseudomembranous colitis, and dietary and environmental stress. The research presented in this book will be of interest to both basic scientists and physicians concerned with the effects of the intestinal flora on human life.
We live in a society as dominated by food preference as by sexual preference, as obsessed with eating too much as with eating too little. In this accessible, cross-disciplinary text, David Goodman and Michael Redclift look at the development of the modern food system, integrating different bodies of knowledge and debate concerning food, agriculture, the environment and the household. They link changes in our diet and concern with the environment to many of the problems afflicting developing countries: food shortages, poor nutrition and wholesale environmental destruction.
Endocrinology: Adult and Pediatric: Reproductive Endocrinology is a new eBook from the same experts responsible for the highly acclaimed two-volume Endocrinology clinical reference book. It puts all of the latest advances in adult and pediatric reproductive endocrinology at your fingertips, instantly accessible on your favorite eReader - so you can give your patients the benefit of today’s best know-how. Stay abreast of the newest knowledge in reproductive endocrinology, including endocrinology of sexual behavior and gender identity; genetic pathways that control gonadal development and sex differentiation; management of PCOS and hirsutism; management of male androgen deficiency; management of gynecomastia; and much more. Effectively review the causes and management of precocious or delayed puberty. Count on all the authority that has made Endocrinology, 6th Edition, edited by leading endocrinologists Drs. Jameson and DeGroot, the go-to clinical reference for endocrinologists worldwide. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices.
An expert guide to targeting protein kinases in cancer therapy Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells. Because of this fact, pharmaceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal roadblocks to sever their malignant means of communication. Complete with full-color presentations, Targeting Protein Kinases for Cancer Therapy defines the structural features of protein kinases and examines their cellular functions. Combining kinase biology with chemistry and pharmacology applications, this book enlists emerging data to drive the discovery of new cancer-fighting drugs. Valuable information includes: Comprehensive overviews of the major kinase families involved in oncology, integrating protein structure and function, and providing important tools to assist pharmaceutical researchers to understand and work in this dynamic area of cancer drug research Focus on small molecule inhibitors as well as other therapeutic modalities Discussion of kinase inhibitors that have entered clinical trials for the treatment of cancer, with an emphasis on molecules that have progressed to late stage clinical trials and, in a few cases, to market Providing a platform for further study, this important work reviews both the successes and challenges of kinase inhibitor therapy, and provides insight into future directions in the war against cancer.
A collection of the theories, practices, and policies of vocational education and training written by international experts The Wiley Handbook of Vocational Education and Training offers an in-depth guide to the theories, practices, and policies of vocational education and training (VET). With contributions from a panel of leading international scholars, the Handbook contains 27 authoritative essays from a wide range of disciplines. The contributors present an integrated analysis of the complex and dynamic field of VET. Drawing on the most recent research, thinking, and practice in the field, the book explores the key debates about the role of VET in the education and training systems of various nations. The Handbook reveals how expertise is developed in an age of considerable transformation in work processes, work organization, and occupational identities. The authors also examine many of the challenges of vocational education and training such as the impact of digital technologies on employment, the demand for (re)training in the context of extended working lives, the emergence of learning regions and skill ecosystems, and the professional development of vocational teachers and trainers. This important text: Offers an original view of VET’s role in both the initial and continuing development of expertise Examines the theories and concepts that underpin international perspectives and explores the differences about the purposes of VET Presents various models of learning used in VET, including apprenticeship, and their relationship with general education Explores how VET is shaped in different ways by the political economy of different countries Reviews how developments in digital technologies are changing VET practice Discusses the challenges for universities offering higher vocational education programs Draws on both recent research as well as historical accounts Written for students, researchers, and scholars in the fields of educational studies, human resource development, social policy, political economy, labor market economics, industrial relations, sociology, The Wiley Handbook of Vocational Education and Training offers an international perspective on the topic of VET.
This book brings together the work of established researcher Professor David Phillips, in one authoritative volume. Including key chapters on education in Germany from the last three decades, topics range from historical studies of universities and schools, to detailed research on the role of the British in reconstructing education in Germany after 1945, and education in post-unification Germany. Together, the body of work draws from a multitude of primary sources and constitutes a comprehensive analysis of educational provision in Germany over a long historical period. In addition to 16 chapters spanning Phillips’ research from 1981 to 2012, the book includes a new introduction, bringing his ideas together and demonstrating their continuing relevance to the field. Investigating Education in Germany will be invaluable reading for academics, researchers and postgraduate students in the fields of international and comparative education, German studies, history of education and sociology.
This book argues that it was primarily the encounter with totalitarianism that dissolved the ideals of American progressivism and crystallized the ideals of postwar liberalism. In politics, the ideal of governance by a strong, independent executive was rejected and a politics of contending interest groups was embraced.
considers what the STEM subjects contribute separately to the curriculum and how they relate to each other in the wider education of secondary school students describes and evaluates different curriculum models for STEM suggests ways in which a critical approach to the pedagogy of the classroom, laboratory and workshop can support and encourage all pupils to engage fully in STEM addresses the practicalities of introducing, organising and sustaining STEM-related activities in the secondary school looks to ways schools can manage and sustain STEM approaches in the long-term
Thoroughly updated to reflect the latest research, discoveries, and practices in this fast-changing field, Principles and Practice of Lymphedema Surgery, 2nd Edition, provides thorough, step-by-step guidance to incorporate or expand the treatment of lymphedema in your practice. Written and edited by world-renowned experts in the field of lymphedema and microsurgery, this highly visual reference helps deepen your understanding of each procedure and how to perform them. From preoperative assessment to postoperative care, you'll find authoritative instruction that equips you to implement the most innovative and latest surgical and nonsurgical approaches and achieve optimal outcomes for your patients. - Provides an outstanding visual introduction to lymphedema and microsurgery techniques for treatment, as well as newer surgeries and more information on all available treatment options. - Offers a step-by-step approach to each procedure, complete with tips and tricks of the trade from leading experts in plastic surgery and lymphedema microsurgery. - Features eight all-new chapters covering primary lymphedema treatment, diagnostic tools of lymphoscintigraphy and indocyanine green lymphography, and immediate lymphatic reconstruction. - Includes procedural videos of leading international experts performing advanced techniques such as end-end lymphovenous bypass, end-side lymphovenous bypass, submental vascularized lymph node flap, supraclavicular vascularized lymph node flap, and lymphatic vessel mapping with ICG. - Enables quick navigation and comprehension with an intuitive, highly templated format and abundant photographs, illustrations, tables, diagrams, and case studies throughout.
EPDF and EPUB available Open Access under CC-BY-NC-ND licence. The transition to more just and sustainable development requires radical change across a wide range of areas and particularly within the nexus between learning and work. This book takes an expansive view of vocational education and training that goes beyond the narrow focus of much of the current literature and policy debate. Drawing on case studies across rural and urban settings in Uganda and South Africa, the book offers a new way of seeing this issue through an exploration of the multiple ways in which people learn to have better livelihoods. Crucially, it explores learning that takes place informally online, within farmers’ groups, and in public and private educational institutions. Offering new insights and ways of thinking about this field, the book draws out clear implications for theory, policy and practice in Africa and beyond.
A controversial new analysis of the relationship between social democratic governments and labor. The book will make a major contribution to the comparative political economy of industrialized democracies.
David Hilfiker has committed his life, both as a writer and a doctor, to people in need, writing about the urban poor with whom he’s spent all his days for the last two decades. In Urban Injustice, he explains in beautiful and simple language how the myth that the urban poor siphon off precious government resources is contradicted by the facts, and how most programs help some of the people some of the time but are almost never sufficiently orchestrated to enable people to escape the cycle of urban poverty. Hilfiker is able to present a surprising history of poverty programs since the New Deal, and shows that many of the biggest programs were extremely successful at attaining the goals set out for them. Even so, Hilfiker reveals, most of the best and biggest programs were "social insurance" programs, like Medicare and Social Security, that primarily assisted the middle class, not the poor. Whereas, "public assistance" programs, directed specifically towards the poor, were often extremely effective as far as they went, but were instituted with far less ambitious goals. In a book that is short, sweet, and completely without academic verboseness or pretension, Hilfiker makes a clear path through the complex history of societal poverty, the obvious weaknesses and surprising strengths of societal responses to poverty thus far, and offers an analysis of models of assistance from around the world that might perhaps assist us in making a better world for our children once we decide that is what we must do.
I am unaware of any textbook which provides such comprehensive coverage of the field and doubt that this work will be surpassed in the foreseeable future, if ever!' From the foreword by Robert C. Moellering, Jr., M.D, Shields Warren-Mallinckrodt Professor of Medical Research, Harvard Medical School, USA Kucers' The Use of Antibiotics is the leading major reference work in this vast and rapidly developing field. More than doubled in length compared to the fifth edition, the sixth edition comprises 3000 pages over 2-volumes in order to cover all new and existing therapies, and emerging drugs not yet fully licensed. Concentrating on the treatment of infectious diseases, the content is divided into 4 sections: antibiotics, anti-fungal drugs, anti-parasitic drugs and anti-viral drugs, and is highly structured for ease of reference.Within each section, each chapter is structured to cover susceptibility, formulations and dosing (adult and paediatric), pharmacokinetics and pharmacodynamics, toxicity and drug distribution, detailed discussion regarding clinical uses, a feature unique to this title. Compiled by an expanded team of internationally renowned and respected editors, with a vast number of contributors spanning Europe, Africa, Asia, Australia, South America, the US and Canada, the sixth edition adopts a truly global approach. It will remain invaluable for anyone using antimicrobial agents in their clinical practice and provides in a systematic and concise manner all the information required when treating infections requiring antimicrobial therapy. Kucers' The Use of Antibiotics is available free to purchasers of the books as an electronic version on line or on your desktop: It provides access to the entire 2-volume print material It is fully searchable, so you can find the relevant information you need quickly Live references are linked to PubMed referring you to the latest journal material Customise the contents - you can highlight sections and make notes Comments can be shared with colleagues/tutors for discussion, teaching and learning The text can also be reflowed for ease of reading Text and illustrations copied will be automatically referenced to Kucers' The Use of Antibiotics
Has Marxism ceased to be part of our political present and future? Has its theory or doctrine anything to contribute to our understanding of the new millennium? In these original, commissioned essays, the contributors argue that Marxism continues as a living tradition. They show how it still engages with other theoretical positions, how it has evolved in response to both these engagements and contemporary world changes, and they assess its relevance and contribution to modern social science.
Johnny Sung and David Ashton are two of the leading scholars in the area of skills. This book combines challenging theories with cutting edge research in a way that should bring skills to life for students. I strongly recommend it for anyone researching or studying in this area. - Irena Grugulis, Leeds University Business School "A much needed contribution to the complex debate of how skills can best be utilised to enhance company performance, with particular emphasis on an innovative sectoral approach. It is a model of clarity in its presentation of the authors’ conceptual models using a historical narrative as well as comparative case studies in both the UK and Singapore." - Bert Clough, Leeds University Business School Public skills policy in most market economies in the last forty years made one repeated error, time and again. We seem to be unable to learn from those mistakes. Consistently, public policies view a wide range of economic and social issues e.g. low productivity, low-skilled jobs, low wage, inequality and in-work poverty as the consequence of skills deficits and a lack of qualifications held by individual workers. Whilst mis-diagnosing the source of the problems and failing to deliver any effective change, public skills policies continue with a policy prescription of ‘more skills’ and ‘more degrees’. If we have not solved the problems with this decade-old approach, why should the same medicine work this time? This book examines the role of public skills policy from a completely different perspective. It starts by challenging the lack of a systematic analysis of the link between skills utilisation and business strategy, and provides a new model for fresh thinking. The book extends this theoretical analysis to examine the implications for the sectoral approach to skills development as a more effective form of public skills policy. David N. Ashton is Emeritus Professor at the University of Leicester and Honorary Professor at Cardiff University. Johnny Sung is at The Institute for Adult Learning, Singapore Workforce Development Agency, Singapore.
Today’s antisemitism is difficult to recognize because it does not come dressed in a Nazi uniform and it does not openly proclaim its hatred or fear of Jews. This book looks at the kind of antisemitism which is tolerated or which goes unacknowledged in apparently democratic spaces: trade unions, churches, left-wing and liberal politics, social gatherings of the chattering classes and the seminars and journals of radical intellectuals. It analyses how criticism of Israel can mushroom into antisemitism and it looks at struggles over how antisemitism is defined. It focuses on ways in which those who raise the issue of antisemitism are often accused of doing so in bad faith in an attempt to silence or smear. Hostility to Israel has become a signifier of identity, connected to opposition to imperialism, neo-liberalism and global capitalism; the ‘community of the good’ takes on toxic ways of imagining most living Jewish people.
In one slim volume, Feldman has managed to combine a history of U.S. water policy, two in-depth case studies on the politics of water, an analysis of the institutional biases affecting U.S. water policy, and a discussion of water policy in France. Nor is that all. The opening and closing chapters of the work set this panoramic view of water policy within a normative framework derived from theorists as disparate as John Muir and John Rawls." -- Journal of Politics
The bestselling author of Grain Brain uncovers the powerful role of gut bacteria in determining your brain's destiny. Debilitating brain disorders are on the rise-from children diagnosed with autism and ADHD to adults developing dementia at younger ages than ever before. But a medical revolution is underway that can solve this problem: Astonishing new research is revealing that the health of your brain is, to an extraordinary degree, dictated by the state of your microbiome - the vast population of organisms that live in your body and outnumber your own cells ten to one. What's taking place in your intestines today is determining your risk for any number of brain-related conditions. In Brain Maker, Dr. Perlmutter explains the potent interplay between intestinal microbes and the brain, describing how the microbiome develops from birth and evolves based on lifestyle choices, how it can become "sick," and how nurturing gut health through a few easy strategies can alter your brain's destiny for the better. With simple dietary recommendations and a highly practical program of six steps to improving gut ecology, Brain Maker opens the door to unprecedented brain health potential.
The purpose of the book is to bring together in one place the different facets of regenerative biology and medicine while providing the reader with an overview of the basic and clinically-oriented research that is being done. Not only does the content cover a plethora tissues and systems, it also includes information about the developmental plasticity of adult stem cells and the regeneration of appendages.As part of its balanced presentation, Regenerative Biology and Medicine does address the biological/bioethical issues and challanges involved in the new and exciting field of regenerative biology and medicine. *Tissues covered include skin, hair, teeth, cornea, and central neural types*Systems presented are digestive, respiratory, urogenital, musculoskeletal, and cardiovascular*Includes amphibians as powerful research models*Discusses appendage regeneration in amphibians and mammals
Though Americans rarely appreciate it, federalism has profoundly shaped their nation’s past, present, and future. Federalism—the division of government authority between the national government and the states—affects the prosperity, security, and daily life of every American. In this nuanced and comprehensive overview, David Brian Robertson shows that past choices shape present circumstances, and that a deep understanding of American government, public policy, political processes, and society requires an understanding of the key steps in federalism’s evolution in American history. The most spectacular political conflicts in American history have been fought on the battlefield of federalism, including states’ rights to leave the union, government power to regulate business, and responses to the problems of race, poverty, pollution, abortion, and gay rights. Federalism helped fragment American politics, encourage innovation, foster the American market economy, and place hurdles in the way of efforts to mitigate the consequences of economic change. Federalism helped construct the path of American political development. Federalism and the Making of America is a sorely needed text that treats the politics of federalism systematically and accessibly, making it indispensible to all students and scholars of American politics. Chosen as one of Choice's Outstanding Academic Titles for 2012.
Chronicles Peter Christian Barrie's efforts to fool horse racing authorities by painting horses with henna dye to disguise good race horses as bad ones, fooling betters and fixing races.
Gerry Adams has disguised himself as a newborn baby and successfully infiltrated my family home. Eric Miller is a Belfast Loyalist. He believes his five-week old granddaughter is Gerry Adams. His family keep telling him to stop living in the past and fighting old battles that nobody cares about anymore, but his cultural heritage is under siege. He must act. David Ireland's black comedy takes one man's identity crisis to the limits as he uncovers the modern day complexity of Ulster Loyalism. Cyprus Avenue was first performed at the Abbey Theatre, Dublin in 2016, before transferring to the Royal Court Theatre, The MAC in Belfast and The Public Theater in New York.
Between 2015 and 2020 the Labour Party was riven by allegations that the party had tolerated antisemitism. For the Labour right, and some in the media, the fact that such allegations could be made was proof of a moral collapse under Jeremy Corbyn’s leadership. Sections of the left, meanwhile, sought to resist the accusations by claiming that the numbers of people accused of racism were few, that the allegations were an orchestrated attack, and that those found guilty were excluded from the party. This important book by one of Britain’s leading historians of anti- fascism gives a more detailed account than any yet published of what went wrong in Labour. Renton rejects those on the right who sought to exploit the issue for factional advantage. He also criticises those of his comrades on the left who were ignorant about what most British Jews think and demonstrated a willingness to antagonise them. This book will appeal to anyone who cares about antisemitism or left- wing politics.
Since the Personal Responsibility and Work Opportunity Reconciliation Act of 1996 was enacted, policy makers, agency administrators, community activists, and academics from a broad range of disciplines have debated and researched the implications of welfare reform in the United States. Most of the attention, however, has focused on urban rather than rural America. Welfare Reform in Persistent Rural Poverty examines welfare participants who live in chronically poor rural areas of the United States where there are few job opportunities and poor systems of education, transportation, and child care. Kathleen Pickering and her colleagues look at welfare reform as it has been experienced in four rural and impoverished regions of the United States: American Indian reservations in South Dakota, the Rio Grande region, Appalachian Kentucky, and the Mississippi Delta. Throughout these areas the rhetoric of reform created expectations of new opportunities to find decent work and receive education and training. In fact, these expectations have largely gone unfulfilled as welfare reform has failed to penetrate poor areas where low-income families remain isolated from the economic and social mainstream of American society. Welfare Reform in Persistent Rural Poverty sheds welcome light on the opportunities and challenges that welfare reform has imposed on low-income families situated in disadvantaged areas. Combining both qualitative and quantitative research, it will be an excellent guide for scholars and practitioners alike seeking to address the problem of poverty in rural America.
Written by the leading names in pediatric oncology and hematology, Nathan and Oski's Hematology and Oncology of Infancy and Childhood offers you the essential tools you need to overcome the unique challenges and complexities of childhood cancers and hematologic disorders. Meticulously updated, this exciting full-color set brings together the pathophysiology of disease with detailed clinical guidance to provide you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children. - Form a definitive diagnosis and create the best treatment plans possible with comprehensive coverage of all pediatric cancers, including less-common tumors, as well as all hematologic disorders, including newly recognized ones. - Develop a thorough, understanding of the underlying science of diseases through summaries of relevant pathophysiology balanced with clear, practical clinical guidance. Nathan and Oski's is the only comprehensive product on the market that relates pathophysiology in such depth to hematologic and oncologic diseases affecting children. - Quickly and effortlessly access the key information you need with the help of a consistent organization from chapter to chapter and from volume to volume. - Stay at the forefront of your field thanks to new and revised chapters covering topics such as paroxysmal nocturnal hemoglobinuria, lysosomal storage diseases, childhood genetic predisposition to cancer, and oncology informatics. - Learn about the latest breakthroughs in diagnosis and management, making this the most complete guide in pediatric hematology and oncology. - Discover the latest in focused molecularly targeted therapies derived from the exponential growth of knowledge about basic biology and genetics underlying the field. - Rely on it anytime, anywhere! Access the full text, images, and more at Expert Consult.
Explores workplace learning as a means of enhancing both work performance and the quality of working life. Identifies characteristics of high performance work organizations, considers the implementation of high performance work practices and investigates how far these practices are embedded in different countries. Examines ways in which public policy can be used to encourage organizations to make more effective use of the skills of their employees.
Solve your toughest neurodiagnostic challenges with Neuropathology, 3rd Edition - the most information-packed, extensively illustrated neuropathology reference available! An expert author team presents more than 3,000 high-quality images - nearly all in full color - to provide unmatched visual guidance on the microscopic and gross pathologic presentation of a full range of neurologic diseases. Diagnose with confidence by consulting the most extensive published image collection in neuropathology, which includes an exceptional number of gross pathology images, a feature poorly represented in other texts. Access the complete contents online and download all the images at www.expertconsult.com. Understand the most recent developments in neurologic diseases and quickly identify important variants and outliers. Meet the needs of an aging population with expanded coverage of Alzheimer's and Parkinson's disease, motor neuron disorders, and prion diseases, as well as conditions such as multiple sclerosis. Apply the latest knowledge on molecular genetics and the growing role of genetic testing. Make optimal use of today’s functional imaging techniques with new information on PET, fMRI, and SPECT. Stay current with the newest diagnostic protocols and guidelines as endorsed by professional societies and national bodies, the most recent WHO classification of central nervous system diseases, and checklists for the handling and diagnosis of CNS tumors and tumor-like lesions. Get outstanding visual guidance with new full-color images, and new and updated drawings that clarify complex entities and concepts.
**Selected for Doody's Core Titles® 2024 in Trauma Surgery** Describing the diagnosis and management of maxillofacial and associated traumatic injuries step by step, Oral and Maxillofacial Trauma, 4th Edition takes you beyond the surgical management of head and neck trauma to cover the general management of traumatic injuries, systemic evaluation of the trauma patient, and special considerations associated with maxillofacial trauma patient care. New to this edition are over 700 full-color illustrations showing details of traumatic injuries and their treatment. Edited by head and neck trauma expert Dr. Raymond J. Fonseca, along with over 80 highly respected contributors, this comprehensive reference provides all of the information you need to offer the best care possible to maxillofacial trauma patients. - One-of-a-kind, comprehensive chapters cover current research literature with topics including advances in maxillofacial trauma surgery, nonpenetrating chest trauma, metabolic response to trauma, maxillofacial prosthetics, and the societal impact of maxillofacial trauma. - Coverage of emerging topics includes firearm injuries, neurologic injuries (the leading cause of death from trauma), wound healing, airway management, shock, and nasal fractures, so you can work confidently with team members from other disciplines such as neurologists, anesthesiologists, and orthopedists. - Over 80 expert contributors represent the specialties of oral and maxillofacial surgery, anesthesiology, and otolaryngology. - UPDATED content reflects current thinking and the latest techniques in the management of traumatic injuries. - NEW full-color illustrations and design highlight clinical areas and show details of injuries and their treatment. - NEW! Streamlined, single-volume format makes information easier to access and the book easier to carry.
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