I’Ve live in an astornshingly complex world, Yet what we do in our everyday lives seems simple enough. Most of us conform to society’s rules, pursue familiar strategies, and achieve reasonably predictable outcomes. In our role as economic agents, we simply peddle our wares and earn our daily bread as best we can.So where on earth does this astonishing complexity come from? Much of it is ubiquitous in nature, to be sure, but part of it lies within and between us. Part of it comes from those games of interaction that humans play—games against nature, games against each other, games of competition, games of cooperation. In bygone eras, people simply hunted and gathered to come up with dinner. Today you can find theoretical economists scratching mysterious equations on whiteboards (not even blackboards) and getting paid to do this. In the modern economy, most of us make our living in a niche created for us by what others do. Because we’ve become more dependent on each other, our economy as a whole has become more strongly interactive.
6. 2 Basic Model Characteristics 185 6. 3 A Closed Model Approach to Interregional Estimation 189 7 Towards an Integrated System of Models for National and Regional Development 205 7. 1 Introduction 205 7. 2 In Search of a Framework for Integration 207 7. 3 National Development Scenarios 222 7. 4 The National-Regional Interlace 231 7. 5 Regional Development Scenarios 236 7. 6 Concluding Remarks 244 Appendixes 253 A Basic Microstate Descriptions 253 B Incomplete Prior Information: A Simple Example 257 C Computing Capital Coefficients and Turnpike Solutions: The DYNIO Package 259 D Minimizing Information Losses in Simple Aggregation: Two Test Problems 274 E Computing Interregional and Intersectoral Flows: 276 References 287 Index 305 vi LIST OF FIGURES 1. 1 A Three-Dimensional Guide to Later Chapters 12 2. 1 Historical Development of the Entropy Concept 32 2. 2 Selected Applications of Information Theory to Input-Output Analysis and Interaction Modelling 48 3. 1 The Bose-Einstein Analogy 58 5. 1 The Dog-Leg Input-Output Table 159 7. 1 A General Multilevel Social System 219 7. 2 The Hierarchical System of Models 219 7. 3 Choice of Production Techniques 230 7. 4 The National-Regional Interface 235 7. 5 A Sequential Compromise Procedure 243 7. 6 The Integrated Modelling System 246 vii LIST OF TABLES 3. 1 Production-Constrained Microstate Descriptions 59 3. 2 Production-Constrained Entropy Formulae 62 3. 3 Production-Constrained Solutions 65 3. 4 Doubly-Constrained Solutions 73 4. 1 The Static Input-Output Table 85 4.
While much of the transportation systems in Europe and the United States are mature (if not senescent), the rest of the world is still planning, developing, and deploying new systems. The accomplishments and mistakes of places like the United Kingdom and the United States, then, can teach us lessons that may be applied to places where transportation remains nascent or adolescent. The Transportation Experience seeks to understand the genesis of transportation policy in America and the UK, along with the roles that this policy plays as systems are innovated, deployed, and reach maturity, and how policies might be improved.
The few reported controlled studies show that bilateral stimulation of the globus pallidus interna (GPi) is a safe and effective long-term treatment for hyperkinetic disorders. However, the recently published data on deep brain stimulation (DBS) applied to different targets or patients (especially those with secondary dystonia) are mainly uncontrolled case reports, precluding a clear determination of its efficacy, and providing little guidance as to the choice of a “good” target in a “good” patient. This chapter reviews the literature on DBS in primary dystonia, paying particular attention to the risk:benefit ratio in focal and segmental dystonias (cervical dystonia, cranial dystonia) and to the predictive factors for a good outcome. The chapter also highlights recent data on the marked benefits of the technique in myoclonus dystonia (in which pallidal, as opposed to thalamic, stimulation is more effective) and in tardive dystonia–dyskinesia. Although, the decision to treat appears relatively straightforward in patients with primary dystonia, myoclonus–dystonia, and tardive dystonia who have a normal findings on magnetic resonance imaging and normal cognitive function, there are still no reliable tools to help predict the timescale of postoperative benefit. This chapter provides a comprehensive analysis of the use of the treatment in various types of secondary dystonia, with little to moderate benefit in most cases, based on single cases or small series. Beyond the reduction in the severity of dystonia, the global motor and functional outcome is difficult to determine owing to the paucity of adequate evaluation tools. Because of the large interpatient variability, different targets may be effective depending on the symptoms in each individual.
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