Cancer Therapy with Radiolabeled Antibodies explores the most current experimental and clinical advances in the newly emerging field of cancer radioimmunotherapy (RAIT). Providing a multidisciplinary and international context, some of the world's leading experts examine the problems and prospects of RAIT from radiation, immunological, chemical, physical, physiological, and clinical perspectives with both overviews and original research. Discussions cover the up-to-date clinical results in the RAIT of ovarian, breast, colorectal, and brain cancers, as well as the current status of RAIT in the management of B cell lymphomas. Radiobiology, dosimetry, radiochemistry, targeting biology in experimental models, clinical experiences in hematopoietic and solid tumors, and new approaches to improve cancer radioimmunotherapy are also discussed. In addition, new dosimetry concepts, new labeling methods, new concepts of antibody pharmacokinetics, and new methods to enhance selective cancer radioimmunotherapy are included.
Capital, Labor, and State is a systematic and thorough examination of American labor policy from the Civil War to the New Deal. David Brian Robertson skillfully demonstrates that although most industrializing nations began to limit employer freedom and regulate labor conditions in the 1900s, the United States continued to allow total employer discretion in decisions concerning hiring, firing, and workplace conditions. Robertson argues that the American constitution made it much more difficult for the American Federation of Labor, government, and business to cooperate for mutual gain as extensively as their counterparts abroad, so that even at the height of New Deal, American labor market policy remained a patchwork of limited protections, uneven laws, and poor enforcement, lacking basic national standards even for child labor.
Examining the area of Nubia and Sudan from the prehistoric to the nineteenth century AD, this is an exceptional study of the area's archaeology and history. The first major work in its field for over thirty years, this is a must for course students.
This book gives an overview of research on graphs associated with commutative rings. The study of the connections between algebraic structures and certain graphs, especially finite groups and their Cayley graphs, is a classical subject which has attracted a lot of interest. More recently, attention has focused on graphs constructed from commutative rings, a field of study which has generated an extensive amount of research over the last three decades. The aim of this text is to consolidate this large body of work into a single volume, with the intention of encouraging interdisciplinary research between algebraists and graph theorists, using the tools of one subject to solve the problems of the other. The topics covered include the graphical and topological properties of zero-divisor graphs, total graphs and their transformations, and other graphs associated with rings. The book will be of interest to researchers in commutative algebra and graph theory and anyone interested in learning about the connections between these two subjects.
This acclaimed text promotes healthy aging by demonstrating how health practitioners, program developers, and policymakers can prevent or manage disease and make large-scale improvements toward health and wellness in the older adult population. The eighth edition encompasses major new research that substantially updates previous recommendations. It provides important new content on Medicare, Medicaid, Social Security and the ACA; clinical preventive services; global aging; sexual health; saving for retirement; long-term care alternatives; and much more. Accessible and comprehensive, this text is supported by abundant tables, figures, and illustrations. It describes practical strategies—including model community and government initiatives—that have proven markedly successful, as well as health-promotion tools, resource lists, assessment tools, and checklists. New trends such as green burials, LGBT aging, yoga, and dancing exercise regimens are also covered. Additionally, each chapter features key terms, learning objectives, summary, and thought-provoking questions. An improved instructor package includes upgraded PowerPoints, a new test bank, sample syllabi, chapter summaries, discussion questions, chapter exams, and more. Purchase includes access to the ebook for use on most mobile devices or computers. New to the Eighth Edition: Updated research findings, demographics, figures, and statistics regarding health/social/medicaltrends/exercise/weight management New content on global aging, sexual health, and substance abuse New information on medical screening recommendations, cancer treatments, complementary and alternative medicine, and more New findings regarding mental health and older adults Significant updates to Medicare, Medicaid, Social Security, and the ACA Expanded section on global health and older adults Upgraded instructor support package Key Features: Provides an interdisciplinary view of how practitioners, program developers, and policymakers can improve health and wellness in older adults Describes successful community and government model programs and initiatives Delivers health-promoting tools, resource lists, checklists, and assessment tools Offers key terms, learning objectives, critical-thinking questions and reflection boxes Includes a robust instructor package
Mammals of Africa (MoA) is a series of six volumes which describes, in detail, every currently recognized species of African land mammal. This is the first time that such extensive coverage has ever been attempted, and the volumes incorporate the very latest information and detailed discussion of the morphology, distribution, biology and evolution (including reference to fossil and molecular data) of Africa's mammals. With 1,160 species and 16 orders, Africa has the greatest diversity and abundance of mammals in the world. The reasons for this and the mechanisms behind their evolution are given special attention in the series. Each volume follows the same format, with detailed profiles of every species and higher taxa. The series includes some 660 colour illustrations by Jonathan Kingdon and his many drawings highlight details of morphology and behaviour of the species concerned. Diagrams, schematic details and line drawings of skulls and jaws are by Jonathan Kingdon and Meredith Happold. Every species also includes a detailed distribution map. Extensive references alert readers to more detailed information. Volume I: Introductory Chapters and Afrotheria (352 pages) Volume II: Primates (560 pages) Volume III: Rodents, Hares and Rabbits (784 pages) Volume IV: Hedgehogs, Shrews and Bats (800 pages) Volume V: Carnivores, Pangolins, Equids and Rhinoceroses (560 pages) Volume VI: Pigs, Hippopotamuses, Chevrotain, Giraffes, Deer and Bovids (704 pages)
This book compiles and integrates highly innovative work aimed at bridging the fields of anthropology and consumer behavior." —Journal of Consumer Affairs " . . . fascinating . . . ambitious and interesting . . . " —Canadian Advertising Foundation Newsletter " . . . an anthropological dig into consumerism brimming with original thought . . . " —The Globe and Mail "Grant McCracken has written a provocative book that puts consumerism in its place in Western society—at the centre." —Report on Business Magazine " . . . a stimulating addition to knowledge and theory about the interrelationship of culture and consumption." —Choice "[McCracken's] synthesis of anthropological and consumer studies material will give historians new ideas and methods to integrate into their thinking." —Maryland Historian "The book offers a fresh and much needed cultural interpretation of consumption." —Journal of Consumer Policy "The volume will help balance the prevailing cognitive and social psychological cast of consumer research and should stimulate more comprehensive investigation into consumer behavior." —Journal of Marketing Research " . . . broad scope, enthusiasm and imagination . . . a significant contribution to the literature on consumption history, consumer behavior, and American material culture." —Winterhur Portfolio "For this is a superb book, a definitive exploration of its subject that makes use of the full range of available literature." —American Journal of Sociology "McCracken's book is a fine synthesis of a new current of thought that strives to create an interdisciplinary social science of consumption behaviors, a current to which folklorists have much to contribute." —Journal of American Folklore This provocative book takes a refreshing new view of the culture of consumption. McCracken examines the interplay of culture and consumer behavior from the anthropologist's point of view and provides new insights into the way we view ourselves and our society.
Covering the full spectrum of rehabilitation after traumatic brain injury, this practical reference by Drs. Blessen C. Eapen and David X. Cifu presents best practices and considerations for numerous patient populations and their unique needs. In an easy-to-read, concise format, it covers the key information you need to guide your treatment plans and help patients relearn critical life skills and regain their independence. - Covers neuroimaging, neurosurgical and critical care management, management of associated complications after TBI, pharmacotherapy, pain management, sports concussion, assistive technologies, and preparing patients for community reintegration. - Discusses special populations, including pediatric, geriatric, and military and veteran patients. - Consolidates today's available information and guidance in this challenging and diverse area into one convenient resource.
Only 15 years ago a conference on dietary fiber, let alone an international conference, would have been considered an extremely unlikely, and in fact an unthinkable, event. Yet in recent years a number of such conferences have taken place at the international level and in different parts of the world; the conference of which the present volume is an outgrowth is the second to have been held in Washington, D. C. This extraordinary development of interest in a hitherto largely neglected component of diet has been reflected by a veritable explosion of scientific literature, with published articles increasing 40-fold, from around ten to over 400 per year, within the decade 1968-1978. Not only has the growth of interest in and knowledge of fiber made it perhaps the most rapidly developing aspect of nutritional science in recent history if not in all time, but epidemiologic studies relating fiber intake to disease patterns, subsequently broadened to include other food components, have been largely responsible for the current concept of diseases characteristic of modern Western culture and lifestyle. The potential importance of this realization is forcefully underlined by the considered judgment of Thomas MacKeown, epidemiologist and medical historian of Birmingham University, England.
David W. Krueger illustrates a novel synthesis of fundamental psychodynamic principles with evolving advances in developmental, self, neuropsychological, and attachment theories. Focusing on action symptoms, self object experiences, gender issues, embodiment, somatic symptoms, affect regulation, and ego states, the theoretical innovations are illustrated by vivid case material. He introduces treatment inroads enabling clinicians to hear and articulate arcane messages spoken in metaphor, actualized in symptoms, and encrypted in the body. A fresh conceptualization from an original thinker, Integrating Body Self and Psychological Self broadens our understanding of the mind and body interplay in the clinical exchange.
John Muir called it the "Range of Light, the most divinely beautiful of all the mountain chains I’ve ever seen." The Sierra Nevada—a single unbroken mountain range stretching north to south over four hundred miles, best understood as a single ecosystem but embracing a number of environmental communities—has been the site of human activity for millennia. From the efforts of ancient Native Americans to encourage game animals by burning brush to create meadows to the burgeoning resort and residential development of the present, the Sierra has endured, and often suffered from, the efforts of humans to exploit its bountiful resources for their own benefit. Historian David Beesley examines the history of the Sierra Nevada from earliest times, beginning with a comprehensive discussion of the geologic development of the range and its various ecological communities. Using a wide range of sources, including the records of explorers and early settlers, scientific and government documents, and newspaper reports, Beesley offers a lively and informed account of the history, environmental challenges, and political controversies that lie behind the breathtaking scenery of the Sierra. Among the highlights are discussions of the impact of the Gold Rush and later mining efforts, as well as the supporting industries that mining spawned, including logging, grazing, water-resource development, market hunting, urbanization, and transportation; the politics and emotions surrounding the establishment of Yosemite and other state and national parks; the transformation of the Hetch Hetchy into a reservoir and the desertification of the once-lush Owens Valley; the roles of the Forest Service, Park Service, and other regulatory agencies; the consequences of the fateful commitment to wildfire suppression in Sierran forests; and the ever-growing impact of tourism and recreational use. Through Beesley’s wide-ranging discussion, John Muir’s "divinely beautiful" range is revealed in all its natural and economic complexity, a place that at the beginning of the twenty-first century is in grave danger of being loved to death. Available in hardcover and paperback.
In March 1983, as the world’s superpowers continued aggressively stockpiling nuclear weapons, President Ronald Reagan described his vision for a world no longer confronted with the concept of mutually assured destruction. A year later the Strategic Defense Initiative was established, followed soon after by the creation of the Strategic Defense Initiative Organization (SDIO). The SDIO was tasked with the development and coordination of missile technologies designed for the strategic defense against civilization’s most dangerous invention, one that carried with it the threat of nuclear destruction—intercontinental ballistic missiles. In The Last Thirty Seconds: A Brief History of the Evolution of Hit-to-Kill Technology, David K. Stumpf details the development of one of many possible solutions for ballistic missile defense commonly known as hit-to-kill. Hit-to-kill is a nonnuclear technique using kinetic energy, rather than explosives, to destroy reentry vehicles carrying chemical, biological, or nuclear warheads. It is the centerpiece of the United States’ current ballistic missile defense systems and has proven invaluable in the conflict between Ukraine and Russia as well as in the ongoing conflict with the Houthi rebels in the Red Sea. While much of the subject remains classified, this detailed study will be welcomed for its substantial references and the inclusion of newly declassified material.
Stephen Shortell, one of the country's leading health care management authorities, and his team of experts use the most current data available to update their classic book Remaking Health Care in America. This expanded second edition includes a clear conceptual framework for health care leaders who must develop more integrative systems of care to meet the challenge of the evolving health care industry. The book also provides practical suggestions and myriad recommAndations for developing cost-effective delivery systems across the United States.
The discipline of silviculture is at a crossroads. Silviculturists are under increasing pressure to develop practices that sustain the full function and dynamics of forested ecosystems and maintain ecosystem diversity and resilience while still providing needed wood products. A Critique of Silviculture offers a penetrating look at the current state of the field and provides suggestions for its future development. The book includes an overview of the historical developments of silvicultural techniques and describes how these developments are best understood in their contemporary philosophical, social, and ecological contexts. It also explains how the traditional strengths of silviculture are becoming limitations as society demands a varied set of benefits from forests and as we learn more about the importance of diversity on ecosystem functions and processes. The authors go on to explain how other fields, specifically ecology and complexity science, have developed in attempts to understand the diversity of nature and the variability and heterogeneity of ecosystems. The authors suggest that ideas and approaches from these fields could offer a road map to a new philosophical and practical approach that endorses managing forests as complex adaptive systems. A Critique of Silviculture bridges a gap between silviculture and ecology that has long hindered the adoption of new ideas. It breaks the mold of disciplinary thinking by directly linking new ideas and findings in ecology and complexity science to the field of silviculture. This is a critically important book that is essential reading for anyone involved with forest ecology, forestry, silviculture, or the management of forested ecosystems.
This book focusses on ground stone tools, stone vessels, and devices carved into rock across the Near East and Egypt from prehistory to the later periods. The aim is to explore all aspects of these tools and stimulate a debate about new methodologies to approach this material.
**Selected for Doody's Core Titles® 2024 with "Essential Purchase" designation in Pediatric Surgery** Now in brilliant full color and reflecting recent significant changes in the field, Critical Heart Disease in Infants and Children, 3rd Edition, keeps you abreast of the skills and knowledge required to safely care for children with congenital and acquired heart disease in the ICU. Pediatric intensivists, cardiologists, cardiac surgeons, and anesthesiologists from leading centers around the world provide a well-rounded perspective on basic scientific principles, medical and pharmacologic treatments, surgical techniques, and equipment. - Features comprehensive updates throughout the text, including indications, techniques, potential complications in perioperative management of patients, and surgical techniques for congenital heart disease. - Covers recent advances in the treatment of pulmonary hypertension, developments in mechanical assist devices, heart and lung transplantation, and interventional cardiac catheterization. - Features an all-new, full-color format that speeds navigation and helps clarify complex concepts. - Contains 27 new chapters with an emphasis on the team approach to patient care in the ICU including creating multidisciplinary teams, quality and performance improvement, training , and challenges and solutions to developing a cohesive team environment. - Includes a detailed chapter on bedside ultrasound, walking you through the techniques you're most likely to encounter in the ICU. - Employs well-documented tables, text boxes, and algorithms to make clinical information easy to access, and more than two dozen video clips provide a more complete understanding of echocardiography, imaging modalities, pulmonary hypertension, and more. - Describes the basic pharmacology and clinical applications of new pharmacologic agents. - Examines issues affecting adults with congenital heart disease. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices. - Offers four completely new chapters: Cardiac Trauma, Congenital Heart Disease in the Adult, Congenitally Corrected Transposition of the Great Arteries, and Outcome Evaluation. - Describes the basic pharmacology and clinical applications of all of the new pharmacologic agents. - Details important refinements and developments in surgical techniques, including the Ross pulmonary autograft replacement of the aortic valve, video-assisted fluoroscopy, and the extracardiac Fontan connection, and discusses their indications and potential complications. - Explores the latest advances in the treatment of pulmonary hypertension, new developments in mechanical assist devices, heart and lung transplantation, and interventional cardiac catheterization. - Examines issues affecting adults with congenital heart disease.
This book brings together the work of scholars from England, France, Germany, Sweden, and the United States to examine the ways in which industrialized nations have used and are developing tax laws to help alleviate environmental problems. For each country, the contributors offer a thorough review of existing and proposed initiatives and an in-depth evaluation of their effectiveness. They also discuss the theoretical framework behind environmental tax initiatives, explain alternative systems to taxation, reveal problems in dealing with environmental concerns that are common to all of the countries studied, and suggest ways to more efficiently coordinate tax and environmental policies. Based on their research, the contributors conclude that the general tax systems of the United States and other countries unintentionally conflict with environmental policies and that no country has yet been able to adequately control automobile pollution, although some have had varying degrees of success in other areas. The volume begins with an introduction that presents a nontechnical discussion of the current economic thinking on environmental taxes and alternatives such as direct government regulation and granting polluters limited or tradable rights to pollute. The following chapters discuss each country in turn. Each chapter first examines the institutional framework of the country--central versus regional government, how legislation is enacted and executed, the distribution of authority over environmental matters, and important environmental policy goals. Next, the compatability of the tax system with environmental goals is analyzed. Finally, there is a thorough treatment of that country's environmental tax initiatives, including an in-depth assessment of their relative success or failure. Policymakers, lobbyists, economists, and attorneys will find Taxation for Environmental Protection enlightening reading.
The era of seemingly unlimited growth in processor performance is over: single chip architectures can no longer overcome the performance limitations imposed by the power they consume and the heat they generate. Today, Intel and other semiconductor firms are abandoning the single fast processor model in favor of multi-core microprocessors--chips that combine two or more processors in a single package. In the fourth edition of Computer Architecture, the authors focus on this historic shift, increasing their coverage of multiprocessors and exploring the most effective ways of achieving parallelism as the key to unlocking the power of multiple processor architectures. Additionally, the new edition has expanded and updated coverage of design topics beyond processor performance, including power, reliability, availability, and dependability. CD System Requirements PDF Viewer The CD material includes PDF documents that you can read with a PDF viewer such as Adobe, Acrobat or Adobe Reader. Recent versions of Adobe Reader for some platforms are included on the CD. HTML Browser The navigation framework on this CD is delivered in HTML and JavaScript. It is recommended that you install the latest version of your favorite HTML browser to view this CD. The content has been verified under Windows XP with the following browsers: Internet Explorer 6.0, Firefox 1.5; under Mac OS X (Panther) with the following browsers: Internet Explorer 5.2, Firefox 1.0.6, Safari 1.3; and under Mandriva Linux 2006 with the following browsers: Firefox 1.0.6, Konqueror 3.4.2, Mozilla 1.7.11. The content is designed to be viewed in a browser window that is at least 720 pixels wide. You may find the content does not display well if your display is not set to at least 1024x768 pixel resolution. Operating System This CD can be used under any operating system that includes an HTML browser and a PDF viewer. This includes Windows, Mac OS, and most Linux and Unix systems. Increased coverage on achieving parallelism with multiprocessors. Case studies of latest technology from industry including the Sun Niagara Multiprocessor, AMD Opteron, and Pentium 4. Three review appendices, included in the printed volume, review the basic and intermediate principles the main text relies upon. Eight reference appendices, collected on the CD, cover a range of topics including specific architectures, embedded systems, application specific processors--some guest authored by subject experts.
Winner, ISHS Annual Award for a Scholarly Publication, 2017 Fort de Chartres, built in 1719-1720 in the heart of what would become the American Midwest, embodied French colonial power for half a century. Lives of Fort de Chartres, by David MacDonald, details the French colonial experience in Illinois from 1720 to 1770 through vivid depictions of the places, people, and events around the fort and its neighboring villages. In the first section, MacDonald explores the fascinating history of French Illinois and the role of Fort de Chartres in this history, focusing on native peoples, settlers, slaves, soldiers, villages, trade routes, military administration, and the decline of French rule in Illinois. The second section profiles the fort’s twelve distinctive and often colorful commandants, who also served as administrative heads of French Illinois. These men’s strong personalities served them well when dealing simultaneously with troops, civilians, and Indians and their multifaceted cultures. In the third section, MacDonald presents ten thought-provoking biographies of people whose lives intersected with Fort de Chartres in various ways, from a Kaskaskia Indian woman known as “the Mother of French Illinois” to an ill-fated chicken thief and a European aristocrat. Subjects treated in the book include French–Native American relations, the fur trade, early Illinois agriculture, and tensions among different religious orders. Together, the biographies and historical narrative in the volume illuminate the challenges that shaped the French colonies in America. The site of Fort de Chartres, recognized as a National Historic Landmark in 1966, still exists today as a testament to the ways in which French, British, Spanish, and American histories have intertwined. Both informative and entertaining, Lives of Fort de Chartres contributes to a more complete understanding of the French colonial experience in the Midwest and portrays a vital and vigorous community well worth our appreciation.
Design and implement a rehab program on your own with Pathology and Intervention in Musculoskeletal Rehabilitation, 2nd Edition. Part of Magee's popular Musculoskeletal Rehabilitation Series, this pathology text for physical therapists provides clear guidance on patient management relative to specific musculoskeletal pathology, injury, and illness - all based on a sound understanding of basic science and principles of practice. It focuses on the specific pathologies most often seen in the clinic, and discusses the best methods for intervention for the different areas of the body in the context of the tissue-healing model. Each intervention features a rationale, along with the pathology and problem presented; stage of healing; evidence in the literature; and clinical reasoning considerations. Dedicated and focused information on the specific pathologies most often seen in the clinic, as well as the best methods for intervention for the different areas of the body, minimizes duplication of information by referring you to other titles in the Musculoskeletal Rehabilitation Series for basic scientific information regarding inflammation, healing, tissue deformation, and the development of muscular strength and endurance. Trusted experts in musculoskeletal rehabilitation, along with internationally recognized contributors, present the best evidence behind contemporary interventions directed toward the treatment of the impairments and functional limitations associated with acute, chronic, and congenital musculoskeletal conditions occurring across the lifespan. Evidence-based content, with over 4,000 references, supports the scientific principles for rehabilitation interventions, providing the best evidence for the management of musculoskeletal pathology and injury. NEW! The Skin and Wound Healing chapter looks at the numerous tools available to assist in objectively monitoring and treating a patient with an acute or chronic wound. NEW! Rotator Cuff Pathology chapter highlights the anatomy, function, and etiology of the rotary cuff, and addresses rotary cuff injuries, physical examination, and non-operative and operative treatment. UPDATED! Substantially revised chapter on the Thoracic Ring ApproachT facilitates clinical reasoning for the treatment of the thoracic spine and ribs through the assessment and treatment of thoracic spine disorders and how they relate to the whole kinetic chain. UPDATED! Revised Lumbar Spine - Treatment of Motor Control Disorders chapter explores some of the research evidence and clinical reasoning pertaining to instability of the lumbar spine so you can better organize your knowledge for immediate use in the clinical setting. UPDATED! Significantly revised chapter on the treatment of pelvic pain and dysfunction presents an overview of specific pathologies pertaining to the various systems of the pelvis - and highlights how "The Integrated Systems Model for Disability and Pain" facilitates evidence-based management of the often complex patient with pelvic pain and dysfunction. NEW! Musculoskeletal Bone and Soft Tissue Tumors chapter covers common bones tumors, anatomic considerations and rehabilitation, pediatric patients, and amputation related to cancer. UPDATED! Thoroughly revised chapters with additional references ensure you get the most recent evidence and information available. NEW! Full color design and illustration program reflects what you see in the physical world to help you recognize and understand concepts more quickly.
The new fifth edition of Ecotourism focuses on an array of economic, social and ecological inconsistencies that continue to plague ecotourism in theory and practice, and examines the sector in reference to other related forms of tourism, impacts, conservation, sustainability, education and interpretation, policy and governance, and the ethical imperative of ecotourism as these apply to the world’s greenest form of tourism. Building on the success of prior editions, the text has been revised throughout to incorporate recent research, including ecotourism taking place in under-represented world regions. It includes new case studies on important themes in research and practice as well as learning objectives in each chapter. David Fennell provides an authoritative and comprehensive review of the most important issues, including climate change and UN Sustainable Development Goals. Ecotourism continues to be embraced as the antithesis of mass tourism because of its promise of achieving sustainability through conservation mindedness, community development, education and learning, and the promotion of nature-based activities that are sensitive to both ecological and social systems. The book debates to what extent this promise has been realised. An essential reference for those interested in ecotourism, the book is accessible to students, but retains the depth required for use by researchers and practitioners in the field. This book will be of interest to students across a range of disciplines including geography, economics, business, ethics, biology, and environmental studies.
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