An expert guide to targeting protein kinases in cancer therapy Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells. Because of this fact, pharmaceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal roadblocks to sever their malignant means of communication. Complete with full-color presentations, Targeting Protein Kinases for Cancer Therapy defines the structural features of protein kinases and examines their cellular functions. Combining kinase biology with chemistry and pharmacology applications, this book enlists emerging data to drive the discovery of new cancer-fighting drugs. Valuable information includes: Comprehensive overviews of the major kinase families involved in oncology, integrating protein structure and function, and providing important tools to assist pharmaceutical researchers to understand and work in this dynamic area of cancer drug research Focus on small molecule inhibitors as well as other therapeutic modalities Discussion of kinase inhibitors that have entered clinical trials for the treatment of cancer, with an emphasis on molecules that have progressed to late stage clinical trials and, in a few cases, to market Providing a platform for further study, this important work reviews both the successes and challenges of kinase inhibitor therapy, and provides insight into future directions in the war against cancer.
Health Psychology students will need to understand how to evaluate and critically-appraise the latest theory and research before it can be applied. This fully-revised and updated fourth edition takes a critical approach and places Health Psychology in a real-world context, enabling students to understand how public policy, theory and research can influence communities and individuals alike. The new edition includes: A new chapter on diet and obesity Updated material on stress and coping, doctor-patient communication, death, dying, bereavement and quality of life Introductions to the social, political and economic conditions that influence our health Breadth of coverage from social inequality through to chronic illness and screening An enhanced SAGE edge™ companion website (edge.sagepub.com/marks4e) with a suite of features to enhance students' learning experience.
The standard reference in the field, this acclaimed work synthesizes findings from hundreds of carefully selected studies of mental health treatments for children and adolescents. Chapters on frequently encountered clinical problems systematically review the available data, identify gaps in what is known, and spell out recommendations for evidence-based practice. The authors draw on extensive clinical experience as well as research expertise. Showcasing the most effective psychosocial and pharmacological interventions for young patients, they also address challenges in translating research into real-world clinical practice. New to This Edition *Incorporates over a decade of research advances and evolving models of evidence-based care. *New chapter topic: child maltreatment. *Separate chapters on self-injurious behavior, eating disorders, and substance use disorders (previously covered in a single chapter on self-harming disorders). *Expanded chapters on depression, anxiety, and conduct disorder. *Includes reviews of the burgeoning range of manualized psychosocial "treatment packages" for children.
The standard reference in the field, this acclaimed work synthesizes findings from hundreds of carefully selected studies of mental health treatments for children and adolescents. Chapters on frequently encountered clinical problems systematically review the available data, identify gaps in what is known, and spell out recommendations for evidence-based practice. The authors draw on extensive clinical experience as well as research expertise. Showcasing the most effective psychosocial and pharmacological interventions for young patients, they also address challenges in translating research into real-world clinical practice. New to This Edition *Incorporates over a decade of research advances and evolving models of evidence-based care. *New chapter topic: child maltreatment. *Separate chapters on self-injurious behavior, eating disorders, and substance use disorders (previously covered in a single chapter on self-harming disorders). *Expanded chapters on depression, anxiety, and conduct disorder. *Includes reviews of the burgeoning range of manualized psychosocial "treatment packages" for children.
As their argument unfolds, the authors reveal that memories do not solely reside in a linear passage of time, linking past, present and future, nor do they soley rest within the individual's conciousness, but that memory sits at the very heart of 'lived experience'; whether collective or individual, the vehicle for how we remember or forget is linked to social interaction, object interaction and the different durations of living that we all have. It is very much connected to the social psychology of experience.
Success in Accounting begins here! The technical details you need to know and decision-making processes you need to understand, with plain-language explanations and unlimited practice. Financial Accounting is an engaging resource that focuses on current accounting theory and practice in Australia, within a business context. It emphasises how financial decision-making is based on accurate and complete accounting information and uses case studies to illustrate this in a practical way. The new 7th edition is accurate and up to date, guided by extensive technical review feedback and incorporating the latest Australian Accounting Standards. It also provides updated coverage of some of the most significant current issues in accounting such as ethics, information systems and sustainability.
A lushly illustrated, magisterial exploration of the imaginative truth of the gospel In the modern academy, truth and imagination are thought to be mutually exclusive. But what if truth can spring from other fonts, like art, literature, and invention? The legacy of the Enlightenment favors historical and empirical inquiry above all other methods for searching for truth. But this assumption stymies our theological explorations. Though the historicity of Jesus’s life, death, and resurrection is important, it is not of sole importance. For instance, is John’s Gospel any less “true” than the Synoptics just because it’s less historically accurate? David Brown challenges us to expand our understanding of the gospel past source criticism and historical Jesus studies to include works of imagination. Reading Scripture in tandem with works of art throughout the centuries, Brown reenvisions the gospel as an open text. Scholars of theology and biblical studies, freed from literalism, will find new avenues of revelation in Gospel as Work of Art. This volume includes over one hundred color illustrations.
In one slim volume, Feldman has managed to combine a history of U.S. water policy, two in-depth case studies on the politics of water, an analysis of the institutional biases affecting U.S. water policy, and a discussion of water policy in France. Nor is that all. The opening and closing chapters of the work set this panoramic view of water policy within a normative framework derived from theorists as disparate as John Muir and John Rawls." -- Journal of Politics
What are the various forces influencing the role of the prison in late modern societies? What changes have there been in penality and use of the prison over the past 40 years that have led to the re-valorization of the prison? Using penal culture as a conceptual and theoretical vehicle, and Australia as a case study, this book analyses international developments in penality and imprisonment. Authored by some of Australia’s leading penal theorists, the book examines the historical and contemporary influences on the use of the prison, with analyses of colonialism, post colonialism, race, and what they term the ’penal/colonial complex,’ in the construction of imprisonment rates and on the development of the phenomenon of hyperincarceration. The authors develop penal culture as an explanatory framework for continuity, change and difference in prisons and the nature of contested penal expansionism. The influence of transformative concepts such as ’risk management’, ’the therapeutic prison’, and ’preventative detention’ are explored as aspects of penal culture. Processes of normalization, transmission and reproduction of penal culture are seen throughout the social realm. Comparative, contemporary and historical in its approach, the book provides a new analysis of penality in the 21st century.
Brain-Gut Interactions serves as a reference source and stimulus for expanded research efforts aimed at unravelling the pathophysiology of brain-gut interactions. Within the general framework of brain-gut interactions, it covers the various areas in which this growing interdisciplinary field has evolved. Topics discussed in this volume include the topography and morphology of afferent and efferent connections between the gut and the medulla and hypothalamic nuclei, the role of afferent and efferent pathways in the regulation of gastrointestinal function, the brain's regulation of gastrointestinal secretory and motor function, and the function of peripheral and central cholecystokinin in the mechanisms of satiety. The final section of this book focuses on topics such as stress, emesis, visceral pain, and brain-related disorders of the intestine based on experimental and clinical data. Students and investigators working with brain-gut interactions, gastroenterologists, psychologists, and psychiatrists will find this book to be an essential reference resource.
An Atlas of Northamptonshire presents an historical atlas of the greater part of Northamptonshire (the first quarter having been published as An Atlas of Rockingham Forest). It presents in map form the results of fieldwork and documentary research undertaken since the mid-1960s to map the landscape of the whole of Northamptonshire prior to enclosure by Parliamentary Act. This is the first time a whole county has been completely studied in this way, and the first time a whole county has had an accurate view of its medieval landscape with details of the medieval fields, woods, pastures and meadows which have been mapped by ground-survey of archaeological remains confirmed where possible from aerial photographs and early maps. It is also the first time a county has been mapped showing all pre-parliamentary enclosure providing comprehensive data for the difficult theme of early enclosure in a midland county. Complete relevant historic map sources are listed, many in private possession and not lodged with county record offices. Settlements are discussed based on the detailed mapping of every house depicted on historic maps as wells the extent of earthworks, which provides much new evidence relative to settlement development in the Midlands. As well as being highly relevant for anyone studying medieval settlements and enclosure, it illustrates how GIS can be used to present a very large amount of historical and landscape data for any region. The clearly laid out maps in full colour throughout contain an immense amount of data which together provide a fascinating new portrait of this historic county.
The first half of this book is primarily a systematic survey of the snails, beginning with glossaries, keys for identification to genera and a checklist of species. This is followed by a synopsis of species, with brief notes on ecology, distribution and parasites. Relationships are then described between snails and schistosomes and with other paras
In The Late Victorian Folksong Revival: The Persistence of English Melody, 1878-1903, E. David Gregory provides a reliable and comprehensive history of the birth and early development of the first English folksong revival. Continuing where Victorian Songhunters, his first book, left off, Gregory systematically explores what the Late Victorian folksong collectors discovered in the field and what they published for posterity, identifying differences between the songs noted from oral tradition and those published in print. In doing so, he determines the extent to which the collectors distorted what they found when publishing the results of their research in an era when some folksong texts were deemed unsuitable for "polite ears." The book provides a reliable overall survey of the birth of a movement, tracing the genesis and development of the first English folksong revival. It discusses the work of more than a dozen song-collectors, focusing in particular on three key figures: the pioneer folklorist in the English west country, Reverend Sabine Baring-Gould; Frank Kidson, who greatly increased the known corpus of Yorkshire song; and Lucy Broadwood, who collected mainly in the counties of Sussex and Surrey, and with Kidson and others, was instrumental in founding the Folk Song Society in the late 1890s. The book includes copious examples of the song tunes and texts collected, including transcriptions of nearly 300 traditional ballads, broadside ballads, folk lyrics, occupational songs, carols, shanties, and "national songs," demonstrating the abundance and high quality of the songs recovered by these early collectors.
Even as classic cytogenetics has given way to molecular karyotyping, and as new deletion and duplication syndromes are identified almost every day, the fundamental role of the genetics clinic remains mostly unchanged. Genetic counselors and medical geneticists explain the "unexplainable," helping families understand why abnormalities occur and whether they're likely to occur again. Chromosome Abnormalities and Genetic Counseling is the genetics professional's definitive guide to navigating both chromosome disorders and the clinical questions of the families they impact. Combining a primer on these disorders with the most current approach to their best clinical approaches, this classic text is more than just a reference; it is a guide to how to think about these disorders, even as our technical understanding of them continues to evolve. Completely updated and still infused with the warmth and voice that have made it essential reading for professionals across medical genetics, this edition of Chromosome Abnormalities and Genetic Counseling represents a leap forward in clinical understanding and communication. It is, as ever, essential reading for the field.
Based on nearly five decades of research, this magisterial work is a biographical register and analysis of the people who most directly influenced the course of the Civil War, its high commanders. Numbering 3,396, they include the presidents and their cabinet members, state governors, general officers of the Union and Confederate armies (regular, provisional, volunteers, and militia), and admirals and commodores of the two navies. Civil War High Commands will become a cornerstone reference work on these personalities and the meaning of their commands, and on the Civil War itself. Errors of fact and interpretation concerning the high commanders are legion in the Civil War literature, in reference works as well as in narrative accounts. The present work brings together for the first time in one volume the most reliable facts available, drawn from more than 1,000 sources and including the most recent research. The biographical entries include complete names, birthplaces, important relatives, education, vocations, publications, military grades, wartime assignments, wounds, captures, exchanges, paroles, honors, and place of death and interment. In addition to its main component, the biographies, the volume also includes a number of essays, tables, and synopses designed to clarify previously obscure matters such as the definition of grades and ranks; the difference between commissions in regular, provisional, volunteer, and militia services; the chronology of military laws and executive decisions before, during, and after the war; and the geographical breakdown of command structures. The book is illustrated with 84 new diagrams of all the insignias used throughout the war and with 129 portraits of the most important high commanders.
Tradition and revelation are often seen as opposites: tradition is viewed as being secondary and reactionary to revelation which is a one-off gift from God. Drawing on examples from Christian history, Judaism, Islam, and the classical world, this book challenges these definitions and presents a controversial examination of the effect history and cultural development has on religious belief: its narratives and art. David Brown pays close attention to the nature of the relationship between historical and imaginative truth, and focuses on the way stories from the Bible have not stood still but are subject to imaginative 'rewriting'. This rewriting is explained as a natural consequence of the interaction between religion and history: God speaks to humanity through the imagination, and human imagination is influenced by historical context. It is the imagination that ensures that religion continues to develop in new and challenging ways.
Seldom has the world seen a man with the grace, style, and intellect of David Brown. Known in his lifetime as a journalist (The Saturday Evening Post, Harper's, and Collier's), a publisher (Cosmpolitan), an Academy Award winning film producer (Jaws, The Sting, The Verdict, Cocoon, Driving Miss Daisy), a Broadway producer (Dirty Rotten Scoundrels, Sweet Smell of Success, A Few Good Men), an author, a one-time astrologer, and husband to long-time Cosmopolitan head Helen Gurley Brown. Throughout his remarkable life he was a friend, acquaintance, and confidant of the world's most powerful, most famous, and most notorious. With his remarkably perfect memory, this raconteur extraordinaire shares in intimate detail his personal encounters and experiences with a cavalcade of world famous personalities - from Mafia chieftains to world leaders, the reclusive Howard Hughes, the super-rich J. Paul Getty, William Randolph Hearst, Marilyn Monroe, Robert Kennedy, Irving Berlin, Paul Newman, Orson Welles, Steven Spielberg, Robert Redford, Darryl Zanuck, David, O. Selznick, John O'Hara, Carl Sandburg, Nikita Khrushchev, Frank Sinatra, Richard Burton, Elizabeth Taylor, Salvador Dali, Irving Lazar, John Belushi, and scores of others.
This book covers two aspects of the career of D Allan Bromley: the science policy aspect and the scientific aspect.In the first half of the book, contributions from Governor John Sununu, former White House Chief of Staff under President George H W Bush; Neal Lane, former Science Adviser to President William Clinton; John Marburger III, Science Adviser to President George W Bush; and Mary Good, former Undersecretary of Commerce, highlight the role of Bromley as Science Adviser to President George H W Bush and a maker of science policy in the second part of the 20th Century. This part is of interest to science policy scholars, historians, and young persons wishing to start a career in science policy.In the second half of the book, articles by directors of laboratories and leading scientists discuss future programs in all areas of nuclear physics ? low-energy, medium-energy and high-energy ? to which Bromley greatly contributed, in the USA, Europe and Japan. This part of the book is of interest to all researchers in the field of nuclear physics, as it provides a comprehensive but succinct overview of the field and indicates directions for future research in the first part of the 21st century.
This practical guide invites teachers to take a journey towards masterly mathematics teaching using the experiences and lessons learnt across five Chinese provinces, Anhui, Beijing, Jiangsu, Jiangxi and Tianjin. On this journey, you will gain a thorough understanding of: (1) the quality and characteristics of master mathematics teachers’ teaching, (2) the quality of mathematics learning they have nurtured amongst their students in affective, metacognitive and cognitive dimensions and (3) the teaching-learning mechanisms that underpin excellent performance in the three dimensions. Alongside the quantitative and qualitative evidence on educational excellence, you will also delve deep into the trajectories and processes of professional development that generate professional excellence amongst master mathematics teachers and their peers within and across primary schools, up and down China. Building on data collected with 70 master mathematics teachers and 3,178 students and from teaching research events at the school, municipal, provincial and national levels, the Master Mathematics Teachers (MasterMT) project is, to date, the first that has looked at the legendary tribe of master mathematics teachers in China at such a large scale, and with such breadth and depth. The book offers invaluable insights for any teacher or teacher educator who wants to improve mathematics teaching and learning and generate educational and professional excellence in primary schools and beyond. More information on the Master Mathematics Teachers (MasterMT) project can be accessed at https://mastermt.org/.
Justice reinvestment was introduced as a response to mass incarceration and racial disparity in the United States in 2003. This book examines justice reinvestment from its origins, its potential as a mechanism for winding back imprisonment rates, and its portability to Australia, the United Kingdom and beyond. The authors analyze the principles and processes of justice reinvestment, including the early neighborhood focus on 'million dollar blocks'. They further scrutinize the claims of evidence-based and data-driven policy, which have been used in the practical implementation strategies featured in bipartisan legislative criminal justice system reforms. This book takes a comparative approach to justice reinvestment by examining the differences in political, legal and cultural contexts between the United States and Australia in particular. It argues for a community-driven approach, originating in vulnerable Indigenous communities with high imprisonment rates, as part of a more general movement for Indigenous democracy. While supporting a social justice approach, the book confronts significantly the problematic features of the politics of locality and community, the process of criminal justice policy transfer, and rationalist conceptions of policy. It will be essential reading for scholars, students and practitioners of criminal justice and criminal law.
The World Atlas of Language Structures is a book and CD combination displaying the structural properties of the world's languages. 142 world maps and numerous regional maps - all in colour - display the geographical distribution of features of pronunciation and grammar, such as number of vowels, tone systems, gender, plurals, tense, word order, and body part terminology. Each world map shows an average of 400 languages and is accompanied by a fully referenced description of the structural feature in question. The CD provides an interactive electronic version of the database which allows the reader to zoom in on or customize the maps, to display bibliographical sources, and to establish correlations between features. The book and the CD together provide an indispensable source of information for linguists and others seeking to understand human languages. The Atlas will be especially valuable for linguistic typologists, grammatical theorists, historical and comparative linguists, and for those studying a region such as Africa, Southeast Asia, North America, Australia, and Europe. It will also interest anthropologists and geographers. More than fifty authors from many different countries have collaborated to produce a work that sets new standards in comparative linguistics. No institution involved in language research can afford to be without it.
The debate about access to scientific research raises questions about the current effectiveness of scholarly communication processes. This book explores, from an independent point of view, the current state of the STM publishing market, new publishing technologies and business models as well as the information habit of researchers, the politics of research funders, and the demand for scientific research as a public good. The book also investigates the democratisation of science including how the information needs of knowledge workers outside academia can be embraced in future.
Emergency physicians assess and manage a wide variety of problems from patients presenting with a diversity of severities, ranging from mild to severe and life-threatening. They are expected to maintain their competency and expertise in areas where there is rapid knowledge change. Evidence-based Emergency Medicine is the first book of its kind in emergency medicine to tackle the problems practicing physicians encounter in the emergency setting using an evidence-based approach. It summarizes the published evidence available for the diagnosis and treatment of common emergency health care problems in adults. Each chapter contextualizes a topic area using a clinical vignette and generates a series of key clinically important diagnostic and treatment questions. By completing detailed reviews of diagnostic and treatment research, using evidence from systematic reviews, RCTs, and prospective observational studies, the authors provide conclusions and practical recommendations. Focusing primarily on diagnosis in areas where evidence for treatment is well accepted (e.g. DVTs), and treatment in other diseases where diagnosis is not complex (e.g. asthma), this text is written by leading emergency physicians at the forefront of evidence-based medicine. Evidence-based Emergency Medicine is ideal for emergency physicians and trainees, emergency department staff, and family physicians specialising in the acute care of medical and injured patients.
Written by nationally recognized insurance law practitioners and academics, Insurance Practices and Coverage in Liability Defense, Second Edition (formerly titled Defending the Insured) provides the first comprehensive and objective analysis of the various duties and potential pitfalls confronting each party in the three-way relationship between insurance carrier, insured, and the appointed counsel in insurance defense. Each chapter provides a detailed discussion of topics engendered by the duty to defend and the consequent obligations of each of the parties. Reference tables and appendices then survey the law in each state on those topics. The result is a book that provides both a national study and state-specific analysis, allowing practitioners, courts and researchers the ability to see the big picture as well as to focus on and compare how states actually deal with the particular issue. Topics covered include: The use of staff counsel Billing guidelines Audits of attorneysand’ fees Reservations of rights Communication privileges and issues, and cooperation duties Conflicts of interest, control of the defense including independent counsel Allocation of defense costs between insurer and insured Allocation of indemnity expense between insurer and insured Allocation and determination of deductibles and SIRs Coverage allocation in multi-year, continuing loss cases, including horizontal and vertical exhaustion, stacking, and and“all sumsand” Application and features of judicial remedies of declaratory relief and intervention Insurance Practices and Coverage in Liability Defense, Second Edition is the book that combines practice and theory, that serves both the insurer and insured, the national practitioner and the local counsel, and informs courts where concurrence and divergence exist on the sometimes thorny, interrelated issues.
Britain's military forces have rarely been busier. It is therefore crucial to understand the developing trends and underlying assumptions of British Defence Policy, in regard to both foreign policy and international security. This volume, which covers both the Blair and Brown eras in defence policy making, places developments post 11 September in a wider context, assessing the impact of key personalities and events on a range of issues, notably the perennial concern of military overstretch. By critically appraising contemporary developments, and examining the driving policy in specific cases, this volume provides a relevant and up-to-date assessment of this vital policy area. As well as being contemporary in its analysis, the work is also comprehensive in scope, embracing both policy objectives - such as the expeditionary strategy and the desire to be a bridge between the US and EU - and the instruments that underpin such policy.
Swift changes in educational technology are transforming the landscape of our society and how we transfer knowledge in a digital world. Teachers, administrators, and education students need to stay abreast of these developments. Yet while the new educational software, technologies, and networks may be available, the learning theories and methods required to take complete advantage of the tools are often neglected. Learning theories are a crucial element of education studies for anyone involved with students from pre-school to higher education and business training. This book is a substantive dictionary of over 500 terms relating to learning theories and environments. Definitions range from approximately 100 to 700 words, and each term is identified by the primary type of learning theory to which it applies: cognitivism, constructivism, behaviorism, humanism, or organizational learning. An annotated bibliography provides further resources to the most important writings about learning theories.
Praised by JAMA as "The most complete description of the development, structure, function, pathophysiology, and treatment of the retina and its diseases to be found anywhere," this monumental three-volume work puts all of today's scientific and clinical knowledge of the retina at readers' fingertips. The New Edition has been comprehensively updated and reorganized to reflect all of the very latest scientific and genetic discoveries, diagnostic imaging methods, drug therapies, treatment recommendations, and surgical techniques. The result is an indispensable reference and diagnostic tool for generalists and specialists alike. Delivers the editorial expertise of four highly respected authorities, as well as contributions from internationally recognized leaders in visual science, ophthalmology, and vitreoretinal studies. Presents more than 3,400 superb illustrations (2,200 in full color) that capture all forms of retinal disease from every perspective. Offers the very latest information on the genetic basis of retinal disease, diagnostic retinal imaging, photodynamic therapy, and age-related macular degeneration. Examines the most recent advances in diagnostic indocyanine green angiography � optical coherence tomography (OCT) and quantitative fluoroscein angiography � macular translocation with 360� peripheral retinectomy � surgery for diffuse macular edema due to multiple causes, including proliferative vitreoretinopathy � artificial vision � and much more. Features a completely restructured section on age-related macular degeneration that includes epidemiology and risk factors � prophylaxis and prevention knowledge gained from large clinical trials like AREDS � proven and experimental treatments for AMD � and pharmacotherapy. Incorporates a multitude of new full-color images, 2200 in all.
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