David Cavalla's Books

Off-label Prescribing

Justifying Unapproved Medicine

By: David Cavalla

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Off-label Prescribing

Justifying Unapproved Medicine

By: David Cavalla

Today’s medicines are regulated for their efficacy and safety and, once approved, they can be marketed for certain uses as justified by the data. Regulatory bodies in developed countries are constituted by legal statute and operate as parts of government, ostensibly in the interests of the people as patients. But once approved, medicines can be used for any purpose the prescriber thinks fit and appropriate for the patient. One in five prescriptions is therefore written outside regulatory purview. Off-label Prescribing looks into the corners of our medicated lives, where drug regulation runs up against medical practice, and concerns the use of a drug that has been approved for one use (in medical parlance, ‘indication’) being used for a different indication; alternatively, being used on a different set of patients from the ones it is approved for, or at a different dose. Usually the patient is unaware of what is going on, having not been informed by their doctor of this aspect of his or her prescribing choice. The book examines how and why this occurs, what the various medical professions have to say about it, and how pharmaceutical companies benefit by moving into this poorly regulated area. Off-label Prescribing pulls these complex issues together in one volume, to highlight current practice, its advantages and weaknesses and how the author suggests practice should evolve in the future. It will therefore be of interest to all those who prescribe (and receive) medicines, combined with a greater objective to provide more transparency and discussion for professionals.

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Page Count

211

Publisher

John Wiley & Sons

Published Date

ISBN 10

1118912071

ISBN 13

9781118912072

Modern Strategy for Preclinical Pharmaceutical R&D

Towards the Virtual Research Company

By: David Cavalla

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Modern Strategy for Preclinical Pharmaceutical R&D

Towards the Virtual Research Company

By: David Cavalla

The twentieth century has been a great success for modern medicine, and has resulted in the generation of a plethora of drugs to treat most common illnesses. However, in the light of increasing regulatory demands, spiralling costs and diminishing commercial returns, the question of how, when, where and whether to conduct pharmaceutical R&D has profound implications, and not just for those within the pharmaceutical industry. In response to these and other dilemmas, the authors define the processes involved in drug research, and examine the advantages and disadvantages of collaborative methods of drug research, and examine the roles that academia, CROs, small "biotechnology" companies and "research boutiques," and possibly even the "virtual research company" might play as contractors and collaborators.

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Page Count

232

Publisher

John Wiley & Sons

Published Date

ISBN 10

0471971170

ISBN 13

9780471971177

Prophet Harris, The 'Black Elijah' of West Africa

Abridged by Jocelyn Murray

By: David A. Shank

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Prophet Harris, The 'Black Elijah' of West Africa

Abridged by Jocelyn Murray

By: David A. Shank

Prophet Harris, The “Black Elijah” of West Africa offers the only comprehensive study of the thought of William Wade Harris, the Glebo (Liberia) loyalist whose prophetic mission from 1910-29 moved tens of thousands of West Africans out of traditional religion into the stream of Christianity and modernization, particularly in the Ivory Coast. It reviews that unparalleled breakthrough, thoroughly examines traditional African, Western missionary and colonial influences which helped determine religious innovation and shape his vocation as prophet of Christ's reign of peace and prosperity. Heretofore unused sources, enriched by documents and photos, expose biblical eschatological and messianic dynamics which tied Harris' words, symbols and charisma together in a holistic African Christianity. The source of long-standing contentions between Ivoirian Harrists, Methodists and Catholics is uncovered in the well-intentioned but changing colonial and missionary responses to his impact.

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346

Publisher

BRILL

Published Date

ISBN 10

9004664599

ISBN 13

9789004664593

USS Princeton

The Life and Loss of "Sweet P"

By: David R. Leick

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USS Princeton

The Life and Loss of "Sweet P"

By: David R. Leick

An in-depth history of the US Navy's light aircraft carrier the USS Princeton and its operational exploits in the Pacific Theater of World War II. This new history of the life and loss of USS Princeton tells the story of the new class of aircraft carrier that proved essential to the US Navy's victory over the Imperial Japanese Navy in the Pacific War. USS Princeton (CVL-23) started life as the light cruiser Tallahassee before being converted while still under construction into a light carrier as part of the plan to ramp up the strength of US naval air power. The vessel joined the Pacific Fleet in August 1943 and was immediately put to work as the United States was assembling new ships and crews for the bitter struggle to come. Princeton played a key role in conducting multiple strikes against the Japanese bastion at Rabaul, and then joined Task Force 58/38 – the Fast Carrier Task Force – for the Central Pacific campaign, culminating in the invasion of the Philippines, where the ship was lost. David R. Leick skillfully uses first-hand accounts to examine the engagements, aircraft, tactics, command decisions and life on board during the Pacific campaign against Japan from early 1943 until Princeton's tragic demise in October 1944. He focuses closely on the ship's crew and embarked Naval Aviators, describing in detail the toll that prolonged combat operations took on the frontline sailor.

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Page Count

338

Publisher

Bloomsbury Publishing

Published Date

ISBN 10

1472868595

ISBN 13

9781472868596

Missions for Science

U.S. Technology and Medicine in America's African World

By: David McBride

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Missions for Science

U.S. Technology and Medicine in America's African World

By: David McBride

This historical analysis explores how disease control aid from the U.S., along with shifting environmental factors, affected the development of Atlantic regions with populations of predominantly African ancestry: the southern United States, the Panama Canal Zone, Haiti, and Liberia. McBride (African American history, Pennsylvania State U.) poses questions such as "what specific technologies and medical resources were transferred by U.S. institutions to black population centers, and why?" McBride also discusses how those regions, with historical ties to the U.S., independently envisioned and utilized technology and science in their formation. Annotation copyrighted by Book News, Inc., Portland, OR

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338

Publisher

Rutgers University Press

Published Date

ISBN 10

0813530679

ISBN 13

9780813530673

The American Colonization Society

And the Founding of the First African Republic

By: John Seh David

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The American Colonization Society

And the Founding of the First African Republic

By: John Seh David

Most historical narratives about Africans in America begin with Jamestown, Virginia, where enslaved Angolans were sold in 1619. However, this book commences with blacks as explorers in the Americas before Christopher Columbus arrival. The point here is to demonstrate that slavery robbed Africa of its heritage and impoverished the continent. Once Africans landed in America as slaves, state laws denied them civil rights and humane treatment. The hopelessness, brutalization, and alienation of blacks aroused the conscientiousness of humanitarian groups to seek the repatriation of freed men to their ancestry homeland in Africa, away from Anglo Americans. This became a risky rescue mission, which put the ACS in direct opposition with anti-colonizationists. This book highlights the complicity of the precarious endeavor and the founding of the first African Republic on the continent.

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Page Count

239

Publisher

iUniverse

Published Date

ISBN 10

1491734248

ISBN 13

9781491734247

Cesare Zavattini’s Neo-realism and the Afterlife of an Idea

An Intellectual Biography

By: David Brancaleone

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Cesare Zavattini’s Neo-realism and the Afterlife of an Idea

An Intellectual Biography

By: David Brancaleone

How many Zavattinis are there? During a life spanning most of the twentieth century, the screenwriter who wrote Sciuscià, Bicycle Thieves, Miracle in Milan, and Umberto D. was also a pioneering magazine publisher in 1930s Milan, a public intellectual, a theorist, a tireless campaigner for change within the film industry, a man of letters, a painter and a poet. This intellectual biography is built on the premise that in order to understand Zavattini's idea of cinema and his legacy of ethical and political cinema (including guerrilla cinema), we must also tease out the multi-faceted strands of his interventions and their interplay over time. The book is for general readers, students and film historians, and anyone with an interest in cinema and its fate.

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310

Publisher

Bloomsbury Publishing USA

Published Date

ISBN 10

1501317008

ISBN 13

9781501317002

Cairo, Jerusalem, & Damascus: three chief cities of the Egyptian Sultans

By: David Samuel Margoliouth

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Cairo, Jerusalem, & Damascus: three chief cities of the Egyptian Sultans

By: David Samuel Margoliouth

The book itself is intensely interesting both in its historical account and its description of these three great cities and is profusely illustrated with most beautiful pictures and drawings of the famous places in them. The difference of "atmosphere” of Cairo and Jerusalem which, though both so distinctly Eastern, are yet in many ways so unlike, is wonderfully conveyed. The pictures in this book make you long to go there and, indeed, this delightful volume must give almost equal pleasure to those who have been in the places and those who have not, for it seems to take back those who have been there and it brings the scenes and places to those who have never actually seen them.

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Page Count

351

Publisher

Jazzybee Verlag

Published Date

ISBN 10

3849649687

ISBN 13

9783849649685

The Genera of Fishes and A Classification of Fishes

By: David Starr Jordan

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The Genera of Fishes and A Classification of Fishes

By: David Starr Jordan

A Stanford University Press classic.

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870

Publisher

Stanford University Press

Published Date

ISBN 10

0804702012

ISBN 13

9780804702010

Violent Peace

Militarized Interstate Bargaining in Latin America

By: David R. Mares

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Violent Peace

Militarized Interstate Bargaining in Latin America

By: David R. Mares

David R. Mares argues that the key factors influencing political leaders in all types of polities are the costs to their constituencies of using force and whether the leader can survive their displeasure if the costs exceed what they are willing to pay. Violent Peace proposes a conceptual scheme for analyzing militarized conflict and supports this framework with evidence from the history of Latin America.

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319

Publisher

Columbia University Press

Published Date

ISBN 10

0231111878

ISBN 13

9780231111874

The Spirit of the East

Vol. II

By: David Urquhart

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The Spirit of the East

Vol. II

By: David Urquhart

Reprint of the original, first published in 1839.

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Page Count

278

Publisher

BoD – Books on Demand

Published Date

ISBN 10

338514616X

ISBN 13

9783385146167

Marine Fishes of Florida

By: David B. Snyder,George H. Burgess

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Marine Fishes of Florida

By: David B. Snyder,George H. Burgess

From the largest sharks to the smallest cryptic gobies, from homely toadfishes to the spectacularly colored reef fishes, this book is certain to help you better understand the fish you've seen or hooked.Features of Marine Fishes of Florida include Color photographs by leading marine photographers Differentiation of adult and juvenile forms Coverage of 133 fish families and hundreds of species Size and geographical range data Natural history and conservation notes Explanations of geologic history and current habitats

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Page Count

384

Publisher

JHU Press

Published Date

ISBN 10

142141872X

ISBN 13

9781421418728

Africa

Geography and Development

By: Alan B Mountjoy,David Hilling

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Africa

Geography and Development

By: Alan B Mountjoy,David Hilling

First published in 1988, Africa examines the varied pattern of development in the continent, the progress and the disappointments experienced, and the prospects. This picture is set firmly within the frame of the continent’s geography. From a general synthesis, the books moves to a country by country analysis of the interdependence of geography and economic development. The authors’ analysis of the effects of varied development strategies in Africa leads them, in the final section, to discuss what lessons maybe learned from these earlier initiatives and to assess the changes in development policies that were later implemented. This book will be of interest to students of geography, economics and development studies.

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Page Count

476

Publisher

Taylor & Francis

Published Date

ISBN 10

1003816177

ISBN 13

9781003816171

Arctic Sea

A Dan Lenson Novel

By: David Poyer

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Arctic Sea

A Dan Lenson Novel

By: David Poyer

New threats surface in the aftermath of WWIII—this time, in the remote waters of the Arctic. Arctic Sea is the next thrilling entry in David Poyer's critically-acclaimed future war series. In the aftermath of a world war with China, Admiral Dan Lenson is assigned to set up a US Navy base on the rugged North Slope of Alaska, in response to Russian seabed claims that reach nearly to the US coast. Yet the current administration seems oddly reluctant to confront Russian aggression. At the same time, the International Criminal Court is accusing Dan of a war crime. Back in Washington, Blair Titus is running Jim Yangerhans’s campaign for president, while Dan’s daughter Nan battles disease in a radiation-soaked Midwest. But when Moscow plans to test the Apocalyps, a nuclear powered citykiller torpedo, in the Arctic Sea, Dan is sucked into a perilous covert mission. Will a barely victorious America survive dangerous new threats...both from without, and within?

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354

Publisher

St. Martin's Press

Published Date

ISBN 10

1250273072

ISBN 13

9781250273079

Birds New to Science

Fifty Years of Avian Discoveries

By: David Brewer

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Birds New to Science

Fifty Years of Avian Discoveries

By: David Brewer

The story of the discovery of nearly 300 bird species new to science since 1960. Amazing as it might sound, ornithologists are still discovering several bird species each year that are completely new to science. These aren't all obscure brown birds on tiny islands – witness the bizarre Bare-faced Bulbul from Laos (2009), spectacular Araripe Manakin from Brazil (1998), or gaudy Bugun Liocichla from north-east India (2006). Birds New to Science documents more than half a century of these remarkable discoveries, covering around 300 species. Each account includes the story of discovery, a brief description of the bird (many with accompanying colour photographs), and details of what is known about its biology, range and conservation status. Written in an engaging style, this is a rich reference to an incredible era of adventure in ornithology.

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Page Count

418

Publisher

Bloomsbury Publishing

Published Date

ISBN 10

1472945891

ISBN 13

9781472945891

The Pacific Naval War 1941–1945

By: David Wragg

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The Pacific Naval War 1941–1945

By: David Wragg

This vividly detailed WWII history chronicles the bitter conflict at sea between Allied and Japanese naval forces. The Pacific War was primarily fought at sea. Naval power allowed the Japanese to mount their attack on Pearl Harbor and then advance westwards and southwards. It also enabled the Allies to strike back and even take the war to Japan itself. The tide turned very quickly, with the US victory at Midway in June of 1942 ending any Japanese hope of domination. The book begins with the decisions that led Japan into war, and the difficult situation faced by the Royal Navy elsewhere. It then describes how, within a couple of years, the Royal Navy was able to send the strongest and most balanced fleet in its history to severely disrupt Japanese operations. Historian David Wragg also covers how the Royal Australian Navy developed into a viable naval force ready to become a major fleet in the immediate postwar years. The progress of the war is supported by eyewitness accounts from those involved in the fighting at sea.

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342

Publisher

Casemate Publishers

Published Date

ISBN 10

1844689719

ISBN 13

9781844689712

Gulf Stream Chronicles

A Naturalist Explores Life in an Ocean River

By: David S. Lee

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Gulf Stream Chronicles

A Naturalist Explores Life in an Ocean River

By: David S. Lee

Off the shore of Hatteras Island, where the inner edge of the Gulf Stream flows northward over the outer continental shelf, the marine life is unlike that of any other area in the Atlantic. Here the powerful ocean river helps foster an extraordinarily rich diversity of life, including Sargassum mats concealing strange creatures and exotic sea beans, whales and sea turtles, sunfish and flying fish, and shearwaters and Bermuda petrels. During his long career as a research scientist, David S. Lee made more than 300 visits to this area off the North Carolina coast, documenting its extraordinary biodiversity. In this collection of twenty linked essays, Lee draws on his personal observations and knowledge of the North Atlantic marine environment to introduce us to the natural wonders of an offshore treasure. Lee guides readers on adventures miles offshore and leagues under the sea, blending personal anecdotes with richly detailed natural history, local culture, and seafaring lore. These journeys provide entertaining and informative connections between the land and the diverse organisms that live in the Gulf Stream off the coast of North Carolina. Lee also reminds us that ocean environments are fragile and vulnerable to threats such as pollution, offshore energy development, and climate change, challenging those of us on land to consider carefully the costs of ignoring sea life that thrives just beyond our view.

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Page Count

303

Publisher

UNC Press Books

Published Date

ISBN 10

1469623943

ISBN 13

9781469623948

Iago

A Novel

By: David Snodin

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Iago

A Novel

By: David Snodin

An unforgettable adventure beginning where Shakespeare's Othello leaves off Wounded in love, tormented by his past, Shakespeare's most complex villain is brought magnificently to life in this tale of two adversaries—one an accused killer; the other, one of the most powerful men in Venice. Having escaped from Cyprus, accused of the murders of the governor, known as the Moor, and his lovely young wife, Iago is now locked in battle with Annibale Malipiero, known as Il Terribile, the chief inquisitor of Italy's greatest city. Malipiero is repelled by the more brutal tasks of the interrogante. His obsession is with the very nature of evil. What makes a man into a murderer, he longs to know? Is Iago a lone psychopath, or does he lie at the heart of a more widespread Ottoman conspiracy? Malipiero knows that torture will not provide him with the answers he seeks. But there is, perhaps, a more audacious and unusual route to the truth . . . Exuberantly inventive, thrillingly complex, and richly entertaining, Iago will captivate fans already familiar with Shakespeare and appeal to anyone who loves a rich historical novel. Iago marks the emergence of a remarkable new literary voice.

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Page Count

451

Publisher

Henry Holt and Company

Published Date

ISBN 10

1429973021

ISBN 13

9781429973021

Migration Ecology of Marine Fishes

By: David Hallock Secor

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Migration Ecology of Marine Fishes

By: David Hallock Secor

A revelatory look at the secrets of marine fish migration. Not since F. R. Harden Jones published his masterwork on fish migration in 1968 has a book so thoroughly demystified the subject. With stunning clarity, David Hallock Secor's Migration Ecology of Fishes finally penetrates the clandestine nature of marine fish migration. Secor explains how the four decades of research since Jones's classic have employed digital-age technologies—including electronic miniaturization, computing, microchemistry, ocean observing systems, and telecommunications—that render overt the previously hidden migration behaviors of fish. Emerging from the millions of observed, telemetered, simulated, and chemically traced movement paths is an appreciation of the individual fish. Members of the same populations may stay put, explore, delay, accelerate, evacuate, and change course as they conditionally respond to their marine existence. But rather than a morass of individual behaviors, Secor shows us that populations are collectively organized through partial migration, which causes groups of individuals to embark on very different migration pathways despite being members of the same population. Case studies throughout the book emphasize how migration ecology confounds current fisheries management. Yet, as Secor explains, conservation frameworks that explicitly consider the influence of migration on yield, stability, and resilience outcomes have the potential to transform fisheries management. A synthetic treatment of all marine fish taxa (teleosts and elasmobranchs), this book employs explanatory frameworks from avian and systems ecology while arguing that migrations are emergent phenomena, structured through schooling, phenotypic plasticity, and other collective agencies. The book provides overviews of the following concepts: • The comparative movement ecology of fishes and birds • The alignment of mating systems with larval dispersal • Schooling and migration as adaptations to marine food webs • Natal homing • Connectivity in populations and metapopulations • The contribution of migration ecology to population resilience

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Page Count

305

Publisher

JHU Press

Published Date

ISBN 10

1421416131

ISBN 13

9781421416137

The Eagle and the Osprey

By: David G. Weaver

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The Eagle and the Osprey

By: David G. Weaver

WWII 1944 The Pacific War Zone In the Pacific Fleet Replacement Pilot Pool at Pearl Harbor, Ensign Bruce Weber receives training in the new Grumman Hellcat fighter planes. He is then assigned to a fighter squadron aboard a carrier. Bruce demonstrates exceptional airmanship skills, shooting down several enemy aircraft. After he has accounted for more than a dozen enemy planes, squadron enlisted personnel repaint their heros plane with white engine speedring and tail to resemble a bald eagle. During the first few months of the deployment, three of Bruces close friends are shot down by Kenji Okada, a Japanese super ace known as The Osprey. Okada flies a Distinctively painted Zero. Bruce swears vengeance and searches for the Osprey on every flight. The two aces eventually meet. The dogfight is long and difficult but Bruce finally shoots Okada down. Returning to the carrier, Bruce lands almost out of fuel just before the ship is disabled by a Kamikaze. Fire decimates the aircraft and the ship is out of action. Both are ordered back to the states, their fighting days over at least for a while.

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Page Count

311

Publisher

AuthorHouse

Published Date

ISBN 10

1468573594

ISBN 13

9781468573596

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