The new edition of Cardiac Intensive Care—the only textbook dedicated to cardiac intensive care medicine—chronicles the progress made in the diagnosis, assessment, and treatment of patients with critical cardiac illness. Editors Allen Jeremias, MD, MSc and David L. Brown, MD present the landmark discoveries, greater understanding of syndromes, and technological advancements that have helped make clinical cardiology a progressive and interventional field. You’ll get coverage of the plethora of noncoronary diseases in the CICU, as well as a complete compendium of up-to-date pharmacologic agents. The new full-color design and layout and nine new chapters give you the latest theoretical, technical, diagnostic, and therapeutic advances in an accessible and visually appealing format. Features the authoritative perspectives of a stellar group of contributors—many of whom are the pioneers in the fields they cover—for the best available guidance. Provides the basic science framework for the clinical material through a section on the scientific foundation of cardiac intensive care to give you the complete picture. Presents a pharmacological introduction to the classes of drugs so you know which are most commonly used in the CICU. Covers which noncoronary diseases frequently result in admittance to the CICU to prepare you for those diagnoses that are not of a cardiac nature. Features nine new chapters—Quality Assurance and Improvement in the Cardiac Intensive Care Unit; Physical Examination in the CICU; Mechanical Treatments for Acute ST-Elevation MI; Non-ST Elevation Myocardial Infarction: Diagnosis, Prognosis, Risk Stratification, and Management; Glycoprotein IIb/IIIa Inhibitors; Vascular Access Procedures; Ventilator Management for the Cardiac Patient; Management of Post-Operative Complications in the Cardiac Surgery Patient; Guidelines Relevant to Care in the Cardiac Intensive Care Unit—to keep the book and you up to date. Presents the text in a new, full-color design and layout for a more visually-appealing and accessible format that makes finding the information you need quick and easy.
The widespread diffusion of digital, connected objects such as smartphones or tablets as well as the increasing integration of computing and connectivity capabilities into everyday artifacts like TVs and cars have significantly changed individual behavior in recent decades: it has become the norm to interact with technology and to be connected with online resources regardless of time and place. Social interactions have increasingly become intertwined with technology, making it almost impossible to fully participate in everyday life activities without IT. As a final example, with the integration of network connectivity, digital technologies, products, and services are not used in isolation anymore, but working together as assemblages, thereby expanding the range of what they and their users can do. Overall, we have witnessed that IT has become deeply socially embedded in everyday life and routines. Understanding individual behavior has a long tradition in information systems research. However, given the fundamental changes in recent years related to technology use, it is questionable whether traditional models and theories are still applicable in the digital age. The goal of this dissertation is to address respective shortcomings. As a first step, a comprehensive review of the literature on digital transformation is performed for a better understanding of this phenomenon surrounding the changes we have witnessed regarding individual behavior. Afterwards, new concepts to explain and measure individual behavior and expectations related to connected objects are developed and examined. Furthermore, as the topic of connected objects is closely connected to the concept of personalization, a design study is performed that 1) provides an artifact to handle the efficiency-personalization trade-off in the provision of firm offerings and 2) illustrates how personalization influences the user perceptions of respective products and services. Based on the findings, a framework for the study of connected objects is synthesized and presented. Overall, the findings of this dissertation have relevant implications for research and practice in the fields of technology acceptance, digital life, and digital transformation.
Counterstrain -- Acupuncture for headache -- Acupuncture for nausea and vomiting -- Saline nasal irrigation -- Bioenergetics -- Integrating spiritual assessment and care -- Therapeutic homeopathy -- Human energetic therapies -- Other therapeutic considerations -- Creating a greener clinic: the impact of global warming on health -- Creating ceremony and ritual in the medical encounter -- Appendix: laboratory testing resources in integrative medicine.
A history illustrating the complexity of medical decision making and risk. Still the leading cause of death worldwide, heart disease challenges researchers, clinicians, and patients alike. Each day, thousands of patients and their doctors make decisions about coronary angioplasty and bypass surgery. In Broken Hearts David S. Jones sheds light on the nature and quality of those decisions. He describes the debates over what causes heart attacks and the efforts to understand such unforeseen complications of cardiac surgery as depression, mental fog, and stroke. Why do doctors and patients overestimate the effectiveness and underestimate the dangers of medical interventions, especially when doing so may lead to the overuse of medical therapies? To answer this question, Jones explores the history of cardiology and cardiac surgery in the United States and probes the ambiguities and inconsistencies in medical decision making. Based on extensive reviews of medical literature and archives, this historical perspective on medical decision making and risk highlights personal, professional, and community outcomes.
What effect does religion have on physical and mental health? In answering this question, this book reviews and discusses research on the relationship between religion and a variety of mental and physical health outcomes, including depression and anxiety; heart disease, stroke, and cancer; and health related behaviors such as smoking and substance abuse. The authors examine the positive and negative effects of religion on health throughout the life span, from childhood to old age. Based on their findings, they build theoretical models illustrating the behavioral, psychological, social, and physiological pathways through which religion may influence health. The authors also review research on the impact of religious affiliation, belief, and practice on the use of health services and compliance with medical treatment. In conclusion, they discuss the clinical relevance of their findings and make recommendations for future research priorities. Offering the first comprehensive examination of its topic, this volume is an indispensable resource for research scientists, health professionals, public policy makers, and anyone interested in the relationship between religion and health.
Clinical application of antithrombotic therapy in both arterial disease (acute coronary syndromes, acute MI, peripheral arterial disease, valvular heart disease, atrial fibrillation) and venous disease, (venous thromboembolic disease and pulmonary embolism). Results of major clinical trials and their implications for clinical practice.
Physical Medicine and Rehabilitation Pocket Companion is designed to meet the day-to-day needs of PM&R residents, practicing physiatrists, and physicians in other specialties seeing rehabilitation patients. Focused solely on clinical care delivery, this handy reference provides the tools necessary to navigate everything from PM&R team coordination to the tailoring of medical management to achieve functional goals. Divided into four sections, the book covers all rehabilitation topics and is packed with practical information useful in daily practice, including disease-specific order sets and tips for managing the wide range of issues that commonly occur during a patient's rehabilitation. The first section introduces the field of rehabilitation medicine, the second reviews the scope of practice of allied health professionals on the rehabilitation team, the third section discusses rehabilitation topics and practice areas, and the fourth is an extensive Appendix of 24 assessment and rating scales, tables, and algorithms, essential for daily clinical use. Physical Medicine and Rehabilitation Pocket Companion is an indispensible resource that belongs in every white coat pocket. Features of Physical Medicine and Rehabilitation Pocket Companion Include: Conciseness and Clinical Orientation: Presents only the key information needed for optimal case management Comprehensive coverage: All major topics in the field of PM&R are represented Consistent approach: Brief text and bulleted format makes information easy to find Order sets provided for most areas to drive clinical care Medication specifics: Covers medications with specific dosages Appendix collects key scales, tables, and algorithms for immediate access
The clinical trial is “the most definitive tool for evaluation of the applicability of clinical research.” It represents “a key research activity with the potential to improve the quality of health care and control costs through careful comparison of alternative treatments” [1]. It has been called on many occasions, “the gold st- dard” against which all other clinical research is measured. Although many clinical trials are of high quality, a careful reader of the medical literature will notice that a large number have deficiencies in design, conduct, analysis, presentation, and/or interpretation of results. Improvements have occurred over the past few decades, but too many trials are still conducted without adequate attention to its fundamental principles. Certainly, numerous studies could have been upgraded if the authors had had a better understanding of the fundamentals. Since the publication of the first edition of this book, a large number of other texts on clinical trials have appeared, most of which are indicated here [2–21]. Several of them, however, discuss only specific issues involved in clinical trials. Additionally, many are no longer current. The purpose of this fourth edition is to update areas in which major progress has been made since the publication of the third edition. We have revised most chapters considerably and added one on ethical issues.
The aim of the book was to produce the most comprehensive examination of a pandemic that has ever been attempted. By cataloging the full extent of the Zika pandemic, this book will be the most complete history and epistemic contextualization ever attempted to date. The work should function as the primary source for students, researchers, and scholars who need information about the Zika pandemic. This book examines the technical literature, digital and popular literature, and online materials to fully contextualize this event and provide a bona fide record of this event and its implications for the future. It is somewhat serendipitous that while this work was underway, we are going through another pandemic. One of the primary lessons we did not learn by Zika was pandemic events will return repeatedly, and we need to learn from each one of them to prepare the planet for the next one. Just because Zika seemed to have died out does not make it less important. We were lucky that the virus evolved into what seemed to be a less virulent version of itself, and the vector mosquitoes were concentrated elsewhere. Finally, this book represents a tour de force in scholarship involving nearly 4,000 sources of information and does not shy from a detailed examination of the controversies, conspiracies, and long-term consequences when we avoid learning from outbreaks, such as Zika.
Using clinical examples and citing liberally from the peer-reviewed literature, this book shows how statistical priniciples can improve medical decisions.
One of the strengths of Marriott's Practical Electrocardiography through its more than 50-year history has been its lucid foundation for understanding the basis for ECG interpretation. Again, in this revision, we have attempted to retain the best of the Marriott tradition--emphasis on the concepts required for everyday ECG interpretation and the simplicities, rather than complexities, of the ECG recordings. During preparation of the 9th and 10th editions, Tobin Lim coauthored many of the 11th edition chapters and served as the primary developer of the digital content associated with that edition. Tobin Lim's input continues into this 12th edition, and David Strauss has led even further into the electronic-based interactive learning experiences. More than 30 of the figures that evolved through previous editions have now been converted through the creative expertise of Mark Flanders into animated movies accessed via QR codes imbedded in the book. David has also collaborated with electrocardiographic educators who are especially skilled in e-based education to add interactive video content to many of the 12th edition chapters. Each of the now 24 chapters is divided (as indicated in the table of contents) into discrete, compact "learning units." Each learning unit begins on a new page to provide blank space for the reader's notes. The purpose of the learning units is to make this book easier to use by allowing the reader to be selective regarding the material to be considered at a particular time. Because the modern student of electrocardiography is primarily oriented to a visual perspective, we have typically begun each page with an illustration"--Provided by publisher.
Now in its third edition, this classic book is widely considered the leading text on Bayesian methods, lauded for its accessible, practical approach to analyzing data and solving research problems. Bayesian Data Analysis, Third Edition continues to take an applied approach to analysis using up-to-date Bayesian methods. The authors—all leaders in the statistics community—introduce basic concepts from a data-analytic perspective before presenting advanced methods. Throughout the text, numerous worked examples drawn from real applications and research emphasize the use of Bayesian inference in practice. New to the Third Edition Four new chapters on nonparametric modeling Coverage of weakly informative priors and boundary-avoiding priors Updated discussion of cross-validation and predictive information criteria Improved convergence monitoring and effective sample size calculations for iterative simulation Presentations of Hamiltonian Monte Carlo, variational Bayes, and expectation propagation New and revised software code The book can be used in three different ways. For undergraduate students, it introduces Bayesian inference starting from first principles. For graduate students, the text presents effective current approaches to Bayesian modeling and computation in statistics and related fields. For researchers, it provides an assortment of Bayesian methods in applied statistics. Additional materials, including data sets used in the examples, solutions to selected exercises, and software instructions, are available on the book’s web page.
Written by residents for residents, the updated 6th edition of this best-selling handbook provides you with exactly the information you need to overcome the vast majority of challenges you encounter during your surgical residency. With its pocket-size and easy-reference format, this resource enables you to quickly access the right guidance...at the right time...about what to do and how to do it. No resident should be without this essential surgical guide! Provides comprehensive guidelines for the treatment of the most common surgical conditions, including preoperative and postoperative care, as well as relevant pathophysiology. Includes surgical management that encompasses state-of-the-art technology and emphasizes minimally invasive techniques, including important coverage of laparoscopic cholecystectomy, appendectomy, and herniorrhaphy. Provides guidelines for proper medical record keeping as well as other mediocolegal aspects of surgical care. Offers detailed figures depicting important anatomical structures and operative techniques. Features new chapters, such as Surgical Education—including a practical discussion of the ACGME Core Competencies—Surgical Intensive Care, and Future of Surgery to provide details of the latest trends in surgical education so you can maximize your time in surgical rotations. Provides the most up-to-date information from current residents at the University of Cincinnati, in an accessible format organized by specialty area.
Now in vibrant full color throughout, Rogers’ Textbook of Pediatric Intensive Care, 5th Edition, continues its tradition of excellence as the gold standard in the field. For more than 25 years, readers have turned to this comprehensive resource for clear explanations of both the principles underlying pediatric critical care disease and trauma as well as how these principles are applied in clinical practice. In the 5th Edition, more than 250 global contributors bring you completely up to date on today’s understanding, treatments, technologies, and outcomes regarding critical illness in children.
LOS ANGELES TIMES AND PUBLISHERS WEEKLY BESTSELLER • The powerful memoir of a young doctor and former college athlete diagnosed with a rare disease who spearheaded the search for a cure—and became a champion for a new approach to medical research. “A wonderful and moving chronicle of a doctor’s relentless pursuit, this book serves both patients and physicians in demystifying the science that lies behind medicine.”—Siddhartha Mukherjee, New York Times bestselling author of The Emperor of All Maladies and The Gene David Fajgenbaum, a former Georgetown quarterback, was nicknamed the Beast in medical school, where he was also known for his unmatched mental stamina. But things changed dramatically when he began suffering from inexplicable fatigue. In a matter of weeks, his organs were failing and he was read his last rites. Doctors were baffled by his condition, which they had yet to even diagnose. Floating in and out of consciousness, Fajgenbaum prayed for a second chance, the equivalent of a dramatic play to second the game into overtime. Miraculously, Fajgenbaum survived—only to endure repeated near-death relapses from what would eventually be identified as a form of Castleman disease, an extremely deadly and rare condition that acts like a cross between cancer and an autoimmune disorder. When he relapsed while on the only drug in development and realized that the medical community was unlikely to make progress in time to save his life, Fajgenbaum turned his desperate hope for a cure into concrete action: Between hospitalizations he studied his own charts and tested his own blood samples, looking for clues that could unlock a new treatment. With the help of family, friends, and mentors, he also reached out to other Castleman disease patients and physicians, and eventually came up with an ambitious plan to crowdsource the most promising research questions and recruit world-class researchers to tackle them. Instead of waiting for the scientific stars to align, he would attempt to align them himself. More than five years later and now married to his college sweetheart, Fajgenbaum has seen his hard work pay off: A treatment he identified has induced a tentative remission and his novel approach to collaborative scientific inquiry has become a blueprint for advancing rare disease research. His incredible story demonstrates the potency of hope, and what can happen when the forces of determination, love, family, faith, and serendipity collide. Praise for Chasing My Cure “A page-turning chronicle of living, nearly dying, and discovering what it really means to be invincible in hope.”—Angela Duckworth, #1 New York Times bestselling author of Grit “[A] remarkable memoir . . . Fajgenbaum writes lucidly and movingly . . . Fajgenbaum’s stirring account of his illness will inspire readers.”—Publishers Weekly
Providing a solid foundation in current ECG technology as well as the newest diagnostic applications, Marriott’s Practical Electrocardiography, Thirteenth Edition, delivers the information you need to quickly improve your ECG interpretive skills. Authors Dr. David G. Strauss and Dr. Douglas D. Schocken offer medical students, residents and fellows a detailed explanation of the ECG, rhythm analysis, and how to rapidly and accurately interpret ECG results. Helpful diagrams, tables, animations, and videos, plus new ECG quizzes online, improve your understanding and skills.
The new edition continues to be a practical, easy to understand, and up to date resource for managing coronary disease. It not only encompasses modern cardiology practice, but also considers how the patient came to arrive on coronary care, and what will happen them after they leave. The combined authorship of doctor and nurse reflects the close teamwork vital to the management of both patients and their families. Management of the cardiac patent is a complex process and this book has a clear approach conveying the necessary information in an easily understood way. It also has an excellent evidence base to ensure best practice and should appeal to staff in every cardiac unit. Up to date coverage of a rapidly developing field Offers a multi-disciplinary approach to coronary care Easy to read and therefore easily understood Research/evidence based content ensures best practice Adds material that reflects the growing literature on nurse-lead approaches to chest pain assessment, defibrillation, thrombolysis and specialist clinics (heart failure and dysrhythmias). Updates content in line with the latest guidelines from various medical bodies.
This book traces the image of the pregnant male as it evolves in classical Greek literature. Originating as a representation of paternity and, by extension, "authorship" of creative works, the image later comes to function also as a means to explore the boundary between the sexes.
This is the second edition of a very successful title from an international team of highly respected opinion leaders. Its emphasis remains on how the clinical guidelines are to be interpreted effectively in everyday practice, and as such it has immense practical importance for clinical psychiatrists as an immediate source of reference. New to this
During the 1930s in coastal South Carolina, ten year old Matt Cogswell (white) and 11 year old George Wigfall (black) become inseparable pals. It is Georges father who gave him the uncomplimentary name Fathead. The boys share many happy adventures and growing experiences until George moves away to a big city. Matt does not understand. He is disillusioned and distressed. Georges widowed mother remarries and the boys name is changed. A decade passes and the US is involved in WWII. The two men find themselves in the crew of the same US Navy destroyer. George recognizes Matt but the white lad, now a commissioned officer, looks down on the unrecognized enlisted stewards mate. Seeing the way the black man dallies with white prostitutes on liberty in foreign and northern US ports further exasperates the situation. Not until the ship is attacked and badly damaged by German aircraft while escorting a convoy to Europe do the two men come to remember their past friendship.
The authoritative guide for Data Monitoring Committees—fully revised and updated The number of clinical trials sponsored by government agencies and pharmaceutical companies has grown in recent years, prompting an increased need for interim monitoring of data on safety and efficacy. Data Monitoring Committees (DMCs) are an essential component of many clinical trials, safeguarding trial participants and protecting the credibility and validity of the study. Data Monitoring Committees in Clinical Trials: A Practical Perspective, 2nd Edition offers practical advice for those managing and conducting clinical trials and serving on Data Monitoring Committees, providing a practical overview of the establishment, purpose, and responsibilities of these committees. Examination of topics such as the composition and independence of DMCs, statistical, philosophical and ethical considerations, and determining when a DMC is needed, presents readers with a comprehensive foundational knowledge of clinical trial oversight. Providing recent examples to illustrate DMC principles, this fully-updated guide reflects current developments and practices in clinical trial oversight and offers expanded coverage of emerging issues and challenges in the field. This new second edition covers the most current information on DMC policies, issues in monitoring trials using new designs, and recent trial publications relevant to DMC decision-making. • Presents practical advice for those managing and conducting clinical trials and serving on Data Monitoring Committees • Illustrates the types of challenging issues Data Monitoring Committees face in practical situations • Provides updated and expanded coverage of topics including regulatory and funding agency guidelines and trial designs and their associated demands and limitations • Includes a new chapter addressing legal issues that affect DMC members and discusses general litigation concerns relevant to clinical research • Expands treatment of current journal publications addressing DMC issues Data Monitoring Committees in Clinical Trials: A Practical Perspective, 2nd Edition is a must-have text for anyone engaged in DMC activities as well as trial sponsors, clinical trial researchers, regulatory and bioethics professionals, and those associated with clinical trials in academic, government and industry settings.
Coronary artery disease continues to be a major cause of morbidity and mortality in the United States and throughout the world. This issue of the Heart Failure Clinics provides a contemporary and concise, yet extensive, review on all aspects of the management of patients with coronary artery disease. Topics include but are not limited to: Epidemiology, Traditional and Novel Risk Factors in Coronary Artery Disease; Acute Coronary Syndromes: Unstable Angina and Non–ST Elevation Myocardial Infarction; Calcium Scoring and Cardiac Computed Tomography; Coronary Artery Disease and Diabetes Mellitus; Cardiac Syndrome X; and Revascularization Options: Coronary Artery Bypass Surgery and Percutaneous Coronary Intervention.
The seventh edition of this classic text champions healthy aging by demonstrating how to prevent or manage disease and make large-scale improvements toward health and wellness in the older adult population. The text synthesizes state-of-the-art research findings—providing convincing evidence that health promotion truly works—with practical, effective strategies. Encompassing important research results that supplant prior recommendations, this new edition provides updated best practices and strategies to ensure the active participation of older adults in all aspects of life. Completely reorganized for ease of use, this textbook features updated demographics and rankings for leading causes of death, new blood pressure screening guidelines and data on obesity and diabetes, updated exercise regimens, older-driver statistics and innovations such as the driverless car, cautions regarding ineffective brain-training programs, and more. Highly practical, the text includes health-promoting tools, resource lists, assessment tools, illustrations, checklists, and tables. Additionally, the book includes key terms and learning objectives at the start of each chapter, along with thought-provoking questions and reflection boxes. An Instructor’s Manual and PowerPoint slides are available to facilitate teaching. New to the Seventh Edition: Provides updated blood pressure, cholesterol, Ductal Carcinoma In Situ (DCIS), and lung cancer screening guidelines Presents updates on exercise regimens ranging from yoga to the tango Expands and updates section on emotional regulation and conflict resolution skills with aging Discusses Boomer Entrepreneurism Provides new policy recommendations including student loan debt among older adults Expands gerotechnology and smart home innovations Updates on “Obamacare” and health care delivery recommendations Addresses “Buyer Beware” regarding brain-training programs Expands global aging and LGBT aging content
With its focus on the advanced topics and procedures employed in this specialized field, Massachusetts General Hospital Manual of Cardiovascular Critical Care provides practical, must-know information to all practitioners caring for the increasing population of critical care patients with severely compromised cardiovascular function. Drs. Aranya Bagchi, David M. Dudzinski, Jonathan Ludmir, Ivana Nikolic, and Kenneth T. Shelton lead a multidisciplinary team of authors who expertly cover cardiology, cardiac surgery, anesthesia, and mechanical circulatory support topics for all ICU clinicians who focus on cardiovascular care.
Clinical trials have become essential research tools for evaluating the benefits and risks of new interventions for the treatment and prevention of diseases, from cardiovascular disease to cancer to AIDS. Based on the authors’ collective experiences in this field, Introduction to Statistical Methods for Clinical Trials presents various statistical topics relevant to the design, monitoring, and analysis of a clinical trial. After reviewing the history, ethics, protocol, and regulatory issues of clinical trials, the book provides guidelines for formulating primary and secondary questions and translating clinical questions into statistical ones. It examines designs used in clinical trials, presents methods for determining sample size, and introduces constrained randomization procedures. The authors also discuss how various types of data must be collected to answer key questions in a trial. In addition, they explore common analysis methods, describe statistical methods that determine what an emerging trend represents, and present issues that arise in the analysis of data. The book concludes with suggestions for reporting trial results that are consistent with universal guidelines recommended by medical journals. Developed from a course taught at the University of Wisconsin for the past 25 years, this textbook provides a solid understanding of the statistical approaches used in the design, conduct, and analysis of clinical trials.
Conducting Health Outcomes Research serves as the definitive guide to successful investigation of health care outcomes and the key resource for ensuring quality care. As consumer, insurer and government demands for quality health care increase, the field of research required to measure such quality stands to grow exponentially. Conducting Health Outcomes Research brings together the practical, actionable information needed to conduct research on health outcomes, with the goal of measuring the quality of the care being delivered. The book details the methodology for performing successful research in this growing field: from formulating models, choosing study design, measuring and gathering data to assessing and presenting results. Important Notice: The digital edition of this book is missing some of the images or content found in the physical edition.
A valuable resource for researchers and workers in the fields of both pharmaceuticals and biotechnology as well as undergraduates in biochemistry, applied biology, biomedical sciences and pharmacy, this book compares established techniques of antibody production with the new. Antibody structure and the implications of antibody engineering are fully
Learn to improve your assessment, investigation, and management of physical health conditions in people with severe mental illness The Maudsley Practice Guidelines for Physical Health Conditions in Psychiatry offers psychiatric and general practitioners an evidence-based and practical guide for the appropriate assessment, investigation, and management of common physical health conditions seen in people with severe mental illness. Written by a renowned team of respected experts in medicine, surgery, pharmacy, dietetics, physiotherapy, and psychiatry, the book bridges the gap between psychiatric and physical health services for the severely mentally ill. The Maudsley Practice Guidelines for Physical Health Conditions in Psychiatry also provides practitioners with expert guidance on making effective referrals to other medical and surgical subspecialties, telling readers what information subspecialties would expect to receive. Its use will improve the quality of clinical care received by mentally ill patients and, by promoting a holistic approach to treatment that considers both body and mind, will enhance the therapeutic relationship between patient and practitioner. The Maudsley Practice Guidelines for Physical Health Conditions in Psychiatry covers the following: Guidance on assessment and management of well over a hundred different medical and surgical presentations commonly seen in people with serious mental illness Management of physical health emergencies in a psychiatric setting Evidence-based approaches to management of physical side effects of psychiatric medications Advice on approaches to promote a healthy lifestyle in people with serious mental illness, such as smoking cessation and changes to diet and physical activity Perfect for both psychiatrists and general practitioners who wish to improve the quality of care they provide to people with serious mental illness, The Maudsley Practice Guidelines for Physical Health Conditions in Psychiatry will be of use to anyone setting out to navigate the divide between the treatment of psychiatric and physical health conditions.
Algorithms serve an important purpose in the field of psychopharmacology as heuristics for avoiding the biases and cognitive lapses that are common when prescribing for many conditions whose treatment is based on complex data. Unique in the field, this title compiles twelve papers from the Psychopharmacology Algorithm Project at the Harvard South Shore Psychiatry Residency Training Program and presents practical ways to adopt evidence-based practices into the day-to-day treatment of patients. Psychopharmacology Algorithms is a useful resource for practicing psychiatrists, residents, and fellows, as well as psychiatric nurse practitioners, psychiatric physician assistants who prescribe, advanced practice pharmacists who prescribe, and primary care clinicians. Teachers of psychopharmacology may find it particularly valuable. Researchers in clinical psychopharmacology may find it helpful in identifying important practice areas that are in need of further study.
This new book provides a unified, in-depth, readable introduction to the multipredictor regression methods most widely used in biostatistics: linear models for continuous outcomes, logistic models for binary outcomes, the Cox model for right-censored survival times, repeated-measures models for longitudinal and hierarchical outcomes, and generalized linear models for counts and other outcomes. Treating these topics together takes advantage of all they have in common. The authors point out the many-shared elements in the methods they present for selecting, estimating, checking, and interpreting each of these models. They also show that these regression methods deal with confounding, mediation, and interaction of causal effects in essentially the same way. The examples, analyzed using Stata, are drawn from the biomedical context but generalize to other areas of application. While a first course in statistics is assumed, a chapter reviewing basic statistical methods is included. Some advanced topics are covered but the presentation remains intuitive. A brief introduction to regression analysis of complex surveys and notes for further reading are provided.
Managing the Drug Discovery Process, Second Edition thoroughly examines the current state of pharmaceutical research and development by providing experienced perspectives on biomedical research, drug hunting and innovation, including the requisite educational paths that enable students to chart a career path in this field. The book also considers the interplay of stakeholders, consumers, and drug firms with respect to a myriad of factors. Since drug research can be a high-risk, high-payoff industry, it is important to students and researchers to understand how to effectively and strategically manage both their careers and the drug discovery process. This new edition takes a closer look at the challenges and opportunities for new medicines and examines not only the current research milieu that will deliver novel therapies, but also how the latest discoveries can be deployed to ensure a robust healthcare and pharmacoeconomic future. All chapters have been revised and expanded with new discussions on remarkable advances including CRISPR and the latest gene therapies, RNA-based technologies being deployed as vaccines as well as therapeutics, checkpoint inhibitors and CAR-T approaches that cure cancer, diagnostics and medical devices, entrepreneurship, and AI. Written in an engaging manner and including memorable insights, this book is aimed at anyone interested in helping to save countless more lives through science. A valuable and compelling resource, this is a must-read for all students, educators, practitioners, and researchers at large—indeed, anyone who touches this critical sphere of global impact—in and around academia and the biotechnology/pharmaceutical industry. - Considers drug discovery in multiple R&D venues - big pharma, large biotech, start-up ventures, academia, and nonprofit research institutes - with a clear description of the degrees and training that will prepare students well for a career in this arena - Analyzes the organization of pharmaceutical R&D, taking into account human resources considerations like recruitment and configuration, management of discovery and development processes, and the coordination of internal research within, and beyond, the organization, including outsourced work - Presents a consistent, well-connected, and logical dialogue that readers will find both comprehensive and approachable - Addresses new areas such as CRISPR gene editing technologies and RNA-based drugs and vaccines, personalized medicine and ethical and moral issues, AI/machine learning and other in silico approaches, as well as completely updating all chapters
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