This textbook provides a concise overview of malignant haematology, including reviews of cell and molecular biology, and implications for new trends in treatment.
The immune system can deal effectively with the majority of viruses and bacteria, less effectively with parasites, and very poorly with cancer. Why is this so? Why are McFarlane Burnet's and Lewis Thomas' predictions that the immune system is in volved in ridding the body of cancer cells, encapsulated in the catchy phrase "immunologic surveillance," so difficult to experi mentally establish? Cancer differs from infectious agents in being derived from the host. Hence, it has been postulated that cancer cells lack anti gens that the immune system can recognize. They are not "im munogenic. " However, this argument is seriously weakened by the existence of numerous human autoimmune diseases, in which the immune system effectively recognizes and attacks a va riety of self tissues. Thus, the potential clearly exists for recogni tion of the surfaces of tumor cells. Professor Naor and his colleagues have written a book that explores another possible reason: cancer cells are recognized by the immune system-but is it possible that the consequence of recognition is inhibition of the immune system-by suppressor T cells or macrophages? The evolution of the malignant state may only occur in individuals who develop this suppression. This book reviews the evidence that suppressor cells, poorly characterized and difficult to study, may be of fundamental im portance in cancer. In fact, our incapacity to understand the na ture of suppressor cells and their mode of action is one of the ma jor problems in immunology research today.
This is a pocket-sized guide to the main features and problems encountered in haematology. With colour photographs and scans, the text summarises clinically-important information about the conditions illustrated.
A full-color clinical reference covering both common and uncommon blood disorders—distilled from the world’s leading hematology text Williams Manual of Hematology, Tenth Edition provides a concise, easy-to-navigate compilation of the pathogenic, diagnostic, and therapeutic essentials of blood cell and coagulation protein disorders. Referenced to the classic Williams Hematology, this portable guide has been carefully edited to deliver only the most clinical point-of-care facts, making differential diagnosis faster, easier, and more efficient. This updated edition reflects the latest research and includes more than 100 full-color clinical photographs. Concise but comprehensive, this complete guide includes sections on: Initial Clinical Evaluation Disorders of Red Cells Disorders of Granulocytes Disorders of Monocytes and Macrophages Principles of Therapy for Neoplastic Hematological Disorders The Clonal Myeloid Disorders The Polyclonal Lymphoid Diseases The Clonal Lymphoid and Plasma Cell Diseases Disorders of Platelet and Hemostasis Disorders of Coagulation Proteins Thrombosis and Antithrombotic Therapy Transfusion and Hemapheresis
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