David Brusick's Books

Methods for Genetic Risk Assessment

By: David Brusick

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Methods for Genetic Risk Assessment

By: David Brusick

Genetic disease contributes to a major portion of our health care costs. While most of the human genetic burden is transmitted from generation to generation, environmental chemicals capable of reacting with germ cell DNA could produce new mutations, resulting in an even greater genetic liability for the next generation. The potential impact of environmental mutagens on the health and viability of other living things is important to consider as well. Methods for Genetic Risk Assessment features contributions from international experts to provide a comprehensive review of the current status of genetic risk assessment. You'll learn about various methods and strategies for when and how to conduct genetic risk assessments on human populations. You will also learn about the potential effects of environmental genotoxins on nonhuman organisms.

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271

Publisher

CRC Press

Published Date

ISBN 10

1040293905

ISBN 13

9781040293904

Principles of Genetic Toxicology

By: David Brusick

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Principles of Genetic Toxicology

By: David Brusick

The field of genetic toxicology is a relatively new one which grew out of the studies of chemical mutagenesis and modern toxicology. Considering that systematic practices to detect chemical mutagenesis are only a little over thirty years old, this field has evolved very rapidly with an abundance of methods for identifying chemical mutagens. To evalulate the usefulness of the methods and to select the assay which will yield the most important information under practical conditions requires the broad experience such as that which Dr. Brusick has acquired over the last decade. Since this field is expanding very rapidly and new test ing methods are being recognized, it should be kept in mind that revisions may have to be made during the next five to ten years. The need for such a book has been obvious to us, particularly since training courses and workshops on genetic toxicology are being organized which find it beneficial to utilize established guidelines and since the reports in the literature do not always describe in detail how the work was carried out during laboratory testing. In addition to his broad background in genetics, Dr. Brusick has had much practical experience, having organized and directed the most extensive laboratory for mutagen testing. I am most pleased to see this volume, for which there is an ever-increasing need. Alexander Hollaender Associated Universities, Inc. 1717 Massachusetts Avenue, N.W.

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249

Publisher

Springer Science & Business Media

Published Date

ISBN 10

146157661X

ISBN 13

9781461576617

Global Competition

Law, Markets, and Globalization

By: David Gerber

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Global Competition

Law, Markets, and Globalization

By: David Gerber

A key factor in the emerging relationship between law and economic globalization is how global competition now shapes economies and societies. Competition law is provided by those players that have sufficient 'power' to apply their laws transnationally. This book examines this important and controversial aspect of globalization.

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416

Publisher

Oxford University Press

Published Date

ISBN 10

0199652007

ISBN 13

9780199652006

Natural, Metal, Fiber, and Macromolecular Carcinogens

Structural Bases and Biological Mechanisms

By: Yin-Tak Woo,David Y. Lai,Joseph C. Arcos

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Natural, Metal, Fiber, and Macromolecular Carcinogens

Structural Bases and Biological Mechanisms

By: Yin-Tak Woo,David Y. Lai,Joseph C. Arcos

Chemical Induction of Cancer: Structural Bases and Biological Mechanisms, Volume IIIC: Natural, Metal, Fiber, and Macromolecular Carcinogens covers structure-carcinogenicity relationships of carcinogenic mycotoxins, carcinogenic substances generated by plants, carcinogenic metals and metalloids, and foreign-body carcinogens. The book discusses the metabolism and mechanism of carcinogenic action, physicochemical properties, other biological activities (principally mutagenicity and teratogenicity), modification of carcinogenic activity, formation and environmental significance. The text also describes the carcinogenic water-soluble high polymers and explores the intriguing problems of the carcinogenic effect of osmotic imbalance in tissue microenvironment, as well as of spontaneous malignant transformation occurring in cell cultures in vitro. Studies on tumor induction and carcinogenesis modification by nonviral nucleic acids, by nucleases, proteases, histones, and by antigenic stimulation as well as by antibodies are also considered. The book further tackles tumor-released factors as possible modifiers of carcinogenesis. The text will prove invaluable to chemists and people involved in cancer research.

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898

Publisher

Academic Press

Published Date

ISBN 10

1483216020

ISBN 13

9781483216027

Aliphatic and Polyhalogenated Carcinogens

Structural Bases and Biological Mechanisms

By: Yin-Tak Woo,David Y. Lai,Joseph C. Arcos

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Aliphatic and Polyhalogenated Carcinogens

Structural Bases and Biological Mechanisms

By: Yin-Tak Woo,David Y. Lai,Joseph C. Arcos

Chemical Induction of Cancer: Structural Bases and Biological Mechanisms, Volume IIIB: Aliphatic and Polyhalogenated Carcinogens covers environmentally and occupationally significant carcinogens of industrial origins. The book discusses the structure-activity relationships, metabolism, and environmental significance of the halogenated linear alkanes and alkenes and the halogenated cycloalkanes; and cycloalkene pesticides, biphenyls, and related aromatics. The text also describes the structure-activity relationships, metabolism, and environmental significance of the halogenated phenoxy acids, aromatic ethers, dibenzofurans, and dibenzo-p-dioxins; and ethylene glycol, diethylene glycol, dioxane, and related compounds. The structure-activity relationships, metabolism, and environmental significance of phenols and phenolic compounds; nitroalkanes and nitroalkenes; and acetamide, dimethylcarbamyl chloride, and related compounds thiocarbonyl compounds are also encompassed. The book further tackles the structure-activity relationships, metabolism, and environmental significance if fatty acids, detergents, and other surfactants with oncogenic potential. The text then looks into the effect of chemical reactivity, molecular geometry, and metabolism on carcinogenic activity. Chemists, geneticists, and those involved in cancer research will find the book invaluable.

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619

Publisher

Academic Press

Published Date

ISBN 10

1483216012

ISBN 13

9781483216010

Mechanisms of DNA Damage and Repair

Implications for Carcinogenesis and Risk Assessment

By: Michael G. Simic,Lawrence Grossman,Arthur C. Upton,David S. Bergtold

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Mechanisms of DNA Damage and Repair

Implications for Carcinogenesis and Risk Assessment

By: Michael G. Simic,Lawrence Grossman,Arthur C. Upton,David S. Bergtold

This book is based on the papers presented at the conference on "Mecha nisms of DNA Damage and Repair: Implications for Carcinogenesis and Risk Assessment," held at the National Bureau of Standards on June 2-7, 1985, This volume deals with mechanisms of DNA damage and repair at the molecular level; consequences of unrepaired or misrepaired damage, with major emphasis on carcinogenesis; drugs which bind selectively to altered and potentially damaging DNA sequences; and potential utilization of DNA damage as an endpoint for assessing risks of UV light, ionizing radiations, chemicals, drugs, and hazardous agents in foods. Because the induction of mutations by radiation and genotoxic chemicals has been observed to follow one-hit kinetics in some instances, it is generally assumed that any level of exposure to a DNA-damaging agent may increase the risk of genetic disease or cancer in an exposed population. At the same time, however, there is evidence that although the DNA of living cells is continually damaged by natural background radiation, free radicals, and other naturally occurring processes, most of the damage is normally repaired.

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567

Publisher

Springer Science & Business Media

Published Date

ISBN 10

1461594626

ISBN 13

9781461594628

Effects of Persistent and Bioactive Organic Pollutants on Human Health

By: David O. Carpenter

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Effects of Persistent and Bioactive Organic Pollutants on Human Health

By: David O. Carpenter

Examines what we know about the relationship between organic chemicals and human disease Organic chemicals are everywhere: in the air we breathe, the water we drink, and the food we eat. They are also found in a myriad of common household and personal care products. Unfortunately, exposure to some organic chemicals can result in adverse health effects, from growth and developmental disorders to cancer and neurodegenerative diseases. This book examines how organic chemicals affect human health. It looks at the different diseases as well as how individual organ systems are affected by organic chemicals. Effects of Persistent and Bioactive Organic Pollutants on Human Health begins with an introductory chapter explaining why we should care about organic chemicals and their effect on human health. Next, the authors address such important topics as: Burden of cancer from organic chemicals Organic chemicals and obesity Effects of organic chemicals on the male reproductive system Organic chemicals and the immune system Intellectual developmental disability syndromes and organic chemicals Mental illness and exposure to organic chemicals The book ends with an assessment of how much human disease is caused by organic chemicals. Chapters have been contributed by leading international experts in public and environmental health and are based on the latest research findings. Readers will find that all of the contributions are clear and easy to comprehend, with extensive references for further investigation of individual topics. Effects of Persistent and Bioactive Organic Pollutants on Human Health is recommended for students and professionals in medicine as well as public and environmental health, bringing them fully up to date with what we know about the relationship between organic chemicals and human health.

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Page Count

485

Publisher

John Wiley & Sons

Published Date

ISBN 10

1118679547

ISBN 13

9781118679548

Performance Requirements and Investment Incentives Under International Economic Law

By: David Collins

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Performance Requirements and Investment Incentives Under International Economic Law

By: David Collins

In this discerning book, David Collins provides an eloquent analysis of performance requirements and investment incentives as vital tools of economic policy. Adopting a consciously broad definition of both instruments, this work provokes a constructively critical assessment of their existing treatment under international economic law.

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281

Publisher

Edward Elgar Publishing

Published Date

ISBN 10

1784712043

ISBN 13

9781784712044

Contract Research and Development Organizations-Their History, Selection, and Utilization

By: Shayne C. Gad,Charles B. Spainhour,David G. Serota

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Contract Research and Development Organizations-Their History, Selection, and Utilization

By: Shayne C. Gad,Charles B. Spainhour,David G. Serota

This volume provides a complete update of all the materials in prior volumes on the subject (including current directories to testing labs and other support establishments worldwide), while adding substantial new material on the following topics: · The history of CROs, including snapshots of CROs and a genealogy chart making clear where they came from and where they went. · Study directors and principal investigators. · The nuts and bolts of study performance. · Electronic reporting requirements – SEND and eCTD (required for NDA, BLA, ANDA, and IND submissions). · Consultants and their roles. · An expanded examination of common problems and their solutions. This book boasts complete directories to the global universe of operating labs – where they are, how to contact them, and what they do (including special capabilities). Additionally, checklists for qualifying labs and manufacturing facilities – and for auditing studies and projects at such facilities – are included. It is directed at those in industry (specifically directed at those working for companies using CRO services) but will also be of interest to scientists or administrators working in research organizations themselves. In this case, the contents of this new work are essential to the target reader because the work, regulations, and actors (CROs) have evolved and changed at a rapid pace in the 10 years since the earlier volume that the author published. Likewise, the companies using these services have come to all be almost completely dependent on outsourcing. The earlier texts remain the only source of their kind (paper or electronic) on the field and the only noncommercial guide to the global industry and this volume provides a complete update.

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Page Count

515

Publisher

Springer Nature

Published Date

ISBN 10

3030430731

ISBN 13

9783030430733

Toxicological Carcinogenesis

By: David B. Clayson

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Toxicological Carcinogenesis

By: David B. Clayson

How do we know if a chemical is carcinogenic? How accurate and relevant to humans are the current assays? With the increasing influx of chemicals in our food and environment, these questions become more critical everyday. Written by an expert with more than fifty years experience in this field, Toxicological Carcinogenesis gives you a balanced and authoritative treatment of the issues. The book provides a summary of the present knowledge of chemicals that induce cancer. The author avoids the overuse of technical jargon and explains scientific concepts clearly and succinctly. He has included an appendix containing bibliographic references, making the text easier to read and keeping the information available as a reference. He covers: How carcinogens are detected in humans using epidemiology, bioassays, and alternative approaches Agents leading to human cancer such as exposure due to occupation, cigarette smoking, and diet and nutrition Carcinogenesis mechanisms The use of legislation to control exposures to noxious agents. Toxicological Carcinogenesis fills a gap in the current literature by providing just enough background information to give a complete general overview of the subject. It explores the emerging debates that related to the potential chemical causes of cancer. In addition to the comprehensive coverage the book provides, it explains the potential problems caused by possible misinformation about chemical carcinogenesis.

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Page Count

212

Publisher

CRC Press

Published Date

ISBN 10

1420032720

ISBN 13

9781420032727

Competition Law

By: Richard Whish,David Bailey

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Competition Law

By: Richard Whish,David Bailey

Definitive and clear, authoritative and comprehensive; the stand alone resource on competition law for students and practitioners, written by the leading academics in the field. This eighth edition addresses key developments, including the Enterprise and Regulatory Reform Act 2013, with an increased emphasis on intellectual property.

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1175

Publisher

Oxford University Press, USA

Published Date

ISBN 10

0199660379

ISBN 13

9780199660377

Trade and Globalization

An Introduction to Regional Trade Agreements

By: David A. Lynch

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Trade and Globalization

An Introduction to Regional Trade Agreements

By: David A. Lynch

Regional trade agreements (RTAs) are not new, but their complexity and importance in global economics and politics has grown exponentially in the past two decades. Tackling this daunting proliferation head on, this book provides a much-needed guide to RTAs. Setting current regional agreements in their economic, political, and historical context, David A. Lynch describes and compares every significant RTA, region by region. He clearly explains their intricate inner workings, their webs of collaboration and conflict, and their primary goals and effectiveness. Lynch's deeply knowledgeable study bridges the ideological divides in scholarly and public debate, including economists' emphases on markets and efficiency versus antiglobalization activists' concerns over inequality and social ills. By building a middle ground between micro and macro analysis and clarifying technical terminology, this concise and accessible book will be an invaluable reference for all readers.

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348

Publisher

Rowman & Littlefield Publishers

Published Date

ISBN 10

0742566900

ISBN 13

9780742566903

Toxicological Testing Handbook

Principles, Applications, and Data Implementation

By: Jacobson-Kram David

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Toxicological Testing Handbook

Principles, Applications, and Data Implementation

By: Jacobson-Kram David

Designed to aid toxicology testing study design, this text provides data on issues such as species selection, dose level and dosing regimes, animal models, routes of exposure, statistical evaluation, data interpretation, fulfillment of regulatory requirements, and adherence to good laboratory practices.

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Page Count

442

Publisher

CRC Press

Published Date

ISBN 10

0824700732

ISBN 13

9780824700737

Methodology for Impact Assessment of Free Trade Agreements

By: Michael G. Plummer,David Cheong,Shintaro Hamanaka

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Methodology for Impact Assessment of Free Trade Agreements

By: Michael G. Plummer,David Cheong,Shintaro Hamanaka

This publication displays the menu for choice of available methods to evaluate the impact of Free Trade Agreements (FTAs). It caters mainly to policy makers from developing countries and aims to equip them with some economic knowledge and techniques that will enable them to conduct their own economic evaluation studies on existing or future FTAs, or to critically re-examine the results of impact assessment studies conducted by others, at the very least.

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194

Publisher

Asian Development Bank

Published Date

ISBN 10

9290921978

ISBN 13

9789290921974

The Chopra Center Herbal Handbook

Forty Natural Prescriptions for Perfect Health

By: David Simon, M.D.,Deepak Chopra, M.D.

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The Chopra Center Herbal Handbook

Forty Natural Prescriptions for Perfect Health

By: David Simon, M.D.,Deepak Chopra, M.D.

People around the world are increasingly working with their own bodies to restore balance. They're using medicinals found in nature to avoid the side effects of antibiotics and turning to traditions that have passed the test of time. The oldest medical system of all is Ayurveda, which dates back 5,000 years to its origins in India. In The Chopra Center Herbal Handbook, Deepak Chopra, M.D., and David Simon, M.D., draw on the forty most important herbs of Ayurveda, from aloe and amrit to ginger and winter cherry, to create a practical, popular reference book that shows how to strengthen immunity, rejuvenate the body, boost energy, and detoxify the system. Each listing in The Chopra Center Herbal Handbook contains botanical information, scientific research, instructions on using the herb, a line drawing, precautions, and most important, the specific ailments each herb is best suited to remedy, including those involving digestion, mind and emotions, women's and men's health matters, metabolism, pain, arthritis and inflammation, circulation, and many more.

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274

Publisher

Harmony

Published Date

ISBN 10

0307829103

ISBN 13

9780307829108

The Feeling Good Handbook

The Groundbreaking Program with Powerful New Techniques and Step-by-Step Exercises to Overcome Depression, Conquer Anxiety, and Enjoy Greater Intimacy

By: David D. Burns

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The Feeling Good Handbook

The Groundbreaking Program with Powerful New Techniques and Step-by-Step Exercises to Overcome Depression, Conquer Anxiety, and Enjoy Greater Intimacy

By: David D. Burns

From the author of the national bestseller Feeling Good: The New Mood Therapy comes a guide to mental wellness that helps you get beyond depression and anxiety and make life an exhilarating experience! With his phenomenally successful Feeling Good: The New Mood Therapy, Dr. David Burns introduced a groundbreaking, drug-free treatment for depression. In this bestselling companion, he reveals powerful new techniques and provides step-by-step exercises that help you cope with the full range of everyday problems. • Free yourself from fears, phobias, and panic attacks. • Overcome self-defeating attitudes. • Discover the five secrets of intimate communication. • Put an end to marital conflict. • Conquer procrastination and unleash your potential for success. With everything you need to know about commonly prescribed psychiatric drugs and anxiety disorders, such as agoraphobia and obsessive-compulsive disorder, this remarkable guide can show you how to feel good about yourself and the people you care about. You will discover that life can be an exhilarating experience. “A wonderful achievement—the best in its class.”—M. Anthony Bates, clinical psychologist at Penn Presbyterian Medical Center in Philadelphia “Clear, systematic, forceful.”—Albert Ellis, PhD, president of the Albert Ellis Institute

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Page Count

769

Publisher

Penguin

Published Date

ISBN 10

0452281326

ISBN 13

9780452281325

Waste Testing and Quality Assurance

Second Volume

By: David Friedman

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Waste Testing and Quality Assurance

Second Volume

By: David Friedman

Annotation Thirty-three papers address: waste and environmental media sampling, property and hazard assessment, chemical and biological analysis, estimating migration of hazardous constituents from wastes, analytical methods development and evaluation, laboratory data management, and quality assurance. Annotation copyrighted by Book News, Inc., Portland, OR.

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Page Count

469

Publisher

ASTM International

Published Date

ISBN 10

0803112939

ISBN 13

9780803112933

Foye's Principles of Medicinal Chemistry

By: Victoria Roche,William S. Zito,Thomas Lemke,David A. Williams

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Foye's Principles of Medicinal Chemistry

By: Victoria Roche,William S. Zito,Thomas Lemke,David A. Williams

With expert contributions from experienced educators, research scientists and clinicians, Foye’s Principles of Medicinal Chemistry, Eighth Edition is an invaluable resource for professional students, graduate students and pharmacy faculty alike. This ‘gold standard’ text explains the chemical basis of drug action, emphasizing the structure-activity relationships, physicochemical-pharmacokinetic properties, and metabolic profiles of the most commonly used drugs.

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Page Count

6058

Publisher

Lippincott Williams & Wilkins

Published Date

ISBN 10

149638587X

ISBN 13

9781496385871

Molecular Toxicology

By: P. David Josephy,Bengt Mannervik

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Molecular Toxicology

By: P. David Josephy,Bengt Mannervik

The science of toxicology has progressed considerably since Molecular Toxicology was first published in 1997. New advances in biochemical and molecular biological experimental techniques have helped researchers understand the precise effects of toxins and foreign compounds on living things atthe molecular, cellular, and organismal levels. Breakthrough research has recently been completed illuminating the human genome and the role of enzymes in toxic biochemical reaction mechanisms. Toxicology now covers drug metabolism and design, carcinogenesis, programmed cell death, and DNA repair,among other subjects. The second edition captures these and other advances, and broadens its scope to address the experimental science of toxicology. The first edition of Molecular Toxicology has become an indispensable resource for graduate students in molecular and biochemical toxicology courses,as well as academic researchers and industrial researchers in toxicology. Rigorously updated and revised, the new edition commands an unrivaled authority in the field of molecular toxicology.

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620

Published Date

ISBN 10

0195176200

ISBN 13

9780195176209

Toxic Hazards in Food

By: David M. Conning,A. B. G. Lansdown

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Toxic Hazards in Food

By: David M. Conning,A. B. G. Lansdown

In the world of plentiful, cheap food that so many of us in the Western World have come to accept as our birthright, it takes sensational journalism and horrific television coverage to make us realise that not all of the world's population shares this abundance. Visits to the Soviet Bloc countries, to China, most African states and various other coun tries of the Third World make one quickly realise that widespread shortage of food is just over the horizon and would be common experi ence to all were it not for the advanced technologies of Western agricul ture, food production and food manufacture. Without doubt, pesticides and other agricultural chemicals have made enormous contributions to world food production - and indeed to world peace. The introduction of many food additives, especially antioxidants, has also contributed greatly to the amount and quality of food which is available, preventing early spoilage and waste, and possibly indirectly contributing to man's health, as these antioxidants have been shown to have beneficial proper ties in the prevention of experimental malignancy and cardiovascular disease. Nevertheless, despite the enormous benefits derived from the use of agrochemicals and food additives, it is essential to remember that these are all selectively toxic chemicals, with no absolute guarantee of safety, and where the benefit to risk ratio is always a compromise adjusted by the expediency of political and financial aspects of food production.

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