David B. Lombard's Books

Biochemistry and Genetics of Recq-Helicases

By: David B. Lombard

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Biochemistry and Genetics of Recq-Helicases

By: David B. Lombard

Biochemistry And Genetics of RecQ-Helicases provides a background into the role of helicases in general and RecQ helicases specifically in DNA repair. Helicases- enzymes which break down hydrogen bonds between nucleic acid strands in a nucleoside triphosphate-dependent manner-are ubiquitous in biology, participating in processes as diverse as replication, repair, recombination, transcription, and translation. The RecQ-family helicases are a group of helicases which have important roles in the maintenance of genomic stability in many organisms. In humans, mutations in three RecQ-family helicases lead to disease. This book thoroughly examines these helicases. Mutations in the BLM gene lead to Bloom syndrome, a disorder characterized by a susceptibility to many types of cancer. Mutations in the WRN gene cause Werner syndrome, a disease which in some respects resembles premature aging. Finally, mutations in a newly characterized RecQ-family member, RECQ4, may lead to the very rare recessive disorder Rothmund-Thomson syndrome, a condition characterized by developmental abnormalities and some aging-like manifestations. This book is intended for any researchers invested in these particular disorders, or with a general interest in DNA.

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Page Count

101

Publisher

Springer Science & Business Media

Published Date

ISBN 10

1461514053

ISBN 13

9781461514053

Building America's First University

An Historical and Architectural Guide to the University of Pennsylvania

By: George E. Thomas,David B. Brownlee

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Building America's First University

An Historical and Architectural Guide to the University of Pennsylvania

By: George E. Thomas,David B. Brownlee

More than a guide, this is a thorough and engaging study of a great American institution."--Choice

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Page Count

414

Publisher

University of Pennsylvania Press

Published Date

ISBN 10

0812235150

ISBN 13

9780812235159

Action and Its Explanation

By: David-Hillel Ruben

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Action and Its Explanation

By: David-Hillel Ruben

David-Hillel Ruben's new book pursues some novel and unusual standpoints in the philosophy of action. He rejects, for example, the most widely held view about how to count actions, and argues for what he calls a 'prolific theory' of act individuation. He also describes and argues against thetwo leading theories of the nature of action, the causal theory and the agent causal theory. The causal theory cannot account for skilled activity, nor for mental action. The agent causalist theory unnecessarily reifies causings. He identifies an assumption that they share, and that most actiontheorists have assumed to be unproblematic and uncontroversial, that an action is, or entails the existence of, an event. Several different meanings to that claim are disentangled and in the most interesting sense of that claim, Ruben denies that it is true. His own alternative is simple andunpretentious: nothing informative can be said about the nature of action that explicates action in any other terms.Ruben sketches a theory of causal explanation of action that eschews the requirement for laws or generalisations, and this effectively quashes one argument for the oft-repeated view that no explanations of action can be causal, on the grounds that there are no convincing cases of laws of humanaction. He addresses a number of questions about the knowledge an agent has of his own actions, looking particularly at examples of pathological cases of action in which, for one reason or another, the agent does not know what he is doing.Inspiring and enlightening in its challenge to received wisdom, and in its convincing defence of some unfashionable positions, Action and its Explanation will be required reading for anyone working in this field.

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Page Count

258

Publisher

Oxford University Press

Published Date

ISBN 10

0198235887

ISBN 13

9780198235880

Book's by David B. Lombard

Biochemistry and Genetics of Recq-Helicases

Biochemistry and Genetics of Recq-Helicases

Building America's First University

Building America's First University

Action and Its Explanation

Action and Its Explanation

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