This autobiography of an outstanding mathematician, dedicated to others, whose career included stints as a senior university and federal administrator, is also the story of a young man of mixed Mexican and American parentage.
Coenzyme Q10 (CoQ) deficiencies are clinically and genetically heterogeneous diseases that can occur due to defects of ubiquinone biosynthesis (primary deficiencies) or other causes (secondary deficiencies). Radical oxygen species (ROS) production and oxidative stress is a common consequence of dysfunctional mitochondria and CoQ deficiency. Mitochondrial damage induced by ROS can trigger mitochondrial permeability transition (MPT) by opening of non-specific high conductance permeability transition pores in the mitochondrial inner membrane. This, in turn, leads to a simultaneous collapse of mitochondrial membrane potential and the activation of selective elimination of depolarized and dysfunctional mitochondria by mitophagy. In this respect, mitophagy could be considered as a protective mechanism for elimination of potential harmful mitochondria. Mitophagy must be accompanied by mitochondrial biogenesis activation to compensate the mitochondrial loss. However, massive and persistent mitophagy may impair cell bioenergetics, autophagy flux, and mitochondrial biogenesis, and eventually may cause cell death.
Along with the growth of RF and microwave technology applications, there is a mounting concern about the possible adverse effects over human health from electromagnetic radiation. Addressing this issue and putting it into perspective, this groundbreaking resource provides critical details on the latest advances in high frequency electromagnetic dosimetry. The book takes a scientific and rigorous engineering point of view, helping you achieve highly accurate exposure assessments.
The book serves as a comprehensive, one-stop resource, including in-depth coverage of multiband integrated antenna design, simulation, testing and manufacturing. This practical book helps you solve integration problems for ever-increasing multiband requirements. You find discussions on important considerations regarding future handset MIMO terminals, such as efficiency and the effect of the user. The book also shows you how to avoid tweaking for fractal multiband designs and printed dipole design.
Discovery Practice, Eighth Edition gives you hard-nosed, trial-tested guidance through all the intricacies of what to do, whether to do it, and how to do it -- at every stage of the discovery process. Turn to this trusted guide for thorough, up-to-date clarification of: Insurance discoverability Discovery abuse -- its penalties and sanctions Confidentiality and discovery of trade secrets Use of experts Use of investigation files Use of witness statements Protective orders Invoking Rule 29 powers Tapes and telephones depositions Using the Manual for Complex Litigation Foreign discovery Discovery in administrative hearings Discovery in arbitration. Plus detailed coverage of such cutting edge areas as e-mail depositions and FOIA proceedings. Appendices include ready to adapt sample forms. Now, with all the practice tips and valuable strategies packed into Discovery Practice, you can Facilitate early and thorough disclosure of information Quickly determine a core of undisputed facts Intensively promote and pursue a negotiated settlement.
This book examines troupes, plays, festivals, performative practices, and audiences active during the final years of the Franco dictatorship and the beginning of the transition to democracy. This period, spanning 1968 to 1982, is considered the historical moment that most directly shaped contemporary Spanish politics and society. The dominant narrative of the Transition has long portrayed it as a normalized, non-confrontational, and consensual process steered by political elites. But the world of Spanish theater tells a very different story - one in which ordinary Spaniards played a vital role in the transition to democracy. The chapters of this book draw on censorship files, photographs, audiovisual and textual material, and the author’s own interviews with more than a dozen audience and troupe members. Using these sources, David Rodriguez-Solas examines the notable experimentation during this period with theatrical performance and music; the establishment of performing spaces and festivals; the development of touring networks as a way to evade censorship; and the creation of networks of support that opposed diverse forms of violence and repression. This study will be of great interest to students and scholars interested in theater and the cultural and political history of Spain in the 1960s and 1970s.
This volume covers most areas in the physics of the solar system, with special emphasis on gravitational dynamics; its gist is the rational, in particular mathematical, understanding of the main processes at work. Special stress is given to the variety of objects in the planetary system and their long-term evolution. The unique character of this book is its breadth and depth, which aims at bringing the reader to the threshold of original research; however, special chapters and introductory sections are included for the benefit of the beginner. The volume is generally suitable for post-graduate students and researchers in physics, especially in the field related to the solar system. A large amount of figures and diagrams is included, often compiled with real data.
For the instructor or student confronting an introductory course in ordinary differential equations there is a need for a brief guide to the key concepts in the subject. Important topics like stability, resonance, existence of periodic solutions, and the essential role of continuation of solutions are often engulfed in a sea of exercises in integration, linear algebra theory, computer programming and an overdose of series expansions. This book is intended as that guide. It is more conceptual than definitive and more light-hearted than pedagogic. It covers key topics and theoretical underpinnings that are necessary for the study of rich topics like nonlinear equations or stability theory. The [Author]; has included a great many illuminating examples and discussions that uncover the conceptual heart of the matter.
Well organized and easy to read, Clinical Procedures in Primary Eye Care, 5th Edition, takes an accessible, step-by-step approach to describing the commonly used primary care procedures that facilitate accurate diagnosis and effective patient management. This practical, clinically-focused text offers succinct descriptions of today's most frequently encountered optometric techniques supported by research-based evidence. You’ll find essential instructions for mastering the procedures you need to know, including recent technical advances in the field. Discusses technical advances that are dramatically altering optometry: Optical Coherence Tomography (OCT) and ultra-wide field imaging (optomaps). Presents outstanding new digital images of OCT cases and optomaps for a wide variety of conditions of the central and peripheral retina. Focuses on evidence-based optometry; all procedures include a section that reviews when and how the procedure should be measured and uses clinical wisdom in addition to research-based evidence. Presents new digital images of normal variations of the eye – crucial visual support for understanding what is normal and what is disease. Helps you clearly visualize procedures and eye disorders through full-color photographs, diagrams, and video clips. Provides fully revised print on dry eye assessment based on the latest international Dry Eye Workshop (DEWS) guidelines. Features coverage of changes in the eye due to high myopia, and expounds the need for myopia control techniques. Offers extensive material online to enhance learning: video clips, interactive testing sections, additional photographs, and more.
This brief modern introduction to ordinary differential equations emphasizes stability theory. Concisely and lucidly expressed, it is intended as a supplementary text for advanced undergraduates or beginning graduate students. 1968 edition.
An expert guide to targeting protein kinases in cancer therapy Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells. Because of this fact, pharmaceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal roadblocks to sever their malignant means of communication. Complete with full-color presentations, Targeting Protein Kinases for Cancer Therapy defines the structural features of protein kinases and examines their cellular functions. Combining kinase biology with chemistry and pharmacology applications, this book enlists emerging data to drive the discovery of new cancer-fighting drugs. Valuable information includes: Comprehensive overviews of the major kinase families involved in oncology, integrating protein structure and function, and providing important tools to assist pharmaceutical researchers to understand and work in this dynamic area of cancer drug research Focus on small molecule inhibitors as well as other therapeutic modalities Discussion of kinase inhibitors that have entered clinical trials for the treatment of cancer, with an emphasis on molecules that have progressed to late stage clinical trials and, in a few cases, to market Providing a platform for further study, this important work reviews both the successes and challenges of kinase inhibitor therapy, and provides insight into future directions in the war against cancer.
This book is a completely revised new edition of the definitive reference on disorders of hemoglobin. Authored by world-renowned experts, the book focuses on basic science aspects and clinical features of hemoglobinopathies, covering diagnosis, treatment, and future applications of current research. While the second edition continues to address the important molecular, cellular, and genetic components, coverage of clinical issues has been significantly expanded, and there is more practical emphasis on diagnosis and management throughout. The book opens with a review of the scientific underpinnings. Pathophysiology of common hemoglobin disorders is discussed next in an entirely new section devoted to vascular biology, the erythrocyte membrane, nitric oxide biology, and hemolysis. Four sections deal with α and β thalassemia, sickle cell disease, and related conditions, followed by special topics. The second edition concludes with current and developing approaches to treatment, incorporating new agents for iron chelation, methods to induce fetal hemoglobin production, novel treatment approaches, stem cell transplantation, and progress in gene therapy.
In the new edition of this successful and authoritative book, the thalassaemias are reviewed in detail with respect to their clinical features, cellular pathology, molecular genetics, prevention and treatment. It is aimed at specialists in haematology in the laboratory or clinical setting, particularly in areas where thalassaemia is common either in the native population or in immigrant communities. The fourth edition has been both updated and re-organized. Three new chapters have been added on the link between alpha-thalassaemia and mental retardation, on avoidance and population control and on global epidemiology. Considerable emphasis is placed on molecular pathology reflecting the huge burst of information to have come out of this field in the last few years.
This brief modern introduction to ordinary differential equations emphasizes stability theory. Concisely and lucidly expressed, it is intended as a supplementary text for advanced undergraduates or beginning graduate students. 1968 edition.
With a focus on improving diagnosis and treatment, Drug Allergy Testing is your new go-to resource for understanding various drug allergies and testing methods, the epidemiology of and economic impact of drug allergies, and new drug and allergy developments. Features a wealth of up-to-date information for allergists, immunologists, and primary care physicians who diagnose and treat patients with drug allergies and hypersensitivity. Covers the basics of drug allergy evaluation and management as well as specific drugs including antibiotics, ASA/NSAIDs, chemotherapeutic agents and monoclonal antibodies.
Offering comprehensive coverage of this fast-changing field for more than 20 years, Urologic Surgical Pathology is an expert guide to all common and rare entities in the genitourinary system. The 4th Edition keeps you fully up to date with discussions of newly recognized tumors and terminologies, the latest classification schemes, current grading approaches, molecular alterations, and commonly used ancillary diagnostic techniques. With its clinical focus on day-to-day urological pathology sign-out and an emphasis on clinicopathologic and radiographic-pathologic correlations, this thoroughly revised uropathology reference is an excellent resource for diagnostic decision making. Includes expanded coverage of differential diagnosis for all tumor types encountered in urological surgical pathology practice. Incorporates the latest TNM staging and WHO classification systems, as well as new diagnostic biomarkers and their utility in differential diagnosis, newly described variants and new histologic entities. Discusses advances in molecular diagnostic testing, its capabilities, and its limitations, including targeted therapy/personalized medicine. Covers new developments in immunohistochemistry and the latest diagnostic tumor markers. Features more than 1,600 high-quality images – all in color – including gross pictures, histopathologic and cytopathologic images, special stains, other ancillaries, drawings, and illustrations. Helps you find information quickly with a consistent chapter format; an abundance of tables, diagrams and flowcharts; boxed lists of types and causes of diseases; differential diagnosis; characteristic features of diseases; complications; classifications; and staging.
Malgré la forte croissance économique que l’Afrique subsaharienne a connue ces vingt dernières années, les niveaux de transformation économique, de réduction de la pauvreté et de développement des compétences dans cette partie du monde sont bien inférieurs à ceux des autres régions. Des investissements judicieux dans le développement des compétences, en accord avec les objectifs politiques de croissance de la productivité, d’inclusion et d’adaptabilité, peuvent aider à accélérer la transformation économique de la région subsaharienne au XXIe siècle. L’augmentation de la population en âge de travailler en Afrique subsaharienne constitue une réelle chance d’accroître la prospérité collective. Les pays de la région ont investi massivement dans le développement des compétences†‰; les dépenses publiques consacrées à l’éducation ont été multipliées par sept au cours des 30 dernières années, et le nombre d’enfants scolarisés est aujourd’hui plus élevé que jamais. Pourtant, les systèmes d’éducation de cette population n’ont pas donné les résultats escomptés, et ces insuffisances entravent considérablement les perspectives économiques. Dans la moitié des pays, moins de deux enfants sur trois terminent l’école primaire, et encore moins atteignent des niveaux supérieurs d’enseignement et obtiennent un diplôme. Les acquis d’apprentissage demeurent faibles, ce qui entraîne des lacunes dans les compétences cognitives de base telles que la lecture, l’écriture et le calcul, aussi bien chez les enfants, les jeunes que les adultes. Le taux d’alphabétisation de la population adulte est inférieur à 50 % dans de nombreux pays†‰; la part des adultes sachant lire, écrire et compter de manière fonctionnelle est encore plus faible. Une réforme du système est nécessaire pour réaliser des progrès significatifs. De multiples agences aux niveaux national et local sont impliquées dans les stratégies de développement des compétences, faisant des compétences «†‰le problème de tous, mais la responsabilité de personne†‰». Les politiques et les réformes doivent permettre de renforcer les capacités des politiques qui ont fait leurs preuves et d’instaurer des mesures incitatives visant à faire converger le comportement de tous les acteurs dans la poursuite des objectifs de développement des compétences au niveau national. Le développement des compétences en Afrique subsaharienne, un exercice d’équilibre. Investir dans les compétences pour la productivité, l’inclusion et l’adaptabilité présente des données qui éclaireront les choix stratégiques des pays en matière d’investissements dans les compétences. Chaque chapitre aborde un ensemble de questions spécifiques, en s’appuyant sur une analyse originale et sur une synthèse des travaux existants pour explorer les domaines principaux : • comment les compétences appropriées à chaque étape du cycle de vie sont-elles acquises et quelles défaillances du marché et des institutions affectent le développement des compétences†‰; • quels systèmes sont nécessaires pour que les individus aient accès à ces compétences, notamment les investissements consentis par les familles, les institutions du secteur privé, les écoles et autres programmes publics†‰; • comment ces systèmes peuvent-ils être renforcés†‰; • comment les personnes les plus vulnérables, à savoir celles qui ne font pas partie des systèmes standards et qui n’ont pas réussi à acquérir des compétences essentielles, peuvent-elles être soutenues. Les pays de la région seront souvent confrontés à des arbitrages difficiles qui auront des effets distributifs et influeront sur leur trajectoire de développement. Des dirigeants engagés, des efforts conjoints de réforme et des politiques bien coordonnées sont essentiels pour aborder le délicat exercice d’équilibre que représente le développement des compétences en Afrique subsaharienne.
David Whisnant provides a comprehensive analysis of the dynamic relationship between culture, power, and policy in Nicaragua over the last 450 years. Spanning a broad spectrum of popular and traditional expressive forms--including literature, music, film, and broadcast media--the book explores the evolution of Nicaraguan culture, its manipulation for political purposes, and the opposition to cultural policy by a variety of marginalized social and regional groups. Within the historical narrative of cultural change over time, Whisnant skillfully discusses important case studies of Nicaraguan cultural politics: the consequences of the unauthorized removal of archaeological treasures from the country in the nineteenth century; the perennial attempts by political factions to capitalize on the reputation of two venerated cultural figures, poet Ruben Dario and rebel General Augusto C. Sandino; and the ongoing struggle by Nicaraguan women for liberation from traditional gender relations. Originally published in 1995. A UNC Press Enduring Edition -- UNC Press Enduring Editions use the latest in digital technology to make available again books from our distinguished backlist that were previously out of print. These editions are published unaltered from the original, and are presented in affordable paperback formats, bringing readers both historical and cultural value.
Four Corners is an integrated four-skills English course for adults and young adults. The interleaved Four Corners Teacher's Edition with Assessment Audio CD/CD-ROM, Level 1 features complete teaching instructions, optional activities, photocopiable video activity sheets, video teaching notes, audio and video scripts, language summaries, and Student Book and Workbook answer keys. The Assessment CD-ROM provides a complete assessment program, including oral and written quizzes, as well as unit tests in printable PDF and Microsoft Word® formats.
This guide offers a comprehensive but concise resource based on extensive, carefully analysed examples from the published literature. It enables students and researchers in science and engineering to write and present material to a professional modern standard, efficiently and painlessly, and with maximum impact.
Gold has traditionally been regarded as inactive as a catalytic metal. However, the advent of nanoparticulate gold on high surface area oxide supports has demonstrated its high catalytic activity in many chemical reactions. Gold is active as a heterogeneous catalyst in both gas and liquid phases, and complexes catalyse reactions homogeneously in solution. Many of the reactions being studied will lead to new application areas for catalysis by gold in pollution control, chemical processing, sensors and fuel cell technology. This book describes the properties of gold, the methods for preparing gold catalysts and ways to characterise and use them effectively in reactions. The reaction mechanisms and reasons for the high activities are discussed and the applications for gold catalysis considered. Sample Chapter(s). Chapter 1: Introduction to Catalysis (892 KB). Contents: Introduction to Catalysis; The Physical and Chemical Properties of Gold; Physical Properties and Characterisation of Small Gold Particles; Preparation of Supported Gold Catalysts; Chemisorption of Simple Molecules on Gold; Oxidation of Carbon Monoxide; The Selective Oxidation of Carbon Monoxide; Selective Oxidation; Reactions Involving Hydrogen; The WaterOCoGas Shift; Reactions of Environmental Importance; Catalysis by Soluble and Supported Gold Compounds; Miscellaneous Reactions Catalysed by Gold; Commercial Applications. Readership: Postgraduate level researchers in academia and industry, as well as general readers.
Modern Sample Preparation for Chromatography, Second Edition explains the principles of sample preparation for chromatographic analysis. A variety of procedures are applied to make real-world samples amenable for chromatographic analysis and to improve results. This book's authors discuss each procedure’s advantages, disadvantages and their applicability to different types of samples, along with their fit for different types of chromatographic analysis. The book contains numerous literature references and examples of sample preparation for different matrices and new sections on green approaches in sample preparation, progress in automation of sample preparation, non-conventional solvents for LLE (ionic liquids, deep eutectic mixtures, and others), and more. Presents numerous techniques applied for sample preparation for chromatographic analysis Provides an up-to-date source of information regarding the progress made in sample preparation for chromatography Describes examples for specific types of matrices, providing a guide for choosing the appropriate sample preparation method for a given analysis
New Mexico was ceded to the United States in 1848, at the end of the war with Mexico, but not until 1912 did President William Howard Taft sign the proclamation that promoted New Mexico from territory to state. Why did New Mexico’s push for statehood last sixty-four years? Conventional wisdom has it that racism was solely to blame. But this fresh look at the history finds a more complex set of obstacles, tied primarily to self-serving politicians. Forty-Seventh Star, published in New Mexico’s centennial year, is the first book on its quest for statehood in more than forty years. David V. Holtby closely examines the final stretch of New Mexico’s tortuous road to statehood, beginning in the 1890s. His deeply researched narrative juxtaposes events in Washington, D.C., and in the territory to present the repeated collisions between New Mexicans seeking to control their destiny and politicians opposing them, including Republican U.S. senators Albert J. Beveridge of Indiana and Nelson W. Aldrich of Rhode Island. Holtby places the quest for statehood in national perspective while examining the territory’s political, economic, and social development. He shows how a few powerful men brewed a concoction of racism, cronyism, corruption, and partisan politics that poisoned New Mexicans’ efforts to join the Union. Drawing on extensive Spanish-language and archival sources, the author also explores the consequences that the drive to become a state had for New Mexico’s Euro-American, Nuevomexicano, American Indian, African American, and Asian communities. Holtby offers a compelling story that shows why and how home rule mattered—then and now—for New Mexicans and for all Americans.
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