In recent times, the boundary between living and non-living has been blurred by advances in genomics, cell biology, and molecular neuroscience, whereby humans are repaired, enhanced, or made anew. Scientists and physicians are now able to keep cells, organs, and bodies alive indefinitely and can return cells or DNA to our bodies and make new cells for the purpose of treating disease or growing new tissue. Meanwhile, transhuman technologies create illusions of immortality. Immortal: Our Cells, DNA, and Bodies synthesizes what we know about life and death from a genetic, molecular, and cellular perspective, demarcates limits of knowledge, and poses new questions. Award-winning researcher and writer David Goldman examines in-depth three keys to understanding the nature and continuity of life: 1) epigenetic (ephemeral) vs genetic (durable) transgenerational memory; 2) life's cellular nature, and the ability to make bodies from cells; and 3) the distinction between bodies and persons. Grounded in recent scientific evidence and real-life cases that test our historical understanding of life and death, Goldman probes the nature of molecular continuity in the face of mortal extinction, encompassing how changes to the DNA code can be both long-lasting and transgenerational, and the continuous nature of cellular and molecular information transmission. In tying these themes together, Immortal asks us to apply fresh scientific concepts to examine, for ourselves, the continuity of being in the face of mortality. - Applies recent genetic, molecular and cellular findings to examine the boundaries between living and non-living, and between person and non-person - Examines the significance of epigenetic memory and transgenerational inheritance and their uses in molecular and precision medicine - Written by a thought-leader in genetic and molecular medicine
Praise for David Darling The Universal Book of Astronomy "A first-rate resource for readers and students of popular astronomy and general science. . . . Highly recommended." -Library Journal "A comprehensive survey and . . . a rare treat." -Focus The Complete Book of Spaceflight "Darling's content and presentation will have any reader moving from entry to entry." -The Observatory magazine Life Everywhere "This remarkable book exemplifies the best of today's popular science writing: it is lucid, informative, and thoroughly enjoyable." -Science Books & Films "An enthralling introduction to the new science of astrobiology." -Lynn Margulis Equations of Eternity "One of the clearest and most eloquent expositions of the quantum conundrum and its philosophical and metaphysical implications that I have read recently." -The New York Times Deep Time "A wonderful book. The perfect overview of the universe." -Larry Niven
An updated, innovative approach to data structures and algorithms Written by an author team of experts in their fields, this authoritative guide demystifies even the most difficult mathematical concepts so that you can gain a clear understanding of data structures and algorithms in C++. The unparalleled author team incorporates the object-oriented design paradigm using C++ as the implementation language, while also providing intuition and analysis of fundamental algorithms. Offers a unique multimedia format for learning the fundamentals of data structures and algorithms Allows you to visualize key analytic concepts, learn about the most recent insights in the field, and do data structure design Provides clear approaches for developing programs Features a clear, easy-to-understand writing style that breaks down even the most difficult mathematical concepts Building on the success of the first edition, this new version offers you an innovative approach to fundamental data structures and algorithms.
This collection explores the structure of consciousness and its place in the world, or inversely the structure of the world and the place of consciousness in it. Amongst the topics covered are: the phenomenological aspects of experience, dependencies between experience and the world and the basic ontological categories found in the world at large. Developing ideas drawn from historical figures such as Descartes, Husserl, Aristotle, and Whitehead, the essays together demonstrate the interdependence of ontology and phenomenology and its significance for the philosophy of mind.
Web applications are used every day by millions of users, which is why they are one of the most popular vectors for attackers. Obfuscation of code has allowed hackers to take one attack and create hundreds-if not millions-of variants that can evade your security measures. Web Application Obfuscation takes a look at common Web infrastructure and security controls from an attacker's perspective, allowing the reader to understand the shortcomings of their security systems. Find out how an attacker would bypass different types of security controls, how these very security controls introduce new types of vulnerabilities, and how to avoid common pitfalls in order to strengthen your defenses. Named a 2011 Best Hacking and Pen Testing Book by InfoSec Reviews Looks at security tools like IDS/IPS that are often the only defense in protecting sensitive data and assets Evaluates Web application vulnerabilties from the attacker's perspective and explains how these very systems introduce new types of vulnerabilities Teaches how to secure your data, including info on browser quirks, new attacks and syntax tricks to add to your defenses against XSS, SQL injection, and more
David Kellogg Lewis (1941-2001) was one of the most influential philosophers of the twentieth century. He made significant contributions to almost every area of analytic philosophy including metaphysics, philosophy of language, philosophy of mind, and philosophy of science, and set the agenda for various debates in these areas which carry on to this day. In several respects he remains a contemporary figure, yet enough time has now passed for historians of philosophy to begin to study his place in twentieth century thought. His philosophy was constructed and refined not just through his published writing, but also crucially through his life-long correspondence with fellow philosophers, including leading figures such as D.M. Armstrong, Saul Kripke, W.V. Quine, J.J.C. Smart, and Peter van Inwagen. His letters formed the undercurrent of his published work and became the medium through which he proposed many of his well-known theories and discussed a range of philosophical topics in depth. A selection of his vast correspondence over a 40-year period is presented here across two volumes. Structured in three parts, Volume 2 explores Lewis' contributions to philosophical questions of mind, language, and epistemology respectively. The letters address Lewis's answer to the mind-body problem, propositional attitudes and the purely subjective character of conscious experience, meaning and reference as well as grammar in language, vagueness, truth in fiction, the problem of scepticism, and Lewis's work on decision theory and rationality, among many other topics. This volume is a testament to Lewis' achievement in these areas and will be an invaluable resource for those exploring contemporary debates concerning mind, language, and epistemology.
Patient-reported outcomes (PROs) are measures of how patients feel or what they are able to do in the context of their health status; PROs are reports, usually on questionnaires, about a patient's health conditions, health behaviors, or experiences with health care that individuals report directly, without modification of responses by clinicians or others; thus, they directly reflect the voice of the patient. PROs cover domains such as physical health, mental and emotional health, functioning, symptoms and symptom burden, and health behaviors. They are relevant for many activities: helping patients and their clinicians make informed decisions about health care, monitoring the progress of care, setting policies for coverage and reimbursement of health services, improving the quality of health care services, and tracking or reporting on the performance of health care delivery organizations. We address the major methodological issues related to choosing, administering, and using PROs for these purposes, particularly in clinical practice settings. We include a framework for best practices in selecting PROs, focusing on choosing appropriate methods and modes for administering PRO measures to accommodate patients with diverse linguistic, cultural, educational, and functional skills, understanding measures developed through both classic and modern test theory, and addressing complex issues relating to scoring and analyzing PRO data.
Live the life of a Celt in Caledonia. A story of migration to the Scottish Highlands circa AD78. The Roman expansion north was resisted by a Celtic Confederation and by their relatives still in Germania causing a contraction that left a vacuum to be filled by other migrants from Saxony. Angles, Jutes, and more. followed.
There is a growing need in both industrial and academic research to obtain accurate quantitative results from continuous wave (CW) electron paramagnetic resonance (EPR) experiments. This book describes various sample-related, instrument-related and software-related aspects of obtaining quantitative results from EPR expe- ments. Some speci?c items to be discussed include: selection of a reference standard, resonator considerations (Q, B ,B ), power saturation, sample position- 1 m ing, and ?nally, the blending of all the factors together to provide a calculation model for obtaining an accurate spin concentration of a sample. This book might, at ?rst glance, appear to be a step back from some of the more advanced pulsed methods discussed in recent EPR texts, but actually quantitative “routine CW EPR” is a challenging technique, and requires a thorough understa- ing of the spectrometer and the spin system. Quantitation of CW EPR can be subdivided into two main categories: (1) intensity and (2) magnetic ?eld/mic- wave frequency measurement. Intensity is important for spin counting. Both re- tive intensity quantitation of EPR samples and their absolute spin concentration of samples are often of interest. This information is important for kinetics, mechanism elucidation, and commercial applications where EPR serves as a detection system for free radicals produced in an industrial process. It is also important for the study of magnetic properties. Magnetic ?eld/microwave frequency is important for g and nuclear hyper?ne coupling measurements that re?ect the electronic structure of the radicals or metal ions.
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