This book investigates the use of palladium modified by bulky ligands as catalysts for new chemical transformations that rapidly assemble several classes of complex heterocyles. It documents the development of new chemical reactions involving carbon–carbon (C‒C) and carbon–halogen (C‒X) bond formation in the context of alkene difunctionalization and dearomatization reactions. Due to the ubiquity of heterocycles in bioactive natural products and life-improving pharmaceutical treatments, a long-term goal for synthetic organic chemists has been to develop novel and creative heterocycle syntheses that illicit a high degree of product diversity and are characterized by mild reaction conditions and limited waste production. A considerable fraction of leading pharmaceutical drugs contain at least one heterocycle within their chemical structure, and their prevalence in these technologies is strong evidence that the fundamental curiosities of organic chemistry lead to real-world solutions for the health and wellness of the global population.
This book investigates the use of palladium modified by bulky ligands as catalysts for new chemical transformations that rapidly assemble several classes of complex heterocyles. It documents the development of new chemical reactions involving carbon–carbon (C‒C) and carbon–halogen (C‒X) bond formation in the context of alkene difunctionalization and dearomatization reactions. Due to the ubiquity of heterocycles in bioactive natural products and life-improving pharmaceutical treatments, a long-term goal for synthetic organic chemists has been to develop novel and creative heterocycle syntheses that illicit a high degree of product diversity and are characterized by mild reaction conditions and limited waste production. A considerable fraction of leading pharmaceutical drugs contain at least one heterocycle within their chemical structure, and their prevalence in these technologies is strong evidence that the fundamental curiosities of organic chemistry lead to real-world solutions for the health and wellness of the global population.
This book tells the story of Apollo 11 and dispels the myth that NASA faked the moon landings. The story is brought to life by exploiting the flight plan, mission report, in-flight transcripts (including conversations among the crew in the spacecraft that were not transmitted) and post-flight debriefing. It features scans recently produced by NASA of the original Hasselblad film. The final chapters discuss what was learned of the moon rocks, and reviews the follow-on missions. The author’s impressive expertise and knowledge of the Moon landings shines through and seamlessly unites the myriad details of the mission.
Imaging in Parkinson's Disease provides up-to-date information concerning new applications of brain imaging to the study of Parkinson's disease. Written by experts in the field, the book focuses on structural and functional imaging methodologies that have recently been applied to study the natural history of Parkinson's disease, with emphasis on the development of the major motor manifestations of the illness as well as cognitive impairment and dementia.
This official NASA history chronicles the behind-the-scenes conflicts and cooperation during the Apollo expeditions. It shows how the space agency's scientists, who were primarily interested in the moon itself, worked out their differences with the engineers, who were charged with the astronauts' safe landing and return. The close collaboration between the scientists and engineers ensured the success of a program that remains a major achievement for both fields. The first half of the book concerns the preparations for the Moon landings, tracing the development of the Apollo science program from the earliest days. The second half documents the flights that followed Apollo 11, during which twelve astronauts explored the lunar surface and returned with samples for investigation. The author drew upon the Lyndon B. Johnson Space Center's collection of more than 31,000 Apollo-related documents and conducted more than 300 interviews with program participants to assemble this definitive survey.
This book provides an overview of the origins of the Apollo program and descriptions of the ground facilities, launch vehicles and spacecraft that were developed in the quest to reach – and return from - the surface of the moon. It will serve as an invaluable single-volume sourcebook for space enthusiasts, space historians, journalists, and others. The text includes a comprehensive collection of tables listing facts and figures for each mission.
The official school drop-out figure in the US in recent years has been 25 per cent of the cohort. Estimates from large cities are often double these rates, and in some areas 60 per cent or worse. This text focuses on this problem in US schools, but from an unusual perspective. It is a study gained from in-depth interviews of 100 "stop-outs" - that is, those who dropped out but then decided to return to school. Four basic questions are posed by this text: who drops out?; why did they drop out?; what caused them to return?; and what intervention policies can be formulated to prevent students dropping out in the first place? The answers provided by this text for the last question are intended to make it of particular interest to school administrators.
Unofficially they called themselves the TFNG, or the Thirty-Five New Guys. Officially, they were NASA’s Group 8 astronauts, selected in January 1978 to train for orbital missions aboard the Space Shuttle. Prior to this time only pilots or scientists trained as pilots had been assigned to fly on America’s spacecraft, but with the advent of the innovative winged spacecraft the door was finally opened to non-pilots, including women and minorities. In all, 15 of those selected were categorised as Pilot Astronauts, while the other 20 would train under the new designation of Mission Specialist. Altogether, the Group 8 astronauts would be launched on a total of 103 space missions; some flying only once, while others flew into orbit as many as five times. Sadly, four of their number would perish in the Challenger tragedy in January 1986. In their latest collaborative effort, the authors bring to life the amazing story behind the selection of the first group of Space Shuttle astronauts, examining their varied backgrounds and many accomplishments in a fresh and accessible way through deep research and revealing interviews. Throughout its remarkable 30-year history as the workhorse of NASA’s human spaceflight exploration, twice halted through tragedy, the Shuttle fleet performed with magnificence. So too did these 35 men and women, swept up in the dynamic thrust and ongoing development of America’s Space Shuttle program. "This book on the Group 8 Astronauts, the TFNGs, is an excellent summation of the individuals first selected for the new Space Shuttle Program. It provides insight into what it took to first get the Space Shuttle flying. For any space enthusiast it is a must read." - Robert L. Crippen PLT on STS-1 “As a reader, I had many moments where long, lost memories of the triumph and tragedy of the space shuttle program were brilliantly reawakened at the turn of a page. Loved it! This is a must-have book for every space enthusiast’s library.” - TFNG Mission Specialist Astronaut Richard ‘Mike’ Mullane, author of Riding Rockets: The Outrageous Tales of a Space Shuttle Astronaut “Many of the anecdotes in the book brought back memories of challenges, opportunities, and a team of men and women who were committed not just to the space program, but to one another...I've gone back to it several times as a reference source.” - TFNG Steve Hawley, 5-time Space Shuttle Mission Specialist Astronaut "The TFNG book is incredible and amazingly thorough! The detail in the book is awesome! It is my go-to book for any of the details I’ve forgotten." - TFNG Dr. Rhea Seddon, 3-time Space Shuttle Mission Specialist Astronaut. "I can't believe how detailed and complete it is!!! FANTASTIC work!!!" - TFNG Robert L."Hoot" Gibson, 5-time Space Shuttle Pilot & Commander and former Chief of the NASA Astronaut Office
Between May 1973 and February 1974 three teams of astronauts increased the American space endurance record from 14 days, set in 1965, to three months aboard the Skylab space station in missions lasting 28, 59 and 84 days. American astronauts did not surpass these records for over 20 years until the NASA Mir missions began in 1995. In "Skylab - America's space station", David Shayler chronicles the evolution of the station, its infrastructure on the ground including astronaut training, each of the three manned missions, summary of results, achievements and the lessons learned. The creation of the International Space Station is the real legacy of Skylab as American astronauts once again embark on extended missions around the Earth.
Social machines are a type of network connected by interactive digital devices made possible by the ubiquitous adoption of technologies such as the Internet, the smartphone, social media and the read/write World Wide Web, connecting people at scale to document situations, cooperate on tasks, exchange information, or even simply to play. Existing social processes may be scaled up, and new social processes enabled, to solve problems, augment reality, create new sources of value, and disrupt existing practice. This book considers what talents one would need to understand or build a social machine, describes the state of the art, and speculates on the future, from the perspective of the EPSRC project SOCIAM – The Theory and Practice of Social Machines. The aim is to develop a set of tools and techniques for investigating, constructing and facilitating social machines, to enable us to narrow down pragmatically what is becoming a wide space, by asking ‘when will it be valuable to use these methods on a sociotechnical system?’ The systems for which the use of these methods adds value are social machines in which there is rich person-to-person communication, and where a large proportion of the machine’s behaviour is constituted by human interaction.
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