Chalcones are a group of plant-derived polyphenolic compounds that possess a wide variety of biological activities. Several lead compounds with various pharmacological properties have been developed based on the chalcone skeleton. The beneficial effect of these substances has been studied in relation to diabetes mellitus. Several studies have demonstrated that chalcones either from natural or synthetic sources can influence carbohydrate pathways, especially glucose metabolism. These studies verified the effectiveness of chalcones as antihyperglycemic and/or hypoglycemic agents through in vitro and in vivo experimental responses. In this context, these molecules are attractive substances which can enrich the current therapy options and they have become the subject of considerable interest in both academia and industry. The purpose of this review is to discuss the recent developments related to the chemistry and medicinal properties of chalcones, especially concerning their role in glucose homeostasis and carbohydrate metabolism. Also, taking into account the relevant structure–activity relationships of these compounds, the development of new approaches to study the interactions of chalcones in specific targets combining in silico (computational modeling) and in vitro pharmacological studies on β-cells represents a challenge for future perspectives aimed at characterizing molecular targets for diabetes therapy.
In the last century, the treatment of victims of involuntary sterilisation and castration in Nordic countries has varied drastically from state-to-state, across time and victim groups. Considering why this is the case, Daniela Alaattinoğlu investigates how laws and practices of involuntary, surgical sterilisation and castration have been established, abolished and remedied in three Nordic states: Sweden, Norway and Finland. Employing a vast range of primary and secondary sources, Alaattinoğlu traces the national and international developments of the last 100 years. Developing the concept of grievance formation, the book explores why some states have claimed public responsibility while others have not, and why some victim groups have mobilised while others have remained silent. Through this pioneering analysis, Alaattinoğlu illuminates issues of human and constitutional rights, the evolution of the welfare state and state responsibility in both a national and global context.
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