The life of Philipp Jaffé (1819–1870), from his youth in Posen; his studies with Leopold von Ranke and career – as a close friend of Theodor Mommsen – at the pinnacle of historical scholarship in Berlin, first at the Monumenta Germaniae Historica and then, after his feud with Georg Heinrich Pertz, with his unprecedented 1862 appointment, while still a Jew, to a Berlin professorship; and on to his baptism in 1868 and suicide in 1870, was a life of transition between East and West and between Judaism and Christianity – and a life of devotion to scholarship, of loneliness, of success and of frustration. Forgotten today, except by medievalists who depend on his numerous editions of Latin texts, Jaffé was a central figure in the heydays of German scholarship. His career illustrates the working conditions of such scholars, their friendships and feuds, and also the limits that hemmed Jews in and the ways they could be overcome. This volume documents Jaffé’s life, accomplishments, and struggles, and also offers insight into his soul via more than two hundred of his letters (in German) – about half to his parents in Posen and half to colleagues around Europe, especially Pertz and Mommsen.
This penetrating examination of a paradox of colonial rule shows how the massive transfers of technology--including equipment, techniques, and experts--from the European imperial powers to their colonies in Asia and Africa resulted not in industrialization but in underdevelopment. Examining the most important technologies--shipping and railways, telegraphs and wireless, urban water supply and sewage disposal, economic botany and plantation agriculture, irrigation, and mining and metallurgy--Headrick provides a new perspective on colonial economic history and reopens the debate on the roots of Asian and African underdevelopment.
Winner of the Merle Curti Award in Intellectual History, Organization of American Historians Co-Winner of the Society for U.S. Intellectual History Book Award Thinking Small tells the story of how the United States sought to rescue the world from poverty through small-scale, community-based approaches. And it also sounds a warning: such strategies, now again in vogue, have been tried before, with often disastrous consequences. “Unfortunately, far from eliminating deprivation and attacking the social status quo, bottom-up community development projects often reinforced them...This is a history with real stakes. If that prior campaign’s record is as checkered as Thinking Small argues, then its intellectual descendants must do some serious rethinking... How might those in twenty-first-century development and anti-poverty work forge a better path? They can start by reading Thinking Small.” —Merlin Chowkwanyun, Boston Review “As the historian Daniel Immerwahr demonstrates brilliantly in Thinking Small, the history of development has seen constant experimentation with community-based and participatory approaches to economic and social improvement...Immerwahr’s account of these failures should give pause to those who insist that going small is always better than going big.” —Jamie Martin, The Nation
The aim of this work is to provide a fuller spectrum of information in a single source on enzyme-catalyzed reactions than is currently available in any published reference work or as part of any Internet database. The Enzyme Reference: A Comprehensive Guidebook to Enzyme Nomenclature, Reactions, and Methods includes 20,000 review articles and seminal research papers. Additionally, it provides a novel treatment of so-called ATPase and GTPase reactions to account for the noncovalent substratelike and productlike states of molecular motors, elongation factors, transporters, DNA helicases, G-reulatory proteins, and other energases. - Includes a compendium of over 6,000 enzyme reactions (including enzyme commission numbers, alternative names, substrates, products, alternative substrates, and properties) - Covers over 900 chemical structures of key metabolites and cofactors - Index directs readers to the exact pages for over 9,500 enzyme names
Metabolic inhibitors and receptor antagonists are indispensable tools for the molecular life scientist. By blocking specific enzymes or receptor-mediated signal transduction cascades, they simplify the analysis of complex cellular processes especially when it is essential to demonstrate that a process of interest is functionally linked to a particular enzyme or receptor. From antibiotics to statins, modern medicine relies on the reliability and ease-of-use of enzyme- and receptor-directed inhibitors and antagonists.The Inhibitor Index is a comprehensive, curated compendium of over 7,800 enzyme inhibitors and receptor antagonists, including many toxins, poisons, and metabolic uncouplers.
Enhanced Edition The Fight for Home: Enhanced E-book Edition is an unprecedented collaboration between Academy Award-winning filmmaker Jonathan Demme and prize-winning author Daniel Wolff.Created especially for video-capable e-readers, with over 30 short film clips, this enhanced edition offers an exclusive look at raw footage from the streets and living rooms of New Orleans -an intimate, behind-the-scenes view of both a ground-breaking piece of non-fiction and an exciting, ongoing documentary film project. After the devastation of Hurricane Katrina, New Orleans became ground zero for the reinvention of the American city, with urban planners, movie stars, anarchists, and politicians all advancing their competing visions for recovery. Meanwhile, residents and volunteers on the ground struggled to build the foundations of a new New Orleans. For over five years, author Daniel Wolff has documented an amazing cross section of the city in upheaval: a born-again preacher with a ministry of ex-addicts, a former Black Panther organizing for a new cause, a single mother "broke as a joke" in a FEMA trailer. The Fight for Home chronicles their battle to survive not just the floods, but the corruption that continues and the base-level emergency of poverty and neglect. From ruin to limbo to triumphant return, Wolff offers an intimate look at the lives of everyday American heroes. As these lives play out against the ruined local landscape and an emerging national recession, The Fight for Home becomes a story of resilience and hope.The Fight for Home is their story, a story that begins after a national disaster and continues into a national recession. It's a story of survival in a ruined landscape, and resistance to the poverty and neglect that helped make those ruins. As Americans across the country battle in their own fight for home, it's also a story of hope.
The topics in this issue represent the most current research areas of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Collaborative Pediatric Critical Care Research Network (CPCCRN). The CPCCRN is a national pediatric critical care research network that is charged with investigating the efficacy of treatment and management strategies to care for critically ill and injured children, as well as to better understand the pathophysiological basis of critical illness and injury in childhood. The proposed authors are past and present principal and co-investigators affiliated with the CPCCRN; the proposed topics represent the individual author’s area of clinical and research expertise. Each review article is an up-to-date review of the topic relevant to practicing clinicians and trainees in critical care medicine, with incorporation of the most recently published research findings pertinent to the topic, some of which may be the author’s own. The specific articles are devoted to the following topics: Cardiopulmonary resuscitation in pediatric and cardiac ICU; Approach to the critically ill pediatric trauma patient; Transfusion Decision Making in Pediatric Critical Illness; Pathophysiology and management of ARDS in children; Ventilator associate pneumonias in critically ill children; Mechanical ventilation and decision support in pediatric intensive care; Inflammation, pathobiology, phenotypes and sepsis: From meningococcemia to H1N1-MRSA, to Ebola; Immune paralysis in pediatric critical care; Molecular biology of critical illness; Sedation in pediatric critical illness; Delirium in pediatric critical illness; Challenges of drug development in pediatric intensive care; Potential of All Steroid Hormone Subclasses as Adjunctive Treatment for Sepsis; Morbidity: Changing the outcome paradigm; and End-of-Life and Bereavement Care in Pediatric Intensive Care Units.
Beginning in the early 1980s Aboriginal Australians found in music, radio, and filmic media a means to make themselves heard across the country and to insert themselves into the center of Australian political life. In The Voice and Its Doubles Daniel Fisher analyzes the great success of this endeavor, asking what is at stake in the sounds of such media for Aboriginal Australians. Drawing on long-term ethnographic research in northern Australia, Fisher describes the close proximity of musical media, shifting forms of governmental intervention, and those public expressions of intimacy and kinship that suffuse Aboriginal Australian social life. Today’s Aboriginal media include genres of country music and hip-hop; radio requests and broadcast speech; visual graphs of a digital audio timeline; as well as the statistical media of audience research and the discursive and numerical figures of state audits and cultural policy formation. In each of these diverse instances the mediatized voice has become a site for overlapping and at times discordant forms of political, expressive, and institutional creativity.
This book is a study of one type of relation between public authorities and the private sector. In the modern world it is becoming increasingly clear that these two ways of organizing economic life must learn to get along with each other and develop vehicles of mutual advantage. This is especially true in the re lations between advanced and developing economies because for historical reasons, the development of non-Western economies today is taking a course quite different from the path of the advanced business economies of the West. It is desirable for both spheres to try and understand each other and look for ways of getting along. International tensions can be alleviated to the degree that positive attitudes are taken and mechanisms of the kind dealt with in this book are created. Much of the problem is simply one of semantics. The term "socialism" or "socialistic pattern of society", for example, which is often used in India as a positive word has very negative conno tations for Americans. There are, of course, socialists in India who would make their economy entirely publicly owned, indis tinguishable from the Chinese or the Russian, but the vast majority of leaders associated with the dominant party in India visualize a present and future mixed economy not too different from that reached by the United States through a very different road. We in the United States have been nurtured on the belief in private enterprise.
The Nazi invasion of Poland was the first step in an unremittingly brutal occupation, one most infamously represented by the network of death camps constructed on Polish soil. The systematic murder of Jews in the camps has understandably been the focus of much historical attention. Less well-remembered today is the fate of millions of non-Jewish Polish civilians, who—when they were not expelled from their homeland or forced into slave labor—were murdered in vast numbers both within and outside of the camps. Drawing on both German and Polish sources, In the Shadow of Auschwitz gives a definitive account of the depredations inflicted upon Polish society, tracing the ruthless implementation of a racial ideology that cast ethnic Poles as an inferior race.
A different set of purposes define culture today than those that preoccupied the world in the immediate decades of decolonization. Focusing on art and music in diverse parts of the world, Daniel Herwitz explores a world that has largely shifted from the earlier days of nationalism, decolonization and cultural exclusion, to one of global markets and networks. Using examples from India and Mexico to South Africa, Australia and China, Herwitz argues that the cultural politics and art being produced in these places are now post- postcolonial. Where the postcolonial downplayed formerly Eurocentric forms and celebrated art with national consciousness, the rules for 21st century cultural authenticity are quickly disappearing. Young people think of themselves in relation to global culture rather than nation-¬-building; the project of producing a new and modern art for the incipient and rising postcolonial nation is out of date. By examining the shift in which art accesses the past and the rise of trends such as hitching consumer culture to celebrity forms and branding, Herwitz's original and engaging exploration of contemporary art captures the ways in which art has given way to a new form of production, altering everything from the role of tradition and heritage in contemporary art to the terms of its vision and circulation.
In Microfoundations, Method, and Causation, Daniel Little combines a purely philosophical perspective on social science, with the theoretical and empirical practice of working scientists. Part 1 focuses on the theory of popular politics constructed within the context of analytical Marxism. In part 2, Little asks if rational choice theory provides an adequate basis for explaining patterns of social, political, and economic behavior in traditional China. The essays in part 3 reveal the philosophy of social science as understood by philosophers. Here, Little probes issues of objectivity, empiricism, and generalizations, and makes the case that social generalizations are not akin to laws of nature.
Differential Diagnosis in Surgical Pathology, 2nd Edition, by Paolo Gattuso, MD, Vijaya B. Reddy, MD, Odile David, MD, and Daniel J. Spitz, MD, is skillfully designed to help you confidently sign out your most complex and challenging cases. Covering a complete range of tumors and tumor-like conditions in all organ systems, it provides a user-friendly road map to the main criteria you should consider in order to differentiate between a variety of potential diagnoses that all have a very similar appearance. Over 1,350 new full-color macro- and microphotographs provide a realistic basis for comparison to what you see under the microscope. Quick checklists cover all diagnostic possibilities to make sure nothing falls through the cracks. A concise, bulleted textual format facilitates quick retrieval of essential facts. A consistent approach to diagnosis and interpretation expedites reference. Coverage of all relevant ancillary diagnostic techniques addresses all of the investigative contexts needed to formulate an accurate diagnosis. Expert "pearls" offer practical tips on what diagnostic criteria to consider or exclude. A comprehensive, yet manageable size allows for quick consultation. Over 1,350 new full-color macro- and microphotographs provide a realistic basis for comparison to what you see under the microscope. Immunohistochemical and molecular techniques throughout enable you to review all of the latest diagnostic considerations in one place. Expanded coverage of non-neoplastic entities assists you in recognizing benign lesions that may mimic the appearance and characteristics of malignant ones. Extensive updates include the latest classification schemes and relevant diagnostic techniques. A brand-new, color-coded layout highlights key points more clearly and helps you turn to the sections you need more speedily.
This timely work reflects the growing importance of research into the nature of sleep and its medical aspects. One of the first of its kind, this work on the neuroimmunology of sleep provides an introduction to the interplay between these two key and interlinked areas. Written both from a basic and a clinical perspective, the volume is an invaluable information resource for biomedical professionals and students of the human biology. Highly practical guide written from both a basic and clinical perspective.
Mucins are glycoproteins that are expressed in cells of different types and fulfill multiple functions that determine participation of these proteins in such processes as signal transduction, regulation of gene expression, cell proliferation, embryogenesis, cell differentiation, immunity, apoptosis and cancer development. This E-book series on mucins presents critical reviews on modern data concerning structures and functions of mucins, their roles in cell physiology and pathology as well as molecular aspects of therapy of mucin-associated diseases. Mucins are represented by two types of molecules: secreted mucins and membrane-bound (receptor) mucins. This e-book series represents a unique attempt to describe the molecular nature of mucin multifunctionality in separate volumes. Chapters in each volume demonstrate the central role of mucins as connectors and regulators of different signaling pathways and their participation metastatic processes. Clinical aspects of mucins, such as their role as diagnostic markers as well as possible applications in mucin-based immuno- and gene-therapies are also discussed. This is the first volume of the series. This volume introduces readers to the general properties of mucins, followed by chapters on specific variants of gel-forming and soluble mucins. The volume concludes with information on the functions of secreted mucins.
Herbal Technology: Recent Trends and Progress is a comprehensive book on the various trends and the aspects of this recent branch of Botany. Herbal Technology encompasses all the myriads of ways of utilizing the multifarious potentialities of plants for human welfare. There are presently five aspects such as Medicinal plants, Natural dyes, Biopesticides, Biofertilizers and Biofuel in this discipline, though more and more may added by the brilliant workers who tread this path at a later stage. Medicinal plants which form the first section contains a number of papers dealing with biomarkers, both pharmacognostic and phytochemical, on a good number of medicinal plants as well as many ethnobotanical surveys. Natural Dyes form the second section and it covers the application of dyes from six plants such as Rohira, Katha, Ravenchi wood, Annatto, Babool, banana on various textiles. In the section on Biofertilizers papers on the utility of marine algae, blue green algae and Am fungi are included. In the last section, Biofuels, the utility of biogas as well as a number of new sources of fatty oils have been presented. This book will serve as a reference book for students, teachers and workers of Medicinal plants, Natural Dyes, Biopesticides, Biofertilisers and Biofuel.
It's 5th July 2014 and the world's biggest cycling race is about to depart from Leeds. 22 teams, 198 riders, 2,000 journalists and 4 million people are converging on this Yorkshire city. Among them are Gizmo the dog, with his owner; a woman carrying a tin full of memories; a refugee with a rose in their pocket; a student; a grandad and grandson; and X. For each of them, 5th July will turn out to be a life changing day. Created by community groups from across the city, The Leeds Story Cycle is what you get when you put a group of young people, asylum seekers, students, retired church folk, writers and recovering addicts in the same room and ask them to tell a story about their home town. Working with the groups, this unique collection of stories has been written by author, Chris Nickson; lyricist, Testament; poet and playwright, Rommi Smith; author, Daniel Ingram-Brown, poet, Jane Steele; playwright, Lorna Poustie; and theatre practitioners, Simon Brewis and Lynsey Jones.
This book argues that there is a new, Sinological form of orientalism at work in the world. It has shifted from a logic of ‘essential difference’ to one of ‘sameness’ or general equivalence. "China" is now in a halting but inevitable process of becoming-the-same as the USA and the West. Orientalism is now closer to the cultural logic of capitalism, even as it shows the afterlives of colonial discourse. This shift reflects our era of increasing globalization; the migration of orientalism to area studies and the pax Americana; the liberal triumph at the "end" of history and the demonization of Maoism; an ever closer Sino-West relationship; and the overlapping of anti-communist and colonial discourses. To make the case for this re-constitution of orientalism, this work offers an inter-disciplinary analysis of the China field broadly defined. Vukovich takes on specialist work on the politics, governance, and history of the Mao and reform eras, from the Great Leap Forward to Tiananmen, 1989; the Western study of Chinese film; recent work in critical theory which turns on ‘the China-reference"; and other global texts about or from China. Through extensive analysis, the production of Sinological knowledge is shown to be of a piece with Western global intellectual political culture. This work will be of great interest to scholars of Asian, postcolonial and cultural studies.
This book identifies the root causes of income inequality in underdeveloped economies and proposes new solutions for structural reform in economies that have long neglected and exploited working people. It focuses on the case of Zimbabwe, a classic example of an African post-colonial state continuing with dualistic economic structures while simultaneously laying the blame for the initiation of this form of underdevelopment with colonialism. The book explores the colonial roots of economic dualism, in which traditional sectors run alongside newer forms of wage employment, and suggests ways for Zimbabwe to move beyond the ingrained inequalities and asymmetries in production and organisation that it generates. Using a combination of theoretical and empirical approaches, Economic Dualism in Zimbabwe demonstrates how economic dualism can be eliminated through structural transformation of the traditional agricultural sector and reallocation of labour across sectors. The author comprehensively discusses the origins of dualism in Zimbabwe, how it developed in land, labour, credit and financial markets, who stands to gain and lose from it, and ultimately what reforms are needed to eliminate dualism from the economic system. The book aims to complement efforts made by both North and South to transform this structurally embedded cause of underdevelopment and seeks to motivate change in the collective development agenda mindset. This book will be of interest to graduate-level students, scholars, researchers and policy practitioners in the fields of Development Studies, Economics, Agricultural Policy, Labour Policy, Economic Planning and African Studies.
Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. This extensive title, which combines scientific principles with up-to-date clinical procedures, has been thoroughly updated for the fourteenth edition. You’ll find in-depth material on the biology and pathophysiology of lymphomas, leukemias, platelet destruction, and other hematological disorders as well as the procedures for diagnosing and treating them.
Insights developed in the past two decades by philosophers of the social sciences can serve to enrich the challenging intellectual tasks of conceptualizing, investigating, and representing the human past. Likewise, intimate engagement with the writings of historians can deepen philosophers’ understanding of the task of knowing the past. This volume brings these perspectives together and considers fundamental questions, such as: What is historical causation? What is a large historical structure? How can we best conceptualize “mentalities” and “identities”? What is involved in understanding the subjectivity of historical actors? What is involved in arriving at an economic history of a large region? How are actions and outcomes related? The arguments touch upon a wide range of historical topics -- the Chinese and French Revolutions, the extension of railroads in the nineteenth century, and the development of agriculture in medieval China.
New York native Dr. Obed Harvey came to California to seek his fortune in the Gold Rush. Like so many others, he turned to farming the great Central Valley. With the help of the Central Pacific Railroad, Dr. Harvey established a town around the railroad that ran through his property. His friend John McFarland, a rancher, chose the name Galt after his boyhood home in Canada. Over the years, unique businesses like the Sego Milk Plant and the Galt Winery came and went. The citizens celebrated the Fourth of July with parades and attended the Sacramento County Fair, held in town. Still a farming community with a small-town atmosphere, Galt is noted for Spaans Cookie Co., McFarland Living History Ranch, and the Rae House Museum.
In this work, Daniel Headrick traces the evolution of Western technologies and sheds light on the environmental and social factors that have brought victory in some cases and unforeseen defeat in others.
Comprehensive in scope and thoroughly up to date, Wintrobe’s Clinical Hematology, 15th Edition, combines the biology and pathophysiology of hematology as well as the diagnosis and treatment of commonly encountered hematological disorders. Editor-in-chief Dr. Robert T. Means, Jr., along with a team of expert section editors and contributing authors, provide authoritative, in-depth information on the biology and pathophysiology of lymphomas, leukemias, platelet destruction, and other hematological disorders as well as the procedures for diagnosing and treating them. Packed with more than 1,500 tables and figures throughout, this trusted text is an indispensable reference for hematologists, oncologists, residents, nurse practitioners, and pathologists.
The postcolonial state, like its European predecessor of the 18th and 19th centuries, deploys heritage institutions and instruments, museums, courts of law, and universities to empower itself with unity, longevity, exaltation of value, origin, and destiny. This book reveals the febrile pitch at which heritage is staked by examining situations in South Africa, India, and the US, to capture its perfect embodiment of the struggle to seize culture and society at moments of profound social change.
In his classic novel, The Pilgrim’s Progress, John Bunyan wrote allegory of the progress of the Christian Pilgrimage from the City of Destruction (this world) to the Celestial City (the world to come). Written in 1678 and now translated into over 200 languages, its message is still significant and relevant for Christians today. As an allegory, it pictures the struggles and challenges that confront Christians at all times. This book, relates the true story of a Christian journey that started over fifty years ago in Africa but extended to Europe (England) and America. It is interspersed with personal stories, encounters and reminiscences that point to the struggles, hurdles and hindrances faced by Christians today in their journey anywhere in the world. It suggests spiritual vitamins essential for spiritual stamina in the Christian journey in spiritual formation. The book evaluates the vital characteristics of spiritual formation and suggests from a biblical and theological perspective the disciplines necessary for its development. It affirms its validity with reference to the way in which class meetings played a major role in the Wesleyan tradition of spiritual formation. It recommends that exploring modern forms of class meetings would address current church decline.
Cases in Medical Microbiology and Infectious Diseases challenges students to develop a working knowledge of the variety of microorganisms that cause infections in humans. This valuable, interactive text will help them better understand the clinical importance of the basic science concepts presented in medical microbiology or infectious disease courses. The cases are presented as "unknowns" and represent actual case presentations of patients the authors have encountered. Each case is accompanied by several questions to test knowledge in four broad areas including the organism's characteristics and laboratory diagnosis; pathogenesis and clinical characteristics of the infection; epidemiology; and prevention and, in some cases, drug resistance and treatment. This new fourth edition includes: an entirely new section, "Advanced Cases," which includes newly recognized disease agents as well as highly complex cases where the interaction of the immune system and human pathogens can be more closely examined a revised "Primer on the Laboratory Diagnosis of Infectious Diseases" section that reflects the increasing importance of molecular-based assays Forty-two new cases that explore the myriad advances in the study of infectious disease in the past decade Thirty-two updated cases that reflect the current state of the art as it relates to the organism causing the infection This textbook also include specific tools to assist students in solving the cases, including a table of normal values, glossary of medical terms, and figures illustrating microscopic organism morphology, laboratory tests, and clinical symptoms. Cases in Medical Microbiology and Infectious Diseases is a proven resource for preparing for Part I of the National Board of Medical Examiners Exam and an excellent reference for infectious disease rotations.
Biochemical kinetics refers to the rate at which a reaction takes place. Kinetic mechanisms have played a major role in defining the metabolic pathways, the mechanistic action of enzymes, and even the processing of genetic material. The Handbook of Biochemical Kinetics provides the "underlying scaffolding" of logic for kinetic approaches to distinguish rival models or mechanisms. The handbook also comments on techniques and their likely limitations and pitfalls, as well as derivations of fundamental rate equations that characterize biochemical processes.Key Features* Over 750 pages devoted to theory and techniques for studying enzymic and metabolic processes* Over 1,500 definitions of kinetic and mechanistic terminology, with key references* Practical advice on experimental design of kinetic experiments* Extended step-by-step methods for deriving rate equations* Over 1,000 enzymes, complete with EC numbers, reactions catalyzed, and references to reviews and/or assay methods* Over 5,000 selected references to kinetic methods appearing in the Methods in Enzymology series* 72-page Wordfinder that allows the reader to search by keywords* Summaries of mechanistic studies on key enzymes and protein systems* Over 250 diagrams, figures, tables, and structures
Inside the 3rd edition of this esteemed masterwork, hundreds of the most distinguished authorities from around the world provide today's best answers to every question that arises in your practice. They deliver in-depth guidance on new diagnostic approaches, operative technique, and treatment option, as well as cogent explanations of every new scientific concept and its clinical importance. With its new streamlined, more user-friendly, full-color format, this 3rd edition makes reference much faster, easier, and more versatile. More than ever, it's the source you need to efficiently and confidently overcome any clinical challenge you may face. Comprehensive, authoritative, and richly illustrated coverage of every scientific and clinical principle in ophthalmology ensures that you will always be able to find the guidance you need to diagnose and manage your patients' ocular problems and meet today's standards of care. Updates include completely new sections on "Refractive Surgery" and "Ethics and Professionalism"... an updated and expanded "Geneitcs" section... an updated "Retina" section featuring OCT imaging and new drug therapies for macular degeneration... and many other important new developments that affect your patient care. A streamlined format and a new, more user-friendly full-color design - with many at-a-glance summary tables, algorithms, boxes, diagrams, and thousands of phenomenal color illustrations - allows you to locate the assistance you need more rapidly than ever.
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