This accessible primer has been completely revised and updated to provide a concise but comprehensive introduction to the basic concepts of population genetics and genomics.
In response to many requests, the Third Edition of A Primer of Population Genetics has been dramatically shortened and streamlined for greater accessibility. Designed primarily for undergraduates, it will also serve for graduate students and professionals in biology and other sciences who desire a concise but comprehensive overview of the field with a primary focus on the integration of experimental results with theory. The abundance of experimental data generated by the use of molecular methods to study genetic polymorphisms sparked a transformation in the field of population genetics. Present in virtually all organisms, molecular polymorphisms allow populations to be studied without regard to species or habitat, and without the need for controlled crosses, mutant genes, or for any prior genetic studies. Thus a familiarity with population genetics has become essential for any biologist whose work is at the population level. These fields include evolution, ecology, systematics, plant breeding, animal breeding, conservation and wildlife management, human genetics, and anthropology. Population genetics seeks to understand the causes of genetic differences within and among species, and molecular biology provides a rich repertoire of techniques for identifying these differences.
Every new print textbook includes access to the student companion website Updated throughout to reflect the latest discoveries in this fast-paced field, Essential Genetics: A Genomics Perspective, Sixth Edition, provides an accessible, student-friendly introduction to modern genetics. Designed for the shorter, less comprehensive course, the Sixth Edition presents carefully chosen topics that provide a solid foundation to the basic understanding of gene mutation, expression, and regulation. It goes on to discuss the development and progression of genetics as a field of study within a societal and historical context. The Sixth Edition includes new learning objectives within each chapter which helps students identify what they should know as a result of their studying and highlights the skills they should acquire through various practice problems. What's new in the Sixth Edition? Chapter 1 includes a new section on the origin of life Chapter 2 includes a revised discussion of the complementation test and how it is used to determine whether two mutations have defects in the same gene Chapter 3 incorporates new data showing that the folding of interphase chromatin into chromosome territories has the form of a fractal globule. It also includes a new section on progenitor cells and embryonic stem cells Chapter 4 includes a new section discussing how copy-number variation in human amylase evolved in response to increased dietary starch as well as the latest on hotspots of recombination Chapter 5 is updated with the latest information on hazards of polycarbonate food containers. It also includes a new section on the genetics of schizophrenia and autism spectrum disorder Chapter 6 includes a revised section on restriction mapping and also discusses the newest massively parallel DNA sequencing technologies that can yield the equivalent of 200 human genomes' worth of DNA sequence in a single sequencing run Chapter 7 has been updated with a shortened and streamlined discussion of recombination in bacteriophage Chapter 8 includes new discoveries concerning the mechanisms of intrinsic transcriptional termination as well as rho-dependent termination Chapter 9 is updated with a new section on stochastic effects on gene expression and an expanded discussion of the lactose operon. There is also a revised discussion of galactose gene regulation in yeast, as well as new sections on lon noncoding RNAs Chapter 10 includes new sections on ancient DNA sequences of the Neandertal and Denisovan genomes Chapter 11 examines master control genes in development Chapter 12 includes a new section on the repair of double-stranded breaks in DNA by nonhomologous end joining or template-directed gap repair Chapter 13 has been extensively revised with the latest data on cancer. Chapter 14 includes a new section on the detection of natural selection, as well as a new section on conservation genetics Key Features of Essential Genetics, Sixth Edition: New Learning Objectives w
In 1865, Gregor Mendel presented "Experiments in Plant-Hybridization," the results of his eight-year study of the principles of inheritance through experimentation with pea plants. Overlooked in its day, Mendel's work would later become the foundation of modern genetics. Did his pioneering research follow the rigors of real scientific inquiry, or was Mendel's data too good to be true—the product of doctored statistics? In Ending the Mendel-Fisher Controversy, leading experts present their conclusions on the legendary controversy surrounding the challenge to Mendel's findings by British statistician and biologist R. A. Fisher. In his 1936 paper "Has Mendel's Work Been Rediscovered?" Fisher suggested that Mendel's data could have been falsified in order to support his expectations. Fisher attributed the falsification to an unknown assistant of Mendel's. At the time, Fisher's criticism did not receive wide attention. Yet beginning in 1964, about the time of the centenary of Mendel's paper, scholars began to publicly discuss whether Fisher had successfully proven that Mendel's data was falsified. Since that time, numerous articles, letters, and comments have been published on the controversy.This self-contained volume includes everything the reader will need to know about the subject: an overview of the controversy; the original papers of Mendel and Fisher; four of the most important papers on the debate; and new updates, by the authors, of the latter four papers. Taken together, the authors contend, these voices argue for an end to the controversy-making this book the definitive last word on the subject.
Essential Genetics and Genomics is the ideal textbook for the shorter, less comprehensive genetics course. It presents carefully chosen topics that provide a solid foundation to the basic understanding of gene mutation, expression, and regulation.
This textbook gives an introduction to genetics and genomics at the college level. It contains a chapter on human genetic evolution. Other chapters treat transmission genetics, molecular genetics and evolutionary genetics and provide an understanding of the basic process of gene transmission, mutation, expression and regulation.
Written for the introductory human biology course, the Seventh Edition of Chiras' acclaimed text maintains the original organizational theme of homeostasis presented in previous editions to present the fundamental concepts of mammalian biology and human structure and function. Chiras discusses the scientific process in a thought-provoking way that asks students to become deeper, more critical thinkers. The focus on health and homeostasis allows students to learn key concepts while also assessing their own health needs. An updated and enhanced ancillary package includes numerous student and instructor tools to help students get the most out of their course!
Updated to reflect the latest discoveries in the field, the Fifth Edition of Hartl's classic text provides an accessible, student-friendly introduction to contemporary genetics. Designed for the shorter, less comprehensive introductory course, Essential Genetics: A Genomic Perspective, Fifth Edition includes carefully chosen topics that provide a solid foundation to the basic understanding of gene mutation, expression, and regulation. New and updated sections on genetic analysis, molecular genetics, probability in genetics, and pathogenicity islands ensure that students are kept up-to-date on current key topics. The text also provides students with a sense of the social and historical context in which genetics has developed. The updated companion web site provides numerous study tools, such as animated flashcards, crosswords, practice quizzes and more! New and expanded end-of-chapter material allows for a mastery of key genetics concepts and is ideal for homework assignments and in-class discussion.
A Primer of Population Genetics and Genomics has been completely revised and updated to provide a concise but comprehensive introduction to the basic concepts of population genetics and genomics. Recent textbooks have tended to focus on such specialized topics as the coalescent, molecular evolution, human population genetics, or genomics. This primer bucks that trend by encouraging a broader familiarity with, and understanding of, population genetics and genomics as a whole. The overview ranges from mating systems through the causes of evolution, molecular population genetics, and the genomics of complex traits. Interwoven are discussions of ancient DNA, gene drive, landscape genetics, identifying risk factors for complex diseases, the genomics of adaptation and speciation, and other active areas of current research. The principles are illuminated by numerous examples from a wide variety of animals, plants, microbes, and human populations. The approach also emphasizes learning by doing, which in this case means solving numerical or conceptual problems. The rationale behind this is that the use of concepts in problem-solving lead to deeper understanding and longer knowledge retention. This accessible, introductory textbook is aimed principally at students of various levels and abilities (from senior undergraduate to postgraduate) as well as practising scientists in the fields of population genetics, ecology, evolutionary biology, computational biology, bioinformatics, biostatistics, physics, and mathematics.
Completely updated to reflect new discoveries and current thinking in the field, the Fourth Edition of Essential Genetics is designed for the shorter, less comprehensive introductory course in genetics. The text is written in a clear, lively, and concise manner and includes many special features that make the book user friendly. Topics were carefully chosen to provide a solid foundation for understanding the basic processes of gene transmission, mutation, expression, and regulation. The text also helps students develop skills in problem solving, achieve a sense of the social and historical context in which genetics has developed, and become aware of the genetic resources and information available through the Internet.
This must-have student resource contains complete solutions to all end-of-chapter problems in Genetics: Analysis of Genes and Genomes, Eighth Edition, by Daniel L. Hartl and Maryellen Ruvolo, as well as a wealth of supplemental problems and exercises with full solutions, a complete chapter summary, and keyword section. The supplemental problems provided in this manual are designed as learning opportunities rather than exercises to be completed by rote. They are organized into chapters that parallel those of the main text, and all problems can be solved through application of the concepts and principles explained in Genetics, Eighth Edition.
This must-have student resource contains complete solutions to all end-of-chapter problems in Genetics: Analysis of Genes and Genomes, Eighth Edition, by Daniel L. Hartl and Maryellen Ruvolo, as well as a wealth of supplemental problems and exercises with full solutions, a complete chapter summary, and keyword section. The supplemental problems provided in this manual are designed as learning opportunities rather than exercises to be completed by rote. They are organized into chapters that parallel those of the main text, and all problems can be solved through application of the concepts and principles explained in Genetics, Eighth Edition.
BIOLOGY: HOW LIFE WORKS has been a revolutionary force for both instructors and students in the majors biology course. It was the first truly comprehensive set of integrated tools for introductory biology, seamlessly incorporating powerful text, media, and assessment to create the best pedagogical experience for students. THE VISUAL PROGRAM The already impressive visual program has been greatly improved and expanded. The powerful Visual Synthesis tools have been reimagined, allowing for more flexibility for both students and instructors. A new Tour Mode allows for learning objective-driven tours of the material and deep linking from the eText allow the student to jump straight from the text into a rich visual representation of the content. Instructors can also create customized tours to use for engaging in-class presentations. And finally, new animations have been added to the library, including a new 3D animation to support the animal physiology content. A FOCUS ON SCIENTIFIC SKILLS The third edition does even more to teach students the skills they need to think like a scientist, along with the content they need to move beyond the introductory course. New Skills Primers are self-paced tutorials that guide students to learn, practice, and use skills like data visualization, experimental design, working with numbers, and more. New How Do We Know? activities accompany the feature in the text and teach students to understand scientific inquiry. THE HUB The best teaching resources in the world aren’t of use if instructors can’t find them. The HUB provides a one-stop destination for valuable teaching and learning resources, including all of our well-vetted in-class activities. IMPROVED ORGANIZATION OF TOPICS We implemented several organizational changes based on extensive user feedback with the goal of creating an improved narrative for students and a more flexible teaching framework for instructors. A new chapter on Animal Form, Function, and Evolutionary History leads off the animal anatomy and physiology chapters to provide a whole-body view of structure and function and to provide better context for the more specific systems in following chapters. The ecology coverage has been enriched and reorganized for a more seamless flow. A new chapter on Ecosystem Ecology combines ecosystem concepts formerly housed in separate chapters to present a more cohesive view of the flow of matter and energy in ecosystems. All of these changes and improvements represent the next step in the life of Biology: How Life Works. We think we have created the best learning resource for introductory biology students, and we think instructors will find joy in the improvements they can make in their classes with these materials.
Updated to reflect the latest discoveries in the field, the Fifth Edition of Hartl's classic text provides an accessible, student-friendly introduction to contemporary genetics. Designed for the shorter, less comprehensive introductory course, Essential Genetics: A Genomic Perspective, Fifth Edition includes carefully chosen topics that provide a solid foundation to the basic understanding of gene mutation, expression, and regulation. New and updated sections on genetic analysis, molecular genetics, probability in genetics, and pathogenicity islands ensure that students are kept up-to-date on current key topics. The text also provides students with a sense of the social and historical context in which genetics has developed. The updated companion web site provides numerous study tools, such as animated flashcards, crosswords, practice quizzes and more! New and expanded end-of-chapter material allows for a mastery of key genetics concepts and is ideal for homework assignments and in-class discussion.
Written for the introductory human biology course, the Seventh Edition of Chiras' acclaimed text maintains the original organizational theme of homeostasis presented in previous editions to present the fundamental concepts of mammalian biology and human structure and function. Chiras discusses the scientific process in a thought-provoking way that asks students to become deeper, more critical thinkers. The focus on health and homeostasis allows students to learn key concepts while also assessing their own health needs. An updated and enhanced ancillary package includes numerous student and instructor tools to help students get the most out of their course!
Essential Genetics and Genomics is the ideal textbook for the shorter, less comprehensive genetics course. It presents carefully chosen topics that provide a solid foundation to the basic understanding of gene mutation, expression, and regulation.
This must-have student resource contains complete solutions to all end-of-chapter problems in Genetics: Analysis of Genes and Genomes, Eighth Edition, by Daniel L. Hartl and Maryellen Ruvolo, as well as a wealth of supplemental problems and exercises with full solutions, a complete chapter summary, and keyword section. The supplemental problems provided in this manual are designed as learning opportunities rather than exercises to be completed by rote. They are organized into chapters that parallel those of the main text, and all problems can be solved through application of the concepts and principles explained in Genetics, Eighth Edition.
This must-have student resource contains complete solutions to all end-of-chapter problems in Genetics: Analysis of Genes and Genomes, Eighth Edition, by Daniel L. Hartl and Maryellen Ruvolo, as well as a wealth of supplemental problems and exercises with full solutions, a complete chapter summary, and keyword section. The supplemental problems provided in this manual are designed as learning opportunities rather than exercises to be completed by rote. They are organized into chapters that parallel those of the main text, and all problems can be solved through application of the concepts and principles explained in Genetics, Eighth Edition.
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