Schmegoogle: n. : a person so insignificant that if you Google his name, nothing comes up. Schmegoogle: Yiddish Words for Modern Times is a hilariously useful lexicon of neologisms that capture the flavor of life as we live it today. This clever book introduces more than 200 new terms rooted in real Yiddish, accompanied funny use-it-in-a-sentence examples and entertaining etymology. • Yiddish has long enriched English language slang. • Covers subjects including technology, family, dating, anxiety, insults and more • All terms are a unique blend of classic Yiddish with modern topics In this fast-changing modern world experienced online and through apps, of foodies, legal weed, and shifting social constructs, our need for the expressive wonders of Yiddish has never been greater. Bothered by that unanswered drift of e-mail piling up (e-charazi), stuffed by food or worry (gifilted), feeling like the dating app sends in only clowns (a zhlub magnet)? Schmegoogle is here to help. • Hilarious useful Yiddish neologisms for the 21st century • Makes a great gift for Jewish holidays or anyone who loves Jewish humor, as well as language nerds. • Perfect to for any occasion • You'll love this book if you love books like Yiddish with Dick and Jane by Ellis Weiner and Barbara Davilman, Born to Kvetch: Yiddish Language and Culture in All of Its Moods by Michael Wex, and Yiddish with George and Laura by Ellis Weiner, Barbara Davilman.
Highlights some computational approaches to the study of new materials that include fullerenes, fractal clusters, charge transfer polymers, incommensurate crystals, and semiconductor nanostructures.
Inside the 3rd edition of this esteemed masterwork, hundreds of the most distinguished authorities from around the world provide today's best answers to every question that arises in your practice. They deliver in-depth guidance on new diagnostic approaches, operative technique, and treatment option, as well as cogent explanations of every new scientific concept and its clinical importance. With its new streamlined, more user-friendly, full-color format, this 3rd edition makes reference much faster, easier, and more versatile. More than ever, it's the source you need to efficiently and confidently overcome any clinical challenge you may face. Comprehensive, authoritative, and richly illustrated coverage of every scientific and clinical principle in ophthalmology ensures that you will always be able to find the guidance you need to diagnose and manage your patients' ocular problems and meet today's standards of care. Updates include completely new sections on "Refractive Surgery" and "Ethics and Professionalism"... an updated and expanded "Geneitcs" section... an updated "Retina" section featuring OCT imaging and new drug therapies for macular degeneration... and many other important new developments that affect your patient care. A streamlined format and a new, more user-friendly full-color design - with many at-a-glance summary tables, algorithms, boxes, diagrams, and thousands of phenomenal color illustrations - allows you to locate the assistance you need more rapidly than ever.
An essential experience of being a baseball fan is the hopeful anticipation of seeing the hometown nine make a run at winning the World Series. In Paths to Glory, Mark L. Armour and Daniel R. Levitt review how teams build themselves up into winners. What makes a winning team like the 1900 Brooklyn Superbas or the 1917 White Sox or the 1997 Florida Marlins? And how are these teams different? What makes each championship team a unique product of its time? Armour and Levitt provide the historical context to show how the sport's business side has changed dramatically but its competitive environment remains the same. Utilizing new statistics to evaluate a player's value and career patterns, Armour and Levitt explore the teams that took risks, created their own opportunities, and changed the game. How did the Washington Senators achieve the unthinkable and blow past Babe Ruth's Yankees in 1924 and 1925? How did the 1965 Minnesota Twins quickly rise to the top and why did they just as suddenly fall? Did Charlie Finley assemble the last old-fashioned championship team before free agency, or was the Moustache Gang another example of winning by building from within? Why did the star-laden Red Sox of the 1930s keep falling short? In exploring these teams and more, Armour and Levitt analyze the players, the managers, and the executives who built teams to win and then lived with the consequences.
In Freud's Lost Chord, Dan Sapen explores what it means for the development of depth psychology that Freud was perplexed by music, and unlike nearly every other aspect of human life, had little to say about it - a problem shared by most others in the early generations of psychoanalytic thought. Psychoanalyst Charles Rycroft wrote One cannot help regretting that none of the pioneers of the unconscious thought naturally in auditory terms; more than this, over 100 years later, not only is music per se rarely looked it in psychodynamic terms, jazz music is almost completely absent from the literature. Dr. Sapen looks in depth at the intricate details of psychodynamic theory and practice, as well as an overview of its development, to address the possibility that a theoretical model that has little to say about such a basic and omni-present aspect of human life must be seriously flawed in its effort to explain what it is to be human, and how the mind functions and what it creates. However, Sapen illustrates how numerous other thinkers (Jung, Winnicott, Bion, Loewald, Rycroft), some seemingly at odds with and others serving as essential developments and re-workings of psychoanalytic principles, have managed to illuminate and integrate those missing principles so basic to music and creativity - to development, dreaming, thinking, and relating among other human beings intimately and in a society. Nearly uniquely in the psychodynamic literature, Sapen looks in depth at the music of Miles Davis and John Coltrane as examples of the living, breathing psychological processes so essential to understanding the meaning and dynamics of being human that Freud could not, for a variety of reasons, conceptualize.
An exploration of how the image and idea of the dragon has evolved through history How did the dragon get its wings? Everyone in the modern West has a clear idea of what a dragon looks like and of the sorts of stories it inhabits, not least devotees of the fantasies of J. R. R. Tolkien, J. K. Rowling, and George R. R. Martin. A cross between a snake and some fearsome mammal, often sporting colossal wings, they live in caves, lie on treasure, maraud, and breathe fire. They are extraordinarily powerful, but even so, ultimately defeated in their battles with humans. What is the origin of this creature? The Dragon in the West is the first serious and substantial account in any language of the evolution of the modern dragon from its ancient forebears. Daniel Ogden's detailed exploration begins with the drakōn of Greek myth and the draco of the dragon-loving Romans, and a look at the ancient world's female dragons. It brings the story forwards though Christian writings, medieval illustrated manuscripts, and the lives of dragon-duelling saints, before concluding with a study of dragons found in the medieval Germanic world, including those of the Anglo-Saxon Beowulf and the Norse sagas.
This text provides a comprehensive introduction to infrared-transparent materials for windows and domes that must withstand harsh environmental conditions, such as high-speed flight or high temperature process monitoring. Introductory material in each section makes the book suitable for anyone with a background in science or engineering.
This is a comprehensive, but accessible text that introduces students to the fields of human factors and ergonomics. The book is intended for undergraduate students, written from the psychological science perspective along with various pedagogical components that will enhance student comprehension and learning. This book is ideal for those introductory courses that wish to introduce students to the multifaceted areas of human factors and ergonomics along with practical knowledge the students can apply in their own lives.
Toward Truth offers the reader a radical psychological guide to healing childhood traumaboth the extreme echelon of damage that the world recognizes as trauma and the other 99% that flies below the radar and is considered normal. Daniel Mackler sides with the truth of the child, not the lies of the parents, and traces the roots of trauma to the family. Toward Truth takes the groundbreaking work of psychologist Alice Miller to the next level, and in so doing offers a vision of deep, permanent, non-dissociative hope.
During the course of any sporting event, critical cognitive and physical tasks are performed within a dynamic, complex, collaborative system comprising multiple humans and artifacts, under pressurized, complex, and rapidly changing conditions. Highly skilled, well-trained individuals walk a fine line between task success and failure, with only slig
The comprehensive "bible" for financial experts providing litigation support The Litigation Services Handbook is the definitive guide for financial experts engaged in litigation services. Attorneys require financial experts now more than ever, and this book provides the guidance you need to provide a high level of service as witness and consultant. Enhance your litigation skills as you delve into the fine points of trial preparation, deposition, and testimony; project authority under examination, and hold up to tough questions under cross-examination. Fraud investigations are a major component of litigation support services, and this book delves deep into Sarbanes-Oxley compliance and other relevant topics to give you a foundational understanding of how these cases are prosecuted, and your role as the financial services expert. This updated sixth edition includes new coverage of technology's role in the financial expert's practice, and the focus on investigations provides practical insight from leading experts in the field. From the process itself to proving damages, this indispensable reference covers all aspects of litigation services. Providing litigation support requires more than just your financial expertise; you also need a working knowledge of relevant case law, and a deep understanding of both the litigation process and the finer points of courtroom appearances. This book provides the insight and perspective you need to provide superior service to attorneys and their clients. Understand your role in trial preparation and testimony presentation Provide authoritative responses to direct and cross examination Examine and analyze Sarbanes-Oxley rulings Lend financial expertise to fraud investigations The growing demand for financial expert litigation services has created a niche market for CPAs, creating a lucrative opportunity for qualified accountants who also possess the specialized knowledge the role requires. The Litigation Services Handbook is THE essential guide for anyone involved in financial litigation.
After revising known representations of the group of Euclidean displacements Daniel Klawitter gives a comprehensive introduction into Clifford algebras. The Clifford algebra calculus is used to construct new models that allow descriptions of the group of projective transformations and inversions with respect to hyperquadrics. Afterwards, chain geometries over Clifford algebras and their subchain geometries are examined. The author applies this theory and the developed methods to the homogeneous Clifford algebra model corresponding to Euclidean geometry. Moreover, kinematic mappings for special Cayley-Klein geometries are developed. These mappings allow a description of existing kinematic mappings in a unifying framework.
Three classic novels in one volume: Summer in Williamsburg (1934), Homage to Blenholt (1936), and Low Company (1937). Fuchs wrote, "I devoted myself simply to the tenement: the life in the hallways, the commotion at the dumbwaiters, the assortment of characters in the building, their strivings and preoccupations, their troubles." These novels are as alive today as the day they were first printed, as exuberant. There are few novelists in America today who possess Fuchs's talent, his energy, his sense of life.
A vivid account of the past, present, and future of economic growth, showing how and why we must continue to pursue it while responding to the challenges it creates. Over the past two centuries, economic growth has freed billions from the struggle for subsistence and made our lives far healthier and longer. Yet prosperity has come at a price: environmental destruction, desolation of local cultures, the rise of vast inequalities and destabilizing technologies. Faced with such damage, many now claim that the only way forward is through “degrowth,” deliberately shrinking our economic footprint. But to abandon humanity’s progress would be folly. Instead, Daniel Susskind argues, we must keep growth but redirect it, making it better reflect what we truly value. In a sweeping analysis full of historical insight, Susskind shows how policymaking came to revolve around a single-minded quest for greater GDP. This is a surprisingly recent development: economic growth was barely discussed until the second half of the twentieth century. And our understanding of what drives it is more recent still. Only lately have we come to see how humankind emerged from its millennia of stagnation: through the sustained discovery of powerful and productive new ideas. This insight undermines the mantra that “we cannot have infinite growth on a finite planet,” for the world of ideas is infinitely vast. Yet growth’s critics are right to insist that we can no longer focus on its upsides alone. We must confront the tradeoffs, Susskind contends: sometimes, societies will have to deliberately pursue less growth for the sake of other goals. These will be moral decisions, not simply economic ones, demanding the engagement not just of politicians and experts but of all citizens.
Winner of the STR Theatre Book Prize 2014 The National Theatre Story is filled with artistic, financial and political battles, onstage triumphs – and the occasional disaster. This definitive account takes readers from the National Theatre's 19th-century origins, through false dawns in the early 1900s, and on to its hard-fought inauguration in 1963. At the Old Vic, Laurence Olivier was for ten years the inspirational Director of the NT Company, before Peter Hall took over and, in 1976, led the move into the National's concrete home on the South Bank. Altogether, the NT has staged more than 800 productions, premiering some of the 20th and 21st centuries' most popular and controversial plays, including Amadeus, The Romans in Britain, Closer, The History Boys, War Horse and One Man, Two Guvnors. Certain to be essential reading for theatre lovers and students, The National Theatre Story is packed with photographs and draws on Daniel Rosenthal's unprecedented access to the National Theatre's own archives, unpublished correspondence and more than 100 new interviews with directors, playwrights and actors, including Olivier's successors as Director (Peter Hall, Richard Eyre, Trevor Nunn and Nicholas Hytner), and other great figures from the last 50 years of British and American drama, among them Edward Albee, Alan Bennett, Judi Dench, Michael Gambon, David Hare, Tony Kushner, Ian McKellen, Diana Rigg, Maggie Smith, Peter Shaffer, Stephen Sondheim and Tom Stoppard.
Winner, 2020 Peter C Rollins Prize, given by the Northeast Popular & American Culture Association Enables a reckoning with the legacy of the Forgotten War through literary and cinematic works of cultural memory Though often considered “the forgotten war,” lost between the end of World War II and the start of the Cold War, the Korean War was, as Daniel Y. Kim argues, a watershed event that fundamentally reshaped both domestic conceptions of race and the interracial dimensions of the global empire that the United States would go on to establish. He uncovers a trail of cultural artefacts that speaks to the trauma experienced by civilians during the conflict but also evokes an expansive web of complicity in the suffering that they endured. Taking up a range of American popular media from the 1950s, Kim offers a portrait of the Korean War as it looked to Americans while they were experiencing it in real time. Kim expands this archive to read a robust host of fiction from US writers like Susan Choi, Rolando Hinojosa, Toni Morrison, and Chang-rae Lee, and the Korean author Hwang Sok-yong. The multiple and ongoing historical trajectories presented in these works testify to the resurgent afterlife of this event in US cultural memory, and of its lasting impact on multiple racialized populations, both within the US and in Korea. The Intimacies of Conflict offers a robust, multifaceted, and multidisciplinary analysis of the pivotal—but often unacknowledged—consequences of the Korean War in both domestic and transnational histories of race.
Presented in an easy-to-digest format with an uplifting message, “How to Get a Life” offers individual chapters on the life views of some of the most important and powerful people in history. Written in an engaging style by college professors Lawrence Baines and Daniel McBrayer, each chapter contains a brief biographical sketch with that luminary’s advice for daily living. Take a trip on “How to Get a Life” and learn easy-to-understand advice from some of the world’s greatest thinkers on: # The importance of relationships # How to get over misunderstandings # How to rise above mediocrity # What to do when things go wrong Along with topics ranging from God and the universe, to conceptions of love, sex and death, historical figures featured include: Martin Luther King, Jr., Joseph Campbell, Bill Wilson, Gerda Weissmann Klein, Albert Schweitzer, Oprah Winfrey, Buddha, Leo Buscaglia, Jane Goodall, the Dalai Lama, Muhammad, Confucius, and Richard of St. Victor
Fetishism (supposing that it existed)": a preface to the translation of Charles de Brosses's Transgression / Rosalind C. Morris -- Introduction: fetishism, figurism, and myths of enlightenment / Daniel H. Leonard -- A note on the translation / Daniel H. Leonard -- On the worship of fetish gods; or, a parallel of the ancient religion of Egypt with the present religion of Nigritia / Charles de Brosses ; translated by Daniel H. Leonard -- After De Brosses: fetishism, translation, comparativism, critique / Rosalind C. Morris -- A fetiche is a fetiche: no knowledge without difference of the word: rereading De Brosses -- Excursus: recontextualizing De Brosses, with Pietz in and out of Africa -- Re Kant and the good fetishists among us -- Hegel: back to the heart of darkness -- Fetishism against itself; or, Marx's two fetishisms -- The great fetish; or, the fetishism of the one -- Freud and the return to the dark continent: the other fetish -- Conjuncture: Freud and Marx, via Lacan -- Anthropology's fetishism: the custodianship of reality -- Fetishism reanimated: surrealism, ethnography, and the war against decay -- Deconstruction's fetish: undecidable, or the mark of Hegel -- Rehistoricizing generalized fetishism: the era of objects -- Anthropological redux: the reality of fetishism -- The fetish is dead, long live fetishism
The History of Men’s Underwear and Swimwear features a detailed, thoroughly illustrated chronology of the development and changing styles of these two “bare necessities” of masculine dress. Interwoven throughout the study is also an examination of how these most intimate forms of men’s clothing not only reflected society but also how the evolution of styles inexorably influenced social change, especially notions of masculinity, modesty, and erotic exhibitionism. In addition, Daniel Delis Hill looks at more than 100 years of the mass marketing of men’s underwear and swimwear, especially the progression of visual presentation and the written message in the era of mass production and mass communication. Cover to cover, the second edition of History of Men’s Underwear and Swimwear is richly illustrated in color throughout with over 200 period photos and artwork, many never published before.
The idea of dedicating a Festschrift to honor Professor Frédéric Manns on the happy occasion of his 70th birthday came to mind in the autumn of 2011 and work on this project had been continuing ever since. Felicitously achieving this goal, the Faculty of Biblical Sciences and Archaeology (Studium Biblicum Franciscanum) and the Franciscan Custody of the Holy Land present this volume to Father Manns with gratitude for his profound scholarship and a lifetime service in the Holy Land. Perusing through Father Manns’ writings, it is easy to see a prominent and distinctive place devoted to the Gospel of John. It seemed therefore suitable to focus on this subject in the Festschrift honoring him: the title, Rediscovering John, relates to Manns’ significant contribution towards the better understanding of the Fourth Gospel. The volume comprises 21 studies authored by renowned scholars from various parts of the world, from different institutions and denominations. While the first half of the studies examines general issues (history of interpretation, textual transmission, intertextuality, theological themes, archaeology), the second half treats literary, narrative and exegetical approaches to particular texts of the Fourth Gospel. We augur that this rich collection will help to stimulate further discussion and reflection on the Gospel of John, as well as constitute an incentive to an already distinguished scholar to continue writing challenging and thought-provoking essays and books. (from the Foreword by the Editor)
Buy a new version of this textbook and receive access to the Connected eBook on CasebookConnect, including: lifetime access to the online ebook with highlight, annotation, and search capabilities, plus an outline tool and other helpful resources. Connected eBooks provide what you need most to be successful in your law school classes. Corporate Criminal Investigations and Prosecutions provides readers a comprehensive understanding of the process behind the investigation, prosecution, and resolution of criminal charges against organizations. Over the past two decades, corporate criminal liability has developed into one of the fastest-growing and most dynamic areas of legal practice. The growth of corporate criminal enforcement has correlated with a broad shift in how the government investigates and resolves corporate criminal violations. As a result of these developments, the practice of investigating, prosecuting, and resolving corporate criminal cases has many significant differences from other areas of criminal or civil law. Notably, one of the most significant aspects that distinguishes corporate criminal practice is that much of it occurs outside of the formal judicial system; nearly all DOJ corporate criminal matters are resolved through negotiated settlements, and very few cases involve court proceedings or go to trial. As a result, many parts of this practice remain relatively unknown to students and practitioners. Until now. With the publication of this book, authors Leo Tsao, Daniel Kahn, and Eugene Soltes, whose resumes collectively reflect the highest levels of practice and expertise in this field, open a window into all aspects of corporate criminal investigations and prosecutions. Professors and students will benefit from: The authors bring a unique perspective and unparalleled qualifications to the subject of corporate criminal liability. Daniel Kahn is the former acting Deputy Assistant Attorney General of the Criminal Division and former Chief of the Fraud Section and FCPA Unit. Leo Tsao is the former Principal Deputy Chief of the Money Laundering and Asset Recovery Section and has held supervisory positions in the Bank Integrity Unit and FCPA Unit within the DOJ’s Criminal Division. Eugene Soltes is a professor at Harvard Business School, and regularly teaches and advises companies on corporate integrity, organizational cultures, and compliance systems. Comprehensive coverage: Part One addresses topics that are generally applicable to all corporate criminal cases, such as the legal principles underlying corporate criminal liability; the individual liability of corporate officers for corporate crimes; and the constitutional rights of criminal corporate defendants—to name a few. Part Two addresses specific categories of federal crimes commonly used to charge corporate defendants, such as conspiracy, the FCPA, the Bank Secrecy Act, antitrust laws, and RICO. Part Two also provides insights into criminal activity and law enforcement within the technology sector as it pertains to virtual currency (e.g., Bitcoin). Extensive online resources include discussion questions, and relevant case material for key chapters
“Daniel Barbarisi plunges into an adventure from another era when he goes in search of buried treasure, guided only by a cryptic poem, a mischievous art collector, and the footsteps another pursuer who died on the quest… Every page draws you deeper into this no-man’s-land where fortune—or tragedy—awaits.” —Christopher McDougall, author of Born to Run When Forrest Fenn was given a fatal cancer diagnosis, he came up with a bold plan: He would hide a chest full of jewels and gold in the wilderness, and publish a poem that would serve as a map leading to the treasure's secret location. But he didn't die, and after hiding the treasure in 2010, Fenn instead presided over a decade-long gold rush that saw many thousands of treasure hunters scrambling across the Rocky Mountains in pursuit of his fortune. Daniel Barbarisi first learned of Fenn's hunt in 2017, when a friend became consumed with decoding the poem and convinced Barbarisi, a reporter, to document his search. What began as an attempt to capture the inner workings of Fenn's hunt quickly turned into a personal quest that led Barbarisi down a reckless and potentially dangerous path, one that found him embroiled in searcher conspiracies and matching wits with Fenn himself. Over the course of four chaotic years, several searchers would die, endless controversies would erupt, and one hunter would ultimately find the chest. But the mystery didn't end there. Full of intrigue, danger, and break-neck action, Chasing the Thrill is a riveting tale of desire, obsession, and unbridled adventure.
Are we born with our fears or do we learn them? Why do our fears persist? What purpose does anxiety serve? How common are anxiety disorders, and which treatments are most effective? What's happening in our brain when we feel fear? And what are Colombian worry dolls? This Very Short Introduction draws on the best scientific research to offer a highly accessible explanation of what anxiety is, why it is such a normal and vital part of our emotional life, and the key factors that cause it. Insights are drawn from psychology, neuroscience, genetics, epidemiology, and clinical trials. Providing a fascinating illustration of the discussion are two interviews conducted specifically for the book, with the actor, writer, director, and television presenter Michael Palin and former England football manager Graham Taylor. The book covers in detail the six major anxiety disorders: phobias; panic disorder and agoraphobia; social anxiety; generalised anxiety disorder; obsessive compulsive disorder; and post-traumatic stress disorder. With a chapter devoted to each disorder, Daniel and Jason Freeman take you through the symptoms, prevalence, and causes of each one. A final chapter describes the treatments available for dealing with anxiety problems. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.
Crimes committed by Jews, especially ritual murders, have long been favorite targets in the antisemitic press. This book investigates popular and scientific conceptualizations of criminals current in Austria and Germany at the turn of the last century and compares these to those in the contemporary antisemitic discourse. It challenges received historiographic assumptions about the centrality of criminal bodies and psyches in late nineteenth- and early twentieth-century criminology and argues that contemporary antisemitic narratives constructed Jewish criminality not as a biologico-racial defect, but rather as a coolly manipulative force that aimed at the deliberate destruction of the basis of society itself. Through the lens of criminality this book provides new insight into the spread and nature of antisemitism in Austria-Hungary around 1900. The book also provides a re-evaluation of the phenomenon of modern Ritual Murder Trials by placing them into the context of wider narratives of Jewish crime.
In a glance at American menswear over the past 150 years, change has been sometimes glacial in its evolution, sometimes regressive and nostalgic, and other times abrupt and revolutionary. In this study of American menswear from the Civil War to the twenty-first century, that evolution is chronicled and documented with more than 700 illustrations. In addition to the main categories of suits, sportswear, and outerwear, each era also includes a detailed examination of sleepwear, underwear, swimwear, hats, neckwear, footwear, and accessories. Further, Daniel Delis Hill examines not only American men’s dress and the structures of the menswear industry, but also the historical and socioeconomic drivers that affected men’s style—particularly the shifting conventions and iconoclasms of American ideas and ideals of masculinity.
Many proprotein convertases (PC), especially furin and PACE4, are involved in pathological processes such as viral infection, inflammation, hypercholesterolemia, and cancer, and have been postulated as therapeutic targets for some of these diseases. In this chapter, we review mostly our work using animal models of squamous cancers that have been induced by chemical or UV carcinogenesis protocols to highlight the role of PCs in the development and progression of experimental tumors. After demonstrating in wild type mice the role of PACE4 in tumor progression as well as detecting the expression of PACE4 and furin in human non-melanoma skin cancers, we developed transgenic mice that over-express either PACE4 or furin in squamous epithelia, including the epidermis. This was accomplished by targeting the expression of the corresponding PC by using the promoter of the bovine keratin 5. Both K5-PACE4 and K5-Furin transgenic mice showed increased susceptibility to a two-stage carcinogenesis protocol of chemical carcinogenesis. Similar studies conducted in K5-PACE4 mice also showed an increased sensitivity to ultraviolet B radiation carcinogenesis. In most of these experiments, we were able to demonstrate that compared to the control wild type mice, the over-expression of the transgene in the epidermis increased the number of benign and malignant skin tumors and also had an effect on tumor progression as evidenced by the presence of less differentiated tumors and more frequent local and distant metastases in many of the transgenic lines. Interestingly, double transgenic mice in which PACE4 and furin are targeted to the epidermis did not show any additive effect, pointing to a probable in vivo overlap of functions at least in cutaneous tissues. The tumor-enhancing effects of PACE4 and furin further support their possible role as therapeutic targets. Furthermore, a proof of principle for PC inhibition as a therapeutic tool has been substantiated by an in vivo experiment in which the PC-inhibitor, decanoyl-RVKRchloromethylketone, was topically administrated to the skin of wild type and transgenic mice treated with chemical carcinogenesis protocols, resulting in a significant decrease of tumor development and progression.
*Major New York Times Bestseller *More than 2.6 million copies sold *One of The New York Times Book Review's ten best books of the year *Selected by The Wall Street Journal as one of the best nonfiction books of the year *Presidential Medal of Freedom Recipient *Daniel Kahneman's work with Amos Tversky is the subject of Michael Lewis's best-selling The Undoing Project: A Friendship That Changed Our Minds In his mega bestseller, Thinking, Fast and Slow, Daniel Kahneman, world-famous psychologist and winner of the Nobel Prize in Economics, takes us on a groundbreaking tour of the mind and explains the two systems that drive the way we think. System 1 is fast, intuitive, and emotional; System 2 is slower, more deliberative, and more logical. The impact of overconfidence on corporate strategies, the difficulties of predicting what will make us happy in the future, the profound effect of cognitive biases on everything from playing the stock market to planning our next vacation—each of these can be understood only by knowing how the two systems shape our judgments and decisions. Engaging the reader in a lively conversation about how we think, Kahneman reveals where we can and cannot trust our intuitions and how we can tap into the benefits of slow thinking. He offers practical and enlightening insights into how choices are made in both our business and our personal lives—and how we can use different techniques to guard against the mental glitches that often get us into trouble. Topping bestseller lists for almost ten years, Thinking, Fast and Slow is a contemporary classic, an essential book that has changed the lives of millions of readers.
In The Wing of Madness, Daniel Burston chronicles R. D. Laing's meteoric rise to fame as one of the first media psycho-gurus of the 20th century, and his spiralling decline in the late 70s and 80s.
Exploring topics from classical and quantum mechnanics and field theory, this book is based on lectures presented in the Graduate Summer School at the Regional Geometry Institute in Park City, Utah, in 1991. The chapter by Bryant treats Lie groups and symplectic geometry, examining not only the connection with mechanics but also the application to differential equations and the recent work of the Gromov school. Rabin's discussion of quantum mechanics and field theory is specifically aimed at mathematicians. Alvarez describes the application of supersymmetry to prove the Atiyah-Singer index theorem, touching on ideas that also underlie more complicated applications of supersymmetry. Quinn's account of the topological quantum field theory captures the formal aspects of the path integral and shows how these ideas can influence branches of mathematics which at first glance may not seem connected. Presenting material at a level between that of textbooks and research papers, much of the book would provide excellent material for graduate courses. The book provides an entree into a field that promises to remain exciting and important for years to come.
The remarkable story of how the Allies used psychoanalysis to delve into the motivations of the Nazi leadership and to explore the mass psychology of fascism.
Recent years have seen fundamental changes to the law and practise of trade mark licensing. "Trade Mark Licensing 2nd edition" offers a completely rounded perspectivce on the subject, integrating discussion of legal concepts with extensive advice on practical concerns. It provides comprehensive coverage of trade mark licensing under UK and US law, and also considers relevant EU law, including EU competition law and trade mark exhaustion. A detailed sample agreement is included, complete with explanatory notes and cross-references to the main text. This edition also contains new chapters on trade mark licensing in France and Germany, and on domain name+ licensing.
A glittering cultural tour of Europe's major capitals during a period of intense musical change. This volume continues the study of the eighteenth century begun in Haydn, Mozart, and the Viennese School 1740–1780 (1995) by focusing on the capital cities other than Vienna that were most important in the creation and diffusion of new music. It tells of events in Naples, where Vinci and Pergolesi went beyond their pre-1720 models to cultivate opera in a simpler, more direct manner, soon after christened the galant style. No less central was Venice, where Vivaldi perfected the concerto, on which were patterned the early symphonies and the newer kind of sonata. Dresden profited first from all these achievements and became, under Hasse's direction, the foremost center of Italian opera in Germany. Mannheim with its great orchestra did much to shape the modern symphony. A few years later, Paris became paramount, especially for its Opéra-Comique; during the 1770s the Opéra provided Gluck with a stage on which to cap his long international career. The book concludes with a description of Christian Bach in London, Paisiello in Saint Petersburg, and Boccherini in Madrid. This long-awaited book offers a view of eighteenth-century music that is broad and innovative while remaining sensitive to the values of those times and places. One comes away from it with an understanding of the European context behind the triumphs of Haydn and Mozart. Lavishly illustrated with music examples and reproductions, both in black-and-white and color, this master study will be of inestimable importance to scholars, cultural historians, performers, and all music lovers.
Have you ever wondered:DT what motivates some people to work for free?DT what the future of work will look like in a post-pandemic world?DT why organizational values and culture are so critical to success?The authors explore the answers to these questions and more in this bestselling introduction to organizational behaviour. Featuring the flagship Junction Hotel running case study, this text is the most practical, critical, and complete guide to the subject.The authors have extensively revised this fourth edition to make it more relevant than ever before. A new chapter on equality, diversity, and inclusion, plus cutting-edge material on wellbeing in the workplace, the climate crisis, ethics in leadership and much more, reflect the importance of theseissues to people and organizations today.Hear first-hand from twelve key professionals as they explain in bespoke video interviews woven throughout the enhanced e-book why leadership, teamwork, and responsible business practice are crucial in the workplace. For the fourth edition, a greater global range of examples is provided through thereal life cases including new examples from Brewdog, Muji, and COP26, all of which help you make the connection between theory and practice.This book is accompanied by the following online resources:For students:DT Practitioner interviewsDT Author videosDT Self-test MCQs with answer feedbackDT Study skills guidesDT Guided readings of key researchDT Extension materialDT Links to additional resourcesDT Flashcard glossaryFor lecturers:DT Seminar activities (including tutor notes and student worksheets)DT PowerPoint presentationsDT Test bankDT Additional case studiesDT Junction Hotel Culture ReportDT Figures from the text
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