This one-of-a-kind guide offers easy-to-understand explanations, advice, and management options for patients or parents of patients with cystic fibrosis. The book explains the disease process, outlines the fundamentals of diagnosing and screening, and addresses the challenges of treatment for those living with CF. As one reviewer said, this book “is the only complete answer book for everyone living with the disease. It is an indispensable resource for families of children with CF, adolescent and adult patients, and physicians, nurses, respiratory therapists, and social workers involved in the care of CF patients.”
As the world continues to recover from one of the most dramatic financial crises in a generation, expanding corporations are increasingly, yet cautiously, seeking out international investment opportunities. At the heart of this fragile investment recovery lie trust and confidence. With an unprecedented number of investment promotion agencies and economic development organisations now competing for the attention and business of a more cautious and discerning investor audience, smart approaches to strategic differentiation, communication, engagement and investment services are becoming increasingly critical if these agencies and organisations are to succeed. At the same time, transparent and responsible approaches to investment, coupled with effective, compelling advocacy, are increasingly important to the success of companies’ investment projects. Daniel Nicholls’ Foreign Direct Investment offers an exploration of some of the key trends, issues and practices that are shaping the global FDI landscape. Along the way he provides insight into how economic developers and investors alike can make the most of their opportunities and mitigate reputational and communications challenges that can impede or hinder a successful investment. By presenting perspectives and priorities from both sides, Daniel Nicholls’ book bridges the ’investment gap’ by giving its readers an important insight into what matters to the other side. This book represents a smart investment for anyone involved.
Kenneth Goldsmith's Recent Works on Paper is the first critical book devoted to Kenneth Goldsmith, the acclaimed conceptual poet, pedagogue, and provocateur. The book’s focus is on Capital, Wasting Time on the Internet, Against Translation, and Theory, all published within a year of Goldsmith's controversial reading of a poem based on the Michael Brown autopsy report at Brown University in March 2015. These four books address issues of historiography, translation, pedagogy, authorship, and celebrity culture. Each book serves a retrospective function for an author who is, mid-career, taking stock of his considerable impact on U.S. (and world) poetics at the very moment when critics are challenging the ethics of his aesthetic judgment in the wake of the controversy surrounding “The Body of Michael Brown.” The author focuses on how Goldsmith stages (and, in some cases, transforms) his metamorphic identity as a post-humanist information manager. His performance in these four books complicates the current image of him among many critics and fellow poets as one of Hillary Clinton’s “basket of deplorables” who displayed extremely poor judgment while contributing to a culture of racial insensitivity by performing “The Body of Michael Brown.”
Environmental Biotechnology: A Biosystems Approach, Second Edition presents valuable information on how biotechnology has acted as a vital buffer among people, pollution, and the environment. It answers the most important questions on the topic, including how, and why, a knowledge and understanding of the physical, chemical, and biological principles of the environment must be achieved in order to develop biotechnology applications. Most texts address either the applications or the implications of biotechnology. This book addresses both. The applications include biological treatment and other environmental engineering processes. The risks posed by biotechnologies are evaluated from both evidence-based and precautionary perspectives. Using a systems biology approach, the book provides a context for researchers and practitioners in environmental science that complements guidebooks on the necessary specifications and criteria for a wide range of environmental designs and applications. Users will find crucial information on the topics scientific researchers must evaluate in order to develop further technologies. - Provides a systems approach to biotechnologies which includes the physical, biological, and chemical processes in context - Presents relevant case studies on cutting-edge technologies, such as nanobiotechnologies and green engineering - Addresses both the applications and implications of biotechnologies by following the lifecycle of a variety of established and developing biotechnologies - Includes crucial information on the topics scientific researchers must evaluate in order to develop further technologies
For six years the Complex Systems Summer School has contributed greatly to education and research into complex systems. 1993 Lectures in Complex Systems presents a wide array of topics in the field, including condensed matter dynamics, self-organized criticality, complex fluids, evolution, time series analysis, and neural models of perception. This book is a compilation of many of the lectures and contributions of the 1993 Complex Systems Summer School. The collective volumes in the Series ( Lectures in the Sciences of Complexity, 1989 Lectures in the Sciences of Complexity, 1990 Lectures in Complex Systems, 1991 Lectures in Complex Systems, 1992 Lectures in Complex Systems and now 1993 Lectures in Complex Systems ) comprise a growing, broad, interdisciplinary review of the many sciences of complexity—a review unavailable elsewhere.Lectures included in This Volume:S.N. Coopersmith: Complex Structures and Dynamics in Condensed Matter SystemsC.A. MacKen and P.F. Stadler: Evolution of Fitness LandscapesB.W. Mel: Information Processing in Dendritic TreesB.K. Sawhill: Self-Organized Criticality and Complexity TheoryO. Aporns: Neural Models of Perception and BehaviorR. Tagg: Instabilities and the Origin of Complexity in Fluid FlowsK. Thearling: Massively Parallel Architectures and Algorithms for Time Series Analysis
This is a revised and very expanded version of the previous second edition of the book. "Pharmacokinetic and Pharmacodynamic Data Analysis" provides an introduction into pharmacokinetic and pharmacodynamic concepts using simple illustrations and reasoning. It describes ways in which pharmacodynamic and pharmacodynamic theory may be used to give insight into modeling questions and how these questions can in turn lead to new knowledge. This book differentiates itself from other texts in this area in that it bridges the gap between relevant theory and the actual application of the theory to real life situations. The book is divided into two parts; the first introduces fundamental principles of PK and PD concepts, and principles of mathematical modeling, while the second provides case studies obtained from drug industry and academia. Topics included in the first part include a discussion of the statistical principles of model fitting, including how to assess the adequacy of the fit of a model, as well as strategies for selection of time points to be included in the design of a study. The first part also introduces basic pharmacokinetic and pharmacodynamic concepts, including an excellent discussion of effect compartment (link) models as well as indirect response models. The second part of the text includes over 70 modeling case studies. These include a discussion of the selection of the model, derivation of initial parameter estimates and interpretation of the corresponding output. Finally, the authors discuss a number of pharmacodynamic modeling situations including receptor binding models, synergy, and tolerance models (feedback and precursor models). This book will be of interest to researchers, to graduate students and advanced undergraduate students in the PK/PD area who wish to learn how to analyze biological data and build models and to become familiar with new areas of application. In addition, the text will be of interest to toxicologists interested in learning about determinants of exposure and performing toxicokinetic modeling. The inclusion of the numerous exercises and models makes it an excellent primary or adjutant text for traditional PK courses taught in pharmacy and medical schools. A diskette is included with the text that includes all of the exercises and solutions using WinNonlin.
Inside the 3rd edition of this esteemed masterwork, hundreds of the most distinguished authorities from around the world provide today's best answers to every question that arises in your practice. They deliver in-depth guidance on new diagnostic approaches, operative technique, and treatment option, as well as cogent explanations of every new scientific concept and its clinical importance. With its new streamlined, more user-friendly, full-color format, this 3rd edition makes reference much faster, easier, and more versatile. More than ever, it's the source you need to efficiently and confidently overcome any clinical challenge you may face. Comprehensive, authoritative, and richly illustrated coverage of every scientific and clinical principle in ophthalmology ensures that you will always be able to find the guidance you need to diagnose and manage your patients' ocular problems and meet today's standards of care. Updates include completely new sections on "Refractive Surgery" and "Ethics and Professionalism"... an updated and expanded "Geneitcs" section... an updated "Retina" section featuring OCT imaging and new drug therapies for macular degeneration... and many other important new developments that affect your patient care. A streamlined format and a new, more user-friendly full-color design - with many at-a-glance summary tables, algorithms, boxes, diagrams, and thousands of phenomenal color illustrations - allows you to locate the assistance you need more rapidly than ever.
Widely acclaimed for its engaging style and provocative perspective, this book has helped thousands transform their working lives -- Now including a 30-page resource guide that explains the basics of working for oneself. It's about fulfillment. A revolution is sweeping America. On its front lines are people fed up with unfulfilling jobs, dysfunctional workplaces, and dead-end careers. Meet today's new economic icon: the free agent-men and women who are working for themselves. And meet your future. It's about freedom. Free agents are the marketing consultant down the street, the home-based "mompreneur," the footloose technology contractor. Already 30 million strong, these 21st-century pioneers are creating lives with more meaning-and often more money. Free Agent Nation is your ticket to this world. It's about time. Now, you can discover: The kind of free agent you can be-"soloist," "temp," or "microbusiness"-and how to launch your new career. How to get the perks you once received from your boss: health insurance, office space, training, workplace togetherness, even water cooler gossip. Why the free agent economy is increasingly a woman's world-and how women are flourishing in it. The transformation of retirement-how older workers are creating successful new businesses (and whole new lives) through the Internet.
An evidence-based approach to crime and justice policy can go a long way toward ensuring that the best available research is considered in decisions that bear on the public good. However, the term "evidence-based" is characterized by a great deal of rhetoric. Indeed, there remains a marked disjuncture between calls for "evidence-based" policy and an understanding of what it means for policy to be "evidence-based." The calls for evidence-based policy nonetheless provide a powerful foundation for propelling a movement toward bringing about rational, cost-effective, and humane policies for the betterment of society. This handbook showcases the state of research on evidence-based crime and justice policy and the challenges that impede its creation and use. The volume has three core objectives: to promote new and productive ways to think about evidence-based policy; to demonstrate how research can contribute to and guide evidence-based policy in juvenile justice, criminal justice, and alternatives to system responses; and to identify strategies that can increase reliance on evidence-based policy. To meet these objectives, each chapter is guided by several central questions: What do we know about evidence-based policy and practice in crime and justice? How can we improve knowledge of evidence-based policy and practice? How can we promote more use of evidence-based policy and practice? Taken as a whole, the volume emphasizes the critical need for policies that are grounded in high-quality research, that address critical research gaps, and that fully acknowledge the limitations of what extant research can do to inform policy decisions"--
News about sleep is everywhere we turn, and the statistics are numbing: Some 50-70 million Americans are affected by chronic sleep disorders and intermittent sleep problems; an estimated 30-35% of adults complain of insomnia; one in every 25 Americans takes a prescription sleep medication; more than a third of American adults don’t get enough sleep on a regular basis; sleep disorders account for an estimated $16 billion in medical costs each year, plus indirect costs due to missed days of work, decreased productivity and related factors. And questions abound: why do we need to sleep at all? What happens when we sleep? What happens to the brain? We know the brain is active when we sleep, but what about the mind? And what are dreams? An accessible and lively take on sleep, this book provides answers to those and other key questions. Along the way, it highlights the lessons a well-known neurologist has learned and what he shares with his patients on a daily basis. It discusses — in terms everyone can understand — what we know about sleep, what can go wrong with it, and what we can do to fix it. It also delves into what some of the great scientists and spiritual teachers have told us about sleep. The book is packed with useful information and suggestions that will improve all aspects of readers’ lives.
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