The scope of Erika Fromm's profound contributions to the clinical and research literature in hypnosis and related areas is reflected in this volume, which consists of chapters written by those who have worked closely with the noted psychologist and/or have been significantly influenced by her. The subject matter presented here ranges from detailed accounts and personal observations relating to Fromm's distinguished career, to some very new and valuable data on the psychophysiological correlates of hypnosis, the phenomenology of self-hypnosis, and an integrative model for short-term therapy. Several extensions of clinical technique for the treatment of trauma and severe psychopathology are also discussed. Professional therapists with an interest in personal growth, self-awareness, and creative mastery, whether or not they already have an interest in hypnosis, will derive significant benefits from this book. Readers who have previously eschewed hypnosis may find that this volume stimulates an interest that enriches their clinical practice and/or research.
The Third Edition of Knowles Neoplastic Hematopathology has been thoroughly updated by the world's experts to cover all aspects of neoplastic hematopathology, a field that covers disorders of the bone marrow, spleen, and lymphatic system. Now in full-color, this completely revised and expanded edition integrates the basic science, modern diagnostic techniques, and clinical aspects of malignant diseases affecting these organs. It is the most comprehensive, encyclopedic textbook concerning neoplastic hematopathology available on the market today.
The past two decades have seen transformative advances in cosmology and string theory. Observations of the cosmic microwave background have revealed strong evidence for inflationary expansion in the very early universe, while new insights about compactifications of string theory have led to a deeper understanding of inflation in a framework that unifies quantum mechanics and general relativity. Written by two of the leading researchers in the field, this complete and accessible volume provides a modern treatment of inflationary cosmology and its connections to string theory and elementary particle theory. After an up-to-date experimental summary, the authors present the foundations of effective field theory, string theory, and string compactifications, setting the stage for a detailed examination of models of inflation in string theory. Three appendices contain background material in geometry and cosmological perturbation theory, making this a self-contained resource for graduate students and researchers in string theory, cosmology, and related fields.
Prepare for every stage of your physician assistant career with Physician Assistant: A Guide to Clinical Practice, 5th Edition - the one text that takes you from your PA coursework through clinical practice! Concise, easy to read, and highly visual, this all-in-one resource by Ruth Ballweg, Edward M. Sullivan, Darwin Brown, and Daniel Vetrosky delivers the current, practical guidance you need to know to succeed in any setting. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. Master all the core competencies you need to know for certification or recertification. Navigate today's professional challenges with new chapters on NCCPA Specialty Recognition; Communication Issues; the Electronic Health Record; Patient Safety and Quality of Care; Population-Based Practice; and Physician Assistants and Supervision. Meet ARC-PA accreditation requirements with coverage of key topics such as Student Safety in Clinical Settings, Health Care Delivery Systems, Population-Based Practice, and Mass Casualties/Disasters. Keep up with the PA competencies that are endorsed by the AAPA, PAEA, NCCPA, and ARC-PA. Master key concepts and clinical applications thanks to a succinct, bulleted writing style; convenient tables; practical case studies; and clinical application questions throughout. Retain what you’ve learned and easily visualize every aspect of clinical practice with a new full-color design and illustrations throughout. Explore global options with expanded coverage of physician assistants in international medicine.
In Schools with Heart , Brown explores voluntarism by using original data gathered from 185 interviews with public school principals, teachers, and volunteers, many of whom worked in schools known for their volunteer programs. Supplementing these data from other studies, this careful inquiry finds that volunteers offer much to schools. School volun
When eighteenth- and nineteenth-century Americans made their Grand Tour of Europe, what did they learn about themselves? While visiting Europe In 1844, Harry McCall of Philadelphia wrote to his cousin back home of his disappointment. He didn’t mind Paris, but he preferred the company of Americans to Parisians. Furthermore, he vowed to be “an American, heart and soul” wherever he traveled, but “particularly in England.” Why was he in Europe if he found it so distasteful? After all, travel in the eighteenth and early nineteenth centuries was expensive, time consuming, and frequently uncomfortable. Being American in Europe, 1750–1860 tracks the adventures of American travelers while exploring large questions about how these experiences affected national identity. Daniel Kilbride searched the diaries, letters, published accounts, and guidebooks written between the late colonial period and the Civil War. His sources are written by people who, while prominent in their own time, are largely obscure today, making this account fresh and unusual. Exposure to the Old World generated varied and contradictory concepts of American nationality. Travelers often had diverse perspectives because of their region of origin, race, gender, and class. Americans in Europe struggled with the tension between defining the United States as a distinct civilization and situating it within a wider world. Kilbride describes how these travelers defined themselves while they observed the politics, economy, morals, manners, and customs of Europeans. He locates an increasingly articulate and refined sense of simplicity and virtue among these visitors and a gradual disappearance of their feelings of awe and inferiority.
Here's the only book dedicated to giving you the complete information that you need to become an effective Physician Assistant and maintain those high standards in practice. This up-to-date edition covers all aspects of the physician assistant profession, the PA curriculum, and the PA's role in practice, all in an easy-to-use textbook format that features convenient tables and clear illustrations, as well as case studies and clinical application questions. You'll find this book invaluable throughout your course of study, when entering the job market, and as an excellent reference in clinical practice. And, with this Expert Consult title, you'll be able to search the entire contents of the book, online, from anywhere. Covers all the core competencies that you need to master for year one or for recertification, so you can excel. Gives you the information you need on all of the rotations and practice areas that are open to you to help you make the right decisions. Offers practical Pros and Cons box for each rotation and area of practice to aid in day-to-day decision making. Utilizes a fresh new two color format for better visual guidance. Focuses on clinical information with case studies included at the end of each chapter. Includes a new chapter on evidence-based medicine to prepare you for daily practice. Provides Expert Consult access so you can search the entire contents of the book, online. Includes a new chapter on Physician Assistants in international medicine to keep you on the cutting edge. Your purchase entitles you to access the website until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the website be discontinued.
The predominant “stewardship model” of creation is the result of an intentional effort to correct approaches that reinforce human sovereignty and the resulting environmental degradation. However, as All God’s Creatures argues, the stewardship model actually does not offer a correction but rather reinscribes many of the very same pitfalls. After close analysis of the stewardship model, this book identifies scriptural, theological, and philosophical sources to support the adoption of a “community of creation” paradigm. Drawing on postcolonial theory, this book proposes the concept of “planetarity” as a framework for conceiving the relationship between human and nonhuman creation, and the Creator, in a new way. This theoretical framework is grounded by a retrieval of the medieval Franciscan theological and philosophical tradition. The result is what can be called a postcolonial Franciscan theology of creation imagined in terms of planetarity, providing a constructive and nonanthropocentric response to the need for a new conceptualization of the doctrine of creation.
Dermatologic and Cosmetic Procedures in Office Practice, by Drs. Richard Usatine, John Pfenninger, Daniel Stulberg, and Rebecca Small, provides you with the clear, step-by-step guidance you need to provide these options to your patients. Full-color photographs and drawings in combination with high-definition narrated videos clearly demonstrate key procedures, including skin biopsies, cryosurgery, electrosurgery, botulinum toxin injections, and more. Access to the full text, and a downloadable image bank online at www.expertconsult.com make this an ideal reference for performing key dermatologic and cosmetic procedures in your practice. Access the fully searchable contents and downloadable image bank online at www.expertconsult.com. Incorporate key dermatologic and cosmetic procedures into your practice with coverage of using dermoscopy to more accurately detect skin cancer, the latest information on lasers, botulinum toxin injections and dermal fillers, the diagnosis and treatment of benign and malignant lesions, and more. Master dermatologic and cosmetic procedures thanks to more than 40 narrated, high-definition videos, on DVD, demonstrating skin biopsies, cryosurgery, electrosurgery, and excision of skin cancers, cysts, and lipomas. See how to perform each procedure clearly from detailed, full-color photographs and drawings and step-by-step instructions. Maximize the value of providing dermatologic and cosmetic procedures with guidance on combination treatments as well as coding and billing details.
Inside the 3rd edition of this esteemed masterwork, hundreds of the most distinguished authorities from around the world provide today's best answers to every question that arises in your practice. They deliver in-depth guidance on new diagnostic approaches, operative technique, and treatment option, as well as cogent explanations of every new scientific concept and its clinical importance. With its new streamlined, more user-friendly, full-color format, this 3rd edition makes reference much faster, easier, and more versatile. More than ever, it's the source you need to efficiently and confidently overcome any clinical challenge you may face. Comprehensive, authoritative, and richly illustrated coverage of every scientific and clinical principle in ophthalmology ensures that you will always be able to find the guidance you need to diagnose and manage your patients' ocular problems and meet today's standards of care. Updates include completely new sections on "Refractive Surgery" and "Ethics and Professionalism"... an updated and expanded "Geneitcs" section... an updated "Retina" section featuring OCT imaging and new drug therapies for macular degeneration... and many other important new developments that affect your patient care. A streamlined format and a new, more user-friendly full-color design - with many at-a-glance summary tables, algorithms, boxes, diagrams, and thousands of phenomenal color illustrations - allows you to locate the assistance you need more rapidly than ever.
Master the latest medical and cosmetic procedures with Surgery of the Skin, the most comprehensive dermatological surgery resource available. Written from the surgeon's perspective, this medical reference book features step-by-step guidance on performing the most updated developments and cutting edge approaches across the entire spectrum of dermatologic surgery. - Improve surgical results and avoid pitfalls with expert, evidence-based guidance. - Stay on the cutting edge with in-depth step-by-step descriptions of tumescent vertical vector facelifts, blepharoplasty, composite grafts, Botox treatments, soft tissue augmentation, management of dysplastic nevi and melanoma, and more. - View immersive videos from an expanded library with more than 130 clips totaling over six hour's footage. - Explore brand-new chapters on rejuvenation of the female external genitalia; hidradenitis suppurativa; and photoaging-related mottled pigmentation. - Improve treatment outcomes for patients with skin of color and gain a truly global perspective of dermatologic surgery through an expanded contributor group of leading international experts. - Master how to perform cutting-edge techniques across the entire spectrum of dermatologic surgery, including botulinum toxins; fillers; cryosurgery; flaps; grafting; scar revisions; lasers; face-lift techniques; blepharoplasty techniques; Mohs surgery; and more. - Effectively manage a full range of complex disorders, such as vitiligo surgery, keloids, and leg ulcers, with a unique section devoted to these special procedures. - Easily visualize complex procedures and concepts with more than 1,000 illustrations, photos, and graphics. - Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, references, and videos from the book on a variety of devices.
The Sherbrooke Fusilier Regiment was a Canadian armored regiment attached to the 2nd Canadian armored Brigade which landed on the beaches of Normandy on D-Day in support of the 3rd Canadian Infantry Division and then fought through France, Belgium, Holland and Germany until VE-Day. As an independent armored regiment, it was assigned to support various infantry formations. As such, it fought the first major tank battle on European soil when it went up against the panzers and panzergrenadiers of the 12.SS-Panzerdivision (Hitlerjugend) on 7 June 1944. Its tanks entered Caen on 9 July and then took part in the advance to and the clearing of the town of Falaise. From there, the regiment pursued the retreating German forces towards the Seine River at Rouen. In a subsequent book, the author will explore the regiment's battles through Antwerp, the Scheldt, the Rhine River and the Hochwald Gap.
Comprehensive in scope and thoroughly up to date, Wintrobe’s Clinical Hematology, 15th Edition, combines the biology and pathophysiology of hematology as well as the diagnosis and treatment of commonly encountered hematological disorders. Editor-in-chief Dr. Robert T. Means, Jr., along with a team of expert section editors and contributing authors, provide authoritative, in-depth information on the biology and pathophysiology of lymphomas, leukemias, platelet destruction, and other hematological disorders as well as the procedures for diagnosing and treating them. Packed with more than 1,500 tables and figures throughout, this trusted text is an indispensable reference for hematologists, oncologists, residents, nurse practitioners, and pathologists.
The treatment of childhood cancer has become increasingly successful over the last forty years, and during the last two decades in particular, and the overall cure rate is now 60-70%. This, in turn, has introduced new issues for the clinician as the number of long-term survivors has increased. Some of the therapies that have contributed most to the
Introducing HEMATOPATHOLOGY, a definitive new diagnostic reference on diseases of the hematopoietic system by Dr. Elaine S. Jaffe and her fellow editors, all collaborators on the World Health Organization's classification of lymphoid and myeloid disorders. These experts provide you with today's most effective guidance in evaluating specimens from the lymph nodes, bone marrow, peripheral blood, and more, equipping you to deliver more accurate and actionable pathology reports. More than 1,100 high-quality color images mirror the findings you encounter in practice. Overcome the toughest diagnostic challenges with authoritative guidance from the world's leading experts. Make optimal use of the newest diagnostic techniques, including molecular, immunohistochemical, and genetic studies. Compare specimens to more than 1,100 high-quality color images to confirm or challenge your diagnostic interpretations. Search the full contents online and download any of the images at expertconsult.com.
Now more streamlined and focused than ever before, the 6th edition of CT and MRI of the Whole Body is a definitive reference that provides you with an enhanced understanding of advances in CT and MR imaging, delivered by a new team of international associate editors. Perfect for radiologists who need a comprehensive reference while working on difficult cases, it presents a complete yet concise overview of imaging applications, findings, and interpretation in every anatomic area. The new edition of this classic reference — released in its 40th year in print — is a must-have resource, now brought fully up to date for today’s radiology practice. Includes both MR and CT imaging applications, allowing you to view correlated images for all areas of the body. Coverage of interventional procedures helps you apply image-guided techniques. Includes clinical manifestations of each disease with cancer staging integrated throughout. Over 5,200 high quality CT, MR, and hybrid technology images in one definitive reference. For the radiologist who needs information on the latest cutting-edge techniques in rapidly changing imaging technologies, such as CT, MRI, and PET/CT, and for the resident who needs a comprehensive resource that gives a broad overview of CT and MRI capabilities. Brand-new team of new international associate editors provides a unique global perspective on the use of CT and MRI across the world. Completely revised in a new, more succinct presentation without redundancies for faster access to critical content. Vastly expanded section on new MRI and CT technology keeps you current with continuously evolving innovations.
The publication of this fourth edition, more than ten years on from the publication of Radiation Therapy Physics third edition, provides a comprehensive and valuable update to the educational offerings in this field. Led by a new team of highly esteemed authors, building on Dr Hendee’s tradition, Hendee’s Radiation Therapy Physics offers a succinctly written, fully modernised update. Radiation physics has undergone many changes in the past ten years: intensity-modulated radiation therapy (IMRT) has become a routine method of radiation treatment delivery, digital imaging has replaced film-screen imaging for localization and verification, image-guided radiation therapy (IGRT) is frequently used, in many centers proton therapy has become a viable mode of radiation therapy, new approaches have been introduced to radiation therapy quality assurance and safety that focus more on process analysis rather than specific performance testing, and the explosion in patient-and machine-related data has necessitated an increased awareness of the role of informatics in radiation therapy. As such, this edition reflects the huge advances made over the last ten years. This book: Provides state of the art content throughout Contains four brand new chapters; image-guided therapy, proton radiation therapy, radiation therapy informatics, and quality and safety improvement Fully revised and expanded imaging chapter discusses the increased role of digital imaging and computed tomography (CT) simulation The chapter on quality and safety contains content in support of new residency training requirements Includes problem and answer sets for self-test This edition is essential reading for radiation oncologists in training, students of medical physics, medical dosimetry, and anyone interested in radiation therapy physics, quality, and safety.
A history of Harvard Law School in the twentieth century, focusing on the school’s precipitous decline prior to 1945 and its dramatic postwar resurgence amid national crises and internal discord. By the late nineteenth century, Harvard Law School had transformed legal education and become the preeminent professional school in the nation. But in the early 1900s, HLS came to the brink of financial failure and lagged its peers in scholarly innovation. It also honed an aggressive intellectual culture famously described by Learned Hand: “In the universe of truth, they lived by the sword. They asked no quarter of absolutes, and they gave none.” After World War II, however, HLS roared back. In this magisterial study, Bruce Kimball and Daniel Coquillette chronicle the school’s near collapse and dramatic resurgence across the twentieth century. The school’s struggles resulted in part from a debilitating cycle of tuition dependence, which deepened through the 1940s, as well as the suicides of two deans and the dalliance of another with the Nazi regime. HLS stubbornly resisted the admission of women, Jews, and African Americans, and fell behind the trend toward legal realism. But in the postwar years, under Dean Erwin Griswold, the school’s resurgence began, and Harvard Law would produce such major political and legal figures as Chief Justice John Roberts, Justice Elena Kagan, and President Barack Obama. Even so, the school faced severe crises arising from the civil rights movement, the Vietnam War, Critical Legal Studies, and its failure to enroll and retain people of color and women, including Justice Ruth Bader Ginsburg. Based on hitherto unavailable sources—including oral histories, personal letters, diaries, and financial records—The Intellectual Sword paints a compelling portrait of the law school widely considered the most influential in the world.
Typically, most people don’t realize when and how they can use the mathematics they were taught in high school – yet many of the mathematical ideas and skills can be a powerful tool for understanding how the world works. Learning and Teaching for Mathematical Literacy addresses this situation, offering practical strategies for developing a broader vision of mathematical literacy in the classroom and recognising the importance of maintaining these skills into adult life. Linked to the material explored throughout this book, classroom activities and lesson materials are freely available for use via the QR codes included in each chapter. Filled with case studies and classroom activities, chapters tackle several topics: Describing a framework for a broader vision of mathematical literacy – what is it, and why is it important? Teaching mathematical literacy in the classroom Applying mathematical literacy to ‘real life’ scenarios: My dad is buying a new dishwasher. Should he buy the extended warranty on offer? My phone works fine but I've been offered an upgrade. How should I decide whether to take it? The role of technology in teaching mathematical literacy Designing mathematical measures for real-word quantities Firmly grounded by practical applications for the classroom and beyond, this is an essential handbook for any teacher, teaching assistant, or mathematics subject lead who wishes to develop their students’ mathematical literacy skills. This is also an ideal resource for those delivering or enrolled in teacher preparation courses.
Great Britain's refusal to yield to Nazi Germany in the Second World War remains one of the greatest survival stories of modern times. Commemorated, evoked, and mythologized as it has been-chiseled and engraved onto countless monuments, the subject of an endless stream of books and films-its triumphant outcome was by no means predetermined. In December 1940, months after war was declared, the director of plans at the War Office in London was asked to draft a paper on how to win the war. He replied that he could only plan "for not losing." Britain's War: Into Battle, 1937-1941 is the first of two volumes in which Daniel Todman offers a brilliantly fresh retelling, an epic history to fit an epic story. "Opening with his discovery of some war medals sitting in a hearing-aid box that likely belonged to his grandfather, Todman realizes that despite it all a new generation seems unaware of what was truly at stake when Churchill invoked Britain's "finest hour." The war was far greater than any single heroic hour. For six years, Britain was at the dark heart of history, finding its way forward hour by hour, day by day, year by year. This volume spans the beginning and the end of the beginning, from the massive changes required to get the country onto a war footing, through the failure of appeasement, the invasion of Poland, the "phony war," the fall of France, the "miracle" of Dunkirk, the Battles of Britain, and the Blitz, ending with America's course-changing entrance into the conflict in late 1941. Todman's colossal project seamlessly merges economic, strategic, social, cultural, and military history in one compelling narrative. Rapid industrialization, social disruption, food rationing, Westminster politics, class snobbery, and the mobilization of a global empire are woven together with the major opening battles. Here, also, are key individuals-the politicians, industrialists, pub owners, housewives, the pilots of the RAF, and the sailors at Dunkirk-caught in the maelstrom that threatened to engulf not just a small island nation but the world itself.
A general-turned-historian reveals the remarkable battlefield heroics of Major General Maurice Rose, the World War II tank commander whose 3rd Armored Division struck fear into the hearts of Hitler's panzer crews. “The Panzer Killers is a great book, vividly written and shrewdly observed.”—The Wall Street Journal Two months after D-Day, the Allies found themselves in a stalemate in Normandy, having suffered enormous casualties attempting to push through hedgerow country. Troops were spent, and American tankers, lacking the tactics and leadership to deal with the terrain, were losing their spirit. General George Patton and the other top U.S. commanders needed an officer who knew how to break the impasse and roll over the Germans—they needed one man with the grit and the vision to take the war all the way to the Rhine. Patton and his peers selected Maurice Rose. The son of a rabbi, Rose never discussed his Jewish heritage. But his ferocity on the battlefield reflected an inner flame. He led his 3rd Armored Division not from a command post but from the first vehicle in formation, charging headfirst into a fight. He devised innovative tactics, made the most of American weapons, and personally chose the cadre of young officers who drove his division forward. From Normandy to the West Wall, from the Battle of the Bulge to the final charge across Germany, Maurice Rose's deadly division of tanks blasted through enemy lines and pursued the enemy with a remarkable intensity. In The Panzer Killers, Daniel P. Bolger, a retired lieutenant general and Iraq War veteran, offers up a lively, dramatic tale of Rose's heroism. Along the way, Bolger infuses the narrative with fascinating insights that could only come from an author who has commanded tank forces in combat. The result is a unique and masterful story of battlefield leadership, destined to become a classic.
This work is a cross-national examination of the relationship between political culture and constitutionalism. The countries studied include Nigeria, Turkey and Japan. Questions explored include whether constitutions must evolve and whether constitutionalism is only a western concept.
This book provides a thorough yet concise introduction to quantitative radiobiology and radiation physics, particularly the practical and medical application. Beginning with a discussion of the basic science of radiobiology, the book explains the fast processes that initiate damage in irradiated tissue and the kinetic patterns in which such damage is expressed at the cellular level. The final section is presented in a highly practical handbook style and offers application-based discussions in radiation oncology, fractionated radiotherapy, and protracted radiation among others. The text is also supplemented by a Web site.
From Marilyn to Mussolini, people captivate people. A&E's Biography, best-selling autobiographies, and biographical novels testify to the popularity of the genre. But where does one begin? Collected here are descriptions and evaluations of over 10,000 biographical works, including books of fact and fiction, biographies for young readers, and documentaries and movies, all based on the lives of over 500 historical figures from scientists and writers, to political and military leaders, to artists and musicians. Each entry includes a brief profile, autobiographical and primary sources, and recommended works. Short reviews describe the pertinent biographical works and offer insight into the qualities and special features of each title, helping readers to find the best biographical material available on hundreds of fascinating individuals.
Rutter’s Child and Adolescent Psychiatry has become an established and accepted textbook of child psychiatry. Now completely revised and updated, the fifth edition provides a coherent appraisal of the current state of the field to help trainee and practising clinicians in their daily work. It is distinctive in being both interdisciplinary and international, in its integration of science and clinical practice, and in its practical discussion of how researchers and practitioners need to think about conflicting or uncertain findings. This new edition now offers an entirely new section on conceptual approaches, and several new chapters, including: neurochemistry and basic pharmacology brain imaging health economics psychopathology in refugees and asylum seekers bipolar disorder attachment disorders statistical methods for clinicians This leading textbook provides an accurate and comprehensive account of current knowledge, through the integration of empirical findings with clinical experience and practice, and is essential reading for professionals working in the field of child and adolescent mental health, and clinicians working in general practice and community pediatric settings.
Based on the author’s experience as a researcher and teacher of lower-track students, Beyond Formulas in Mathematics and Teaching illuminates the complex dynamics of the algebra classroom. From within this setting, Daniel Chazan thoughtfully explores topics that concern all dedicated educators, how to really know one’s students, how to find engaging material, and how to inspire meaningful classroom conversations. Throughout, he addresses the predicaments that are central to the lives of teachers who work in standard educational settings. By highlighting teaching dilemmas, Chazan prompts readers to consider what their own responses would be in similar situations. With an eye to ways of restructuring roles and relationships, Beyond Formulas in Mathematics and Teaching is essential reading for educators seeking to enhance their teaching practices and understanding of students who may be estranged from school.
The internationally acclaimed story of Hannah's Heirs now resumes in this updated paperback edition with the discovery in June, 1995 of Hannah's gene--now known to account for the majority of mutations causing early onset familial Alzheimer's disease--and the equally important identification of the major genetic risk factor rendering increased susceptibility to the more frequently occurring late-onset Alzheimer's. With these recent discoveries, medical science is now poised to reach for an understanding of the causes of the various forms of Alzheimer's disease which, in turn, will inevitably lead to rational attempts to treat and prevent Alzheimer's. This fascinating medical detective story of modern science's promising assault on "the disease of the century" continues to unfold with suspense and to inform and inspire through the final word. In Hannah's Heirs, neurologist Dr. Dan Pollen himself tells the compelling story of Hannah's family and their monumental contributions to the fight against Alzheimer's. We are there in 1985 when Charles presents Pollen with three decades' worth of family medical records as well as data from studies that even Pollen and his associates did not then know existed. We see the selfless acts of Hannah's descendants in their struggle against Alzheimer's: great-grandson Jeff's conviction that after his death his brain be used for all possible research; great-granddaughter Lucy's decision to overcome her dread of flying in order to reach the research center for testing; and Charles's continued research in the face of a disease that might strike him at any moment. Pollen sets this gripping story within the larger context of the efforts to solve the mysteries of Alzheimer's. He presents the foundations of modern genetic research, from Gregor Mendel's classic discovery of genes, to Alois Alzheimer's work on the brains of presenile dementia victims, to Watson and Crick's double helix model for the structure of DNA. He narrates the latter-twentieth-century efforts of scientists to systematically narrow down the causes of Alzheimer's: Carlton Gajdusek's research excluding slow viruses as a cause of Alzheimer's; and the stunning discovery of Peter St. George-Hyslop's group in Toronto in June, 1995 identifying Hannah's gene and thereby opening a new era in understanding the origins of Alzheimer's disease. At the same time, Pollen offers a penetrating look at the ongoing conflicts involved in scientific research, revealing how intense competition for prestige and funding has driven some scientists to hoard precious cell lines. These practices have impeded efforts to discover both the causes and the treatment of Alzheimer's in the shortest possible time. As Hannah's great-grandson Ben has written, "This is a story that had to be told. Aspirations were transcendent, but because it involved people it could not be told without tears." Written by a physician-scientist who has been a central figure in the study of familial Alzheimer's, Hannah's Heirs is an inspiring portrait of the efforts of a courageous family to confront and overcome a "personal biological Holocaust," and an encouraging look at the advances in science that have created the basis for the eventual understanding and treatment of Alzheimer's disease. And for those who have seen the horrors of Alzheimer's, for all who fear the aging process that will take its toll on everyone, here is an inside look at one of the great medical detective stories of our time.
The book collects articles published by Daniel Hamermesh between 1969 and 2013 dealing with the general topic of the demand for labor. The first section presents empirical studies of basic issues in labor demand, including the extent to which different types of labor are substitutes, how firms' and workers' investments affect labor turnover, and how costs of adjusting employment affect the dynamics of employment and patterns of labor turnover. The second section examines the impacts of various labor-market policies, including minimum wages, penalty pay for using overtime hours or hours worked on weekends or nights, severance pay for displaced workers, and payroll taxes to finance unemployment insurance benefits. The final section deals with general questions of discrimination by employers along various dimensions, including looks, gender and ethnicity, in all cases focusing on the process of discrimination and the behavior that results. Throughout the focus is on the development of theoretically-based hypotheses and testing them using the most appropriate data, often data collected uniquely for the particular project.
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