The book presents a new general theory of language as a collectively-constructed communication technology - not unlike the social media on the Net today - that is dedicated to a very particular communicative function: the instruction of imagination. The theory re-frames all the major questions in the linguistic sciences, and opens the way towards the re-unification of the field.
Designed for quick, everyday reference, Handbook of Targeted Cancer Therapy and Immunotherapy, 3rd Edition, includes clinical trial results of more than 250 state-of-the-art targeted therapy and immunotherapy agents, providing a practical, intuitive, colorful overview of this rapidly advancing field. Comprehensive yet concise, this easy-access resource by Drs. Daniel D. Karp, Gerald S. Falchook, and JoAnn D. Lim, helps you navigate through the newest research reports and apply the most recent discoveries as they pertain to specific tumor types, actionable molecular targets, and clinical performance of investigational targeted agents and combinations of agents. This handbook presents information distilled by dozens of translational research clinicians and other healthcare experts with hundreds of years of cumulative experience in the revolutionary area of genomically based precision oncology.
Uniting attachment-focused therapy and neurobiology to help distrustful and traumatized children revive a sense of trust and connection. How can therapists and caregivers help maltreated children recover what they were born with: the potential to experience the safety, comfort, and joy of having trustworthy, loving adults in their lives? This groundbreaking book explores, for the first time, how the attachment-focused family therapy model can respond to this question at a neural level. It is a rich, accessible investigation of the brain science of early childhood and developmental trauma. Each chapter offers clinicians new insights—and powerful new methods—to help neglected and insecurely attached children regain a sense of safety and security with caring adults. Throughout, vibrant clinical vignettes drawn from the authors' own experience illustrate how informed clinical processes can promote positive change. Authors Baylin and Hughes have collaborated for many years on the treatment of maltreated children and their caregivers. Both experienced psychologists, their shared project has bee the development of the science-based model of attachment-focused therapy in this book—a model that links clinical interventions to the crucial underlying processes of trust, mistrust, and trust building—helping children learn to trust caregivers and caregivers to be the "trust builders" these children need. The book begins by explaining the neurobiology of blocked trust, using the latest social neuroscience to show how the child's early development gets channeled into a core strategy of defensive living. Subsequent chapters address, among other valuable subjects, how new research on behavioral epigenetics has shown ways that highly stressful early life experiences affect brain development through patterns of gene expression, adapting the child's brain for mistrust rather than trust, and what it means for treatment approaches. Finally, readers will learn what goes on in the child's brain during attachment-focused therapy, honing in on the dyadic processes of adult-child interaction that seem to embody the core "mechanisms of change": elements of attachment-focused interventions that target the child's defensive brain, calm this system, and reopen the child's potential to learn from new experiences with caring adults, and that it is safe to depend upon them. If trust is to develop and care is to be restored, clinicians need to know what prevents the development of trust in the first place, particularly when a child is living in an environment of good care for a long period of time. What do abuse and neglect do to the development of children's brains that makes it so difficult for them to trust adults who are so different from those who hurt them? This book presents a brain-based understanding that professionals can apply to answering these questions and encouraging the development of healthy trust.
Proven Patterns for Designing Evolvable High-Quality APIs--For Any Domain, Technology, or Platform APIs enable breakthrough innovation and digital transformation in organizations and ecosystems of all kinds. To create user-friendly, reliable and well-performing APIs, architects, designers, and developers need expert design guidance. This practical guide cuts through the complexity of API conversations and their message contents, introducing comprehensive guidelines and heuristics for designing APIs sustainably and specifying them clearly, for whatever technologies or platforms you use. In Patterns for API Design: Simplifying Integration with Loosely Coupled Message Exchanges, five expert architects and developers cover the entire API lifecycle, from launching projects and establishing goals through defining requirements, elaborating designs, planning evolution, and creating useful documentation. They crystallize the collective knowledge of many practitioners into 44 API design patterns, consistently explained with context, pros and cons, conceptual solutions, and concrete examples. To make their pattern language accessible, they present a domain model, a running case study, decision narratives with pattern selection options and criteria, and walkthroughs of real-world projects applying the patterns in two different industries. Identify and overcome API design challenges with patterns Size your endpoint types and operations adequately Design request and response messages and their representations Refine your message design for quality Plan to evolve your APIs Document and communicate your API contracts Combine patterns to solve real-world problems and make the right tradeoffs "This book provides a healthy mix of theory and practice, containing numerous nuggets of deep advice but never losing the big picture . . . grounded in real-world experience and documented with academic rigor applied and practitioner community feedback incorporated. I am confident that [it] will serve the community well, today and tomorrow." --Prof. Dr. Dr. h. c. Frank Leymann, Managing Director, Institute of Architecture of Application Systems, University of Stuttgart
With this careful, nuanced exegetical volume in the New Studies in Biblical Theology, J. Daniel Hays provides a clear theological foundation for life in contemporary multiracial cultures and challenges churches to pursue racial unity in Christ.
Jeremy Smoak presents a synthesis of recent discoveries bearing upon the early history and function of the biblical priestly blessing of Numbers 6:24-26. The book gives special focus to the importance of the discovery of the blessing on two silver amulets from Jerusalem dating to the late Iron Age and several other Iron Age inscriptions containing parallels to the blessing. The analysis of the inscriptions provides a new way to approach the meaning and significance of the instructions for the blessing in the biblical book of Numbers.
This book provides a comprehensive, interdisciplinary and holistic analysis of the socio-psychological dynamics of intractable conflicts. Daniel Bar-Tal's original conceptual framework is supported by evidence drawn from different disciplines, including empirical data and illustrative case studies. His analysis rests on the premise that intractable conflicts share certain socio-psychological foundations, despite differences in context and other characteristics. He describes a full cycle of intractable conflicts - their outbreak, escalation and reconciliation through peace building. Bar-Tal's framework provides a broad theoretical view of the of the socio-psychological repertoire that develops in the course of long-term and violent conflicts, outlines the factors affecting its formation, demonstrates how it is maintained, points out its functions and describes its consequences. The book also elaborates on the contents, processes and other factors involved in the peace building process.
Robust statistics is the study of designing estimators that perform well even when the dataset significantly deviates from the idealized modeling assumptions, such as in the presence of model misspecification or adversarial outliers in the dataset. The classical statistical theory, dating back to pioneering works by Tukey and Huber, characterizes the information-theoretic limits of robust estimation for most common problems. A recent line of work in computer science gave the first computationally efficient robust estimators in high dimensions for a range of learning tasks. This reference text for graduate students, researchers, and professionals in machine learning theory, provides an overview of recent developments in algorithmic high-dimensional robust statistics, presenting the underlying ideas in a clear and unified manner, while leveraging new perspectives on the developed techniques to provide streamlined proofs of these results. The most basic and illustrative results are analyzed in each chapter, while more tangential developments are explored in the exercises.
Reverse Engineering in Control Design proposes practical approaches to building a standard H-infinity problem taking into account an initial controller. Such approaches allow us to mix various control objectives and to initialize procedures for a fixed-structure controller design. They are based on the Observer-Based Realization (OBR) of controllers. The interest of OBR from the controller implementation point of view is detailed and highlighted in this book through academic examples. An open-source toolbox is available to implement these approaches in Matlab®. Throughout the book academic applications are proposed to illustrate the various basic principles. These applications have been chosen by the author for their pedagogic contents and demo files and embedded Matlab® functions can be downloaded so readers can run these illustrations on their personal computers. Contents 1. Observer-based Realization of a Given Controller. 2. Cross Standard Form and Reverse Engineering. 3. Reverse Engineering for Mechanical Systems. Appendix 1. A Preliminary Methodological Example. Appendix 2. Discrete-time Case. Appendix 3. Nominal State-feedback for Mechanical Systems. Appendix 4. Help of Matlab® Functions. About the Authors Daniel Alazard is Professor in System Dynamics and Control at Institut Supérieur de l'Aéronautique et de l’Espace (ISAE), Toulouse, France – SUPAERO Graduate Program. His main research interests concern robust control, flexible structure control and their applications to various aerospace systems.
This book highlights two essential analyses of data collected during the LHCb experiment, based on the Large Hadron Collider at CERN. The first comprises the first observation and studies of matter-antimatter asymmetries in two three-body b-baryon decays, paving the way for more precise measurements of the relatively unknown decay properties of b-baryon decays. The second is an analysis of a charged B meson decay to three charged pions, where previously large matter-antimatter asymmetries were observed in a model-independent analysis. Here a model of the decay amplitude is constructed using the unitarity-conserving ‘K-matrix’ model for the scalar contributions, so as to gain an understanding of how the previously observed matter-antimatter asymmetries arise; further, the model’s construction yields the most precise and comprehensive study of this decay mode to date.
In this latest volume in the Belief series, Daniel L. Migliore plumbs the depth of Paul's letters to the Philippians and to Philemon. With splendid theological reflection, Migliore explores central themes of these remarkable letters--themes that include the practice of prayer, righteousness from God, and the work of reconciliation and transformation through Jesus Christ. Migliore shows how Philippians continues to speak to churches that, like the church at Philippi, struggle to be faithful to Christ, worry about the future, and need guidance. And in Philemon, Migliore finds a letter with importance far beyond its size--a letter that can enrich our understanding of the fullness of the gospel that Paul proclaims. In both books, Migliore deftly shows Paul as a remarkable theologian and pastor with a message instructive to the church of every age.
Thought-provoking, pertinent and engaging, this book provides an overview of every aspect of carrying out research with children. It is unique in its particular focus on vulnerable groups of children such as those with mental-health problems, physical health problems and learning disabilities, along with young offenders and looked after children. The book helpfully addresses each stage of the research process: -Part I introduces the main elements of doing research with children, including seeking ethical approval for sensitive research topics. -Part II guides the reader through the initial stages of the research project including recruitment issues and communicating with gatekeepers. -Part III outlines the data collection, data analysis, writing up and dissemination stages of research and covers both quantitative and qualitative methods. Filled with practical advice and useful activities for each chapter, this book is an essential resource for any student, academic or professional working with, or doing research with, children.
In one sense, human heads function much like those of other mammals. We use them to chew, smell, swallow, think, hear, and so on. But, in other respects, the human head is quite unusual. Unlike other animals, even our great ape cousins, our heads are short and wide, very big brained, snoutless, largely furless, and perched on a short, nearly vertical neck. Daniel E. Lieberman sets out to explain how the human head works, and why our heads evolved in this peculiarly human way. Exhaustively researched and years in the making, this innovative book documents how the many components of the head function, how they evolved since we diverged from the apes, and how they interact in diverse ways both functionally and developmentally, causing them to be highly integrated. This integration not only permits the head’s many units to accommodate each other as they grow and work, but also facilitates evolutionary change. Lieberman shows how, when, and why the major transformations evident in the evolution of the human head occurred. The special way the head is integrated, Lieberman argues, made it possible for a few developmental shifts to have had widespread effects on craniofacial growth, yet still permit the head to function exquisitely. This is the first book to explore in depth what happened in human evolution by integrating principles of development and functional morphology with the hominin fossil record. The Evolution of the Human Head will permanently change the study of human evolution and has widespread ramifications for thinking about other branches of evolutionary biology.
The fifth and thoroughly revised edition of Regional Geography of the United States and Canada provides a rich and comprehensive overview of both the physical and human geography of these two countries, and in the true spirit of geography, the interactions and interrelations of the physical and human. Following long traditions of the discipline of geography, this text incorporates words, maps, drawings, photographs, and numerical data to present its information in an engaging way. After covering beneficial precursor topics—such as the basics of physical and human geography—the text explores fifteen regions of the US and Canada. The authors observe and describe our planet’s geography in thorough and accessible detail, while laying out the spatial basics of the location, shape, and size of the different regions, and summarizes their most distinctive thematic qualities. Physical topics covered include the region’s topography and landforms, soils, climate, hydrography, vegetation, and wildlife. The human topics include the region’s population; the ethnicities and settlement history of its people; economic activities, including agriculture, forestry, mining, fishing, manufacturing, and service industries; cities; and transportation. In-depth essays expand on specific topics of interest and importance, while outlook sections prognosticate about the near future of the regions. Each chapter concludes with a bibliography of books, articles, and reports that provide further sources for the interested reader.
This book defines and examines the counterpart of Schur functions and Schur analysis in the slice hyperholomorphic setting. It is organized into three parts: the first introduces readers to classical Schur analysis, while the second offers background material on quaternions, slice hyperholomorphic functions, and quaternionic functional analysis. The third part represents the core of the book and explores quaternionic Schur analysis and its various applications. The book includes previously unpublished results and provides the basis for new directions of research.
The National Kidney Foundation Primer on Kidney Diseases is your ideal companion in clinical nephrology! From anatomy, histology, and physiology, through the diagnosis and management of kidney disease, fluid and electrolyte disorders, hypertension, dialysis, and kidney transplantation, this trusted manual from Elsevier and the National Kidney Foundation provides an accessible, efficient overview of kidney diseases that’s perfect for residency, fellowship, clinical practice, and board review. Incorporate the latest NKF Kidney/ Outcome Quality Initiative guidelines on chronic kidney disease staging and management. Review the basics with a current and practical review of the anatomy, physiology, pathophysiology, diagnosis, and management of kidney disease, fluid and electrolyte disorders, hypertension, dialysis, and renal transplantation.
This is the second edition of Holdsworth and Simpson’s highly practical work on a subject of growing importance in this age of convenience foods. As before, it discusses the physical and engineering aspects of the thermal processing of packaged foods, and examines the methods which have been used to establish the time and temperature of processes to sterilize or pasteurize the food. However, there is lots of new material too. Unlike other texts on thermal processing, which cover very adequately the technology of the subject, the unique emphasis of this text is on processing engineering and its relation to the safety of processed foods products.
Nat Turner's 1831 slave insurrection made Virginia's Southampton County notorious. Gradually, however, the bloody spectacle receded from national memory. Although the timeless rhythms of rural life resumed after the insurrection, Southampton could not escape the forces of change. From the Age of Jackson through to secession, wartime, and Reconstruction, it shared the fate of the Old South. Many who had witnessed the insurrection lived to see Tuner's cause triumph as war destroyed the slave system, inaugurating an intense struggle to shape the new postwar order. Old Southampton links local and national history. It explains how partian loyalties developed, how white democracy flourished in the late antebellum years, how secession sharply divded neighborhoods with few slaves from those with large plantations, and how, following emancipation, former slaves challenged the prerogatives of former slaveholders. Crofts draws on two volumnious diaries and other rich records, plus rare poll lists that show how individuals voted. He vividly re-creates the experiences of planters and plain folk, slave owners and slaves, the powerful and the obscure. This deft combination of political and social history is must reading for anyone interested in the Old South and the Civil War era.
A general-turned-historian reveals the remarkable battlefield heroics of Major General Maurice Rose, the World War II tank commander whose 3rd Armored Division struck fear into the hearts of Hitler's panzer crews. “The Panzer Killers is a great book, vividly written and shrewdly observed.”—The Wall Street Journal Two months after D-Day, the Allies found themselves in a stalemate in Normandy, having suffered enormous casualties attempting to push through hedgerow country. Troops were spent, and American tankers, lacking the tactics and leadership to deal with the terrain, were losing their spirit. General George Patton and the other top U.S. commanders needed an officer who knew how to break the impasse and roll over the Germans—they needed one man with the grit and the vision to take the war all the way to the Rhine. Patton and his peers selected Maurice Rose. The son of a rabbi, Rose never discussed his Jewish heritage. But his ferocity on the battlefield reflected an inner flame. He led his 3rd Armored Division not from a command post but from the first vehicle in formation, charging headfirst into a fight. He devised innovative tactics, made the most of American weapons, and personally chose the cadre of young officers who drove his division forward. From Normandy to the West Wall, from the Battle of the Bulge to the final charge across Germany, Maurice Rose's deadly division of tanks blasted through enemy lines and pursued the enemy with a remarkable intensity. In The Panzer Killers, Daniel P. Bolger, a retired lieutenant general and Iraq War veteran, offers up a lively, dramatic tale of Rose's heroism. Along the way, Bolger infuses the narrative with fascinating insights that could only come from an author who has commanded tank forces in combat. The result is a unique and masterful story of battlefield leadership, destined to become a classic.
Following the release of a Mobility article entitled "Where Have All the Elders Gone?," Daniel Bloom SCRP spent two years compiling a written history of the relocation industry. Just Get Me There takes the reader on a journey from the early days of the industry in the 1950's to the present day. Divided into four parts, the book looks at the journey through the years, the role of the real estate relocation departments, the evolution of the relocation policies, and the trends which will dictate whether the industry survives until the year 2020. Reviewed by some of the leaders of the industry, the preliminary response has been outstanding.
Daniel Crofts examines Unionists in three pivotal southern states--Virginia, North Carolina, and Tennessee--and shows why the outbreak of the war enabled the Confederacy to gain the allegiance of these essential, if ambivalent, governments. "Crofts's study focuses on Virginia, North Carolina, and Tennessee, but it includes analyses of the North and Deep South as well. As a result, his volume presents the views of all parties to the sectional conflict and offers a vivid portrait of the interaction between them.--American Historical Review "Refocuses our attention on an important but surprisingly neglected group--the Unionists of the upper South during the secession crisis, who have been too readily ignored by other historians.--Journal of Southern History
A state-of-the-art assessment of welfare provision, policy and reform at national and at EU level which spans the whole of Europe - East, West and Central. Uniquely broad-ranging in scope, and covering the latest research findings and theoretical debates, it provides a genuinely comparative overview text for students of 21st century Europe.
When They Hid the Fire examines the American social perceptions of electricity as an energy technology that were adopted between the mid-nineteenth and early decades of the twentieth centuries. Arguing that both technical and cultural factors played a role, Daniel French shows how electricity became an invisible and abstract form of energy in American society. As technological advancements allowed for an increasing physical distance between power generation and power consumption, the commodity of electricity became consciously detached from the environmentally destructive fire and coal that produced it. This development, along with cultural forces, led the public to define electricity as mysterious, utopian, and an alternative to nearby fire-based energy sources. With its adoption occurring simultaneously with Progressivism and consumerism, electricity use was encouraged and seen as an integral part of improvement and modernity, leading Americans to culturally construct electricity as unlimited and environmentally inconsequential—a newfound "basic right" of life in the United States.
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