Economic growth has traditionally been attributed to the increase in national production arising from technological innovation. Using a panel of seventy-nine countries bridging the North-South divide, Patent Intensity and Economic Growth is an important empirical study on the uncertain relationship between patents and economic growth. It considers the impact of one-size-fits-all patent policies on developing countries and their innovation-based economic growth, including those policies originating from the World Intellectual Property Organization, the World Trade Organization and the World Health Organization, as well as initiatives derived from the TRIPS Agreement and the Washington Consensus. This book argues against patent harmonization across countries and provides an analytical framework for country group coalitioning on policy at UN level. It will appeal to scholars and students of patent law, national and international policy makers, venture capitalist investors, and research and development managers, as well as researchers in intellectual property, innovation and economic growth.
Comprehensive in scope and thoroughly up to date, Wintrobe’s Clinical Hematology, 15th Edition, combines the biology and pathophysiology of hematology as well as the diagnosis and treatment of commonly encountered hematological disorders. Editor-in-chief Dr. Robert T. Means, Jr., along with a team of expert section editors and contributing authors, provide authoritative, in-depth information on the biology and pathophysiology of lymphomas, leukemias, platelet destruction, and other hematological disorders as well as the procedures for diagnosing and treating them. Packed with more than 1,500 tables and figures throughout, this trusted text is an indispensable reference for hematologists, oncologists, residents, nurse practitioners, and pathologists.
Surveying six decades of scholarship, Recovering International Relations suggests new ethical and methodological foundations for the study of world politics. IR is conceived as a vocation; one that must balance the insights of normative and empirical theory against each other to address a densely populated, heavily armed, and persistently diverse world.
It used to be that two laptops, sitting side by side, couldn't communicate with each other; they may as well have been a thousand miles apart. But that was then, before the advent of Zero Configuration Networking technology. This amazing cross-platform open source technology automatically connects electronic devices on a network, allowing them to interoperate seamlessly-without any user configuration. So now you don't have to lift a finger! Needless to say, it has completely changed the way people connect to devices and programs for printing, file sharing, and other activities. Zero Configuration Networking: The Definitive Guide walks you through this groundbreaking network technology, with a complete description of the protocols and ways to implement network-aware applications and devices. Written by two Zero Configuration Networking experts, including one of Apple's own computer scientists, the book covers more than just file sharing and printing. Zero Configuration Networking also enables activities such as music and photo sharing and automatic buddy discovery on Instant Messaging applications. In fact, Zero Configuration Networking can be used for virtually any device that can be controlled by a computer. And this handy guide has the inside scoop on all of its capabilities-and how you can easily apply them in your own environment. For the technically advanced, Zero Configuration Networking: The Definitive Guide examines the three core technologies that make up Zero Configuration Networking: Link-Local Addressing, Multicast DNS, and DNS Service Discovery. It also reviews a series of APIs, including C-API, Java API, CFNetServices, and Cocoa's NSNetServices. Whether you want to understand how iTunes works, or you want to network a series of laptops and other devices at your office for maximum efficiency, you'll find all the answers in this authoritative guide.
With the 13th edition, Wintrobe’s Clinical Hematology once again bridges the gap between the clinical practice of hematology and the basic foundations of science. Broken down into eight parts, this book provides readers with a comprehensive overview of: Laboratory Hematology, The Normal Hematologic System, Transfusion Medicine, Disorders of Red Cells, Hemostasis and Coagulation; Benign Disorders of Leukocytes, The Spleen and/or Immunoglobulins; Hematologic Malignancies, and Transplantation. Within these sections, there is a heavy focus on the morphological exam of the peripheral blood smear, bone marrow, lymph nodes, and other tissues. With the knowledge about gene therapy and immunotherapy expanding, new, up-to-date information about the process and application of these therapies is included. Likewise, the editors have completely revised material on stem cell transplantation in regards to both malignant and benign disorders, graft versus host disease, and the importance of long-term follow-up of transplantation survivors.
Many proprotein convertases (PC), especially furin and PACE4, are involved in pathological processes such as viral infection, inflammation, hypercholesterolemia, and cancer, and have been postulated as therapeutic targets for some of these diseases. In this chapter, we review mostly our work using animal models of squamous cancers that have been induced by chemical or UV carcinogenesis protocols to highlight the role of PCs in the development and progression of experimental tumors. After demonstrating in wild type mice the role of PACE4 in tumor progression as well as detecting the expression of PACE4 and furin in human non-melanoma skin cancers, we developed transgenic mice that over-express either PACE4 or furin in squamous epithelia, including the epidermis. This was accomplished by targeting the expression of the corresponding PC by using the promoter of the bovine keratin 5. Both K5-PACE4 and K5-Furin transgenic mice showed increased susceptibility to a two-stage carcinogenesis protocol of chemical carcinogenesis. Similar studies conducted in K5-PACE4 mice also showed an increased sensitivity to ultraviolet B radiation carcinogenesis. In most of these experiments, we were able to demonstrate that compared to the control wild type mice, the over-expression of the transgene in the epidermis increased the number of benign and malignant skin tumors and also had an effect on tumor progression as evidenced by the presence of less differentiated tumors and more frequent local and distant metastases in many of the transgenic lines. Interestingly, double transgenic mice in which PACE4 and furin are targeted to the epidermis did not show any additive effect, pointing to a probable in vivo overlap of functions at least in cutaneous tissues. The tumor-enhancing effects of PACE4 and furin further support their possible role as therapeutic targets. Furthermore, a proof of principle for PC inhibition as a therapeutic tool has been substantiated by an in vivo experiment in which the PC-inhibitor, decanoyl-RVKRchloromethylketone, was topically administrated to the skin of wild type and transgenic mice treated with chemical carcinogenesis protocols, resulting in a significant decrease of tumor development and progression.
An easy read with a OC how-toOCO intent, this book provides the insights and process of a practical and viable community mental health team. The authors of the book have produced a book which is as close an account to the reality of making the REACH team a value add to the mental wellness of students. This is the first book in Singapore that details the synergy of the various levels of decision making to enable a child and adolescent community mental health team to take shape, allowing hospital staff to reach students and service providers in primary care.
The morning after his six year old daughter died suddenly and unexpectedly, her father began a blog. The entries from the first five months make up the chapters of this book. This is a raw mixture of memories and self-examination.
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