Achieve optimal outcomes for your patients with this new multimedia reference. Organized by tumor then by region, this resource details diagnostic and therapeutic options for primary and malignant spinal tumors. Over 25 key procedures--including minimally invasive surgery--are presented in a concise, stepwise fashion, putting the key information you need right at your fingertips! Over 600 illustrations round out this exhaustive new reference. Keep up to date on the latest advances in diagnosis and therapy with discussions of the latest surgical techniques, including minimally invasive spine surgery. Chapter templating helps you understand the entire procedure as well as key aspects, pearls and pitfalls, before heading into the OR. Have all the information you need to make a diagnosis and plan patient management with oversized, full color clinical photos and line drawings that illustrate key diagnoses and surgical procedures.
The Third Edition of Knowles Neoplastic Hematopathology has been thoroughly updated by the world's experts to cover all aspects of neoplastic hematopathology, a field that covers disorders of the bone marrow, spleen, and lymphatic system. Now in full-color, this completely revised and expanded edition integrates the basic science, modern diagnostic techniques, and clinical aspects of malignant diseases affecting these organs. It is the most comprehensive, encyclopedic textbook concerning neoplastic hematopathology available on the market today.
This monograph explores Intrabody communication (IBC) as a novel non-RF wireless data communication technique using the human body itself as the communication channel or transmission medium. In particular, the book investigates Intrabody Communication considering limb joint effects within the transmission frequency range 0.3-200 MHz. Based on in-vivo experiments which determine the effects of size, situations, and locations of joints on the IBC, the book proposes a new IBC circuit model explaining elbow joint effects. This model not only takes the limb joint effects of the body into account but also considers the influence of measurement equipment in higher frequency band thus predicting signal attenuation behavior over wider frequency ranges. Finally, this work proposes transmitter and receiver architectures for intrabody communication. A carrier-free scheme based on impulse radio for the IBC is implemented on a FPGA.
The chemistry of nanomaterials has developed considerably in the past two decades, and concepts that have emerged from these developments are now well established. The surface modification of nanoparticles is a subject of intense research interest given its importance for many applications across a number of disciplines. This comprehensive guide is the first to be devoted to the surface chemistry of inorganic nanocrystals. Following an introduction to the physical chemistry of surfaces, chapters cover topics such as the surface modification of nanoparticles, water compatible, polymer-based, and inorganic nanocomposites, as well as relevant applications in catalysis, biotechnology and nanomedicine. Highlighting recent advances, Surface Chemistry of Colloidal Nanocrystals provides an integrated approach to chemical aspects related to the surface of nanocrystals. Written by prestigious scientists, this will be a useful resource for students and researchers working in surface science, nanoscience and materials science as well as those interested in the applications of the nanomaterials in areas such as health science, biology, and environmental engineering.
The feasible operation region (FOR) allows capturing the aggregated flexibility potential of DER within radial distribution networks, while respecting the technical restrictions of both plants and grid. This thesis proposes a novel approach to compute the FOR, the Linear Flexibility Aggregation (LFA) method, based on the solution of a sequence of linear OPF. With the objective of reducing the computation time, without compromising the accuracy of the assessed FOR. It is shown that the proposed method provides a considerable reduction in processing time compared to similar methods, e.g. Monte-Carlo simulations or non-linear OPF-based methods.
Internet Gaming Disorder: Theory, Assessment, Treatment, and Prevention is an informative and practical introduction to the topics of Internet gaming disorder and problematic gaming. This book provides mental health clinicians with hands-on assessment, prevention, and treatment techniques for clients with problematic gaming behaviors and Internet gaming disorder. It provides an overview of the existing research on epidemiology, risk and protective factors, and discusses the distinct cognitive features that distinguish gaming from gambling and other related activities and disorders. Clinicians will find interest in discussion of the latest developments in cognitive-behavioral approaches to gaming disorder as well as the best structure for clinical interviews. Included in clinical sections are details of the key indicators of harm and impairment associated with problem gaming and how these might present in clinical cases. Internet Gaming Disorder is strongly evidence-based, draws extensively upon the latest international research literature, and provides insights into the likely future developments in this emerging field both in terms of technological development and new research approaches. - Discusses the conceptual basis of Internet gaming disorder as a behavioral addiction - Provides screening approaches for measuring excessive gaming - Details a structured clinical interview approach for assessing gaming disorder - Provides evidence-based clinical strategies for prevention and treatment - Covers cognitive behavioral therapy and harm reduction strategies
A comprehensive overview of nanomaterials that are inspired by or targeted at biology, including some of the latest breakthrough research. Throughout, valuable contributions from top-level scientists illustrate how bionanomaterials could lead to novel devices or structures with unique properties. The first and second part cover the most relevant synthetic and bioinspired nanomaterials, including surfaces with extreme wettability properties, functional materials with improved adhesion or structural and functional systems based on the complex and hierarchical organization of natural composites. These lessons from nature are explored in the last section where bioinspired materials are proposed for biomedical applications, showing their potential for future applications in drug delivery, theragnosis, and regenerative medicine. A navigational guide aimed at advanced and specialist readers, while equally relevant for readers in research, academia or private companies focused on high added-value contributions. Young researchers will also find this an indispensable guide in choosing or continuing to work in this stimulating area, which involves a wide range of disciplines, including chemistry, physics, materials science and engineering, biology, and medicine.
Offering authoritative, comprehensive coverage of hip surgery, the 2nd Edition of Surgery of the Hip is the definitive guide to hip replacement, other open and arthroscopic surgical procedures, and surgical and nonsurgical management of the hip across the lifespan. Modeled after Insall & Scott Surgery of the Knee, it keeps you fully up to date with the latest research, techniques, tools, and implants, enabling you to offer both adults and children the best possible outcomes. Detailed guidance from expert surgeons assists you with your toughest clinical challenges, including total hip arthroplasty, pediatric hip surgery, trauma, and hip tumor surgery. - Discusses new topics such as direct anterior approach for total hip arthroplasty, hip pain in the young adult, and hip preservation surgery. - Contains new coverage of minimally invasive procedures, bearing surface selection, management of complications associated with metal and metal bearing surfaces, management of bone loss associated with revision THA, and more. - Provides expert, personal advice in "Author's Preferred Technique" sections. - Helps you make optimal use of the latest imaging techniques, surgical procedures, equipment, and implants available. - Covers tumors of the hip, hip instability and displacement in infants and young children, traumatic injuries, degenerative joint disorders, and rehabilitation considerations—all from both a basic science and practical clinical perspective.
Featuring an expanded focus on in-demand endoscopic and minimally invasive spine procedures, Surgical Anatomy and Techniques to the Spine, 2nd Edition pairs new anatomic photographs and radiographic images with expertly rendered color illustrations and clear, step-by-step descriptions to help you effectively perform all of the latest and most effective spine surgery techniques. A multidisciplinary approach makes this medical reference book relevant and informative to all surgeons regardless of their specialty or level of surgical experience with the spine. - Proceed with confidence. An atlas-style format featuring clear, concise, step-by-step descriptions of the anatomy and procedures along with clinical hints and pearls, tables, and management algorithms provideing swift answers and trusted guidance. - Sharpen your surgical acumen with a deeper understanding of the anatomy of the surgical target and related anatomy. Comprehensive information on cervical, cervical/thoracic, thoracic/lumbar, lumbar spine, lumbar/pelvis, and other surgical locations ensures the best approaches to spine surgery and results. - Understand the spine from all angles with multiple-viewpoint, full-color photographs, and illustrations. - Master surgical anatomy of the spine and the latest minimally invasive techniques. Sweeping revisions and updates—including 22 new chapters—provide new and expanded coverage of spine surgery procedures and topics such as surgical management in gunshot wound to the spine, vertebroplasty, and kyphoplasty. - Visualize every step of each procedure thanks to new anatomic photographs and radiographic images, corresponding with expertly rendered illustrations which more in-depth than ever before. - Access the entire text and illustrations online, fully searchable, at Expert Consult.
Modeling spatial and spatio-temporal continuous processes is an important and challenging problem in spatial statistics. Advanced Spatial Modeling with Stochastic Partial Differential Equations Using R and INLA describes in detail the stochastic partial differential equations (SPDE) approach for modeling continuous spatial processes with a Matérn covariance, which has been implemented using the integrated nested Laplace approximation (INLA) in the R-INLA package. Key concepts about modeling spatial processes and the SPDE approach are explained with examples using simulated data and real applications. This book has been authored by leading experts in spatial statistics, including the main developers of the INLA and SPDE methodologies and the R-INLA package. It also includes a wide range of applications: * Spatial and spatio-temporal models for continuous outcomes * Analysis of spatial and spatio-temporal point patterns * Coregionalization spatial and spatio-temporal models * Measurement error spatial models * Modeling preferential sampling * Spatial and spatio-temporal models with physical barriers * Survival analysis with spatial effects * Dynamic space-time regression * Spatial and spatio-temporal models for extremes * Hurdle models with spatial effects * Penalized Complexity priors for spatial models All the examples in the book are fully reproducible. Further information about this book, as well as the R code and datasets used, is available from the book website at http://www.r-inla.org/spde-book. The tools described in this book will be useful to researchers in many fields such as biostatistics, spatial statistics, environmental sciences, epidemiology, ecology and others. Graduate and Ph.D. students will also find this book and associated files a valuable resource to learn INLA and the SPDE approach for spatial modeling.
Carbon nanotubes and graphene have been the subject of intense scientific research since their relatively recent discoveries. This book introduces the reader to the science behind these rapidly developing fields, and covers both the fundamentals and latest advances. Uniquely, this book covers the topics in a pedagogical manner suitable for undergraduate students. The book also uses the simple systems of nanotubes and graphene as models to teach concepts such as molecular orbital theory, tight binding theory and the Laue treatment of diffraction. Suitable for undergraduate students with a working knowledge of basic quantum mechanics, and for postgraduate researchers commencing their studies into the field, this book will equip the reader to critically evaluate the physical properties and potential for applications of graphene and carbon nanotubes.
Cardiac resynchronization therapy is a new therapy for advanced heart failure patients. This therapy has been shown to improve quality of life, exercise capacity, NYHA classification, and even reverse the detrimental "reverse remodeling" that occurs in advanced heart failure - in patients already receiving optimal pharmacological therapy. The typical patient has NYHA III/IV HF symptoms, a QRS > 120 ms, LVEDD > 55 mm, without any indication required for pacing. The therapy is available in an ICD device, too. CRT has been shown to be effective in patients with both ischemic and non-ischemic cardiomyopathy. The implant procedure is part of a learning curve. Many physicians who already perform electrophysiology procedures, or PPM, or ICD implants are the ideal implanter - but are surprised at the challenges this implant presents. This book will help "flatten" the learning curve for new physician implanting, and will provide a "guide' for those who have already started implanting. The success rate is about 90% - so after 10 years of application, we have found that there are still patients who do not get access to this great therapy because of the complexity of the patient's anatomy, or physician skills. The book is written by three authors with a great deal of experience culminating in over 3000 cases between them. This book is intended for cardiologists who currently implant either or both pacemakers and cardioverter defibrillators with cardiac resynchronization therapy (also called bi-ventricular pacing), or plan to implant in the future. This book will be extremely useful for the new cardiologist in training who is learning to implant devices.
Venomous" Bites from "Non-Venomous" Snakes, Second Edition thoroughly examines the potential hazards associated with bites by non-front-fanged snakes (popularly, but inaccurately, called "rear-fanged snakes"). This diverse group contains approximately 80% of living snake species (approximately 2,900 species). A large proportion of these snakes were previously assigned to the family Colubridae but, as a consequence of expanding systematics investigations, have been split into multiple families and subfamilies. Many of these snakes produce venoms or oral secretions that contain toxins and other biologically active substances. A large variety of non–front-fanged snakes figure in the pet industry, yet little documented information or formal study of their potential medical importance has been published. Therefore, although the possible medical importance of many of these species has been subjected to speculation since the mid-19th century, there is a limited amount of useful descriptive information regarding the real hazard (or lack thereof) of this wide variety of snakes. The first edition of this book provided "one-stop shopping" by offering information regarding their possible toxicity and clinical relevance as well as recommendations for medical management of their bites. The second edition expands and updates the content with detailed information about the effects and medical management of bites by a broad representation of non–front-fanged species. The hypothetical venomous nature of some lizards considered as non-venomous such as the Komodo monitor or dragon and their allies, as well as the medical effects of their bites, is also examined. The dynamic taxonomy of advanced snakes is updated, and the bases for some of these fluid changes are discussed. Likewise, terminology is also updated in order to reflect the ongoing debates regarding the definition of "venom" and the balanced reinforcement of nonmedical criteria used to define the biological basis of the term "venomous." - Fills a gap in toxicological, medical, and herpetological literature by providing a comprehensive review of this entire assemblage of non–front-fanged snakes, with particular attention given to their capacity to cause harm to humans - Offers a patient-centered, evidence-based approach which is applied to analyzing documented case reports of bites inflicted by a broad representation of species - Provides expanded and updated detailed information on the clinical management of medically significant bites from non–front-fanged snakes, which is also methodically reviewed, and specific recommendations are provided - Includes updates of the fluid taxonomy of advanced snakes and also of terminology with particular regard to the definition of "venom" and the nonmedical criteria used to define the biological basis of the "venomous condition" in snakes and lizards
Intelligent Vehicular Network and Communications: Fundamentals, Architectures and Solutions begins with discussions on how the transportation system has transformed into today's Intelligent Transportation System (ITS). It explores the design goals, challenges, and frameworks for modeling an ITS network, discussing vehicular network model technologies, mobility management architectures, and routing mechanisms and protocols. It looks at the Internet of Vehicles, the vehicular cloud, and vehicular network security and privacy issues. The book investigates cooperative vehicular systems, a promising solution for addressing current and future traffic safety needs, also exploring cooperative cognitive intelligence, with special attention to spectral efficiency, spectral scarcity, and high mobility. In addition, users will find a thorough examination of experimental work in such areas as Controller Area Network protocol and working function of On Board Unit, as well as working principles of roadside unit and other infrastructural nodes. Finally, the book examines big data in vehicular networks, exploring various business models, application scenarios, and real-time analytics, concluding with a look at autonomous vehicles. - Proposes cooperative, cognitive, intelligent vehicular networks - Examines how intelligent transportation systems make more efficient transportation in urban environments - Outlines next generation vehicular networks technology
The rise of the Internet of Things (IoT) and Artificial Intelligence (AI) leads to the emergence of edge computing systems that push the training and deployment of AI models to the edge of networks for reduced bandwidth cost, improved responsiveness, and better privacy protection, allowing for the ubiquitous AI that can happen anywhere and anytime. Motivated by the above trend, this book introduces a new computing paradigm, the Social Edge Computing (SEC), that empowers human-centric edge intelligent applications by revolutionizing the computing, intelligence, and the training of the AI models at the edge. The SEC paradigm introduces a set of critical human-centric challenges such as the rational nature of edge device owners, pronounced heterogeneity of the edge devices, real-time AI at the edge, human and AI interaction, and the privacy of the edge users. The book addresses these challenges by presenting a series of principled models and systems that enable the confluence of the computing capabilities of devices and the domain knowledge of the people, while explicitly addressing the unique concerns and constraints from humans. Compared to existing books in the field of edge computing, the vision of this book is unique: we focus on the social edge computing (SEC), an emerging paradigm at the intersection of edge computing, AI, and social computing. This book discusses the unique vision, challenges and applications in SEC. To our knowledge, keeping humans in the loop of edge intelligence has not been systematically reviewed and studied in an existing book. The SEC vision generalizes the current machine-to-machine interactions in edge computing (e.g., mobile edge computing literature), and machine-to-AI interactions (e.g., edge intelligence literature) into a holistic human-machine-AI ecosystem.
Biobased Surfactants: Synthesis, Properties, and Applications, Second Edition, covers biosurfactant synthesis and applications and demonstrates how to reduce manufacturing and purification costs, impurities, and by-products. Fully updated, this book covers surfactants in biomedical applications, detergents, personal care, food, pharmaceuticals, cosmetics, and nanotechnology. It reflects on the latest developments in biobased surfactant science and provides case scenarios to guide readers in efficient and effective biobased surfactant application, along with strategies for research into new applications. This book is written from a biorefinery-based perspective by an international team of experts and acts as a key text for researchers and practitioners involved in the synthesis, utilization, and development of biobased surfactants. - Describes new and emerging biobased surfactants and their synthesis and development - Showcases an interdisciplinary approach to the topic, featuring applications to chemistry, biotechnology, biomedicine, and other areas - Presents the entire lifecycle of biobased surfactants in detail
Introducing HEMATOPATHOLOGY, a definitive new diagnostic reference on diseases of the hematopoietic system by Dr. Elaine S. Jaffe and her fellow editors, all collaborators on the World Health Organization's classification of lymphoid and myeloid disorders. These experts provide you with today's most effective guidance in evaluating specimens from the lymph nodes, bone marrow, peripheral blood, and more, equipping you to deliver more accurate and actionable pathology reports. More than 1,100 high-quality color images mirror the findings you encounter in practice. Overcome the toughest diagnostic challenges with authoritative guidance from the world's leading experts. Make optimal use of the newest diagnostic techniques, including molecular, immunohistochemical, and genetic studies. Compare specimens to more than 1,100 high-quality color images to confirm or challenge your diagnostic interpretations. Search the full contents online and download any of the images at expertconsult.com.
Wireless Coexistence Explore a comprehensive review of the motivation for wireless coexistence and the standards and technology used to achieve it Wireless Coexistence: Standards, Challenges, and Intelligent Solutions delivers a thorough exploration of wireless ecosystems sharing the spectrum, including the multiple standards and key requirements driving the current state of wireless technology. The book surveys several standards, including IEEE 802.22, 802.15.2, and 802.19.1 and expands upon recent advances in machine learning and artificial intelligence to demonstrate how these technologies might be used to meet or exceed the challenges of wireless coexistence. The text discusses cognitive radio in the context of spectrum coexistence and provides a comparison and assessment of using artificial intelligence in place of, or in addition to, current techniques. It also considers applications to communication theory, learning algorithms for passive wireless coexistence strategies, spectrum situational awareness, and active wireless coexistence strategies. With the necessity of spectrum sharing and the scarcity of unused spectrum on the rise, the standardization of wireless coexistence becomes more important with each passing day. Readers will learn about the challenges posed by shrinking wireless real estate and from the inclusion of topics like: A thorough introduction to the concept of, and motivation for, wireless coexistence, including congestion and interference, policies, and regulations An exploration of different wireless coexistence standards, including the need for standardization and various protocols, including 802.22, 802.15.2, 802.19.1, P1900, and 3GPP Release 13/14 LAA A discussion of the applications of communication theory, including primary user strategies, primary multi-user protocols, and successive interference cancellation A treatment of concepts in learning algorithms Perfect for scientists, researchers, engineers, developers, educators, and administrators working in the area of wireless networks, Wireless Coexistence: Standards, Challenges, and Intelligent Solutions will also earn a place in the libraries of graduate students studying wireless networks and seeking a one-stop reference for subjects related to wireless coexistence standards.
Based on the highly regarded Walls Manual of Emergency Airway Management and part of the Manual of Emergency Medicine series envisioned by leading authority in emergency medicine, Dr. Ron M. Walls, Manual of Eye, Ear, Nose, and Throat Emergencies provides evidence-based, easy-to-read coverage of these commonly seen emergencies. Through the direction and expertise of lead editor Dr. Daniel J. Egan and associate editors Drs. Gareth M.C. Lema, Di (Fan) Coneybeare, and Marita S. Teng, this reference is a practical guide to approaching the patient with an EENT complaint in a systematic way, providing a hands-on framework for clinical decision making and therapeutic interventions.
Multilingual Natural Language Processing Applications is the first comprehensive single-source guide to building robust and accurate multilingual NLP systems. Edited by two leading experts, it integrates cutting-edge advances with practical solutions drawn from extensive field experience. Part I introduces the core concepts and theoretical foundations of modern multilingual natural language processing, presenting today’s best practices for understanding word and document structure, analyzing syntax, modeling language, recognizing entailment, and detecting redundancy. Part II thoroughly addresses the practical considerations associated with building real-world applications, including information extraction, machine translation, information retrieval/search, summarization, question answering, distillation, processing pipelines, and more. This book contains important new contributions from leading researchers at IBM, Google, Microsoft, Thomson Reuters, BBN, CMU, University of Edinburgh, University of Washington, University of North Texas, and others. Coverage includes Core NLP problems, and today’s best algorithms for attacking them Processing the diverse morphologies present in the world’s languages Uncovering syntactical structure, parsing semantics, using semantic role labeling, and scoring grammaticality Recognizing inferences, subjectivity, and opinion polarity Managing key algorithmic and design tradeoffs in real-world applications Extracting information via mention detection, coreference resolution, and events Building large-scale systems for machine translation, information retrieval, and summarization Answering complex questions through distillation and other advanced techniques Creating dialog systems that leverage advances in speech recognition, synthesis, and dialog management Constructing common infrastructure for multiple multilingual text processing applications This book will be invaluable for all engineers, software developers, researchers, and graduate students who want to process large quantities of text in multiple languages, in any environment: government, corporate, or academic.
Artificial intelligence has already enabled pivotal advances in diverse fields, yet its impact on computer architecture has only just begun. In particular, recent work has explored broader application to the design, optimization, and simulation of computer architecture. Notably, machine-learning-based strategies often surpass prior state-of-the-art analytical, heuristic, and human-expert approaches. This book reviews the application of machine learning in system-wide simulation and run-time optimization, and in many individual components such as caches/memories, branch predictors, networks-on-chip, and GPUs. The book further analyzes current practice to highlight useful design strategies and identify areas for future work, based on optimized implementation strategies, opportune extensions to existing work, and ambitious long term possibilities. Taken together, these strategies and techniques present a promising future for increasingly automated computer architecture designs.
New York Times bestselling author and neuroscientist Daniel J. Levitin shifts his keen insights from your brain on music to your brain in a sea of details. The information age is drowning us with an unprecedented deluge of data. At the same time, we’re expected to make more—and faster—decisions about our lives than ever before. No wonder, then, that the average American reports frequently losing car keys or reading glasses, missing appointments, and feeling worn out by the effort required just to keep up. But somehow some people become quite accomplished at managing information flow. In The Organized Mind, Daniel J. Levitin, PhD, uses the latest brain science to demonstrate how those people excel—and how readers can use their methods to regain a sense of mastery over the way they organize their homes, workplaces, and time. With lively, entertaining chapters on everything from the kitchen junk drawer to health care to executive office workflow, Levitin reveals how new research into the cognitive neuroscience of attention and memory can be applied to the challenges of our daily lives. This Is Your Brain on Music showed how to better play and appreciate music through an understanding of how the brain works. The Organized Mind shows how to navigate the churning flood of information in the twenty-first century with the same neuroscientific perspective.
NEW YORK TIMES BESTSELLER • The author of The Talent Code unlocks the secrets of highly successful groups and provides tomorrow’s leaders with the tools to build a cohesive, motivated culture. NAMED ONE OF THE BEST BOOKS OF THE YEAR BY BLOOMBERG AND LIBRARY JOURNAL Where does great culture come from? How do you build and sustain it in your group, or strengthen a culture that needs fixing? In The Culture Code, Daniel Coyle goes inside some of the world’s most successful organizations—including the U.S. Navy’s SEAL Team Six, IDEO, and the San Antonio Spurs—and reveals what makes them tick. He demystifies the culture-building process by identifying three key skills that generate cohesion and cooperation, and explains how diverse groups learn to function with a single mind. Drawing on examples that range from Internet retailer Zappos to the comedy troupe Upright Citizens Brigade to a daring gang of jewel thieves, Coyle offers specific strategies that trigger learning, spark collaboration, build trust, and drive positive change. Coyle unearths helpful stories of failure that illustrate what not to do, troubleshoots common pitfalls, and shares advice about reforming a toxic culture. Combining leading-edge science, on-the-ground insights from world-class leaders, and practical ideas for action, The Culture Code offers a roadmap for creating an environment where innovation flourishes, problems get solved, and expectations are exceeded. Culture is not something you are—it’s something you do. The Culture Code puts the power in your hands. No matter the size of your group or your goal, this book can teach you the principles of cultural chemistry that transform individuals into teams that can accomplish amazing things together. Praise for The Culture Code “I’ve been waiting years for someone to write this book—I’ve built it up in my mind into something extraordinary. But it is even better than I imagined. Daniel Coyle has produced a truly brilliant, mesmerizing read that demystifies the magic of great groups. It blows all other books on culture right out of the water.”—Adam Grant, New York Times bestselling author of Option B, Originals, and Give and Take “If you want to understand how successful groups work—the signals they transmit, the language they speak, the cues that foster creativity—you won’t find a more essential guide than The Culture Code.”—Charles Duhigg, New York Times bestselling author of The Power of Habit and Smarter Faster Better
Even as its rise as a nuclear power unfolds on the nightly news, North Korea remains arguably the most mysterious country in the world. A virtual blackout of statistical information coming from the reclusive regime has shrouded the day-to-day lives of its inhabitants in secrecy. This groundbreaking study--which relies on rare U.N.-assisted household data and carefully scrutinized propaganda materials--offers the first comprehensive examination of the social and economic history of North Korea from its founding in 1948 to the present day. Included are a chronicle of the political formation of the two Koreas, an exploration of the social aspects of life in North Korea, a discussion of the country's economic structure and development, and cutting-edge anthropometric analysis that reveals how life in seclusion has affected the physical development of North Koreans. A concluding socioeconomic forecast predicts what lies ahead for the "hermit kingdom." Instructors considering this book for use in a course may request an examination copy here.
Wastewater Treatment Residues as Resources for Biorefinery Products and Energy reviews wastewater treatment processes and the use of residues. The viability of end use processes for residues, such as incineration, cement additives, agricultural fertilizers, and methane production are reviewed and analyzed, as are new processes for the use of residues within a fuels production system, such as pyrolysis, hydrothermal liquefaction and syngas. Specialized chapters discuss fractionation of biomass, the production of compounds from volatile fatty acids that conceptually proceed from the anaerobic acidogenesis of residues, and a final analysis of the overall productivity and viability that can be expected from these production schemes. - Discusses processes for the production of high value-added products and energy development from sludge - Provides value-added technologies for resource utilization in wastewater systems - Outlines sustainability assessments and comparisons of technologies and processes
This issue of Hematology/Oncology Clinics will focus on Gene Therapy. Topics include, but are not limited to Historical Perspective and Current Renaissance, Integrating Vectors, Nonintegrating Vectors, Gene Editing, Conditioning Therapies for Autologous HSCT, Approaches to Immunodeficiency, Approaches to Hemoglobinopathy, Approaches to Hemophilia, Hematopoietic Gene Therapies for Neurologic and Metabolic Disease, Gene Therapy Approaches to HIV and other Infectious Diseases, HSC Approaches to Cancer, and Gene Modified T Cell Therapies for Cancer.
The world's leading knee reconstruction and sports medicine surgeons guide you to manage the toughest cases you'll see. Step-by-step guidance for more than 70 advanced reconstruction techniques.
The aim of this work is to provide a fuller spectrum of information in a single source on enzyme-catalyzed reactions than is currently available in any published reference work or as part of any Internet database. The Enzyme Reference: A Comprehensive Guidebook to Enzyme Nomenclature, Reactions, and Methods includes 20,000 review articles and seminal research papers. Additionally, it provides a novel treatment of so-called ATPase and GTPase reactions to account for the noncovalent substratelike and productlike states of molecular motors, elongation factors, transporters, DNA helicases, G-reulatory proteins, and other energases. - Includes a compendium of over 6,000 enzyme reactions (including enzyme commission numbers, alternative names, substrates, products, alternative substrates, and properties) - Covers over 900 chemical structures of key metabolites and cofactors - Index directs readers to the exact pages for over 9,500 enzyme names
“Electrical Conductive Adhesives with Nanotechnologies” begins with an overview of electronic packaging and discusses the various adhesives options currently available, including lead-free solder and ECAs (Electrically Conductive Adhesives). The material presented focuses on the three ECA categories specifically, Isotropically Conductive Adhesives (ICAs) Anisotropically Conductive Adhesives/Films (ACA/ACF) and Nonconductive Adhesives/Films (NCA/NCF). Discussing the advantages and limitations of each technique, and how each technique is currently applied. Lastly, a detailed presentation of how nano techniques can be applied to conductive adhesives is discussed, including recent research and development of nano component adhesives/nano component films, their electrical properties, thermal performance, bonding pressure and assembly and reliability.
This multi-contributed, comprehensive book covers revision surgery for total hip and knee arthroplasty. The focus of Revision Total Hip and Knee Arthroplasty will be on the techniques of revision surgery. Separated into a hip section and a knee section, each will include evaluation of the failed replacement, revision surgery, surgical technique, revision for specific diagnosis, complications, and postoperative management.
In this revolutionary, comprehensive, and accessible guide on how the brain learns, discover how to study more efficiently and effectively, shrug away exam stress, and most of all, enjoy learning. When we study, we tend to focus on the tasks we can most easily control—such as highlighting and rereading—but these practices only give the illusion of mastery. As Dan Willingham, professor of psychology and bestselling author, explains, familiarity is not the same as comprehension. Perfect for teachers and students of all ages, Outsmart Your Brain provides real-world practices and the latest research on how to train your brain for better learning. Each chapter provides clear and specific strategies while also explaining why traditional study processes do not work. Grounded in scientifically backed practical advice, this is the ultimate guide to improving grades and better understanding the power of our own brains.
Biochemical kinetics refers to the rate at which a reaction takes place. Kinetic mechanisms have played a major role in defining the metabolic pathways, the mechanistic action of enzymes, and even the processing of genetic material. The Handbook of Biochemical Kinetics provides the "underlying scaffolding" of logic for kinetic approaches to distinguish rival models or mechanisms. The handbook also comments on techniques and their likely limitations and pitfalls, as well as derivations of fundamental rate equations that characterize biochemical processes.Key Features* Over 750 pages devoted to theory and techniques for studying enzymic and metabolic processes* Over 1,500 definitions of kinetic and mechanistic terminology, with key references* Practical advice on experimental design of kinetic experiments* Extended step-by-step methods for deriving rate equations* Over 1,000 enzymes, complete with EC numbers, reactions catalyzed, and references to reviews and/or assay methods* Over 5,000 selected references to kinetic methods appearing in the Methods in Enzymology series* 72-page Wordfinder that allows the reader to search by keywords* Summaries of mechanistic studies on key enzymes and protein systems* Over 250 diagrams, figures, tables, and structures
Be a part of the nanotechnology revolution in telecommunications This book provides a unique and thought-provoking perspective on how nanotechnology is poised to revolutionize the telecommunications, computing, and networking industries. The author discusses emerging technologies as well as technologies under development that will lay the foundation for such innovations as: * Nanomaterials with novel optical, electrical, and magnetic properties * Faster and smaller non-silicon-based chipsets, memory, and processors * New-science computers based on Quantum Computing * Advanced microscopy and manufacturing systems * Faster and smaller telecom switches, including optical switches * Higher-speed transmission phenomena based on plasmonics and other quantum-level phenomena * Nanoscale MEMS: micro-electro-mechanical systems The author of this cutting-edge publication has played a role in the development of actual nanotechnology-based communication systems. In this book, he examines a broad range of the science of nanotechnology and how this field will affect every facet of the telecommunications and computing industries, in both the near and far term, including: * Basic concepts of nanotechnology and its applications * Essential physics and chemistry underlying nanotechnology science * Nanotubes, nanomaterials, and nanomaterial processing * Promising applications in nanophotonics, including nanocrystals and nanocrystal fibers * Nanoelectronics, including metal nanoclusters, semiconducting nanoclusters, nanocrystals, nanowires, and quantum dots This book is written for telecommunications professionals, researchers, and students who need to discover and exploit emerging revenue-generating opportunities to develop the next generation of nanoscale telecommunications and network systems. Non-scientists will find the treatment completely accessible. A detailed glossary clarifies unfamiliar terms and concepts. Appendices are provided for readers who want to delve further into the hard-core science, including nanoinstrumentation and quantum computing. Nanotechnology is the next industrial revolution, and the telecommunications industry will be radically transformed by it in a few years. This is the publication that readers need to understand how that transformation will happen, the science behind it, and how they can be a part of it.
Nowadays the term dose-response is used in many different contexts and many different scientific disciplines including agriculture, biochemistry, chemistry, environmental sciences, genetics, pharmacology, plant sciences, toxicology, and zoology. In the 1940 and 1950s, dose-response analysis was intimately linked to evaluation of toxicity in terms of binary responses, such as immobility and mortality, with a limited number of doses of a toxic compound being compared to a control group (dose 0). Later, dose-response analysis has been extended to other types of data and to more complex experimental designs. Moreover, estimation of model parameters has undergone a dramatic change, from struggling with cumbersome manual operations and transformations with pen and paper to rapid calculations on any laptop. Advances in statistical software have fueled this development. Key Features: Provides a practical and comprehensive overview of dose-response analysis. Includes numerous real data examples to illustrate the methodology. R code is integrated into the text to give guidance on applying the methods. Written with minimal mathematics to be suitable for practitioners. Includes code and datasets on the book’s GitHub: https://github.com/DoseResponse. This book focuses on estimation and interpretation of entirely parametric nonlinear dose-response models using the powerful statistical environment R. Specifically, this book introduces dose-response analysis of continuous, binomial, count, multinomial, and event-time dose-response data. The statistical models used are partly special cases, partly extensions of nonlinear regression models, generalized linear and nonlinear regression models, and nonlinear mixed-effects models (for hierarchical dose-response data). Both simple and complex dose-response experiments will be analyzed.
Corporate market power has risen in recent decades, and new estimates in this note suggest that the likely wave of small and medium-sized enterprise bankruptcies from the ongoing pandemic will further strengthen market concentration. Whether and how policymakers should address this issue is hotly debated. This note provides new evidence on the policy relevance of rising market power and highlights possible implications for the design of competition policy frameworks and macroeconomic policies.
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