The Comprehensive Sourcebook of Bacterial Protein Toxins, Fourth Edition, contains chapters written by internationally known and well-respected specialists. This book contains chapters devoted to individual toxins, as well as chapters that consider the different applications of these toxins. Considerable progress has been made in understanding the structure, function, interaction and trafficking into cells, as well as mechanism of action of toxins. Bacterial toxins are involved in the pathogenesis of many bacteria, some of which are responsible for severe diseases in human and animals, but can also be used as tools in cell biology to dissect cellular processes or used as therapeutic agents. Novel recombinant toxins are already proposed in the treatment of some diseases, as well as new vaccines. Alternatively, certain toxins are also considered as biological weapons or bioterrorism threats. Given the multifaceted aspects of toxin research and the multidisciplinary approaches adopted, toxins are of great interest in many scientific areas from microbiology, virology, cell biology to biochemistry and protein structure. This new edition is written with a multidisciplinary audience in mind and contains 5 new chapters that reflect the latest research in this area. Other chapters have been combined, deleted and fully revised as necessary to deliver relevant and valuable content. - Descriptions of relevant toxins as well as representative toxins of the main bacterial toxin families to allow for a better comparison between them - Focused chapters on toxin applications and common properties or general features of toxins
Daniel Galmiche, a Michelin-starred chef and author of the French Brasserie Cookbook shows how to make authentic French dishes, using the ingredients found in the rural parts of the country, from orchard to meadow, river to seashore, in sustainable and stunningly inventive ways. Multiple-Michelin-starred Daniel Galmiche presents a fresh approach to French cooking. Taking inspiration and ingredients from meadow and orchard, from field to forest, and from river to sea, each recipe takes authentic French rural classics and elevates them to sophisticated dishes, full of flavour and easy to create at home. French cooking centres around one maxim: start with quality ingredients, and the resulting flavour and freshness of the dish will shine. Daniel shows how to showcase the humblest of ingredients, with tips on how to source them sustainably and seasonally. Starters, mains, sides and desserts are organised by the origin of their key ingredient. From the orchard, spice a peach to make a mouth-watering accompaniment to duck. From the farmyard, make use of a chicken carcass to create a beautifully clear and nourishing broth. Or from the sea, home-smoke cod fillets with fennel-infused smoke and serve with a warm bean salad. With short ingredients lists and straightforward guidance on how to perfect chef-level techniques such as dehydrating and sous-vide without the fancy equipment, this book will allow you to master innovative French cuisine – and reduce food waste – with simplicity.
The definitive illustrated resource on the surgical management of infants and children -- with an emphasis on operative technique Operative Pediatric Surgery, Second Edition is a comprehensive, well-illustrated text that delivers expert coverage of the pathophysiology, diagnosis, and treatment of pediatric surgical disease. This detailed single-volume resource is enhanced by numerous drawings, radiographs, and photographs that illustrate the authors’ preferred operative techniques. Wherever appropriate, diagnostic and care guidelines are also included. Operative Pediatric Surgery, Second Edition is divided into 11 sections that include a total of 100 chapters. The book opens with an informative General Principles section that provides important background information on topics such as the history of pediatric surgery, ethical considerations, pediatric surgical critical care, and office-based ambulatory surgery. The rest of the text is organized primarily by organ, enhanced by a timely section on solid organ transplantation. In this Second Edition, each chapter author has thoroughly updated and refreshed their topic, and in many instances, minimally invasive operative techniques are included with open approaches. There are also exciting new chapters on: Hypospadias Vesicoureteral reflux Non-rhabdomyosarcoma soft tissue sarcomas Gastrointestinal polyps and cancer Adolescent bariatric surgery Operative Pediatric Surgery will prove to be an essential reference for pediatric surgeons seeking optimal diagnosis and treatment approaches for their patients.
Franz Kafka was a self-conscious writer whose texts were highly if mysteriously autobiographical. Three giants of contemporary fiction—J. M. Coetzee, Philip Roth, and W. G. Sebald—have all acknowledged their debt to the work of Kafka, both in interviews and in their own academic essays and articles for a general readership about him. In this striking feat of literary scholarship, Daniel Medin finds that the use of Kafka by Coetzee, Roth, and Sebald is similarly self-reflexive and autobiographical. That writers from such divergent national and ethnic traditions can have such unique critical readings of Kafka, and that Kafka could exert such a powerful influence over their oeuvres, Medin contends, attests to the central place of Kafka in the contemporary literary imagination.
This distinguished reference carries on a 70-year legacy as the world's most thorough, useful, readable, and understandable text on the principles and techniques of surgery. Its peerless contributors deliver all the well-rounded, state-of-the-art knowledge you need to richly grasp the pathophysiology and optimal management of every surgical condition-so you can make the best clinical decisions, avoid complications, manage unusual situations, and achieve the best possible outcomes. It is a valuable review tool for certification/recertification preparation, and an indispensable source of guidance on overcoming the challenges that arise in everyday practice. As an Expert Consult title, the thoroughly updated 18th edition comes with access to the complete contents online, fully searchable-enabling you to consult it rapidly from any computer with an Internet connection. In addition, this Premium Edition includes timely clinical updates online, plus links to MEDLINE, downloadable illustrations, bonus journal articles, review questions, and much more. Offers a more distinguished team of contributors and a better blend of clinical and basic-science information than any other source, providing you with the best possible understanding of the clinical issues surrounding every operative situation. Features a more user-friendly format, a larger and more helpful array of full-color illustrations, and a more versatile and well-constructed web site than other resources-making the answers that you need easier to locate and understand quickly. Offers an organization and content that parallels the written board American Board of Surgery exam, providing excellent preparation for certification and recertification. Includes access to the complete contents online, fully searchable, PLUS timely updates to reflect new scientific and clinical developments · references linked to MEDLINE · downloadable illustrations · bonus articles from important surgery periodicals (such as Surgical Clinics of North America, the American Journal of Surgery, Operative Techniques in General Surgery, and Seminars in Colon and Rectal Surgery) · review questions · and other valuable features. Incorporates an enhanced emphasis on surgical outcomes to mirror the growing importance of this topic. Delivers comprehensive updates to keep you current with the latest research, techniques, and emerging procedures in the field, as well as completely new chapters on "Surgical Patient Safety" and "Regenerative Medicine.
Capsule Endoscopy Simplified is a comprehensive reference for all gastroenterologists that are performing capsule endoscopic procedures. Inside you will find relevant information regarding the equipment used for the procedure, patient preparation, interpretation, and management. Drs. Roberto de Franchis, Blair S. Lewis, and Daniel S. Mishkin provide data, as well as experience, in addressing state-of-the-art capsule endoscopy in regards to small bowel imaging. The pages of this timely book are full of essential information regarding the trials and tribulations that gastroenterologists may encounter to ensure the best possible patient care. What is covered inside: * Pre-capsule clinical evaluation * Data and image transfer * Review of normal findings * Pathology to recognize such as Crohn's disease and celiac disease * Capsule retention * Esophageal capsule, colon capsule, and other capsule systems * Pearls from the experts Capsule Endoscopy Simplified includes full color images as well as an informative accompanying DVD. This concise, user-friendly book offers "tricks of the trade," focusing on key elements one needs to know in order to be successful in capsule endoscopy and small bowel imaging. While providing today's most advanced information, Capsule Endoscopy Simplified is ideal for gastroenterologists, gastroenterology fellows, and nurses that are either new or in need of a quick and concise refresher to capsule endoscopy.
Guest edited by Dr. Daniel Levi, this issue of Interventional Cardiology Clinics will cover several key areas of interest related to Congenital Heart Disease Intervention. This issue is one of four selected each year by our series Editor-in-Chief, Dr. Matthew Price of Scripps Translational Science Center. Articles in this issue include, but are not limited to: Current Transcatheter Approaches for the Treatment of Aortic Coarctation in Children and Adults, Biodegradable Stents for Congenital Heart Disease, State of the Art ASD Closure Devices for Congenital Heart, New PDA Closure Devices and Techniques, Lymphatic Interventions, VSD Closure Devices, Techniques and Outcomes, Pulmonary Artery and Bronchial Stenting: Available Devices, Techniques and Outcomes, and Transcatheter Valve, and Interventions for Adults with Congenital Heart Disease.
This book introduces contemporary Buddhists from across Asia and from various walks of life. Eschewing traditional hagiographies, the editors have collected sixty-six profiles of individuals who would be excluded from most Buddhist histories and ethnographies. In addition to monks and nuns, readers will encounter artists, psychologists, social workers, part-time priests, healers, and librarians as well as charlatans, hucksters, profiteers, and rabble-rousers—all whose lives reflect changes in modern Buddhism even as they themselves shape the course of these changes. The editors and contributors are fundamentally concerned with how individual Buddhists make meaning and display this understanding to others. Some practitioners profiled look to the past, lamenting the transformations Buddhism has undergone in recent times, while others embrace these. Some have adopted a “new asceticism,” while others are eager to explore different religious traditions as they think about their own ways of being Buddhist. Arranging the profiles according to these themes—looking backward, forward, inward, and outward—reveals the value of studying individual Buddhists and their idiosyncratic religious backgrounds and attitudes, thus highlighting the diversity of approaches to the practice and study of Buddhism in Asia today. Students and teachers will welcome sections on further readings and additional tables of contents that organize the profiles thematically, as well as by tradition (Theravada, Mahayana, Vajrayana), region, and country.
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