The whole point of a race is to find a winner... I chose to race, so I chose to win.' For 14 years between 1965 and 1978, cyclist Edouard Louis Joseph Merckx simply devoured his rivals, their hopes and their careers. His legacy resides as much in the careers he ruined as the 445 victories - including five Tour de France wins and all the monument races - he amassed in his own right. So dominant had Merckx become by 1973 that he was ordered to stay away from the Tour for the good of the event. Stage 17 of the 1969 Tour de France perfectly illustrates his untouchable brilliance. Already wearing the yellow jersey on the col du Tourmalet, the Tour's most famous peak, Merckx powered clear and rode the last 140 kilometres to the finish-line in jaw-dropping solitude, eight minutes ahead of his nearest competitor. Merckx's era has been called cycling's Golden Age.It was full of memorable characters who, at any other time, would all have gone on to become legends. Yet Merckx's phenomenal career overshadowed them all. How did he achieve such incredible success? And how did his rivals really feel about him? Merckx failed drug tests three times in his career - were they really stitch ups as he claimed? And what of the crash at a track meet in Blois, France that killed Merckx's pacer Fernand Wambst, which Merckx claimed deeply affected him psychologically and physically? Or the attack by a spectator in 1975? Despite his unique achievements, we know little about the Cannibal beyond his victories. This will be the first comprehensive biography of Merckx in English, and will finally expose the truth behind this legendary man.
Jan Ullrich: The Best There Never Was is the first biography of Jan Ullrich, arguably the most naturally talented cyclist of his generation, and also one of the most controversial champions of the Tour de France. 'Magnificent' – Matt Dickinson, The Times 'A superlative biography as well as social and sporting history' – Observer In 1997, Jan Ullrich announced himself to the world by obliterating his rivals at the Tour de France and becoming Germany’s first ever winner. Everyone agreed: Jan Ullrich would dominate the future of cycling. But he never quite managed it. This is a gripping account of how unbearable expectation, mental and physical fragility, the effects of a complicated childhood, a morally corrupt sport and one individual – Lance Armstrong – can conspire to reroute destiny. Acclaimed journalist Daniel Friebe takes us from the legacy of East Germany’s drugs programme to the pinnacle of pro cycling and asks: what price are you willing to pay for immortality?
The whole point of a race is to find a winner... I chose to race, so I chose to win.' For 14 years between 1965 and 1978, cyclist Edouard Louis Joseph Merckx simply devoured his rivals, their hopes and their careers. His legacy resides as much in the careers he ruined as the 445 victories - including five Tour de France wins and all the monument races - he amassed in his own right. So dominant had Merckx become by 1973 that he was ordered to stay away from the Tour for the good of the event. Stage 17 of the 1969 Tour de France perfectly illustrates his untouchable brilliance. Already wearing the yellow jersey on the col du Tourmalet, the Tour's most famous peak, Merckx powered clear and rode the last 140 kilometres to the finish-line in jaw-dropping solitude, eight minutes ahead of his nearest competitor. Merckx's era has been called cycling's Golden Age.It was full of memorable characters who, at any other time, would all have gone on to become legends. Yet Merckx's phenomenal career overshadowed them all. How did he achieve such incredible success? And how did his rivals really feel about him? Merckx failed drug tests three times in his career - were they really stitch ups as he claimed? And what of the crash at a track meet in Blois, France that killed Merckx's pacer Fernand Wambst, which Merckx claimed deeply affected him psychologically and physically? Or the attack by a spectator in 1975? Despite his unique achievements, we know little about the Cannibal beyond his victories. This will be the first comprehensive biography of Merckx in English, and will finally expose the truth behind this legendary man.
“Greg LeMond was Lance Armstrong before Lance Armstrong . . . the story of a true hero . . . This is a must read if you believe in miracles.”―John Feinstein, New York Times–bestselling author In July 1986, Greg LeMond stunned the sporting world by becoming the first American to win the Tour de France, the world’s pre-eminent bicycle race, defeating French cycling legend Bernard Hinault. Nine months later, LeMond lay in a hospital bed, his life in peril after a hunting accident, his career as a bicycle racer seemingly over. And yet, barely two years after this crisis, LeMond mounted a comeback almost without parallel in professional sports. In summer 1989, he again won the Tour—arguably the world’s most grueling athletic contest—by the almost impossibly narrow margin of 8 seconds over another French legend, Laurent Fignon. It remains the closest Tour de France in history. “[A] blend of chaos, kindness and cruelty typifies the scenes that journalist de Visé brings to life in this sympathetic-verging-on-reverential retelling of LeMond’s trailblazing career (first American to enter the tour, first to win it) . . . As an author in quest of his protagonist’s motivation, [de Visé] subjects it to extreme torque.”—The Washington Post “A great book . . . Well written and thoroughly researched . . . Engrossing and hard to put down. If you’re a Greg LeMond fan, The Comeback is a must read because it’s a detailed accounting of his career and―more importantly―his life and person off the bike. It’s also an important reminder that American cycling did not begin and end with Lance Armstrong.”—PEZ
Dengue is a major public health concern throughout the tropical and sub-tropical regions of the world. It is the most rapidly spreading mosquito-borne viral disease, with a 30-fold increase in global incidence over the past 50 years. Infection with any of the Dengue virus serotypes can be asymptomatic, cause the classic dengue fever, or evolve to severe disease, which leads to hypovolemic shock and death if untreated. There is no approved specific treatment, prognostic markers, or vaccines for dengue, in part because there is insufficient knowledge of dengue pathogenesis. In this e-book, we will focus on what we believe to be a true challenge in dengue research: to understand host–pathogen interactions. Disease development results from the interaction between host and viral factors, in which the host immune response is critical. Recent advances in dengue experimental models together with clinical data have provided useful information indicating that severe dengue hallmarks (excessive production of pro-inflammatory cytokines, endothelial activation, and plasma leakage) are immune-mediated events. We hope to present readers with a comprehensive description of the immune response to the Dengue virus, detailing how DENV unbalances host homeostasis.
The aim of this work is to provide a fuller spectrum of information in a single source on enzyme-catalyzed reactions than is currently available in any published reference work or as part of any Internet database. The Enzyme Reference: A Comprehensive Guidebook to Enzyme Nomenclature, Reactions, and Methods includes 20,000 review articles and seminal research papers. Additionally, it provides a novel treatment of so-called ATPase and GTPase reactions to account for the noncovalent substratelike and productlike states of molecular motors, elongation factors, transporters, DNA helicases, G-reulatory proteins, and other energases. - Includes a compendium of over 6,000 enzyme reactions (including enzyme commission numbers, alternative names, substrates, products, alternative substrates, and properties) - Covers over 900 chemical structures of key metabolites and cofactors - Index directs readers to the exact pages for over 9,500 enzyme names
Stress in the DSM is referred to only in the sense of post traumatic stress disorder (PTSD). However, some research studies estimate up to two thirds of illnesses seen by general practitioners are ‘stress related’–GI problems, sleep disturbance, mental concentration, headaches, fatigue, shortness of breath, high blood pressure, dermatitis, illnesses from lowered immune system, and vague aches and pains – all can be symptoms and outcomes of the elusive stress factor. This issue of Psychiatric Clinics of North America discusses the scientific medical facets of stress, written by mental health and medical practitioners. It looks at the brain-body connection of stress – what the body does to result in stress and varying results stress has on the body. This fascinating cross-discipline look at stress is intended for psychiatrists, general practitioners, cardiologists, GI specialists, neurologists, sleep medicine specialists, respiratory specialists, and others who diagnose and treat patients with stress suspected as part of the illness equation or with self-reported stress. Topics include: Measurement of stress; Anxiety and stress-how they work together; Relationship between genetics and stress; Role of glia in stress; Sleep and stress; Diet and stress; Supplements and stress; Effect of severe stress on early brain development, attachment, and emotions; Role of stress and fear on the development of psychopathology; Expressions of stress in psychiatric illness; Dermatologic manifestations of stress in normal and psychiatric populations; Humor and the psychological buffers of stress; Stress expression in children and adolescents; Stress in service members; Stress in the geriatric population.
This book critically assesses arguments for the existence of the God of classical theism, develops an innovative account of objects’ persistence, and defends new arguments against classical theism. The authors engage the following classical theistic proofs: Aquinas’s First Way, Aquinas’s De Ente argument, and Feser’s Aristotelian, Neo-Platonic, Augustinian, Thomistic, and Rationalist proofs. The authors also provide the first systematic treatment of the ‘existential inertia thesis’. By connecting the thesis to relativity theory and recent developments in the philosophy of physics, and by developing a variety of novel existential-inertia-friendly explanations of persistence, they mount a formidable new case against classical theistic proofs. Finally, they defend new arguments against classical theism based on abstract objects and changing divine knowledge. The text appeals to students, researchers, and others interested in classical theistic proofs, the existence and nature of God, and the ultimate explanations of persistence, change, and contingency.
The life and songs of singer-songwriter Momus during his time at Creation records and beyond. Momus - the stage name of musician Nicholas Currie - is one of the most prolific and talented indie songwriters of the last forty years. His work is controversial, influential and highly regarded. From aspiring indie pop star of the 1980s to Japanese chart success in the 1990s through many experimental works to the present day, he has been a constant in the search for intelligent, thinking person's pop. Jarvis Cocker asked him to produce his band Pulp, the NME memorably awarded his album "Hippopotamomus" 0/10, Creation Records dropped him when he proved too dangerous for them, and his more controversial work led to astounding legal tussles. His personal life has involved scandal and heartbreak and he lost an eye following an infection, resulting in his distinctive eye-patch. His songs including "The Hairstyle of the Devil", "The Guitar Lesson" and "I Want You but I Don't Need You" are acclaimed and have been covered by artists including Amanda Palmer and Steven Wilson.
To many, the racing bicycle is a cult object, a vehicle of dreams, a marvel of engineering and aesthetics. With such enthusiasts in mind, Bike! Is the first book to be produced on the history of the world's most famous racing-bike and component manufacturers. Within its pages you will discover the beautifully illustrated story of the artisans and visionary sportspeople who joined forces to create two-wheeled legends. From the cradle of road biking on the plains of northern Italy to the birthplace of mountain biking, Marin County, California, Bike! unmasks the soul behind names like Colnago, Shimano and Campagnolo. Distributed throughout the book are special double-page photographic features on ten landmark bikes that were the first to introduce groundbreaking technology, from Maurice Garin's Ondiana cycle in the first Tour de France of 1903 to the Team Sky Pinarello Dogma of 2010. Completed by sublime photography and graphic timelines, this book is the most striking tribute ever created to the craftsmanship, precision and speed of the racing bicycle. Edited by seasoned cycling veteran and bestselling author Richard Moore, Bike! is the perfect book for cycling fanatics and design aficionados alike.
Metabolic inhibitors and receptor antagonists are indispensable tools for the molecular life scientist. By blocking specific enzymes or receptor-mediated signal transduction cascades, they simplify the analysis of complex cellular processes especially when it is essential to demonstrate that a process of interest is functionally linked to a particular enzyme or receptor. From antibiotics to statins, modern medicine relies on the reliability and ease-of-use of enzyme- and receptor-directed inhibitors and antagonists.The Inhibitor Index is a comprehensive, curated compendium of over 7,800 enzyme inhibitors and receptor antagonists, including many toxins, poisons, and metabolic uncouplers.
The report provides insight into common airport self-inspection practices. For the purposes of ACRP Synthesis 27, a comprehensive self-inspection program includes the components of training; inspecting; reporting discrepancies and findings; follow-up, resolution, and close-out; and quality control. The report may be useful to airports in benchmarking their self-inspection programs to peer airports and practices considered successful by regional U.S. Federal Aviation Administration personnel.
The Tour de France is a phenomenon of such scale that it transcends sport. Whether you are mesmerised by the scenery, captivated by its sporting drama or spellbound by the sheer athleticism of the riders, the Tour de France is one of sport’s most compelling events. It’s a race of mythical proportions, filled with spectacle and superhuman feats of endurance. But what makes the Tour truly unique is that almost all who ride it are equally revered. That a rider has never worn the yellow jersey, let alone won the race, does not make him any less of a hero. The Tour de France inspires the powerful of mind and body to extraordinary achievements, and shines a light on the true nature of the men who battle for glory over three torturous weeks. Legends of the Tour is a tribute to the dedication of the latest generation of riders to tackle the race, from those who stand proud atop the podium, to those who work tirelessly to help elevate their teammates to champions. These are the cycling legends of today and tomorrow.
Bradley Wiggins is Britain's most successful and best known cyclist - winner of the 2012 Tour de France, gold in the Olympic time trial at the London 2012 Olympics and Olympic gold on the track. Daniel Friebe celebrates Wiggo's record breaking summer, as Team Sky took on the Tour de France and brought home the yellow jersey. 'Allez Wiggo!' - the cry of the French fans lining the roads who fell in love with our mod genius on two wheels.
Readers as well as listeners can now embark on a journey through the cycling year with The Cycling Podcast, which has been entertaining and informing fans since 2013. Richard Moore, Lionel Birnie and Daniel Friebe share their diaries from three incident-filled Grand Tours, the Giro d’Italia, Tour de France and Vuelta a España. These take readers behind the scenes and explore the culture and landscape as well as the racing, while the ‘Lionel of Flanders’, complete with beer recommendations, does the same for the Classics in Belgium. There are appearances, too, by leading journalists and podcast favourites François Thomazeau, who takes responsiblity for the French Tour de France jinx, Ciro Scognamiglio, with a heartfelt love letter to cult favourite Filippo Pozzato, Fran Reyes, who pens a farewell to El Pistolero, Alberto Contador, and Orla Chennaoui, who hits the road to cover La Course in a one-woman karaoke-booth-on-wheels. Further contributions from professional riders Ashleigh Moolman Pasio and Joe Dombrowski and the voice of the Tour de France, Sebastien Piquet, as well as stunning galleries from the podcast world’s first and only dedicated photographer, Simon Gill, make this the perfect celebration of a year in cycling.
The hidden gems of Europe's best roads and passes, from the authors of the hugely successful Mountain High. Following the success of Mountain High: Europe's Greatest Cycle Climbs comes a volume focusing on the continent's lesser-known, challenging and spectacular mountain roads and passes. From the heights of the Ötztal Glacier Road in Austria to the 'secret' side of the legendary Alpe d'Huez, Mountain Higher: Europe's Extreme, Undiscovered and Unforgettable Cycle Climbs explores 50 soon-to-be cult locations and captures stunning scenery from off the beaten track. Featuring the technical details (maps, profiles, lengths, heights) that made Mountain High an indispensable reference book, as well as dynamic descriptions of the routes themselves and Pete Goding's breathtaking photography, this book is a stylish and practical guide to the hidden gems that every true cycling enthusiast needs to know about.
In these meditations Daniel Bourguet enables us to draw alongside the thief on the cross and enter his dialogue with Christ; he guides us downward into the darkness of hell through a reading of Psalm 88; and finally we discover on Easter morning both the confusion and then faith of Mary Magdalene as she meets the Risen Lord (John 20). Bourguet's confidence in the biblical text means that he engages with it and follows wherever it leads, however risky . . . and he emerges--with us--miraculously enriched.
From Lo-Debar to the King's Table is a truly inspiring and uplifting account of Daniel's life and journey from having an orphan heart to Sonship. The book takes you through Daniel's heart-wrenching childhood experiences of feeling unloved, abandoned, lonely, alienated, and isolated. However, his resilience and determination to overcome the obstacles that life has dealt him show his unwavering faith and trust in God. Daniel's story teaches us that even in the face of adversity, we can find strength and hope through our faith in Father God and ultimately that our true identity is only found in Him. Do you know who you are? Where does your identity lie? This book will show you how to find your identity in Christ by seeking His face, ending up in His embrace, as you become an eternal son or daughter of King Jesus! --Lisa Clayton, founder of Get Them to Jesus Ministries and author of A Map from the Womb to Eternity Do you know who you are? Where does your identity lie? This book will show you how to find your identity in Christ by seeking His face, ending up in His embrace, as you become an eternal son or daughter of King Jesus! --Lisa Clayton, founder of Get Them to Jesus Ministries and author of A Map from the Womb to Eternity
Schaeffer takes a personal look at God's providence in difficult circumstances. This insightful study takes readers through the often overlooked book of Esther, uncovering the way God moves in all our lives--silent yet active. Discussion questions and studies of the main characters in the story of Esther help readers find a practical perspective on how God moves in our daily lives.
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