This issue of Hematology/Oncology Clinics will focus on Gene Therapy. Topics include, but are not limited to Historical Perspective and Current Renaissance, Integrating Vectors, Nonintegrating Vectors, Gene Editing, Conditioning Therapies for Autologous HSCT, Approaches to Immunodeficiency, Approaches to Hemoglobinopathy, Approaches to Hemophilia, Hematopoietic Gene Therapies for Neurologic and Metabolic Disease, Gene Therapy Approaches to HIV and other Infectious Diseases, HSC Approaches to Cancer, and Gene Modified T Cell Therapies for Cancer.
Editors Daniel B. Spagnoli, Brian B. Farrell, and Myron R. Tucker review important areas in Orthognathic Surgery. Articles will include: Timing of Three-Dimensional Virtual Treatment Planning of Orthognathic Surgery: a Prospective Single-Surgeon Evaluation on 350 Consecutive Cases; Orthodontic Preparation for Orthognathic Surgery; Applications of Navigation for Orthognathic Surgery; Mandibular Surgery: Technologic and Technical Improvements; Maxillary Orthognathic Surgery; Surgical Assistance for Rapid Orthodontic Treatment and Temporary Skeletal Anchorage; Management of Cleft Lip and Palate and Cleft Orthognathic Considerations; Orthognathic Surgery and the TMJ Patient; Complications in Orthognathic Surgery: Report of 1000 Cases; Orthognathic Surgery in the Office Setting; Esthetic Adjuncts with Orthognathic Surgery; Virtual Surgical Planning in Orthognathic Surgery; and more!
Get the latest, most reliable cancer management recommendations in the famous fast-access Washington Manual® outline format! Concise, clearly written sections on principles of oncology, site-specific diseases, and supportive therapy make The Washington Manual® of Oncology, 3rd Edition, an invaluable resource for the daily care of cancer patients. The Washington Manual® is a registered mark belonging to Washington University in St. Louis to which international legal protection applies. The mark is used in this publication by LWW under license from Washington University. Better understand innovative developments in oncology with new chapters on Genome Sequencing, Personalized Therapy, Endocrine Tumors, Myelodysplastic Syndromes, Anti-emesis and Survivorship. Focus on new ideas in the field thanks to a greater emphasis on molecular diagnosis, genome sequencing, and targeted therapies. Quickly locate key information in the appendices, such as body surface area, dose adjustments of chemotherapy agents in renal and hepatic failure, and online resources for oncologists. Benefit from proven treatment recommendations from the experts at Washington University in St. Louis – ideal for the busy third and fourth year student, resident, or clinician.
Polls tell us that most Americans--whether they earn $20,000 or $200,000 a year--think of themselves as middle class. As this phenomenon suggests, "middle class" is a category whose definition is not necessarily self-evident. In this book, historian Daniel Walkowitz approaches the question of what it means to be middle class from an innovative angle. Focusing on the history of social workers--who daily patrol the boundaries of class--he examines the changed and contested meaning of the term over the last one hundred years. Walkowitz uses the study of social workers to explore the interplay of race, ethnicity, and gender with class. He examines the trade union movement within the mostly female field of social work and looks at how a paradigmatic conflict between blacks and Jews in New York City during the 1960s shaped late-twentieth-century social policy concerning work, opportunity, and entitlements. In all, this is a story about the ways race and gender divisions in American society have underlain the confusion about the identity and role of the middle class.
Integrative tools for healing the traumatized mind and body • Combines cutting-edge Western cognitive-behavioral therapy (CBT) and ancient Eastern wisdom to heal Post-Traumatic Stress Disorder (PTSD) • Teaches Kundalini yoga practices specifically designed to reset parts of the brain and body affected by PTSD • Presents a fast-acting, holistic, evidence-based, and drug-free program for eliminating PTSD symptoms and restoring health, vitality, and joy Trauma, the Greek word for “wound,” is the most common form of suffering in the world today. An inescapable part of living, the bad things that happen to us always leave aftereffects in both body and mind. While many people experience these aftereffects and move on, millions of others develop Post-Traumatic Stress Disorder (PTSD)--a painful, chronic, and debilitating barrier to happiness. Reclaiming Life after Trauma addresses both the physical and psychological expressions of PTSD, presenting an integrative, fast-acting, evidence-based, and drug-free path to recovery. Authors Daniel Mintie, LCSW, and Julie K. Staples, Ph.D., begin with an overview of PTSD and the ways in which it changes our bodies and minds. They present research findings on cognitive-behavioral therapy (CBT) and yoga, giving the reader insights into how these powerful modalities can counteract and reverse the physical and mental aftereffects of trauma. The authors provide a suite of simple, powerful, and easily learned tools readers can put to immediate use to reset their traumatized bodies and minds. On the physical side, they teach four Kundalini yoga techniques that address the hypervigilance, flashbacks, and insomnia characteristic of PTSD. On the psychological side, they present 25 powerful CBT tools that target the self-defeating beliefs, negative emotions, and self-sabotaging behaviors that accompany the disorder. Drawing on many years of clinical work and their experience administering the successful Integrative Trauma Recovery Program, the authors help readers understand PTSD as a mind-body disorder from which we can use our own minds and bodies to recover. Woven throughout the book are inspiring real-life accounts of PTSD recoveries showing how men and women of all ages have used these tools to reclaim their vitality, physical health, peace, and joy.
How humanity brought about the climate crisis by departing from its evolutionary trajectory 15,000 years ago—and how we can use evolutionary principles to save ourselves from the worst outcomes. Despite efforts to sustain civilization, humanity faces existential threats from overpopulation, globalized trade and travel, urbanization, and global climate change. In A Darwinian Survival Guide, Daniel Brooks and Salvatore Agosta offer a novel—and hopeful—perspective on how to meet these tremendous challenges by changing the discourse from sustainability to survival. Darwinian evolution, the world’s only theory of survival, is the means by which the biosphere has persisted and renewed itself following past environmental perturbations, and it has never failed, they explain. Even in the aftermath of mass extinctions, enough survivors remain with the potential to produce a new diversified biosphere. Drawing on their expertise as field biologists, Brooks and Agosta trace the evolutionary path from the early days of humans through the Late Pleistocene and the beginning of the Anthropocene all the way to the Great Acceleration of technological humanity around 1950, demonstrating how our creative capacities have allowed humanity to survive. However, constant conflict without resolution has made the Anthropocene not only unsustainable, but unsurvivable. Guided by the four laws of biotics, the authors explain how humanity should interact with the rest of the biosphere and with each other in accordance with Darwinian principles. They reveal a middle ground between apocalypse and utopia, with two options: alter our behavior now at great expense and extend civilization or fail to act and rebuild in accordance with those same principles. If we take the latter, then our immediate goal ought to focus on preserving as many of humanity’s positive achievements—from high technology to high art—as possible to shorten the time needed to rebuild.
Global warming and climate change present complex interlocking issues of public policy, multilateral negotiation, and technological advancement. This book explores both the problems and the opportunities presented by international agreements, and examines the technological developments and policy goals that can be pursued to effect the changes necessary. Specific steps are proposed in the form of a list of priorities. This book represents a cooperative enterprise between two authors of different backgrounds - engineering and international relations - and is directed to an educated but non-professional lay audience without any formal training in either science or international relations. The points of view of negotiators from both developed and developing nations are presented and compared. Each topic is presented from both technical and policy perspectives as a means to evaluate the variety of proposals that have been offered as remedies to global warming. The text is supported by illustrations and tables where appropriate, including a list of References at the end of each chapter.
This work completes Daniel Block's two-volume commentary on the book of Ezekiel. The result of twelve years of studying this difficult section of Scripture, this volume, like the one on chapters 1-24, provides an excellent discussion of the background of Ezekiel and offers a verse-by-verse exposition that makes clear the message of this obscure and often misunderstood prophet. Block also shows that Ezekiel's ancient wisdom and vision are still very much needed as we enter the twenty-first century.
Acclaimed for its unsurpassed readability and manageable scope, Ashcraft’s Pediatric Surgery presents authoritative, practical guidance on treating the entire range of general surgical and urological problems in infants, children, and adolescents. State-of-the-art, expert coverage equips you to implement all the latest approaches and achieve optimal outcomes for all of your patients. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Make the most effective use of today’s best open and minimally invasive techniques, including single-site umbilical laparoscopic surgery, with guidance from internationally recognized experts in the field. Focus on evidence-based treatments and outcomes to apply today’s best practices. Stay current with timely topics thanks to brand-new chapters on Choledochal Cyst and Gallbladder Disease, Tissue Engineering, and Ethics in Pediatric Surgery, plus comprehensive updates throughout. Hone and expand your surgical skills by watching videos of minimally invasive procedures for recto urethral fistula, biliary atresia, laparoscopic splenectomy, uterine horn, and more. Grasp the visual nuances of surgery from over 1,000 images depicting today’s best surgical practices.
Inside the 3rd edition of this esteemed masterwork, hundreds of the most distinguished authorities from around the world provide today's best answers to every question that arises in your practice. They deliver in-depth guidance on new diagnostic approaches, operative technique, and treatment option, as well as cogent explanations of every new scientific concept and its clinical importance. With its new streamlined, more user-friendly, full-color format, this 3rd edition makes reference much faster, easier, and more versatile. More than ever, it's the source you need to efficiently and confidently overcome any clinical challenge you may face. Comprehensive, authoritative, and richly illustrated coverage of every scientific and clinical principle in ophthalmology ensures that you will always be able to find the guidance you need to diagnose and manage your patients' ocular problems and meet today's standards of care. Updates include completely new sections on "Refractive Surgery" and "Ethics and Professionalism"... an updated and expanded "Geneitcs" section... an updated "Retina" section featuring OCT imaging and new drug therapies for macular degeneration... and many other important new developments that affect your patient care. A streamlined format and a new, more user-friendly full-color design - with many at-a-glance summary tables, algorithms, boxes, diagrams, and thousands of phenomenal color illustrations - allows you to locate the assistance you need more rapidly than ever.
The aim of this work is to provide a fuller spectrum of information in a single source on enzyme-catalyzed reactions than is currently available in any published reference work or as part of any Internet database. The Enzyme Reference: A Comprehensive Guidebook to Enzyme Nomenclature, Reactions, and Methods includes 20,000 review articles and seminal research papers. Additionally, it provides a novel treatment of so-called ATPase and GTPase reactions to account for the noncovalent substratelike and productlike states of molecular motors, elongation factors, transporters, DNA helicases, G-reulatory proteins, and other energases. - Includes a compendium of over 6,000 enzyme reactions (including enzyme commission numbers, alternative names, substrates, products, alternative substrates, and properties) - Covers over 900 chemical structures of key metabolites and cofactors - Index directs readers to the exact pages for over 9,500 enzyme names
The recent discovery of high-temperature superconductivity in copper based oxides is an event of major importance not only with respect to the physical phenomenon itself but also because it definitely shows that solid state chemistry, and especially the crystal chemistry of oxides, has a crucial place in the synthesis and understanding of new materials for future appli cations. The numerous papers published in the field of high Tc supercon ductors in the last five years demonstrate that the great complexity of these materials necessitates a close collaboration between physicists and solid state chemists. This book is based to a large extent on our experience of the crystal chemistry of copper oxides, which we have been studying in the laboratory for more than twelve years, but it also summarizes the main results which have been obtained for these compounds in the last five years relating to their spectacular superconducting properties. We have focused on the struc ture, chemical bonding and nonstoichiometry of these materials, bearing in mind that redox reactions are the key to the optimization of their supercon ducting properties, owing to the importance of the mixed valence of copper and its Jahn-Teller effect. We have also drawn on studies of extended defects by high-resolution electron microscopy and on their creation by ir radiation effects.
Based on DeVita, Hellman, and Rosenberg’s Cancer: Principles and Practice of Oncology, Eleventh Edition, this comprehensive review book covers the entire specialty of oncology, including new or expanded coverage of molecular biology; epidemiology and etiology; screen and prevention; genetics; clinical trials; and immunotherapy. Inside, readers will discover hundreds of multiple-choice and case-based questions, along with detailed answers and explanations to help explain the how and why behind each correct response. The ideal way to maximize exam scores for today’s student and residents! Learning and review features include: Hundreds of multiple-choice and case-based questions to build comprehension and improve retention. All topics cross-referenced to the latest edition of DeVita, Hellman, and Rosenberg’s Cancer: Principles & Practice of Oncology, Eleventh Edition. Material on all aspects of oncology, including medical, radiation and surgical oncology, as well as hematology/oncology issues.
This work focuses on the therapeutics, safety and risk information of herbs and supplements used during pregnancy and lactation for obstetricians, maternal-fetal medicine specialists and primary care physicians.
The contemporary crisis of emerging disease has been a century and a half in the making. Human, veterinary, and crop health practitioners convinced themselves that disease could be controlled by medicating the sick, vaccinating those at risk, and eradicating the parts of the biosphere responsible for disease transmission. Evolutionary biologists assured themselves that coevolution between pathogens and hosts provided a firewall against disease emergence in new hosts. Most climate scientists made no connection between climate changes and disease. None of these traditional perspectives anticipated the onslaught of emerging infectious diseases confronting humanity today. As this book reveals, a new understanding of the evolution of pathogen-host systems, called the Stockholm Paradigm, explains what is happening. The planet is a minefield of pathogens with preexisting capacities to infect susceptible but unexposed hosts, needing only the opportunity for contact. Climate change has always been the major catalyst for such new opportunities, because it disrupts local ecosystem structure and allows pathogens and hosts to move. Once pathogens expand to new hosts, novel variants may emerge, each with new infection capacities. Mathematical models and real-world examples uniformly support these ideas. Emerging disease is thus one of the greatest climate change–related threats confronting humanity. Even without deadly global catastrophes on the scale of the 1918 Spanish Influenza pandemic, emerging diseases cost humanity more than a trillion dollars per year in treatment and lost productivity. But while time is short, the danger is great, and we are largely unprepared, the Stockholm Paradigm offers hope for managing the crisis. By using the DAMA (document, assess, monitor, act) protocol, we can “anticipate to mitigate” emerging disease, buying time and saving money while we search for more effective ways to cope with this challenge.
Few modern innovations have spread quite so quickly as the cell phone. This technology has transformed communication throughout the world. Mobile telecommunications have had a dramatic effect in many regions, but perhaps nowhere more than for low-income populations in countries such as Jamaica, where in the last few years many people have moved from no phone to cell phone. This book reveals the central role of communication in helping low-income households cope with poverty. The book traces the impact of the cell phone from personal issues of loneliness and depression to the global concerns of the modern economy and the transnational family. As the technology of social networking, the cell phone has become central to establishing and maintaining relationships in areas from religion to love. The Cell Phone presents the first detailed ethnography of the impact of this new technology through the exploration of the cell phone's role in everyday lives.
The Comprehensive Sourcebook of Bacterial Protein Toxins, Fourth Edition, contains chapters written by internationally known and well-respected specialists. This book contains chapters devoted to individual toxins, as well as chapters that consider the different applications of these toxins. Considerable progress has been made in understanding the structure, function, interaction and trafficking into cells, as well as mechanism of action of toxins. Bacterial toxins are involved in the pathogenesis of many bacteria, some of which are responsible for severe diseases in human and animals, but can also be used as tools in cell biology to dissect cellular processes or used as therapeutic agents. Novel recombinant toxins are already proposed in the treatment of some diseases, as well as new vaccines. Alternatively, certain toxins are also considered as biological weapons or bioterrorism threats. Given the multifaceted aspects of toxin research and the multidisciplinary approaches adopted, toxins are of great interest in many scientific areas from microbiology, virology, cell biology to biochemistry and protein structure. This new edition is written with a multidisciplinary audience in mind and contains 5 new chapters that reflect the latest research in this area. Other chapters have been combined, deleted and fully revised as necessary to deliver relevant and valuable content. - Descriptions of relevant toxins as well as representative toxins of the main bacterial toxin families to allow for a better comparison between them - Focused chapters on toxin applications and common properties or general features of toxins
Designed for quick, everyday reference, Handbook of Targeted Cancer Therapy and Immunotherapy, 3rd Edition, includes clinical trial results of more than 250 state-of-the-art targeted therapy and immunotherapy agents, providing a practical, intuitive, colorful overview of this rapidly advancing field. Comprehensive yet concise, this easy-access resource by Drs. Daniel D. Karp, Gerald S. Falchook, and JoAnn D. Lim, helps you navigate through the newest research reports and apply the most recent discoveries as they pertain to specific tumor types, actionable molecular targets, and clinical performance of investigational targeted agents and combinations of agents. This handbook presents information distilled by dozens of translational research clinicians and other healthcare experts with hundreds of years of cumulative experience in the revolutionary area of genomically based precision oncology.
This Volume contains the papers presented by twenty-eight invited speakers at the symposium entitled, "Genetic Manipulation of Woody Plants," held at Michigan State University, East Lansing, Michigan, from June 21-25, 1987. Also included are abstracts of contributed poster papers presented during the meeting. That the molecular biology of woody plants is a rapidly expanding field is attested to by the large attendance and high level of enthusiasm generated at the conference. Leading scientists from throughout the world discussed challenging problems and presented new insights into the devel opment of in vitro culture systems, techniques for DNA analysis and manipulation, gene vector systems, and experimental systems that will lead to a clearer understanding of gene expression and regulation for woody plant species. The presence at the conference of both invited speakers and other scientists who work with nonwoody plant species also added depth to the discussions and applicability of the information presented at the conference. The editors want to commend the speakers for their well-organized and informative talks, and feel particularly indebted to the late Dr. Alexander Hollaender and others on the planning committee who assist ed in the selection of the invited speakers. The committee consisted of David Burger (University of California, Davis), Don J. Durzan (University of California, Davis) , Bruce Haissig (U. S. Department of Agriculture Forest Service), Stanley Krugman (U. S. Department of Agriculture Forest Service) , Ralph Mott (North Carolina State University), Otto Schwarz (Univer.sity of Tennessee, Knoxville), and Roger Timmis (Weyerhaeuser Company).
This will help us customize your experience to showcase the most relevant content to your age group
Please select from below
Login
Not registered?
Sign up
Already registered?
Success – Your message will goes here
We'd love to hear from you!
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.