Investing in commercial real estate can provide excellent risk-return opportunities for both the large and small investor. Unlike equity securities, commercial real estate often generates a substantial and predictable cash flow over time--and the compounding effect of this cash flow can significantly enhance the performance of most investment portfolios. Filled with in-depth insight and practical advice, The Real Estate Investment Handbook is an essential tool for current and aspiring commercial real estate investors looking to develop and evaluate commercial real estate properties. Throughout the book, experts G. Timothy Haight and Daniel D. Singer offer careful examinations of the various types of commercial real estate available, the measures within the markets used to evaluate their performance, and the intricacies of the markets in which they are traded. The discussions of breakeven analysis, present value, financial leverage, loan packaging, and practical real-life situations found in The Real Estate Investment Handbook will help you make better-informed decisions when investing in properties such as: * Apartments, condominiums, and time-shares * Single-family homes * Self-storage facilities * Office buildings * Industrial properties * Parking lots * Shopping centers * Hotels and motels Successful real estate investing is not just about net income or cash flow; it's about the fit between an investor and an investment. With The Real Estate Investment Handbook as your guide, you'll learn how to choose properties that make sense--and money--for you.
This book will change the way you think about and invest in your retirement savings plan-forever. Internationally bestselling author and consumer advocate Dan Solin challenges some basic and misguided assumptions about traditional retirement plans to reveal that: ? 401(k) and 403(b) plans are laden with Porky Pig fees, poor investment choices, and conflicts of interest. You may be better off just saying "No!" ? There is a simple way to make smart choices in these plans- and this book shows you exactly what to do and which funds to avoid. ? There is one investment that could be the key to a successful retirement plan. You can do it yourself, with pre-tax or after-tax money. Create your own, inflation-proof pension plan that is guaranteed to provide you with monthly income for as long as you live, and beyond! Smart Investing is not complicated. You have the power to make meaningful changes to your retirement savings plan-no matter what your age or financial status. "If you haven't taken a recent look at what your own retirement investments are doing and-perhaps even more important-how they are put together, reading Solin's smart little book might provide the impetus for action." -Miami Herald
This management manual and textbook introduces the theoretical basics of process management and provides a procedural model for process innovation. The procedural model makes it possible to develop customer-oriented processes in a structured manner and to design them in order to meet changing requirements. This textbook has been recommended and developed for university courses in Germany, Austria and Switzerland. This book enables readers to understand and apply the seven phase procedural model for process innovation in order to design and implement innovative processes. Exercises and review questions test understanding of the theoretically acquired knowledge.
In this chapter we discuss sepsis-induced inflammation and organ dysfunction, as well as the role of autophagy as a protective cell signaling mechanism. Sepsis is a leading cause of death worldwide, and is the most common precipitant of organ dysfunction. It has been noted that a minimal amount of cell death is present in patients who succumb to sepsis-induced organ failure and that, after the septic insult has passed, organs have the potential to regain function, suggesting a hibernating state of the cell in order to protect it from apoptosis and death. The cellular and molecular processes involved in sepsis are complex, and continue to be elucidated. Autophagy has been extensively studied in recent decades and an exponential increase in knowledge regarding this physiological pathway used by cells has been found. It is known to be activated under stress conditions in order to protect the cell from dying. In the setting of sepsis it has been demonstrated to play an important role for recycling of unhealthy mitochondria and damaged organelles, thus decreasing injury by ROS and providing nutrients and amino acids that the cell can use in this stressful environment. The purpose of this chapter is to review what is known about autophagy in sepsis and describe the contributing mechanisms by which autophagy can protect against organ injury.
This highly influential work--now in a revised and expanded third edition incorporating major advances in the field--gives clinicians, educators, and students a new understanding of what the mind is, how it grows, and how to promote healthy development and resilience. Daniel J. Siegel synthesizes cutting-edge research from multiple disciplines, revealing the ways in which neural processes are fundamentally shaped by interpersonal relationships throughout life. And even when early experiences are not optimal, building deeper connections to other people and to one's own internal experience remains a powerful resource for growth. Professors praise the book’s utility in courses from developmental psychology and child development to neuroscience and counseling. New to This Edition *Incorporates findings from a huge body of recent research; over 1,000 citations added. *Revisits and refines the core hypotheses of interpersonal neurobiology. *Chapter on the experience of belonging and the development of identity. *New or expanded discussions of behavioral epigenetics, the default mode network of the brain, social neuroscience, cultural and gender issues, theory of mind, the Wheel of Awareness contemplative practice, the science of consciousness, and more.
An essential history of the May 1968 upheaval in France--and how it changed the world. Prelude to Revolution is the indispensable study of May 1968. Generations have looked to this book for inspiration. Singer, who died in 2000, was widely considered the most adept interpreter of European politics for American audiences. He shows here how change happens--and why it is needed
Topics in Behavioral Neurology and Neuropsychology provides information pertinent to neuropsychology and behavioral neurology. This book serves as a guide to those caring for patients with disorders of higher cortical function. Organized into 18 chapters, this book begins with an overview of the classes of disorders of higher cortical function according to major behavioral disturbance. This text then presents the various classification schemes for aphasic syndromes. Other chapters consider the multidimensional process of the analysis of various speech disorders, including dysprosody, dysarthria, hysteria, anomia, and aphasia. This book discusses as well the various forms of alexia, including pure alexia, alexia, alexia with agraphia, and frontal alexia. The final chapter deals with stroke and other brain disorders. This book is a valuable resource for neurologists, psychiatrists, neuroscientists, neuropsychologists, neurology residents, speech pathologists, and rehabilitation medicine specialists. Readers who are interested in the study of the disorders of the higher cortical function will also find this book useful.
The aim of this work is to provide a fuller spectrum of information in a single source on enzyme-catalyzed reactions than is currently available in any published reference work or as part of any Internet database. The Enzyme Reference: A Comprehensive Guidebook to Enzyme Nomenclature, Reactions, and Methods includes 20,000 review articles and seminal research papers. Additionally, it provides a novel treatment of so-called ATPase and GTPase reactions to account for the noncovalent substratelike and productlike states of molecular motors, elongation factors, transporters, DNA helicases, G-reulatory proteins, and other energases. - Includes a compendium of over 6,000 enzyme reactions (including enzyme commission numbers, alternative names, substrates, products, alternative substrates, and properties) - Covers over 900 chemical structures of key metabolites and cofactors - Index directs readers to the exact pages for over 9,500 enzyme names
Clinical psychologist Daniel J. Flannery reveals the impact of violence and victimization in the lives of children and adolescents from a developmental perspective. He offers case studies and professional resources, including web sites and readings related to violence and mental health. It is an essential resource for parents and public health practitioners in school systems, mental health, and social work, as well as professionals in juvenile justice and law enforcement.
This bestselling book put the field of interpersonal neurobiology on the map for over 100,000 readers. Daniel J. Siegel goes beyond the nature and nurture divisions that traditionally have constrained much of our thinking about development, exploring the role of interpersonal relationships in forging key connections in the brain. He presents a groundbreaking new way of thinking about the emergence of the human mind and the process by which each of us becomes a feeling, thinking, remembering individual. Illuminating how and why neurobiology matters, this book is essential reading for clinicians, educators, researchers, and students interested in promoting healthy development and resilience. Professors praise the book’s utility in courses from developmental psychology and child development to neuroscience and counseling. New to This Edition *Incorporates significant scientific and technical advances. *Expanded discussions of cutting-edge topics, including neuroplasticity, epigenetics, mindfulness, and the neural correlates of consciousness. *Useful pedagogical features: pull-outs, diagrams, and a glossary. *Epilogue on domains of integration--specific pathways to well-being and therapeutic change.
Are you looking for concise, practical answers to those questions that are often left unanswered by traditional pediatric neurology references? Are you seeking brief, evidence-based advice for complicated cases or controversial decisions? Curbside Consultation in Pediatric Neurology: 49 Clinical Questions provides quick answers to the tricky questions most commonly posed during a “curbside consultation” between pediatricians. Dr. Daniel Licht and Dr. Nicole R. Ryan have designed this unique reference which offers expert advice, preferences, and opinions on tough clinical questions commonly associated with pediatric neurology. The unique Q&A format provides quick access to current information related to pediatric neurology with the simplicity of a conversation between two colleagues. Numerous images, diagrams, and references allow readers to browse large amounts of information in an expedited fashion. Some of the questions that are answered: When should I consider head imaging in a child with headache? CT or MRI? What is the acute management after a concussion? When can a child return to school and sports? What are the important things to consider when you see a child with the complaint of vision changes? Are there any diet changes or vitamins that may help a child with epilepsy? What are the signs of a stroke in a child? Are there other conditions that can present like a stroke? What are common causes of acute ataxia? What are the neurodevelopmental disorders leading to language delay and what work-up is needed? What are the Causes of Guillain-Barré Syndrome, How Often Does It Occur, and How Do You Treat It? Curbside Consultation in Pediatric Neurology: 49 Clinical Questions provides information basic enough for residents while also incorporating expert advice that even high-volume pediatricians will appreciate. Pediatricians, family practitioners, and pediatric residents will benefit from the user-friendly, casual format and the expert advice contained within.
The essence of the covenant tradition is the idea of human beings freely associating for common purposes through pacts of mutual commitment. In the political realm, the idea of covenant has been particularly influential in frontierlands. Reinformed by the idea of the federated commonwealth that emerged out of the Protestant Reformation, covenant eventually fostered the establishment of the United States of America and our modern idea of federalism. More recently, these great products of the covenant tradition helped to bring about the collapse of twentieth-century totalitarianism and fueled a new spirit in contemporary political life throughout the world. A return to political covenantalism seems to be an appropriate response to the crisis of modern civilization and the new epoch after World War II. Covenant and Civil Society is the final volume in Elazar's monumental series The Covenant Tradition in Politics. In it, he traces the tradition's rebirth and development in the modern epoch.Covenant and Civil Society also considers issues of communal solidarity on a postmodern basis. Elazar traces the transition from the covenanted commonwealth of the Protestant Reformation to the civil society of the modern epoch, and explores the covenant's role in the modern statist era and the development of modern democracy. Scandiriavia, and the Latin-Germanic borderlands, many of which are typically thought of as examples of organic or hierarchical models. Elazar argues that a covenantal model is more appropriate and is part of the Western tradition as such.The book concludes with examination of the present and future of covenantal thought. Today, the global spread of federalism, most clearly seen in the formation of the European Union, is also seen in local and private arenas. Elazar considers the benefits of covenantal thought while balancing such optimism with a realistic sense of its limits. As a prescription for change, Covenant and Civil Society is a fundamental and original contribution. Along with the previous volumes in this series, all available from Transaction, it will be of deep interest to historians, social scientists, political theorists, and theologians of all persuasions.
This book examines and evaluates the strategies utilized to design and synthesize pharmaceutically active agents. Significant updates over the last 10 years since the publication of the 1st edition include synthesis of enantiomerically pure isomers, novel chemical methodologies, and new pharmaceutical agents targeted at novel biological endpoints. Written by an experienced successful author, this book meets the needs of a growing community of researchers in pharmaceutical R &D, as well as medical professionals, by providing a useful guide for designing and synthesizing pharmaceutical agents. Additionally, it is a useful text for medicinal chemistry students.
This book describes the major achievements and discoveries relevant to bacterial protein toxins since the turn of the new century illustrated by the discovery of more than fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates. - Edited by two of the most highly regarded experts in the field from the Institut Pasteur, France - 14 brand new chapters dedicated to coverage of historical and general aspects of toxinology - Includes the major toxins of both basic and clinical interest are described in depth - Details applied aspects of toxins such as therapy, vaccinology, and toolkits in cell biology - Evolutionary and functional aspects of bacterial toxins evaluated and summarized - Toxin applications in cell biology presented - Therapy (cancer therapy, dystonias) discussed - Vaccines (native and genetically engineered vaccines) featured - Toxins discussed as biological weapons, comprising chapters on anthrax, diphtheria, ricin etc.
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