This book describes the major achievements and discoveries relevant to bacterial protein toxins since the turn of the new century illustrated by the discovery of more than fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates. - Edited by two of the most highly regarded experts in the field from the Institut Pasteur, France - 14 brand new chapters dedicated to coverage of historical and general aspects of toxinology - Includes the major toxins of both basic and clinical interest are described in depth - Details applied aspects of toxins such as therapy, vaccinology, and toolkits in cell biology - Evolutionary and functional aspects of bacterial toxins evaluated and summarized - Toxin applications in cell biology presented - Therapy (cancer therapy, dystonias) discussed - Vaccines (native and genetically engineered vaccines) featured - Toxins discussed as biological weapons, comprising chapters on anthrax, diphtheria, ricin etc.
Discover how to best provide effective mental health treatments for criminal offenders Prisons and jails are increasingly being filled with inmates who suffer from mental illness and need treatment. Mental Health Issues in the Criminal Justice System examines a wide range of the latest research and learned perspectives focusing on the intersection of mental health services and the criminal justice system. Top experts and academics discuss mental health treatment, its availability, it effectiveness, and just how cost effective it truly is to treat those in prisons and jails. This valuable text provides a broad interdisciplinary view of the topic and presents important qualitative and quantitative research of specific topics, such as the effectiveness of prisoner representatives, the causal link between incarceration and mental illness, and the expanding rates of correctional offenders with mental illness. Mental Health Issues in the Criminal Justice System discusses a wide range of pertinent topics focusing on the viability and functioning of mental health treatment models in prisons and jails. Recommendations on desired correctional mental health programs are presented, along with strategies to better provide therapeutic services. Respected experts provide practical suggestions on research that needs to be addressed in the future. The book is extensively referenced and includes several tables and figures to clearly present data. Other topics in Mental Health Issues in the Criminal Justice System include: the prevalence of mental illness in jails and prisons—and the duty society has to provide appropriate mental health treatment three components critical to the success of jail diversion programs ethics of doing research on prisoners an extended care community corrections model the experience of mitigation experts in first degree murder cases in the penalty phase of the trial the criminalization of the mentally ill because of fragmentation of mental health services correctional offenders with mental illness (OMIs)—and their differences from the general offender population the role of the helping alliance in juvenile probation settings and much more! Mental Health Issues in the Criminal Justice System is a timely, insightful text for anyone in the criminal justice or mental health fields, educators, graduate students, and upper-level undergraduate students.
Fully updated and revised, this new edition of a highly successful text provides students, clinicians, and academics with a thorough introduction to aging and mental health. The third edition of Aging and Mental Health is filled with new updates and features, including the impact of the DSM-5 on diagnosis and treatment of older adults. Like its predecessors, it uses case examples to introduce readers to the field of aging and mental health. It also provides both a synopsis of basic gerontology needed for clinical work with older adults and an analysis of several facets of aging well. Introductory chapters are followed by a series of chapters that describe the major theoretical models used to understand mental health and mental disorders among older adults. Following entries are devoted to the major forms of mental disorders in later life, with a focus on diagnosis, assessment, and treatment issues. Finally, the book focuses on the settings and contexts of professional mental health practice and on emerging policy issues that affect research and practice. This combination of theory and practice helps readers conceptualize mental health problems in later life and negotiate the complex decisions involved with the assessment and treatment of those problems. Features new material on important topics including positive mental health, hoarding disorder, chronic pain, housing, caregiving, and ethical and legal concerns Substantially revised and updated throughout, including reference to the DSM-5 Offers chapter-end recommendations of websites for further information Includes discussion questions and critical thinking questions at the end of each chapter Aging and Mental Health, Third Edition is an ideal text for advanced undergraduate and graduate students in psychology, for service providers in psychology, psychiatry, social work, and counseling, and for clinicians who are experienced mental health service providers but who have not had much experience working specifically with older adults and their families.
This enjoyable book first introduces sign language and communication, follows with a history of sign languages in general, then delves into the structure of American Sign Language (ASL). Later chapters outline the special skills of fingerspelling and assess artificial sign systems and their net worth. Language in Motion also describes the process required to learn sign language, then explains how to use it to communicate in the Deaf community. Appendices featuring the manual alphabets of three countries complete this enriching book.
Why the Gig Academy is the dominant organizational form within the higher education economy—and its troubling implications for faculty, students, and the future of college education. Over the past two decades, higher education employment has undergone a radical transformation with faculty becoming contingent, staff being outsourced, and postdocs and graduate students becoming a larger share of the workforce. For example, the faculty has shifted from one composed mostly of tenure-track, full-time employees to one made up of contingent, part-time teachers. Non-tenure-track instructors now make up 70 percent of college faculty. Their pay for teaching eight courses averages $22,400 a year—less than the annual salary of most fast-food workers. In The Gig Academy, Adrianna Kezar, Tom DePaola, and Daniel T. Scott assess the impact of this disturbing workforce development. Providing an overarching framework that takes the concept of the gig economy and applies it to the university workforce, this book scrutinizes labor restructuring across both academic and nonacademic spheres. By synthesizing these employment trends, the book reveals the magnitude of the problem for individual workers across all institutional types and job categories while illustrating the damaging effects of these changes on student outcomes, campus community, and institutional effectiveness. A pointed critique of contemporary neoliberalism, the book also includes an analysis of the growing divide between employees and administrators. The authors conclude by examining the strengthening state of unionization among university workers. Advocating a collectivist, action-oriented vision for reversing the tide of exploitation, Kezar, DePaola, and Scott urge readers to use the book as a tool to interrogate the state of working relations on their own campuses and fight for a system that is run democratically for the benefit of all. Ultimately, The Gig Academy is a call to arms, one that encourages non-tenure-track faculty, staff, postdocs, graduate students, and administrative and tenure-track allies to unite in a common struggle against the neoliberal Gig Academy.
In July 1989 coal miners throughout the Soviet Union engaged in a massive strike that briefly captured world headlines and inaugurated a movement of strike committees that persisted across the Soviet/post-Soviet divide. In this collection of interviews and essays based on encounters over a three-year period, the voices of industrial workers and their families in the eastern Ukrainian city of Donetsk, the coal capital of the Donbass, are heard. The stories collected here allow Western readers to "hear" these people describe their struggles for survival and identity in conditions of economic, political and social disintegration/transformation; and to analyze their testimonies and other kinds of texts in terms of changing meanings of work, gender, and national identity. Included are an examination of the "older generation" that came of age during the Stalin era; an analysis of the miners' movement and the trade union politics that emerged out of the strike of 1989; and a focus on the social crises and cultural disorientations accompanying Ukrainian independence.
Comprehensive in scope and thoroughly up to date, Wintrobe’s Clinical Hematology, 15th Edition, combines the biology and pathophysiology of hematology as well as the diagnosis and treatment of commonly encountered hematological disorders. Editor-in-chief Dr. Robert T. Means, Jr., along with a team of expert section editors and contributing authors, provide authoritative, in-depth information on the biology and pathophysiology of lymphomas, leukemias, platelet destruction, and other hematological disorders as well as the procedures for diagnosing and treating them. Packed with more than 1,500 tables and figures throughout, this trusted text is an indispensable reference for hematologists, oncologists, residents, nurse practitioners, and pathologists.
Covering the broad range of benign and malignant disorders that affect the hematopoietic system, Hematopathology, 3rd Edition, remains your #1 source of authoritative information in this fast-changing field. Edited by Dr. Elaine Jaffe and a team of globally renowned, expert co-editors, it offers a wealth of up-to-date information in an easily accessible format, equipping you to deliver more accurate and actionable pathology reports. Comprehensive in scope, this highly illustrated, practical text is a must-have resource for residents and practicing pathologists alike. - Helps you navigate the latest changes in the classification of hematolymphoid neoplasms, providing guidance for use of both the International Consensus Classification (ICC) and 5th edition of the WHO classification. - Incorporates the latest molecular/cytogenetic information, regarding newly recognized entities and the latest diagnostic criteria. - Provides you with today's most effective guidance in evaluating specimens from the lymph nodes, bone marrow, peripheral blood, and more, with authoritative information on the pathogenesis, clinical and pathologic diagnosis, and treatment for each. - Details the latest insights on the molecular biology of benign and malignant hematologic disorders. - Features more than 1,100 high-quality color images that mirror the findings you encounter in practice. - Uses an easy-to-navigate, templated format with standard headings in each chapter. - Includes information on disease progression and prognosis, helping you better understand the clinical implications of diagnosis. - Shares the knowledge and expertise of new editors, Drs. Lisa Rimsza, Attilio Orazi, and Steven Swerdlow, providing expertise in molecular diagnostics, bone marrow and lymph node biopsies.
With the 13th edition, Wintrobe’s Clinical Hematology once again bridges the gap between the clinical practice of hematology and the basic foundations of science. Broken down into eight parts, this book provides readers with a comprehensive overview of: Laboratory Hematology, The Normal Hematologic System, Transfusion Medicine, Disorders of Red Cells, Hemostasis and Coagulation; Benign Disorders of Leukocytes, The Spleen and/or Immunoglobulins; Hematologic Malignancies, and Transplantation. Within these sections, there is a heavy focus on the morphological exam of the peripheral blood smear, bone marrow, lymph nodes, and other tissues. With the knowledge about gene therapy and immunotherapy expanding, new, up-to-date information about the process and application of these therapies is included. Likewise, the editors have completely revised material on stem cell transplantation in regards to both malignant and benign disorders, graft versus host disease, and the importance of long-term follow-up of transplantation survivors.
This is an examination of the emotional and psychological effects of job loss along with practical strategies for coping. All kinds of layoffs, from plant closings, work slow downs, corporate downsizings, and mergers and acquisitions are discussed, illustrated with case studies of Pittsburgh steel workers and Florida Space Coast engineers. The authors document the turmoil that often follows layoffs and the ways that many laid-off workers have succeeded in putting their lives back together. They also evaluate available support services, including extended benefits, outplacement, and retraining programmes.
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