Daniel A. Escobar's Books

Autophagy

Chapter 17. Sepsis-Induced Autophagy is a Protective Mechanism against Cell Death

By: Daniel A. Escobar,Ana M. Botero,Hernando Gomez,Brian S. Zuckerbraun

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Autophagy

Chapter 17. Sepsis-Induced Autophagy is a Protective Mechanism against Cell Death

By: Daniel A. Escobar,Ana M. Botero,Hernando Gomez,Brian S. Zuckerbraun

In this chapter we discuss sepsis-induced inflammation and organ dysfunction, as well as the role of autophagy as a protective cell signaling mechanism. Sepsis is a leading cause of death worldwide, and is the most common precipitant of organ dysfunction. It has been noted that a minimal amount of cell death is present in patients who succumb to sepsis-induced organ failure and that, after the septic insult has passed, organs have the potential to regain function, suggesting a hibernating state of the cell in order to protect it from apoptosis and death. The cellular and molecular processes involved in sepsis are complex, and continue to be elucidated. Autophagy has been extensively studied in recent decades and an exponential increase in knowledge regarding this physiological pathway used by cells has been found. It is known to be activated under stress conditions in order to protect the cell from dying. In the setting of sepsis it has been demonstrated to play an important role for recycling of unhealthy mitochondria and damaged organelles, thus decreasing injury by ROS and providing nutrients and amino acids that the cell can use in this stressful environment. The purpose of this chapter is to review what is known about autophagy in sepsis and describe the contributing mechanisms by which autophagy can protect against organ injury.

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Elsevier Inc. Chapters

Published Date

ISBN 10

0128069430

ISBN 13

9780128069431

Biostatistics

A Foundation for Analysis in the Health Sciences

By: Wayne W. Daniel,Chad L. Cross

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Biostatistics

A Foundation for Analysis in the Health Sciences

By: Wayne W. Daniel,Chad L. Cross

The ability to analyze and interpret enormous amounts of data has become a prerequisite for success in allied healthcare and the health sciences. Now in its 11th edition, Biostatistics: A Foundation for Analysis in the Health Sciences continues to offer in-depth guidance toward biostatistical concepts, techniques, and practical applications in the modern healthcare setting. Comprehensive in scope yet detailed in coverage, this text helps students understand—and appropriately use—probability distributions, sampling distributions, estimation, hypothesis testing, variance analysis, regression, correlation analysis, and other statistical tools fundamental to the science and practice of medicine. Clearly-defined pedagogical tools help students stay up-to-date on new material, and an emphasis on statistical software allows faster, more accurate calculation while putting the focus on the underlying concepts rather than the math. Students develop highly relevant skills in inferential and differential statistical techniques, equipping them with the ability to organize, summarize, and interpret large bodies of data. Suitable for both graduate and advanced undergraduate coursework, this text retains the rigor required for use as a professional reference.

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Page Count

720

Publisher

Wiley

Published Date

ISBN 10

1119282373

ISBN 13

9781119282372

The Spectacular City

Violence and Performance in Urban Bolivia

By: Daniel M. Goldstein

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The Spectacular City

Violence and Performance in Urban Bolivia

By: Daniel M. Goldstein

Since the Bolivian revolution in 1952, migrants have come to the city of Cochabamba, seeking opportunity and relief from rural poverty. They have settled in barrios on the city’s outskirts only to find that the rights of citizens—basic rights of property and security, especially protection from crime—are not available to them. In this ethnography, Daniel M. Goldstein considers the significance of and similarities between two kinds of spectacles—street festivals and the vigilante lynching of criminals—as they are performed in the Cochabamba barrio of Villa Pagador. By examining folkloric festivals and vigilante violence within the same analytical framework, Goldstein shows how marginalized urban migrants, shut out of the city and neglected by the state, use performance to assert their national belonging and to express their grievances against the inadequacies of the state’s official legal order. During the period of Goldstein’s fieldwork in Villa Pagador in the mid-1990s, residents attempted to lynch several thieves and attacked the police who tried to intervene. Since that time, there have been hundreds of lynchings in the poor barrios surrounding Cochabamba. Goldstein presents the lynchings of thieves as a form of horrific performance, with elements of critique and political action that echo those of local festivals. He explores the consequences and implications of extralegal violence for human rights and the rule of law in the contemporary Andes. In rich detail, he provides an in-depth look at the development of Villa Pagador and of the larger metropolitan area of Cochabamba, illuminating a contemporary Andean city from both microethnographic and macrohistorical perspectives. Focusing on indigenous peoples’ experiences of urban life and their attempts to manage their sociopolitical status within the broader context of neoliberal capitalism and political decentralization, The Spectacular City highlights the deep connections between performance, law, violence, and the state.

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290

Publisher

Duke University Press

Published Date

ISBN 10

0822386011

ISBN 13

9780822386018

Ashcraft's Pediatric Surgery E-Book

By: George W. Holcomb,J. Patrick Murphy,Daniel J Ostlie

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Ashcraft's Pediatric Surgery E-Book

By: George W. Holcomb,J. Patrick Murphy,Daniel J Ostlie

Acclaimed for its unsurpassed readability and manageable scope, Ashcraft’s Pediatric Surgery presents authoritative, practical guidance on treating the entire range of general surgical and urological problems in infants, children, and adolescents. State-of-the-art, expert coverage equips you to implement all the latest approaches and achieve optimal outcomes for all of your patients. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Make the most effective use of today’s best open and minimally invasive techniques, including single-site umbilical laparoscopic surgery, with guidance from internationally recognized experts in the field. Focus on evidence-based treatments and outcomes to apply today’s best practices. Stay current with timely topics thanks to brand-new chapters on Choledochal Cyst and Gallbladder Disease, Tissue Engineering, and Ethics in Pediatric Surgery, plus comprehensive updates throughout. Hone and expand your surgical skills by watching videos of minimally invasive procedures for recto urethral fistula, biliary atresia, laparoscopic splenectomy, uterine horn, and more. Grasp the visual nuances of surgery from over 1,000 images depicting today’s best surgical practices.

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1191

Publisher

Elsevier Health Sciences

Published Date

ISBN 10

0323187366

ISBN 13

9780323187367

The Developing Mind

How Relationships and the Brain Interact to Shape Who We Are

By: Daniel J. Siegel

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The Developing Mind

How Relationships and the Brain Interact to Shape Who We Are

By: Daniel J. Siegel

This highly influential work--now in a revised and expanded third edition incorporating major advances in the field--gives clinicians, educators, and students a new understanding of what the mind is, how it grows, and how to promote healthy development and resilience. Daniel J. Siegel synthesizes cutting-edge research from multiple disciplines, revealing the ways in which neural processes are fundamentally shaped by interpersonal relationships throughout life. And even when early experiences are not optimal, building deeper connections to other people and to one's own internal experience remains a powerful resource for growth. Professors praise the book’s utility in courses from developmental psychology and child development to neuroscience and counseling. New to This Edition *Incorporates findings from a huge body of recent research; over 1,000 citations added. *Revisits and refines the core hypotheses of interpersonal neurobiology. *Chapter on the experience of belonging and the development of identity. *New or expanded discussions of behavioral epigenetics, the default mode network of the brain, social neuroscience, cultural and gender issues, theory of mind, the Wheel of Awareness contemplative practice, the science of consciousness, and more.

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Page Count

690

Publisher

Guilford Publications

Published Date

ISBN 10

1462542832

ISBN 13

9781462542833

Operative Pediatric Surgery

By: Moritz Ziegler,Richard G. Azizkhan,Daniel von Allmen,Thomas R. Weber

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Operative Pediatric Surgery

By: Moritz Ziegler,Richard G. Azizkhan,Daniel von Allmen,Thomas R. Weber

The definitive illustrated resource on the surgical management of infants and children -- with an emphasis on operative technique Operative Pediatric Surgery, Second Edition is a comprehensive, well-illustrated text that delivers expert coverage of the pathophysiology, diagnosis, and treatment of pediatric surgical disease. This detailed single-volume resource is enhanced by numerous drawings, radiographs, and photographs that illustrate the authors’ preferred operative techniques. Wherever appropriate, diagnostic and care guidelines are also included. Operative Pediatric Surgery, Second Edition is divided into 11 sections that include a total of 100 chapters. The book opens with an informative General Principles section that provides important background information on topics such as the history of pediatric surgery, ethical considerations, pediatric surgical critical care, and office-based ambulatory surgery. The rest of the text is organized primarily by organ, enhanced by a timely section on solid organ transplantation. In this Second Edition, each chapter author has thoroughly updated and refreshed their topic, and in many instances, minimally invasive operative techniques are included with open approaches. There are also exciting new chapters on: Hypospadias Vesicoureteral reflux Non-rhabdomyosarcoma soft tissue sarcomas Gastrointestinal polyps and cancer Adolescent bariatric surgery Operative Pediatric Surgery will prove to be an essential reference for pediatric surgeons seeking optimal diagnosis and treatment approaches for their patients.

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1424

Publisher

McGraw Hill Professional

Published Date

ISBN 10

0071667814

ISBN 13

9780071667814

Elinor Ostrom and the Bloomington School of Political Economy

A Framework for Policy Analysis

By: Daniel H. Cole,Michael D. McGinnis

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Elinor Ostrom and the Bloomington School of Political Economy

A Framework for Policy Analysis

By: Daniel H. Cole,Michael D. McGinnis

In addition to winning the 2009 Nobel Prize in Economic Sciences for her path-breaking research on “economic governance, especially the commons,” Elinor (Lin) Ostrom also made important contributions to other fields of political economy and public policy. This four-volume compendium of papers written by Lin (often with coauthors, most notably her husband, Vincent), along with papers by others expanding on her work, brings together the strands of her entire empirical, analytical, theoretical, and methodological research program. Together with Vincent’s important theoretical contributions, they defined a distinctive “Bloomington School” of political-economic thought. Volume 3 collects explores the historical development of the Institutional Analysis and Development (IAD) framework, illustrates its application to a wide range of specific policy problems, and highlights recent extensions that ensure it will remain a vibrant focus of research for years to come. The IAD framework emerged from a long series of interdisciplinary collaborative research projects, but the guiding figure in its development was Elinor Ostrom. Anyone familiar with the full range of her research will recognize common presuppositions and themes for which she used the IAD framework as an organizing device. This book collects examples of policy-relevant applications of IAD to a wide range of policy sectors. In a fundamental sense, the IAD framework helps us understand how Ostrom’s mind worked when she approached a particular problem of policy, and it highlights those factors that she asserted needed to be considered in any complete analysis. Unfortunately, she did not leave us a complete or definitive guidebook on how to apply this framework. This volume collects important components of such a guidebook from a wide range of sources, including previously unpublished papers, and as such it should help anyone seeking to use this framework to analyze a variety of policy areas.

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Page Count

457

Publisher

Lexington Books

Published Date

ISBN 10

0739191101

ISBN 13

9780739191101

Book's by Daniel A. Escobar

Autophagy

Autophagy

Biostatistics

Biostatistics

The Spectacular City

The Spectacular City

Ashcraft's Pediatric Surgery E-Book

Ashcraft's Pediatric Surgery E-Book

The Developing Mind

The Developing Mind

Operative Pediatric Surgery

Operative Pediatric Surgery

Elinor Ostrom and the Bloomington School of Political Economy

Elinor Ostrom and the Bloomington School of Political Economy

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